Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

The two major isoforms of the oncogenic Bcr-Abl tyrosine kinase, p210 and p190, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p190 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein interactions and activated signaling pathways that may be associated with the different diseases driven by p210 and p190 are unknown. We have performed a quantitative comparative proteomics study of p210 and p190. Strong differences in the interactome and tyrosine phosphoproteome were found and validated. Whereas the AP2 adaptor complex that regulates clathrin-mediated endocytosis interacts preferentially with p190, the phosphatase Sts1 is enriched with p210. Stronger activation of the Stat5 transcription factor and the Erk1/2 kinases is observed with p210, whereas Lyn kinase is activated by p190. Our findings provide a more coherent understanding of Bcr-Abl signaling, mechanisms of leukemic transformation, resulting disease pathobiology and responses to kinase inhibitors.Leukemia accepted article preview online, 23 January 2017. doi:10.1038/leu.2017.36

Machine Autonomy : Definition, Approaches, Challenges and Research Gaps

Postprin

Note sur le budget d'une famille Ottomane au debut du XXéme siecle.

Donated by Klaus KreiserReprint from : Revue d'Histoire Maghrébine, Tunis 31–32, 1983

THE QUALITY OF BEHAVIORAL AND ENVIRONMENTAL INDICATORS USED TO INFER THE INTENTION TO CHANGE LANES

Summary: This study focuses on the examination and comparison of selected behavioural and environmental indicators that predict the intention to change lanes. These indicators were chosen from previous driving studies and driver models. The data were gathered in a field study with an instrumented car that can log data from the driver, the car, and the environment. The collected data were analysed and modelled with the help of a “knowledge discovery framework” (Georgeon, Mille, & Bellet, 2006). The first analysis of all lane changes caused by a slow leading vehicle focuses on the following indicators: glance to the left outside mirror, turn signal, and lane crossing. It is shown that the glance to the left outside mirror could serve as a predictor with a high potential to get information about the intention to change lanes in a very early stage. However, it is important to combine this predictor with additional predictors to avoid a high false alarm rate

The quality of behavioral and environmental indicators used to infer the intention to change lanes

International audienceThis study focuses on the examination and comparison of selected behavioural and environmental indicators that predict the intention to change lanes. These indicators were chosen from previous driving studies and driver models. The data were gathered in a field study with an instrumented car that can log data from the driver, the car, and the environment. The collected data were analysed and modelled with the help of a "knowledge discovery framework" (Georgeon, Mille, & Bellet, 2006). The first analysis of all lane changes caused by a slow leading vehicle focuses on the following indicators: glance to the left outside mirror, turn signal, and lane crossing. It is shown that the glance to the left outside mirror could serve as a predictor with a high potential to get information about the intention to change lanes in a very early stage. However, it is important to combine this predictor with additional predictors to avoid a high false alarm rate

Cognitive activity modelling: a case study of lane change schemas and sensation seeking

We propose a method to investigate differences of driving at a tactical level, between different categories of drivers. We analysed the naturalistic driving performance of 19 French drivers using an instrumented vehicle. We assessed their sensation seeking scores with the Zuckerman questionnaire. We observed a significant correlation between their sensation seeking score and their mean speed on motorway. We set up a method to model their tactical behaviour and investigate possible correlation between their sensation seeking score and their tendency to perform certain types of behaviour. We applied it to the study of lane changes on motorways. We could model two categories of lane changes but we show that they were not correlated with the sensation seeking score. Despite this negative first result, we are proposing an innovative approach for this kind of study