Fluctuation diamagnetism around the superconducting transition in a cuprate crystal with a reduced Meissner fraction

The magnetization around the superconducting transition was measured in a Tl$_{0.5}$Pb$_{0.5}$Sr$_2$CaCu$_2$O$_7$ crystal affected by a considerable reduction ($\sim$55%) of its effective superconducting volume fraction but still with a relatively sharp low-field Meissner transition, a behaviour that may be attributed to the presence of structural inhomogeneities. By taking into account these inhomogeneities just through the Meissner fraction, the observed diamagnetism may still be explained, consistently above and below the superconducting transition, in terms of the conventional Ginzburg-Landau approach with fluctuations of Cooper pairs and vortices.Comment: 4 pages, 4 figure

Influence of M-phase chromatin on the anisotropy of microtubule asters

In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range stabilization effects may affect microtubules in close contact with the chromatin, while long-range stabilization effects may "guide" microtubule growth towards the chromatin (e.g., by introducing a diffusive gradient of an enzymatic activity that affects microtubule assembly). Here, we use both meiotic and mitotic extracts from Xenopus laevis eggs to study microtubule aster formation and microtubule dynamics in the presence of chromatin. In "low-speed" meiotic extracts, in the presence of salmon sperm chromatin, we find that short-range stabilization effects lead to a strong anisotropy of the microtubule asters. Analysis of the dynamic parameters of microtubule growth show that this anisotropy arises from a decrease in the catastrophe frequency, an increase in the rescue frequency and a decrease in the growth velocity. In this system we also find evidence for long-range "guidance" effects, which lead to a weak anisotropy of the asters. Statistically relevant results on these long-range effects are obtained in "high-speed" mitotic extracts in the presence of artificially constructed chromatin stripes. We find that aster anisotropy is biased in the direction of the chromatin and that the catastrophe frequency is reduced in its vicinity. In this system we also find a surprising dependence of the catastrophe and the rescue frequencies on the length of microtubules nucleated from centrosomes: the catastrophe frequency increase and the rescue frequency decreases with microtubule length

Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis

Patterning of C. elegans vulval cell fates relies on inductive signaling. In this induction event, a single cell, the gonadal anchor cell, secretes LIN-3/EGF and induces three out of six competent precursor cells to acquire a vulval fate. We previously showed that this developmental system is robust to a four-fold variation in lin-3/EGF genetic dose. Here using single-molecule FISH, we find that the mean level of expression of lin-3 in the anchor cell is remarkably conserved. No change in lin-3 expression level could be detected among C. elegans wild isolates and only a low level of change-less than 30%-in the Caenorhabditis genus and in Oscheius tipulae. In C. elegans, lin-3 expression in the anchor cell is known to require three transcription factor binding sites, specifically two E-boxes and a nuclear-hormone-receptor (NHR) binding site. Mutation of any of these three elements in C. elegans results in a dramatic decrease in lin-3 expression. Yet only a single E-box is found in the Drosophilae supergroup of Caenorhabditis species, including C. angaria, while the NHR-binding site likely only evolved at the base of the Elegans group. We find that a transgene from C. angaria bearing a single E-box is sufficient for normal expression in C. elegans. Even a short 58 bp cis-regulatory fragment from C. angaria with this single E-box is able to replace the three transcription factor binding sites at the endogenous C. elegans lin-3 locus, resulting in the wild-type expression level. Thus, regulatory evolution occurring in cis within a 58 bp lin-3 fragment, results in a strict requirement for the NHR binding site and a second E-box in C. elegans. This single-cell, single-molecule, quantitative and functional evo-devo study demonstrates that conserved expression levels can hide extensive change in cis-regulatory site requirements and highlights the evolution of new cis-regulatory elements required for cell-specific gene expression

Lepton masses, mixings and FCNC in a minimal S_3-invariant extension of the Standard Model

The mass matrices of the charged leptons and neutrinos, previously derived in a minimal S_3-invariant extension of the Standard Model, were reparametrized in terms of their eigenvalues. We obtained explicit, analytical expressions for all entries in the neutrino mixing matrix, V_PMNS, the neutrino mixing angles and the Majorana phases as functions of the masses of charged leptons and neutrinos in excellent agreement with the latest experimental values. The resulting V_PMNS matrix is very close to the tri-bimaximal form of the neutrino mixing matrix. We also derived explicit analytical expressions for the matrices of the Yukawa couplings and computed the branching ratios of some selected flavour changing neutral current processes as functions of the masses of the charged leptons and the neutral Higgs bosons. We find that the S_3 x Z_2 flavour symmetry and the strong mass hierarchy of the charged leptons strongly suppress the FCNC processes in the leptonic sector well below the present experimental upper bounds by many orders of magnitude.Comment: One paragraph added with comparison to tri-bimaximal mixing, two lines changed in abstract, references added, typographical errors correcte

Characteristics of stress-induced defects under positive bias in high-k/InGaAs stacks

The introduction of InGaAs as a channel material for complementary metal-oxide-semiconductor technology presents major challenges in terms of the characterization of the various defects that affect the performance and reliability. Understanding the generation of defects by constant voltage stresses is crucial in terms of their concentration profiles and energy levels. In particular, we want to understand the real nature of the defects responsible for the dispersion of C-V in strong accumulation. Here, we show that the degradation under positive bias of metal/Al2O3/n-InGaAs capacitors reveals two contributions depending on the temperature that affects the C-V curves in a different way. Based on features of stressed C-V curves, it is possible to estimate the onset point of the distribution of border traps near the midgap condition. The results suggest that these defects are strongly related to the characteristics of the InGaAs substrate.Fil: Palumbo, Félix Roberto Mario. Technion - Israel Institute of Technology; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Winter, R.. Technion - Israel Institute of Technology; IsraelFil: Krylov, I.. Technion - Israel Institute of Technology; IsraelFil: Eizenberg, M.. Technion - Israel Institute of Technology; Israe

Anomalous precursor diamagnetism at low reduced magnetic fields and the role of Tc inhomogeneities in the superconductors Pb55In45 and underdoped La1.9Sr0.1CuO4

The magnetic field dependence of the magnetization was measured above the superconducting transition in a high-Tc underdoped cuprate La1.9Sr0.1CuO4 and in a low-Tc alloy (Pb55In45). Near the superconducting transition [typically for (T-Tc)/Tc<0.05] and under low applied magnetic field amplitudes [typically for H/Hc2(0)<0.01, where Hc2(0) is the corresponding upper critical field extrapolated to T=0 K] the magnetization of both samples presents a diamagnetic contribution much larger than the one predicted by the Gaussian Ginzburg-Landau (GGL) approach for superconducting fluctuations. These anomalies have been already observed in cuprate compounds by various groups and attributed to intrinsic effects associated with the own nature of these high-Tc superconductors. However, we will see here that our results in both high and low-Tc superconductors may be explained quantitatively, and consistently with the GGL behavior observed at higher fields, by just taking into account the presence in the samples of an uniform distribution of Tc inhomogeneities. These Tc inhomogeneities, which may be in turn associated with stoichiometric inhomogeneities, were estimated from independent measurements of the temperature dependence of the field-cooled magnetic susceptibility under low applied magnetic fields.Comment: 25 pages, including 6 figures and 1 table. Typos corrected. Compacte