2,085 research outputs found
Playing in school or at home?
The goal of this study is to gain insight into the effects of context on educational game experience. Using a quasi-experimental setup, it compares the playing and learning experiences of adolescent players of the awareness-raising game PING in a domestic (N=135) and a school (N=121) context. Results indicate that both gaming (identification, enjoyment) and learning experiences are more intense in a home compared to a school context. However, all of the variance in gaming and part of that in learning experience are caused by longer playing times and better computer equipment. Moreover, the overall impact of context on perceived learning is significantly smaller than that of other experiential factors such as identification and enjoyment. Thus context should be considered as a significant yet relatively small determinant of learning experience
What do HIV-positive drug users’ experience tell us about their antiretroviral medications taking? An international integrated literature review
Particle detectors, geodesic motion, and the equivalence principle
It is shown that quantum particle detectors are not reliable probes of
spacetime structure. In particular, they fail to distinguish between inertial
and non-inertial motion in a general spacetime. To prove this, we consider
detectors undergoing circular motion in an arbitrary static spherically
symmetric spacetime, and give a necessary and sufficient condition for the
response function to vanish when the field is in the static vacuum state. By
examining two particular cases, we show that there is no relation, in general,
between the vanishing of the response function and the fact that the detector
motion is, or is not, geodesic. In static asymptotically flat spacetimes,
however, all rotating detectors are excited in the static vacuum. Thus, in this
particular case the static vacuum appears to be associated with a non-rotating
frame. The implications of these results for the equivalence principle are
considered. In particular, we discuss how to properly formulate the principle
for particle detectors, and show that it is satisfied.Comment: 14 pages. Revised version, with corrections; added two references.
Accepted for publication in Class. Quantum Gra
Reduction of circulating cholesterol and apolipoprotein levels during sepsis
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered cholesterol homeostasis. The host response during sepsis is mediated by cytokines and growth factors, which are capable of influencing lipid metabolism. Conversely lipoproteins are also capable of modulating cytokine production during the inflammatory response. Therefore the decrease in circulating cholesterol levels seems to play a crucial role in the pathophysiology of sepsis. In this review the interaction between cytokines and lipid metabolism and its clinical consequences will be discussed
Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease
Objectives
Innate lymphoid cells (ILCs) secrete cytokines, such as IFN-γ, IL-13 and IL-17, which are linked to chronic obstructive pulmonary disease (COPD). Here, we investigated the role of pulmonary ILCs in COPD pathogenesis.
Methods
Lung ILC subsets in COPD and control subjects were quantified using flow cytometry and associated with clinical parameters. Tissue localisation of ILC and T-cell subsets was determined by immunohistochemistry. Mice were exposed to air or cigarette smoke (CS) for 1, 4 or 24 weeks to investigate whether pulmonary ILC numbers and activation are altered and whether they contribute to CS-induced innate inflammatory responses.
Results
Quantification of lung ILC subsets demonstrated that ILC1 frequency in the total ILC population was elevated in COPD and was associated with smoking and severity of respiratory symptoms (COPD Assessment Test [CAT] score). All three ILC subsets localised near lymphoid aggregates in COPD. In the COPD mouse model, CS exposure in C57BL/6J mice increased ILC numbers at all time points, with relative increases in ILC1 in bronchoalveolar lavage (BAL) fluid. Importantly, CS exposure induced increases in neutrophils, monocytes and dendritic cells that remained elevated in Rag2/Il2rg-deficient mice that lack adaptive immune cells and ILCs. However, CS-induced CXCL1, IL-6, TNF-α and IFN-γ levels were reduced by ILC deficiency.
Conclusion
The ILC1 subset is increased in COPD patients and correlates with smoking and severity of respiratory symptoms. ILCs also increase upon CS exposure in C57BL/6J mice. In the absence of adaptive immunity, ILCs contribute to CS-induced pro-inflammatory mediator release, but are redundant in CS-induced innate inflammation
Shell model calculation of the beta- and beta+ partial halflifes of 54Mn and other unique second forbidden beta decays
The nucleus 54Mn has been observed in cosmic rays. In astrophysical
environments it is fully stripped of its atomic electrons and its decay is
dominated by the beta- branch to the 54Fe ground state. Application of 54Mn
based chronometer to study the confinement of the iron group cosmic rays
requires knowledge of the corresponding halflife, but its measurement is
impossible at the present time. However, the branching ratio for the related
beta+ decay of 54Mn was determined recently. We use the shell model with only a
minimal truncation and calculate both beta+ and beta- decay rates of 54Mn. Good
agreement for the beta+ branch suggests that the calculated partial halflife of
the beta- decay, (4.94 \pm 0.06) x 10^5 years, should be reliable. However,
this halflife is noticeably shorter than the range 1-2 x 10^6 y indicated by
the fit based on the 54Mn abundance in cosmic rays. We also evaluate other
known unique second forbidden beta decays from the nuclear p and sd shells
(10Be, 22Na, and two decay branches of 26Al) and show that the shell model can
describe them with reasonable accuracy as well.Comment: 4 pages, RevTeX, 2 figure
On the structure of phase transition maps for three or more coexisting phases
This paper is partly based on a lecture delivered by the author at the ERC
workshop "Geometric Partial Differential Equations" held in Pisa in September
2012. What is presented here is an expanded version of that lecture.Comment: 23 pages, 6 figure
Search for Early Gamma-ray Production in Supernovae Located in a Dense Circumstellar Medium with the Fermi LAT
Supernovae (SNe) exploding in a dense circumstellar medium (CSM) are
hypothesized to accelerate cosmic rays in collisionless shocks and emit GeV
gamma rays and TeV neutrinos on a time scale of several months. We perform the
first systematic search for gamma-ray emission in Fermi LAT data in the energy
range from 100 MeV to 300 GeV from the ensemble of 147 SNe Type IIn exploding
in dense CSM. We search for a gamma-ray excess at each SNe location in a one
year time window. In order to enhance a possible weak signal, we simultaneously
study the closest and optically brightest sources of our sample in a
joint-likelihood analysis in three different time windows (1 year, 6 months and
3 months). For the most promising source of the sample, SN 2010jl (PTF10aaxf),
we repeat the analysis with an extended time window lasting 4.5 years. We do
not find a significant excess in gamma rays for any individual source nor for
the combined sources and provide model-independent flux upper limits for both
cases. In addition, we derive limits on the gamma-ray luminosity and the ratio
of gamma-ray-to-optical luminosity ratio as a function of the index of the
proton injection spectrum assuming a generic gamma-ray production model.
