AMI observations of 10 CLASH galaxy clusters: SZ and X-ray data used together to determine cluster dynamical states

© 2016 The Authors. Published by Oxford University Press on behalf of The Royal Astronomical Society.Using Arcminute Microkelvin Imager (AMI) Sunyaev-Zel'dovich (SZ) observations towards 10 CLASH (Cluster Lensing and Supernova Survey with Hubble) clusters, we investigate the influence of cluster mergers on observational galaxy cluster studies. Although selected to be largely relaxed, there is disagreement in the literature on the dynamical states of CLASH sample members. We analyse ourAMIdata in a fully Bayesianway to produce estimated cluster parameters and consider the intrinsic correlations in our Navarro, Frenk and White/generalized Navarro, Frenk and White-based model. Varying pressure profile shape parameters, illustrating an influence of mergers on scaling relations, induces small deviations from the canonical selfsimilar predictions - in agreement with simulations of Poole et al. (2007) who found that merger activity causes only small scatter perpendicular to the relations. We demonstrate this effect observationally using the different dependences of SZ and X-ray signals to ne that cause different sensitivities to the shocking and/or fractionation produced by mergers. Plotting YX-Mgas relations (where YX = MgasT) derived from AMI SZ and from Chandra X-ray gives ratios of AMI and Chandra YX and Mgas estimates that indicate movement of clusters along the scaling relation, as predicted by Poole et al. (2007). Clusters that have moved most along the relation have the most discrepant TSZ and TX estimates: all the other clusters (apart from one) have SZ and X-ray estimates of Mgas, T and YX that agree within r500. We use SZ versus X-ray discrepancies in conjunction with Chandra maps and TX profiles, making comparisons with simulated cluster merger maps in Poole et al. (2006) to identify disturbed members of our sample and estimate merger stages.We thank the staff of the Mullard Radio Astronomy Observatory for their invaluable assistance in the commissioning and operation of AMI, which is supported by Cambridge University. WJH and CR are grateful for the support of STFC Studentships. CR also acknowledges the support of Cambridge University. MO and YCP acknowledge support from Research Fellowships from Sidney Sussex College and Trinity College, Cambridge, respectively. We thank Arif Babul for his assistance in accessing the Poole et al. online materials. Much of this work was undertaken on the COSMOS Shared Memory system at DAMTP, Cambridge University, operated on behalf of the STFC DiRAC HPC Facility. This equipment is funded by BIS National E-infrastructure capital grant ST/J005673/1 and STFC grants ST/H008586/1, ST/K00333X/1

Free-form modelling of galaxy clusters: A Bayesian and data-driven approach

A new method is presented for modelling the physical properties of galaxy clusters. Our technique moves away from the traditional approach of assuming specific parameterized functional forms for the variation of physical quantities within the cluster, and instead allows for a 'freeform' reconstruction, but one for which the level of complexity is determined automatically by the observational data and may depend on position within the cluster. This is achieved by representing each independent cluster property as some interpolating or approximating function that is specified by a set of control points, or 'nodes', for which the number of nodes, together with their positions and amplitudes, are allowed to vary and are inferred in a Bayesian manner from the data. We illustrate our nodal approach in the case of a spherical cluster by modelling the electron pressure profile P e (r) in analyses both of simulated Sunyaev-Zel'dovich (SZ) data from the Arcminute MicroKelvin Imager (AMI) and of real AMI observations of the cluster MACS J0744+3927 in the CLASH sample. We demonstrate that one may indeed determine the complexity supported by the data in the reconstructed P e (r), and that one may constrain two very important quantities in such an analysis: the cluster total volume integrated Comptonization parameter (Y tot ) and the extent of the gas distribution in the cluster (r max ). The approach is also well-suited to detecting clusters in blind SZ surveys, in the case where the population of radio sources is known in advance.This work was performed using both the Darwin Supercomputer of the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/), and COSMOS Shared Memory system at DAMTP, University of Cambridge operated on behalf of the STFC DiRAC HPC Facility. Darwin Supercomputer is provided by Dell Inc. using Strategic Research Infrastructure Funding from the Higher Education Funding Council for England and funding from the Science and Technology Facilities Council. COSMOS Shared Memory system is funded by BIS National E-infrastructure capital grant ST/J005673/1 and STFC grants ST/H008586/1, ST/K00333X/1 ... YCP acknowledges support from a Trinity College Junior Research Fellowship

