Dry Magnetic Separation of Iron Ore of the Bakchar Deposit

Currently, the development of iron ore of the Bakchar deposit (Tomsk region) is considered promising because of the extremely large reserves of iron ore. Ores of this deposit are related to the high-grade type and expected to have a magnetic concentration for iron extraction. The main task of magnetic separation is to increase the total iron content in concentrates to a value which allows its further metallurgical processing. Ferruginous ore particles have a rounded shape that facilitates a separation process. The paper considers the influence of technological parameters on the magnetic concentrate yield and recovery rate of iron-containing fractions

RECENT ADVANCES IN THE APPLICATION OF HIGH DOSES OF ATORVASTATIN IN PATIENTS WITH CORONARY HEART DISEASE

The results of the recently completed clinical studies on the efficacy of atorvastatin in high doses are presented. In these studies high dose atorvastatin therapy was used in patients with acute coronary syndrome, chronic coronary heart disease, and percutaneous coronary interventions. Studies completed in Russia and devoted to efficacy of the high dose atorvastatin therapy are discussed specially

Prospects of controlling the propagation of high-power THz radiation by passive optical elements including 3D printed

Optical properties of different commercial plastics for fused deposition modeling 3D printing are defined at room temperature in the spectral range 0.2˗1.2 THz. We compare absorption coefficients and refractive index of ABS, PETG, and SBS printed 1-4 mm plates. Different types of optical elements for controlling high-power THz radiation are studied. A comparison is made of the efficiency of attenuation of linearly polarized THz radiation with homemade band-pass polarizers obtained by etching copper from a flexible polyimide substrate. Filters and polarizers created using 3D printing or by deposition of polymer matrix with magnetic particles under external field are cost-effective and can be easily changed or replaced. Comparison between plastic insets, filters based on magnetic particles, and polyimide film filters are made

Prospects of controlling the propagation of high power THz radiation by passive optical elements including 3D printed

Different types of optical elements for controlling high power THz radiation were studied. Controlling was performed utilizing amplitude modulation of the electric field and effective spatial modulation of the complex dielectric susceptibility in the volume of the THz filter. We make a comparison of attenuation efficiency of various options of 3D printed filters when ABS filament is mixed with perovskite microparticles. Another type of filter was obtained by the deposition of magnetic particles in the presence of an external magnetic field in a transparent polymer matrix. Industrial isotropic cut-off filters based on layered meta structures have also been investigated. A comparison is made of the efficiency of attenuation of linearly polarized THz radiation with homemade band-pass polarizers obtained by etching copper from a flexible polyimide substrate and industrial filters. Filters and polarizers created using 3D printing, or by deposition of polymer matrix with magnetic particles under external field, are attractive cost effective elements

Development of electrochemical sensor based on aptamer specific to lung cancer tumor marker

Electrochemical aptasensor is a sensor based on an indicator electrode covered with a layer of an aptamer that is able to bind target molecules with high specificity. In this work, DNA-aptamer LC-2108 specific to lung cancer tumor marker was immobilized onto the surface of golden screen-printed and disc electrodes. The electrodes were studied by conventional electrochemical methods–cyclic voltammetry and electrochemical impedance spectroscopy. The current increase and electron transfer resistance decrease were registered. It seems as if the aptamer presence facilitated the electron transfer through the electrode-solution boundary. As the possible reasons of such an unusual electrochemical behavior we proposed the unordinary or irregular structure of the aptamer layer on the Au surface or the specific electrochemical properties of the aptamer itself

Lipoprotein(a) Lowering-From Lipoprotein Apheresis to Antisense Oligonucleotide Approach

It is well-known that elevated lipoprotein(a)-Lp(a)-levels are associated with a higher risk of cardiovascular (CV) mortality and all-cause mortality, although a standard pharmacotherapeutic approach is still undefined for patients with high CV risk dependent on hyperlipoproteinemia(a). Combined with high Lp(a) levels, familial hypercholesterolemia (FH) leads to a greater CVD risk. In suspected FH patients, the proportion of cases explained by a rise of Lp(a) levels ranges between 5% and 20%. In the absence of a specific pharmacological approach able to lower Lp(a) to the extent required to achieve CV benefits, the most effective strategy today is lipoprotein apheresis (LA). Although limited, a clear effect on Lp(a) is exerted by PCSK9 antagonists, with apparently different mechanisms when given with statins (raised catabolism) or as monotherapy (reduced production). In the era of RNA-based therapies, a new dawn is represented by the use of antisense oligonucleotides APO(a)Lrx, able to reduce Lp(a) from 35% to over 80%, with generally modest injection site reactions. The improved knowledge of Lp(a) atherogenicity and possible prevention will be of benefit for patients with residual CV risk remaining after the most effective available lipid-lowering agents

Detailed study on optical properties of Li2B4O7 for down-conversion to millimeter waves

Optical properties of single axes Li2B4O7 (LB4) crystal are defined at room temperature in the spectral range 0.03˗0.5 THz. Dispersion of the refractive index components are approximated in the form of Sellmeier equations. Dispersion properties were used to determine phase-matching conditions for THz wave generation by collinear difference frequency generation processes. To the damage threshold under the pump by train of hundreds of 60 fs pulses of Ti:sapphire laser operating at 950 nm is found to be 250 TW/cm2, as well as the coherence length and efficiency of all possible types of three wave interactions are defined