Bandwidth and Electron Correlation-Tuned Superconductivity in Rb0.8_{0.8}Fe2_{2}(Se1−z_{1-z}Sz_z)2_2

We present a systematic angle-resolved photoemission spectroscopy study of the substitution-dependence of the electronic structure of Rb$_{0.8}$Fe$_{2}$(Se$_{1-z}$S$_z$)$_2$ (z = 0, 0.5, 1), where superconductivity is continuously suppressed into a metallic phase. Going from the non-superconducting Rb$_{0.8}$Fe$_{2}$(Se$_{1-z}$S$_z$)$_2$ to superconducting Rb$_{0.8}$Fe$_{2}$Se$_2$, we observe little change of the Fermi surface topology, but a reduction of the overall bandwidth by a factor of 2 as well as an increase of the orbital-dependent renormalization in the $d_{xy}$ orbital. Hence for these heavily electron-doped iron chalcogenides, we have identified electron correlation as explicitly manifested in the quasiparticle bandwidth to be the important tuning parameter for superconductivity, and that moderate correlation is essential to achieving high $T_C$

Impact of an Extreme Storm Event on River Corridor Bank Erosion and Phosphorus Mobilization in a Mountainous Watershed in the Northeastern United States

Movement of sediment, and associated phosphorus, from stream banks to freshwater lakes is predicted to increase with greater frequency of extreme precipitation events. This higher phosphorus load may accelerate harmful algal blooms in affected water bodies, such as Lake Champlain in Vermont, New York, and Québec. In the Mad River, a subwatershed in central Vermont\u27s Lake Champlain Basin, extreme flooding from Tropical Storm Irene in 2011 caused extensive erosion. We measured stream channel change along the main stem between 2008 and 2011 by digitizing available prestorm and poststorm aerial imagery. Soils were sampled post Irene at six active stream erosion sites, using an experimental design to measure differences in soil texture and phosphorus both with depth (90 cm) and distance from the stream. In addition to total phosphorus (TP), we determined bioavailable (soil test) phosphorus (STP) and the degree of phosphorus saturation (DPS). The six sites represented a 0.87-km length of stream bank that contributed an estimated 17.6 × 10 3 Mg of sediment and 15.8 Mg of TP, roughly the same as average annual watershed export estimates. At four sites, the STP and DPS were low and suggested little potential for short-term phosphorus release. At two agricultural sites where the lateral extent of erosion was high, imagery showed a clear loss of well-established riparian buffer. Present-day near-stream soils were elevated in STP and DPS. An increase in these extreme events will clearly increase sediment loads. There will also be increasing concentration of sediment phosphorus if stream banks continue to erode into actively managed agricultural fields

Autism as a disorder of neural information processing: directions for research and targets for therapy

The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself

Opening a window on the past: paleo-horizons across Pleistocene and Holocene. Madonna della Grotta, Praia a Mare, Southern Italy

The goal of this study was to identify and characterize three paleo-horizons along a stratigraphic succession embracing sediments from Paleolithic to historic that has been preserved inside a grotto close to the Tyrrhenian Sea in southern Italy. The studied paleo-horizons date back to the transition period between Pleistocene and Holocene, when swift alternations of cold and warm phases profoundly altered the range dynamics of many organisms, including salmonids like Salmo trutta and, consequently, the behavior of the humans that occupied the grotto. Morphological observations and preliminary analysis were run to assess if the paleo-horizons preserved information of the human modified behavior. Results confirmed that one of the three paleo-horizons (Bud horizon, dating back to 10,300 cal YBP) had a strongly affected anthropic origin as it contains the rests of terrestrial (mammals, birds, and snails) and sea food (Salmo trutta and Patella spp.), and showed a hard compaction acquired via hydroconsolidation

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.

Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD

Attentional differences in a driving hazard perception task in adults with autism spectrum disorders

The current study explored attentional processing of social and non social stimuli in ASD within the context of a driving hazard perception task. Participants watched videos of road scenes and detected hazards while their eye movements were recorded. Although individuals with ASD demonstrated relatively good detection of driving hazards, they were slower to orient to hazards. Greater attentional capture in the time preceding the hazards’ onset was associated with lower verbal IQ. The findings suggest that individuals with ASD may distribute and direct their attention diferently when identifying driving hazards

MRI Study of Minor Physical Anomaly in Childhood Autism Implicates Aberrant Neurodevelopment in Infancy

Background: MPAs (minor physical anomalies) frequently occur in neurodevelopmental disorders because both face and brain are derived from neuroectoderm in the first trimester. Conventionally, MPAs are measured by evaluation of external appearance. Using MRI can help overcome inherent observer bias, facilitate multi-centre data acquisition, and explore how MPAs relate to brain dysmorphology in the same individual. Optical MPAs exhibit a tightly synchronized trajectory through fetal, postnatal and adult life. As head size enlarges with age, inter-orbital distance increases, and is mostly completed before age 3 years. We hypothesized that optical MPAs might afford a retrospective 'window' to early neurodevelopment; specifically, inter-orbital distance increase may represent a biomarker for early brain dysmaturation in autism. Methods: We recruited 91 children aged 7-16; 36 with an autism spectrum disorder and 55 age- and gender-matched typically developing controls. All children had normal IQ. Inter-orbital distance was measured on T1-weighted MRI scans. This value was entered into a voxel-by-voxel linear regression analysis with grey matter segmented from a bimodal MRI data-set. Age and total brain tissue volume were entered as covariates. Results: Intra-class coefficient for measurement of the inter-orbital distance was 0.95. Inter-orbital distance was significantly increased in the autism group (p = 0.03, 2-tailed). The autism group showed a significant relationship between inter-orbital distance grey matter volume of bilateral amygdalae extending to the unci and inferior temporal poles. Conclusions: Greater inter-orbital distance in the autism group compared with healthy controls is consistent with infant head size expansion in autism. Inter-orbital distance positively correlated with volume of medial temporal lobe structures, suggesting a link to "social brain" dysmorphology in the autism group. We suggest these data support the role of optical MPAs as a "fossil record" of early aberrant neurodevelopment, and potential biomarker for brain dysmaturation in autism. © 2011 Cheung et al.published_or_final_versio