Design and testing of a microchannel reactor for the PROX reaction

The different steps for manufacturing a microchannel reactor for the PROX reaction are discussed. Transient Liquid Phase bonding (TLP) using a Ni-B-Si amorphous melt spun is used for joining micromilled Al-alloyed ferritic stainless steel plates followed by recrystallization at 1200°C for 5h. A CuOx-CeO2 catalyst synthesized by the coprecipitation method was washcoated on the microchannel block resulting in a homogenous 20-30μm thick layer. The catalytic activity for CO-PROX reaction is similar in both the powder catalyst and the microchannel coated reactor but the selectivity is higher in the microchannel reactor. © 2010 Elsevier B.V.Ministerio de Ciencia e Innovación MAT-2006-12386-C05, ENE-2009-14522-C05-01, BES-2007-14409, BES-2007-15297Junta de Andalucía P06-TEP-0848

Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in Wistar rats

Methylmercury (MeHg) is an organic bioaccumulated mercury derivative that strongly affects the environment and represents a public health problem primarily to riparian communities in South America. Our objective was to investigate the hepatic and neurological effects of MeHg exposure during the phases foetal and breast-feeding and adult in Wistar rats. Wistar rats (n = 10) were divided into 3 groups. Control group received mineral oil; The simple exposure (SE) group was exposed only in adulthood (0.5 mg/kg/day); and double exposure (DE) was pre-exposed to MeHg 0.5 mg/kg/day during pregnancy and breastfeeding (±40 days) and re-exposed to MeHg for 45 days from day 100. After, we evaluated possible abnormalities. Behavioral and biochemical parameters in liver and occipital cortex (CO), markers of liver injury, redox and AKT/GSK3β/mTOR signaling pathway. Our results showed that both groups treated with MeHg presented significant alterations, such as decreased locomotion and exploration and impaired visuospatial perception. The rats exposed to MeHg showed severe liver damage and increased hepatic glycogen concentration. The MeHg groups showed significant impairment in redox balance and oxidative damage to liver macromolecules and CO. MeHg upregulated the AKT/GSK3β/mTOR pathway and the phosphorylated form of the Tau protein. In addition, we found a reduction in NeuN and GFAP immunocontent. These results represent the first approach to the hepatotoxic and neural effects of foetal and adult MeHg exposure

ANIMAL MODELS FOR THE STUDY OF LEISHMANIASIS IMMUNOLOGY

Leishmaniasis remains a major public health problem worldwide and is classified as Category I by the TDR/WHO, mainly due to the absence of control. Many experimental models like rodents, dogs and monkeys have been developed, each with specific features, in order to characterize the immune response to Leishmania species, but none reproduces the pathology observed in human disease. Conflicting data may arise in part because different parasite strains or species are being examined, different tissue targets (mice footpad, ear, or base of tail) are being infected, and different numbers (“low” 1×102 and “high” 1×106) of metacyclic promastigotes have been inoculated. Recently, new approaches have been proposed to provide more meaningful data regarding the host response and pathogenesis that parallels human disease. The use of sand fly saliva and low numbers of parasites in experimental infections has led to mimic natural transmission and find new molecules and immune mechanisms which should be considered when designing vaccines and control strategies. Moreover, the use of wild rodents as experimental models has been proposed as a good alternative for studying the host-pathogen relationships and for testing candidate vaccines. To date, using natural reservoirs to study Leishmania infection has been challenging because immunologic reagents for use in wild rodents are lacking. This review discusses the principal immunological findings against Leishmania infection in different animal models highlighting the importance of using experimental conditions similar to natural transmission and reservoir species as experimental models to study the immunopathology of the disease

This supplementary material is created to support the data described in the manuscript: Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccine

Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccin

This supplementary material is created to support the data described in the manuscript: Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccine

Supplementary material: Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccin

Complementary material

Additional material of the article: Photophysical study and in vitro approach against Leishmania panamensis of dicloro-5,10,15,20-tetrakis(4-bromophenyl)porphyrinato Sn(IV

This supplementary material is created to support the data described in the manuscript: Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccine

Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccin

Artículo estrés académico y estilos de vida en estudiantes de ciencias de la salud

Material complementario Artículo estrés académico y estilos de vida en estudiantes de ciencias de la saludTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

This supplementary material is created to support the data described in the manuscript: Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccine

Supplementary material: Covid-19 in Cartagena and the Bolívar Department, Colombia. Current status, perspectives and challenges until the arrival of the vaccin

Complementary material, Dietary habits and nutritional status in students of the University Corporation Rafael Nunez, Cartagena-Colombia

Raw data and surve