738 research outputs found
On the Role of Pre-Determined Rules for HRM Policies
Using simple game-theoretical models, this paper studies the role of pre-determined rules for HRM policies. We consider a model in which HRM decisions affect employees' self-images and thereby their motivation. We show that in the absence of written rules, managers are too reluctant (1) to differentiate between employees on the basis of their abilities, and (2) to terminate employment of employees on probation. Generally, organizations benefit from committing to strict rules for various HRM practices
A reference relative time-scale as an alternative to chronological age for cohorts with long follow-up
Background: Epidemiologists have debated the appropriate time-scale for cohort survival studies; chronological age or time-on-study being two such time-scales. Importantly, assessment of risk factors may depend on the choice of time-scale. Recently, chronological or attained age has gained support but a case can be made for a ‘reference relative time-scale’ as an alternative which circumvents difficulties that arise with this and other scales. The reference relative time of an individual participant is the integral of a reference population hazard function between time of entry and time of exit of the individual. The objective here is to describe the reference relative time-scale, illustrate its use, make comparison with attained age by simulation and explain its relationship to modern and traditional epidemiologic methods.
Results: A comparison was made between two models; a stratified Cox model with age as the time-scale versus an un-stratified Cox model using the reference relative time-scale. The illustrative comparison used a UK cohort of cotton workers, with differing ages at entry to the study, with accrual over a time period and with long follow-up. Additionally, exponential and Weibull models were fitted since the reference relative time-scale analysis need not be restricted to the Cox model. A simulation study showed that analysis using the reference relative time-scale and analysis using chronological age had very similar power to detect a significant risk factor and both were equally unbiased. Further, the analysis using the reference relative time-scale supported fully-parametric survival modelling and allowed percentile predictions and mortality curves to be constructed.
Conclusions: The reference relative time-scale was a viable alternative to chronological age, led to simplification of the modelling process and possessed the defined features of a good time-scale as defined in reliability theory. The reference relative time-scale has several interpretations and provides a unifying concept that links contemporary approaches in survival and reliability analysis to the traditional epidemiologic methods of Poisson regression and standardised mortality ratios. The community of practitioners has not previously made this connection
Advances in ab-initio theory of Multiferroics. Materials and mechanisms: modelling and understanding
Within the broad class of multiferroics (compounds showing a coexistence of
magnetism and ferroelectricity), we focus on the subclass of "improper
electronic ferroelectrics", i.e. correlated materials where electronic degrees
of freedom (such as spin, charge or orbital) drive ferroelectricity. In
particular, in spin-induced ferroelectrics, there is not only a {\em
coexistence} of the two intriguing magnetic and dipolar orders; rather, there
is such an intimate link that one drives the other, suggesting a giant
magnetoelectric coupling. Via first-principles approaches based on density
functional theory, we review the microscopic mechanisms at the basis of
multiferroicity in several compounds, ranging from transition metal oxides to
organic multiferroics (MFs) to organic-inorganic hybrids (i.e. metal-organic
frameworks, MOFs)Comment: 22 pages, 9 figure
BaFe12O19 single-particle-chain nanofibers : preparation, characterization, formation principle, and magnetization reversal mechanism
BaFe12O19 single-particle-chain
nanofibers have been successfully prepared by
an electrospinning method and calcination
process, and their morphology, chemistry,
and crystal structure have been characterized
at the nanoscale. It is found that individual
BaFe12O19 nanofibers consist of single nanoparticles which are found to stack along the
nanofiber axis. The chemical analysis shows that the atomic ratio of Ba/Fe is 1:12, suggesting a
BaFe12O19 composition. The crystal structure of the BaFe12O19 single-particle-chain nanofibers
is proved to be M-type hexagonal. The single crystallites on each BaFe12O19 single-particlechain
nanofibers have random orientations. A formation mechanism is proposed based on
thermogravimetry/differential thermal analysis (TG-DTA), X-ray diffraction (XRD), and transmission
electron microscopy (TEM) at six temperatures, 250, 400, 500, 600, 650, and 800 �C.
