Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis

We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 cells

Undetectable Communication: The Online Social Networks Case

Online Social Networks (OSNs) provide users with an easy way to share content, communicate, and update others about their activities. They also play an increasingly fundamental role in coordinating and amplifying grassroots movements, as demonstrated by recent uprisings in, e.g., Egypt, Tunisia, and Turkey. At the same time, OSNs have become primary targets of tracking, profiling, as well as censorship and surveillance. In this paper, we explore the notion of undetectable communication in OSNs and introduce formal definitions, alongside system and adversarial models, that complement better understood notions of anonymity and confidentiality. We present a novel scheme for secure covert information sharing that, to the best of our knowledge, is the first to achieve undetectable communication in OSNs. We demonstrate, via an open-source prototype, that additional costs are tolerably low

Large Eddy Simulation of the internal injector flow during pilot injection

The aim of this work is to simulate the internal flow of a Diesel injector during an entire pilot injection event. In common rail systems a small quantity of fuel can be injected before the main injection is started. This increases the temperature in the combustion chamber and improves the combustion, leading to higher engine efficiency and reduced emissions. The internal nozzle flow during this short event is highly dynamic and vapor cavities may appear at the end of the injection. In order to study the flow characteristics, a numerical methodology based on the Eulerian multi-fluid approach is adopted. The filtered Navier-Stokes equations are discretized with the finite volume method and then solved with an implicit pressure-based solver. The flow field is modelled considering single pressure and velocity fields. The Coherent Structure Model is used to derive the eddy viscosity applied to the Large Eddy Simulation approach. The liquid evaporation rate is evaluated with a cavitation model based on the Rayleigh-Plesset equation for a single bubble. Even though thermodynamic equilibrium is not satisfied a priori, the main parameter is adjusted in order to limit the thermodynamic states to be in a range close to the equilibrium conditions. The liquid compressibility is modelled with a linear correlation between pressure and density variations. The needle longitudinal movement obtained from the experiments is applied to the simulation. The adopted geometry is the Spray A case defined by the Engine Combustion Network. It is an asymmetric single hole Diesel injector that has been extensively studied in the past both experimentally and numerically. The injection pressure is 1,500 [bar] and the ambient pressure is 60 [bar] with a fuel temperature of 363 K inside the injector. Pure n-dodecane is used as fluid in order to have a precise specification of the physical properties. Although both experiments and simulations showed no cavitation for completely open needle at fixed position, recent studies demonstrated that phase-change of the liquid can appear during the needle closing phase. Cavitation erosion prone locations are then evaluated by recording the maximum intensity of pressure on the surface

An EpiDoc ontological perspective: the epigraphs of the Castello Ursino Civic Museum of Catania via CIDOC CRM

The rich epigraphic heritage of the Castello Ursino Civic Museum of Catania has been studied by the EpiCUM project that encoded it in EpiDoc TEI XML, an XML based standard digital representation for cultural heritage contents. The project made the epigraphic heritage available in a digital museum: under the guise of the ‘Voci di Pietra’ exhibition, a selection of epigraphs were presented, implementing innovative presentation modalities thanks to a smart use of technological and digital means. Information contained in the epigraphs was semantically reorganized in a unique homogeneous container, the EpiONT ontology, constructed according to the Linked Open Data paradigm and to consolidated international standards. The encoding of the ancient texts, by the TEI standard and its EpiDoc subset, is wedded to the paradigmatic semantic web model for museums and cultural heritage. The EpiONT ontology is currently populated by 580 epigraphs collected in the Castello Ursino Civic Museum. Designed according to the CIDOC CRM standard, it makes use of the SKOS vocabularies of the EAGLE project concerning material, execution technique, type of inscription, and type of support of an epigraph. The EpiONT ontology additionally can handle any uncertainty in the origin and place of discovery of the epigraphs

Journey through crohn’s disease complication: From fistula formation to future therapies