Furthermore, we present detailed flux predictions based on multi-wavelength
observations and the corresponding flux upper limit at 95% confidence level
(CL) for the source SN 2010jl (PTF10aaxf).Comment: Accepted for publication in ApJ. Corresponding author: A. Franckowiak
([email protected]), updated author list and acknowledgement
Eight gamma-ray pulsars discovered in blind frequency searches of Fermi LAT data
We report the discovery of eight gamma-ray pulsars in blind frequency
searches using the LAT, onboard the Fermi Gamma-ray Space Telescope. Five of
the eight pulsars are young (tau_c10^36 erg/s), and
located within the Galactic plane (|b|<3 deg). The remaining three are older,
less energetic, and located off the plane. Five pulsars are associated with
sources included in the LAT bright gamma-ray source list, but only one, PSR
J1413-6205, is clearly associated with an EGRET source. PSR J1023-5746 has the
smallest characteristic age (tau_c=4.6 kyr) and is the most energetic
(Edot=1.1E37 erg/s) of all gamma-ray pulsars discovered so far in blind
searches. PSRs J1957+5033 and J2055+25 have the largest characteristic ages
(tau_c~1 Myr) and are the least energetic (Edot~5E33 erg/s) of the
newly-discovered pulsars. We present the timing models, light curves, and
detailed spectral parameters of the new pulsars. We used recent XMM
observations to identify the counterpart of PSR J2055+25 as XMMU
J205549.4+253959. In addition, publicly available archival Chandra X-ray data
allowed us to identify the likely counterpart of PSR J1023-5746 as a faint,
highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption
indicates that this could be among the most distant gamma-ray pulsars detected
so far. PSR J1023-5746 is positionally coincident with the TeV source HESS
J1023-575, located near the young stellar cluster Westerlund 2, while PSR
J1954+2836 is coincident with a 4.3 sigma excess reported by Milagro at a
median energy of 35 TeV. Deep radio follow-up observations of the eight pulsars
resulted in no detections of pulsations and upper limits comparable to the
faintest known radio pulsars, indicating that these can be included among the
growing population of radio-quiet pulsars in our Galaxy being uncovered by the
LAT, and currently numbering more than 20.Comment: Submitted to Ap
Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT
The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope
routinely detects the highly dust-absorbed, reddened, and MeV-peaked flat
spectrum radio quasar PKS 1830-211 (z=2.507). Its apparent isotropic gamma-ray
luminosity (E>100 MeV) averaged over 3 years of observations and peaking
on 2010 October 14/15 at 2.9 X 10^{50} erg s^{-1}, makes it among the brightest
high-redshift Fermi blazars. No published model with a single lens can account
for all of the observed characteristics of this complex system. Based on radio
observations, one expects time delayed variability to follow about 25 days
after a primary flare, with flux about a factor 1.5 less. Two large gamma-ray
flares of PKS 1830-211 have been detected by the LAT in the considered period
and no substantial evidence for such a delayed activity was found. This allows
us to place a lower limit of about 6 on the gamma rays flux ratio between the
two lensed images. Swift XRT observations from a dedicated Target of
Opportunity program indicate a hard spectrum and with no significant
correlation of X-ray flux with the gamma-ray variability. The spectral energy
distribution can be modeled with inverse Compton scattering of thermal photons
from the dusty torus. The implications of the LAT data in terms of variability,
the lack of evident delayed flare events, and different radio and gamma-ray
flux ratios are discussed. Microlensing effects, absorption, size and location
of the emitting regions, the complex mass distribution of the system, an
energy-dependent inner structure of the source, and flux suppression by the
lens galaxy for one image path may be considered as hypotheses for
understanding our results.Comment: 14 pages, 6 figures, 2 tables. Accepted by the The Astrophysical
Journal. Corresponding authors: S. Ciprini (ASI ASDC & INAF OAR, Rome,
Italy), S. Buson (INAF Padova & Univ. of Padova, Padova, Italy), J. Finke
(NRL, Washington, DC, USA), F. D'Ammando (INAF IRA, Bologna, Italy
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