AMI-CL J0300+2613: A Galactic anomalous-microwave-emission ring masquerading as a galaxy cluster

The Arcminute Microkelvin Imager (AMI) carried out a blind survey for galaxy clusters via their Sunyaev-Zel'dovich effect decrements between 2008 and 2011. The first detection, known as AMI-CL J0300+2613, has been reobserved with AMI equipped with a new digital correlator with high dynamic range. The combination of the new AMI data and more recent high-resolution sub-mm and infra-red maps now shows the feature in fact to be a ring of positive dust-correlated Galactic emission, which is likely to be anomalous microwave emission (AME). If so, this is the first completely blind detection of AME at arcminute scales

The impact of oral conditions on children in England, Wales and Northern Ireland 2013

Background: The 2013 Children's Dental Health survey is the fifth in a series of national surveys. / Aim: To summarise key findings on oral health perceptions, oral symptoms, and the impacts of oral conditions on the daily life of children and their families. / Methodology: A representative sample of children (aged 5, 8 12 and 15 years) and their parents in England, Wales and Northern Ireland completed relevant questionnaires. / Results: Oral symptoms, even more profound ones such as toothache, were prevalent among all age groups. Overall, 58% of 12- and 45% of 15-year-olds reported at least one oral impact in the past three months. The most prevalent oral impact was feeling embarrassed to smile or laugh, followed by difficulty eating. These symptoms and oral impacts were disproportionately high among children eligible for free school meals. Furthermore, one fifth to one third of parents reported that their children's oral conditions had some impact on their family life. / Conclusion: Oral symptoms were common and oral conditions had a negative impact on the quality of life of large proportions of children. There were clear and marked socioeconomic inequalities, with considerably worse oral health perceptions and higher levels of oral impacts among the more deprived children

MRX87 family with Aristaless X dup24bp mutation and implication for polyAlanine expansions

<p>Abstract</p> <p>Background</p> <p>Cognitive impairments are heterogeneous conditions, and it is estimated that 10% may be caused by a defect of mental function genes on the X chromosome. One of those genes is <it>Aristaless related homeobox </it>(<it>ARX</it>) encoding a polyA-rich homeobox transcription factor essential for cerebral patterning and its mutations cause different neurologic disorders. We reported on the clinical and genetic analysis of an Italian family with X-linked mental retardation (XLMR) and intra-familial heterogeneity, and provided insight into its molecular defect.</p> <p>Methods</p> <p>We carried out on linkage-candidate gene studies in a new MRX family (MRX87). All coding regions and exon-intron boundaries of ARX gene were analysed by direct sequencing.</p> <p>Results</p> <p>MRX87 patients had moderate to profound cognition impairment and a combination of minor congenital anomalies. The disease locus, MRX87, was mapped between DXS7104 and DXS1214, placing it in Xp22-p21 interval, a hot spot region for mental handicap. An in frame duplication of 24 bp (ARXdup24) in the second polyAlanine tract (polyA_II) in ARX was identified.</p> <p>Conclusion</p> <p>Our study underlines the role of ARXdup24 as a critical mutational site causing mental retardation linked to Xp22. Phenotypic heterogeneity of MRX87 patients represents a new observation relevant to the functional consequences of polyAlanine expansions enriching the puzzling complexity of ARXdup24-linked diseases.</p

Effect of ABCB1 and ABCC3 Polymorphisms on Osteosarcoma Survival after Chemotherapy: A Pharmacogenetic Study

