Optimizing fire station locations for the Istanbul metropolitan municipality

Copyright @ 2013 INFORMSThe Istanbul Metropolitan Municipality (IMM) seeks to determine locations for additional fire stations to build in Istanbul; its objective is to make residences and historic sites reachable by emergency vehicles within five minutes of a fire station’s receipt of a service request. In this paper, we discuss our development of a mathematical model to aid IMM in determining these locations by using data retrieved from its fire incident records. We use a geographic information system to implement the model on Istanbul’s road network, and solve two location models—set-covering and maximal-covering—as what-if scenarios. We discuss 10 scenarios, including the situation that existed when we initiated the project and the scenario that IMM implemented. The scenario implemented increases the city’s fire station coverage from 58.6 percent to 85.9 percent, based on a five-minute response time, with an implementation plan that spans three years

On renormalizability of the massless Thirring model

We discuss the renormalizability of the massless Thirring model in terms of the causal fermion Green functions and correlation functions of left-right fermion densities. We obtain the most general expressions for the causal two-point Green function and correlation function of left-right fermion densities with dynamical dimensions of fermion fields, parameterised by two parameters. The region of variation of these parameters is constrained by the positive definiteness of the norms of the wave functions of the states related to components of the fermion vector current. We show that the dynamical dimensions of fermion fields calculated for causal Green functions and correlation functions of left-right fermion densities can be made equal. This implies the renormalizability of the massless Thirring model in the sense that the ultra-violet cut-off dependence, appearing in the causal fermion Green functions and correlation functions of left-right fermion densities, can be removed by renormalization of the wave function of the massless Thirring fermion fields only.Comment: 17 pages, Latex, the contribution of fermions with opposite chirality is added,the parameterisation of fermion determinant by two parameters is confirmed,it is shown that dynamical dimensions of fermion fields calculated from different correlation functions can be made equal.This allows to remove the dependence on the ultra-violet cut-off by the renormalization of the wave function of Thirring fermion fields onl

Locating temporary shelter areas after an earthquake: A case for Turkey

In this study, we propose a mixed integer linear programming based methodology for selecting the location of temporary shelter sites. The mathematical model maximizes the minimum weight of open shelter areas while deciding on the location of shelter areas, the assigned population points to each open shelter area and controls the utilization of open shelter areas. We validate the mathematical model by generating a base case scenario using real data for Kartal, Istanbul, Turkey. Also, we perform a sensitivity analysis on the parameters of the mentioned mathematical model and discuss our findings. Lastly, we perform a case study using the data from the 2011 Van earthquake. © 2014 Elsevier B.V. All rights reserved

On "full" twisted Poincare' symmetry and QFT on Moyal-Weyl spaces

We explore some general consequences of a proper, full enforcement of the "twisted Poincare'" covariance of Chaichian et al. [14], Wess [50], Koch et al. [34], Oeckl [41] upon many-particle quantum mechanics and field quantization on a Moyal-Weyl noncommutative space(time). This entails the associated braided tensor product with an involutive braiding (or $\star$-tensor product in the parlance of Aschieri et al. [3,4]) prescription for any coordinates pair of $x,y$ generating two different copies of the space(time); the associated nontrivial commutation relations between them imply that $x-y$ is central and its Poincar\'e transformation properties remain undeformed. As a consequence, in QFT (even with space-time noncommutativity) one can reproduce notions (like space-like separation, time- and normal-ordering, Wightman or Green's functions, etc), impose constraints (Wightman axioms), and construct free or interacting theories which essentially coincide with the undeformed ones, since the only observable quantities involve coordinate differences. In other words, one may thus well realize QM and QFT's where the effect of space(time) noncommutativity amounts to a practically unobservable common noncommutative translation of all reference frames.Comment: Latex file, 24 pages. Final version to appear in PR

Phase Structure and Compactness

In order to study the influence of compactness on low-energy properties, we compare the phase structures of the compact and non-compact two-dimensional multi-frequency sine-Gordon models. It is shown that the high-energy scaling of the compact and non-compact models coincides, but their low-energy behaviors differ. The critical frequency $\beta^2 = 8\pi$ at which the sine-Gordon model undergoes a topological phase transition is found to be unaffected by the compactness of the field since it is determined by high-energy scaling laws. However, the compact two-frequency sine-Gordon model has first and second order phase transitions determined by the low-energy scaling: we show that these are absent in the non-compact model.Comment: 21 pages, 5 figures, minor changes, final version, accepted for publication in JHE

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients.

Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2. We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS). Thirty DADA2 patients from 12 countries received a total of 38 HCTs. The indications for HCT were BMF, immune cytopenia, malignancy, or immunodeficiency. Median age at HCT was 9 years (range: 2-28 years). The conditioning regimens for the final transplants were myeloablative (n = 20), reduced intensity (n = 8), or non-myeloablative (n = 2). Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). After a median follow-up of 2 years (range: 0.5-16 years), 2-year OS was 97%, and 2-year GvHD-free relapse-free survival was 73%. The hematological and immunological phenotypes resolved, and there were no new vascular events. Plasma ADA2 enzyme activity normalized in 16/17 patients tested. Six patients required more than one HCT. HCT was an effective treatment for DADA2, successfully reversing the refractory cytopenia, as well as the vasculopathy and immunodeficiency. HCT is a definitive cure for DADA2 with > 95% survival