Crohn’s Disease (CD) is a chronic inflammatory disorder in which up to 50% of patients develop fistula within 20 years after the initial diagnosis, and half of these patients suffer perianal fistulizing disease. The etiopathogenesis of CD-related perianal fistula is still unclear, and its phe-notypical and molecular characteristics are even more indefinite. A better understanding would be crucial to develop targeted and more effective therapeutic strategies. At present, the most accredited theory for the formation of CD-related fistula identifies the epithelial-to-mesenchymal transition (EMT) as the driving force. It has been well recognized that CD carries an increased risk of malig-nancy, particularly mucinous adenocarcinoma is often associated with long-standing fistula in CD patients. Despite the availability of multiple treatment options, perianal fistulizing CD represents a therapeutic challenge and is associated with an important impact on patients’ quality of life. To date, the most effective management is multidisciplinary with the cooperation of gastroenterologists, surgeons, radiologists, and nutritionists and the best recommended treatment is a combination of medical and surgical approaches

Conference Proceedings of the 1st Conference in Business Research and Management

This edited book contains the conference proceedings of the “1st Conference in Business Research and Management”, organized by the University of Castilla – La Mancha and the University of Rome “Tor Vergata”. The Conference took place on May 26th and 27th 2022, at the University of Castilla – La Mancha in Toledo. The aim of the Conference was to discuss the most important managerial and organizational implications of the pandemic and the future challenges that public and private organizations will have to face in the coming years, the so–called “New Normal”. The volume contains all the 49 extended abstracts presented during the Conference

Multi-risk assessment in a historical city

AbstractNatural hazards pose a significant threat to historical cities which have an authentic and universal value for mankind. This study aims at codifying a multi-risk workflow for seismic and flood hazards, for site-scale applications in historical cities, which provides the Average Annual Loss for buildings within a coherent multi-exposure and multi-vulnerability framework. The proposed methodology includes a multi-risk correlation and joint probability analysis to identify the role of urban development in re-shaping risk components in historical contexts. The workflow is unified by exposure modelling which adopts the same assumptions and parameters. Seismic vulnerability is modelled through an empirical approach by assigning to each building a vulnerability value depending on the European Macroseismic Scale (EMS-98) and modifiers available in literature. Flood vulnerability is modelled by means of stage-damage curves developed for the study area and validated against ex-post damage claims. The method is applied to the city centre of Florence (Italy) listed as UNESCO World Heritage site since 1982. Direct multi-hazard, multi-vulnerability losses are modelled for four probabilistic scenarios. A multi-risk of 3.15 M€/year is estimated for the current situation. In case of adoption of local mitigation measures like floodproofing of basements and installation of steel tie rods, multi-risk reduces to 1.55 M€/yr. The analysis of multi-risk correlation and joint probability distribution shows that the historical evolution of the city centre, from the roman castrum followed by rebuilding in the Middle Ages, the late XIX century and the post WWII, has significantly affected multi-risk in the area. Three identified portions of the study area with a different multi-risk spatial probability distribution highlight that the urban development of the historical city influenced the flood hazard and the seismic vulnerability. The presented multi-risk workflow could be applied to other historical cities and further extended to other natural hazards

Understanding the Use of Fauxtography on Social Media

Despite the influence that image-based communication has on online discourse, the role played by images in disinformation is still not well understood. In this paper, we present the first large-scale study of fauxtography, analyzing the use of manipulated or misleading images in news discussion on online communities. First, we develop a computational pipeline geared to detect fauxtography, and identify over 61k instances of fauxtography discussed on Twitter, 4chan, and Reddit. Then, we study how posting fauxtography affects engagement of posts on social media, finding that posts containing it receive more interactions in the form of re-shares, likes, and comments. Finally, we show that fauxtography images are often turned into memes by Web communities. Our findings show that effective mitigation against disinformation need to take images into account, and highlight a number of challenges in dealing with image-based disinformation