Background: Standard treatment for osteosarcoma patients consists of a combination of cisplatin, adriamycin, and methotrexate before surgical resection of the primary tumour, followed by postoperative chemotherapy including vincristine and cyclophosphamide. Unfortunately, many patients still relapse or suffer adverse events. We examined whether common germline polymorphisms in chemotherapeutic transporter and metabolic pathway genes of the drugs used in standard osteosarcoma treatment may predict treatment response. Methodology/Principal Findings: In this study we screened 102 osteosarcoma patients for 346 Single Nucleotide Polymorphisms (SNPs) and 2 Copy Number Variants (CNVs) in 24 genes involved in the metabolism or transport of cisplatin, adriamycin, methotrexate, vincristine, and cyclophosphamide. We studied the association of the genotypes with tumour response and overall survival. We found that four SNPs in two ATP-binding cassette genes were significantly associated with overall survival: rs4148416 in ABCC3 (per-allele HR = 8.14, 95%CI = 2.73-20.2, p-value = 5.1×10 -5), and three SNPs in ABCB1, rs4148737 (per-allele HR = 3.66, 95%CI = 1.85-6.11, p-value = 6.9×10 -5), rs1128503 and rs10276036 (r 2 = 1, per-allele HR = 0.24, 95%CI = 0.11-0.47 p-value = 7.9×10 -5). Associations with these SNPs remained statistically significant after correction for multiple testing (all corrected p-values [permutation test] ≤0.03). Conclusions: Our findings suggest that these polymorphisms may affect osteosarcoma treatment efficacy. If these associations are independently validated, these variants could be used as genetic predictors of clinical outcome in the treatment of osteosarcoma, helping in the design of individualized therapyThis work was supported by the AECC (Asociación Española contra el Cáncer), FIS (Fondo de Investigación Sanitaria-Instituto de Salud Carlos III) and the ‘‘Inocente Inocente’’ Foundatio

Two Distinct Triatoma dimidiata (Latreille, 1811) Taxa Are Found in Sympatry in Guatemala and Mexico

Approximately 10 million people are infected with Trypanosoma cruzi, the causative agent of Chagas disease, which remains the most serious parasitic disease in the Americas. Most people are infected via triatomine vectors. Transmission has been largely halted in South America in areas with predominantly domestic vectors. However, one of the main Chagas vectors in Mesoamerica, Triatoma dimidiata, poses special challenges to control due to its diversity across its large geographic range (from Mexico into northern South America), and peridomestic and sylvatic populations that repopulate houses following pesticide treatment. Recent evidence suggests T. dimidiata may be a complex of species, perhaps including cryptic species; taxonomic ambiguity which confounds control. The nuclear sequence of the internal transcribed spacer 2 (ITS2) of the ribosomal DNA and the mitochondrial cytochrome b (mt cyt b) gene were used to analyze the taxonomy of T. dimidiata from southern Mexico throughout Central America. ITS2 sequence divides T. dimidiata into four taxa. The first three are found mostly localized to specific geographic regions with some overlap: (1) southern Mexico and Guatemala (Group 2); (2) Guatemala, Honduras, El Salvador, Nicaragua, and Costa Rica (Group 1A); (3) and Panama (Group 1B). We extend ITS2 Group 1A south into Costa Rica, Group 2 into southern Guatemala and show the first information on isolates in Belize, identifying Groups 2 and 3 in that country. The fourth group (Group 3), a potential cryptic species, is dispersed across parts of Mexico, Guatemala, and Belize. We show it exists in sympatry with other groups in Peten, Guatemala, and Yucatan, Mexico. Mitochondrial cyt b data supports this putative cryptic species in sympatry with others. However, unlike the clear distinction of the remaining groups by ITS2, the remaining groups are not separated by mt cyt b. This work contributes to an understanding of the taxonomy and population subdivision of T. dimidiata, essential for designing effective control strategies