Rainfall induced landslides in December 2004 in south-western Umbria, central Italy: types, extent, damage and risk assessment

International audienceThe autumn of 2004 was particularly wet in Umbria, with cumulative rainfall in the period from October to December exceeding 600 mm. On 4?6 December and on 25?27 December 2004, two storms hit the Umbria Region producing numerous landslides, which were abundant near the town of Orvieto where they affected volcanic deposits and marine sediments. In this work, we document the type and abundance of the rainfall-induced landslides in the Orvieto area, in south-western Umbria, we study the rainfall conditions that triggered the landslides, including the timing of the slope failures, we determine the geotechnical properties of the failed volcanic materials, and we discuss the type and extent of damage produced by the landslides. We then use the recent event landslide information to test a geomorphological assessment of landslide hazards and risk prepared for the village of Sugano, in the Orvieto area. Based on the results of the test, we update the existing landslide hazards and risk scenario for extremely rapid landslides, mostly rock falls, and we introduce a new landslide scenario for rapid and very rapid landslides, including soil slides, debris flows and debris avalanches

Fluorescent amino acids as versatile building blocks for chemical biology

Fluorophores have transformed the way we study biological systems, enabling non-invasive studies in cells and intact organisms, which increase our understanding of complex processes at the molecular level. Fluorescent amino acids have become an essential chemical tool because they can be used to construct fluorescent macromolecules, such as peptides and proteins, without disrupting their native biomolecular properties. Fluorescent and fluorogenic amino acids with unique photophysical properties have been designed for tracking protein–protein interactions in situ or imaging nanoscopic events in real time with high spatial resolution. In this Review, we discuss advances in the design and synthesis of fluorescent amino acids and how they have contributed to the field of chemical biology in the past 10 years. Important areas of research that we review include novel methodologies to synthesize building blocks with tunable spectral properties, their integration into peptide and protein scaffolds using site-specific genetic encoding and bioorthogonal approaches, and their application to design novel artificial proteins, as well as to investigate biological processes in cells by means of optical imaging. [Figure not available: see fulltext.]

Premio letterario "Elio Filippo Accrocca - Città di Cori"

Il volume curato da Fiorella Bartoccini e Donatella Strangio ha vinto il Premio letterario "Elio Filippo Accrocca - Città di Cori" I edizione come I classificato, 18 luglio 1998

Lo stato del Lazio (1860-1870)

Il volume raccoglie risultati di una ricerca condotta da Fiorella Bartoccini e Donatella Strangio e che ha coinvolto diversi studiosi esperti nei campi oggetto di approfondimento ed indagine. I campi nei quali si è indagato individuando cambiamenti e continuità in una realtà, all’indomani del 1860, quale quella dello Stato Pontificio ridotta, dopo noti avvenimenti storici al solo Lazio sono quello del governo della legislazione amministrazione centrale dello stato romano agli aspetti più propriamente territoriali, alle dinamiche sociale all’economia e alla finanza senza tralasciare l’aspetto culturale anch’esso colpito da questo mutilamento territoriale e dall’attesa di fare parte dell’Italia.The book contains the results of a research conducted by Fiorella Bartoccini Donatella and Strangio and that involved several expert scholars in the fields being examined and investigated. The fields in which it is investigated by identifying changes and continuity in a reality, in the aftermath of 1860, which reduced the Papal State, after the only known historical events Lazio are one of the government's legislation central administration of the Roman state to the most properly territorial dynamics social economy and finance without neglecting the cultural aspect too impressed by this and by the expectation of territorial mutilamento part of Italy

Development of a Practical and Sustainable Strategy for the Synthesis of ST1535 by an Iron-Catalyzed Kumada Cross-Coupling Reaction

A simple, convenient, and environmentally friendly route to ST1535 employing an iron-catalyzed cross-coupling reaction and butylmagnesium chloride is described

Improved Synthesis of gamma-nitro-alfa-Amino ester and Acid Derivatives

A useful microwave-assisted synthesis of γ-nitro-α-amino esters and corresponding acids, under mild conditions and without solvent, is described. The desired products were obtained via Michael addition from methyl N-(diphenylmethylene)-2,3-didehydroalaninate and commercially available nitroalkanes

Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions.

A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps