Математическая модель потоков покупателей двухпродуктовой торговой компании в виде системы массового обслуживания с повторными обращениями к блокам

Построена математическая модель формирования потока покупателей торговой компании в виде системы параллельного обслуживания кратных заявок с повторным обращением и неограниченным числом обслуживающих приборов, получено выражение для математического ожидания капитала торговой компании, а также найдено условие для существования максимума этой функции. Для конкретного примера определено оптимальное отношение стоимости подарка к средней стоимости покупки, обеспечивающее максимальную прибыль компании

Heat transfer in separated flows on the pressure side of turbine blades

Heat transfer in separated flows on the pressure side of a typical high lift turbine profile is numerically investigated by means of an in-house CFD code. The numerical code was first validated on attached flows in turbine blades. To obtain flow separation cases, the profile is subject to large negative incidences so that a separation bubble is obtained at the pressure side. The numerical results are compared to available experimental data for code validation. It is shown how local minima and maxima values of the heat transfer coefficient are related to the separation and reattachment points, where the velocity component perpendicular to the wall is shown to have a significant effect on the heat transfe

European economic constitution and the transformation of democracy : on class and the state of law

In the context of contemporary analyses of the Europe Union as a post-democratic form of economic governance, this article explores the (ordo)liberal character of monetary union as a regime of imposed liberty. The argument holds that rather than forcing the member states into retreat, the economic constitution of Europe strengthens their liberal foundation, securing their utility as the organised force of a mode of social reproduction founded on free labour. It develops the character of the liberal state as the political form of a free market economy with reference to Adam Smith’s classical political economy and the German ordoliberal tradition, which calls for a rule-based system of federated forms of economic governance to secure a free labour economy in conditions of mass democratic aspirations for a freedom from want. It explores the rationale of the ordoliberal distinction between the liberal character and the democratic character of the state and, in this context, assesses the meaning of liberal democracy in a post-democratic Eurozone

Polar Invasion and Translocation of Neisseria meningitidis and Streptococcus suis in a Novel Human Model of the Blood-Cerebrospinal Fluid Barrier

Acute bacterial meningitis is a life-threatening disease in humans. Discussed as entry sites for pathogens into the brain are the blood-brain and the blood-cerebrospinal fluid barrier (BCSFB). Although human brain microvascular endothelial cells (HBMEC) constitute a well established human in vitro model for the blood-brain barrier, until now no reliable human system presenting the BCSFB has been developed. Here, we describe for the first time a functional human BCSFB model based on human choroid plexus papilloma cells (HIBCPP), which display typical hallmarks of a BCSFB as the expression of junctional proteins and formation of tight junctions, a high electrical resistance and minimal levels of macromolecular flux when grown on transwell filters. Importantly, when challenged with the zoonotic pathogen Streptococcus suis or the human pathogenic bacterium Neisseria meningitidis the HIBCPP show polar bacterial invasion only from the physiologically relevant basolateral side. Meningococcal invasion is attenuated by the presence of a capsule and translocated N. meningitidis form microcolonies on the apical side of HIBCPP opposite of sites of entry. As a functionally relevant human model of the BCSFB the HIBCPP offer a wide range of options for analysis of disease-related mechanisms at the choroid plexus epithelium, especially involving human pathogens

Effect of roughness and unsteadiness on the performance of a new LPT blade at low Reynolds numbers

This paper presents a study of the performance of a high lift profile for low pressure turbines at Reynolds numbers lower than in previous investigations. The separate and combined effects of roughness and wake passing are compared. The effect of incidence on cascade losses is also evaluated. The experimental investigation was carried out in the high speed wind tunnel of Whittle Laboratory, University of Cambridge. This is a closed circuit, continuous wind tunnel where the Reynolds number and Mach number can be fixed independently. The unsteadiness caused by wake passing in front of the blades is reproduced using a wake generator with rotating bars. The results obtained confirm that the beneficial effect of unsteadiness on losses is also present at the lowest Reynolds number examined (Re3 = 0.2×105). Roughening the surface also had a beneficial effect on the losses but this effect vanishes at the lower Reynolds numbers, i.e. (Re3 0.3×105), where the surface becomes hydraulically smooth. The present study suggests that a blade with as-cast surface roughness has a lower loss than a polished one