The magnetic measurement of the BaFe12O19 single-particle-chain nanofibers reveals that the
coercivity reaches a maximum of 5943 Oe and the saturated magnetization is 71.5 emu/g at
room temperature. Theoretical analysis at the micromagnetism level is adapted to describe the
magnetic behavior of the BaFe12O19 single-particle-chain nanofibers
Resonant X-ray Scattering in Manganites - Study of Orbital Degree of Freedom -
Orbital degree of freedom of electrons and its interplay with spin, charge
and lattice degrees of freedom are one of the central issues in colossal
magnetoresistive manganites. The orbital degree of freedom has until recently
remained hidden, since it does not couple directly to most of experimental
probes. Development of synchrotron light sources has changed the situation; by
the resonant x-ray scattering (RXS) technique the orbital ordering has
successfully been observed . In this article, we review progress in the recent
studies of RXS in manganites. We start with a detailed review of the RXS
experiments applied to the orbital ordered manganites and other correlated
electron systems. We derive the scattering cross section of RXS where the
tensor character of the atomic scattering factor (ASF) with respect to the
x-ray polarization is stressed. Microscopic mechanisms of the anisotropic
tensor character of ASF is introduced and numerical results of ASF and the
scattering intensity are presented. The azimuthal angle scan is a unique
experimental method to identify RXS from the orbital degree of freedom. A
theory of the azimuthal angle and polarization dependence of the RXS intensity
is presented. The theoretical results show good agreement with the experiments
in manganites. Apart from the microscopic description of ASF, a theoretical
framework of RXS to relate directly to the 3d orbital is presented. The
scattering cross section is represented by the correlation function of the
pseudo-spin operator for the orbital degree of freedom. A theory is extended to
the resonant inelastic x-ray scattering and methods to observe excitations of
the orbital degree of freedom are proposed.Comment: 47 pages, 24 figures, submitted to Rep. Prog. Phy
In the Shadow of Celebrity? World-Class University Policies and Public Value in Higher Education
The growing popularity of the concept of world-class universities raises the question of whether investing in such universities is a worthwhile use of public resources. Does concentrating public resources on the most excellent universities improve the overall quality of a higher education system, especially if definitions of excellence and world-class are made by external ranking organizations? This paper addresses that question by developing a framework for weighing up trade-offs between institutional and system performance, focusing on the potential system-wide improvements which world-class university programmes (WCUPs) may bring. Because WCUPs are in a relatively early stage of their development, systemic effects are not yet clear. We therefore analyse the ex ante reasons that policy makers have for adopting WCUPs to see if they at least seek to create these systemic benefit
Killer acquisitions
This paper argues incumbent firms may acquire innovative targets solely to discontinue the target’s innovation projects and preempt future competition. We call such acquisitions “killer acquisitions.” We develop a model illustrating this phenomenon. Using pharmaceutical industry data, we show that acquired drug projects are less likely to be developed when they overlap with the acquirer’s existing product portfolio, especially when the acquirer’s market power is large due to weak competition or distant patent expiration. Conservative estimates indicate 5.3 percent to 7.4 percent of acquisitions in our sample are killer acquisitions. These acquisitions disproportionately occur just below thresholds for antitrust scrutiny
The impact of life tables adjusted for smoking on the socio-economic difference in net survival for laryngeal and lung cancer.
BACKGROUND: Net survival is a key measure in cancer control, but estimates for cancers that are strongly associated with smoking may be biased. General population life tables represent background mortality in net survival, but may not adequately reflect the higher mortality experienced by smokers. METHODS: Life tables adjusted for smoking were developed, and their impact on net survival and inequalities in net survival for laryngeal and lung cancers was examined. RESULTS: The 5-year net survival estimated with smoking-adjusted life tables was consistently higher than the survival estimated with unadjusted life tables: 7% higher for laryngeal cancer and 1.5% higher for lung cancer. The impact of using smoking-adjusted life tables was more pronounced in affluent patients; the deprivation gap in 5-year net survival for laryngeal cancer widened by 3%, from 11% to 14%. CONCLUSIONS: Using smoking-adjusted life tables to estimate net survival has only a small impact on the deprivation gap in survival, even when inequalities are substantial. Adjusting for the higher, smoking-related background mortality did increase the estimates of net survival for all deprivation groups, and may be more important when measuring the public health impact of differences or changes in survival, such as avoidable deaths or crude probabilities of death
The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth
Hydrogen sulfide (H2S) impairs mitochondrial respiration by potently inhibiting the heme-copper
cytochrome c oxidase. Since many prokaryotes, including Escherichia (E.) coli, generate H2S and
encounter high H2S levels particularly in the human gut, herein we tested whether bacteria can sustain
sulfide-resistant O2-dependent respiration. E. coli has three respiratory oxidases, the cyanide-sensitive
heme-copper bo3 enzyme and two bd oxidases much less sensitive to cyanide. Working on the isolated
enzymes, we found that, whereas the bo3 oxidase is inhibited by sulfide with half-maximal inhibitory
concentration IC50=1.1±0.1μM, under identical experimental conditions both bd oxidases are
insensitive to sulfide up to 58μM. In E. coli respiratory mutants, both O2-consumption and aerobic
growth proved to be severely impaired by sulfide when respiration was sustained by the bo3 oxidase
alone, but unaffected by ≤200μM sulfide when either bd enzyme acted as the only terminal oxidase.
Accordingly, wild-type E. coli showed sulfide-insensitive respiration and growth under conditions
favouring the expression of bd oxidases. In all tested conditions, cyanide mimicked the functional
effect of sulfide on bacterial respiration. We conclude that bd oxidases promote sulfide-resistant O2-
consumption and growth in E. coli and possibly other bacteria. The impact of this discovery is discussed
Age adjustment of cancer survival rates: methods, point estimates and standard errors
We empirically evaluated the performance of a new method for age adjustment of cancer survival compared to traditional age adjustment using data from the Finnish Cancer Registry. We find that both methods provide almost identical results for absolute survival but the new method generally provides more meaningful estimates of relative survival with often a smaller standard error
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