Distribution and diversity of gelatinous zooplankton in Indian EEZ

Link between increases of gelatinous zooplankton and global warming is recent emerging research in world Ocean. Indian seas are less documented areas of the world regarding gelatinous zooplankton taxonomy and ecology. Considerable amount of work has been done to understand zooplankton populations in Indian waters have tended to focus mainly on copepods, the major zooplankton component. The other groups are being of secondary importance in terms of numerical abundance and hence not treated in detail as distributional pattern and their seasonal variation. To fulfill the gap, the present study was made on survey of gelatinous zooplankton in Indian EEZ during 2008-2012 to explore the distributional patterns and diversity of gelatinous zooplankton. The result showed that new occurrences of salps species of Pegea socia and hydromedusae of Haliscera bigelowi were identified for the first time from Arabian Sea. Totally, 115 species of gelatinous zooplankton were recorded in the Indian EEZ. Among them, 11 species of Scyphomedusae, 22 species of Hydromedusae, 17 species of Siphonophores, 5 species of Ctenophore, 9 species of Doliolids, 17 species of Salps, 15 species of Appendicularians and 19 species of Chaetognaths were recorded. The vertical distributional abundance was ranged from 7.37 to 1266.276 inds/100m3 and diversity was ranged from 3.176 to 3.91 bits/inds in the Arabian Sea. In the Bay of Bengal, abundance was ranged from 11.69 to 1174.11 inds/100m3 and diversity was ranged from 2.19 to 3.94 bits/inds. In the two water mass, maximum abundance and diversity was observed in 0-50m depth and minimum was in 500-1000m depth. Abundance of gelatinous zooplankton was gradually decreased upto 200m depth and sudden decreased below 200m to 1000m depth.

On the occurrence of buckler crab Cryptopodia angulata in the coastal waters of India

464-467The trend of marine non-indigenous species in India has been increasing, with more than half of the species probably being introduced by shipping. A live specimen of buckler crab Cryptopodia angulata was found along the west coast of India at 40 m depth. The recent new records at different Indian coastal locations suggest that the crab is widening its distribution. Shipping is thought to be the possible introduction vector (via ballast) for the spread of C. angulata in the coastal waters of India. Further, the favorable environmental conditions prevalent in the Indian coastal waters may facilitate the establishment and subsequent spread of C. angulata. The invasion of this buckler crab may have negative impact on the native species. Although not present in detectable numbers, C. angulata may pose a major threat to the native species, if it establishes. Information on the establishment and distribution of C. angulata from other locations along the Indian coast would be essential to comprehensively and effectively address the threat

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF

Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed CAPTURE , a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. We demonstrate that heterogeneous clones, either preexisting or emerging from drug-tolerant persister cells, dominated resistance to vemurafenib in BRA

GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma

A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM

GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma

A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM

On comparison of luminescence properties of La2Zr2O7 and La2Hf2O7 nanoparticles

Unveiling the underlying mechanisms of properties of functional materials, including the luminescence differences among similar pyrochlores A2B2O7, opens new gateways to select proper hosts for various optoelectronic applications by scientists and engineers. For example, although La2Zr2O7 (LZO) and La2Hf2O7 (LHO) pyrochlores have similar chemical compositional and crystallographic structural features, they demonstrate different luminescence properties both before and after doped with Eu3+ ions. Based on our earlier work, LHO‐based nanophosphors display higher photo‐ and radioluminescence intensity, higher quantum efficiency, and longer excited state lifetime compared to LZO‐based nanophosphors. Moreover, under electronic O2−→Zr4+/Hf4+ transition excitation at 306 nm, undoped LHO nanoparticles (NPs) have only violet blue emission, whereas LZO NPs show violet blue and red emissions. In this study, we have combined experimental and density functional theory (DFT) based theoretical calculation to explain the observed results. First, we calculated the density of state (DOS) based on DFT and studied the energetics of ionized oxygen vacancies in the band gaps of LZO and LHO theoretically, which explain their underlying luminescence difference. For Eu3+‐doped NPs, we performed emission intensity and lifetime calculations and found that the LHOE NPs have higher host to dopant energy transfer efficiency than the LZOE NPs (59.3% vs 24.6%), which accounts for the optical performance superiority of the former over the latter. Moreover, by corroborating our experimental data with the DFT calculations, we suggest that the Eu3+ doping states in LHO present at exact energy position (both in majority and minority spin components) where oxygen defect states are located unlike those in LZO. Lastly, both the NPs show negligible photobleaching highlighting their potential for bioimaging applications. This current report provides a deeper understanding of the advantages of LHO over LZO as an advanced host for phosphors, scintillators, and fluoroimmunoassays

On comparison of luminescence properties of La 2

Unveiling the underlying mechanisms of properties of functional materials, including the luminescence differences among similar pyrochlores A2B2O7, opens new gateways to select proper hosts for various optoelectronic applications by scientists and engineers. For example, although La2Zr2O7 (LZO) and La2Hf2O7 (LHO) pyrochlores have similar chemical compositional and crystallographic structural features, they demonstrate different luminescence properties both before and after doped with Eu3+ ions. Based on our earlier work, LHO‐based nanophosphors display higher photo‐ and radioluminescence intensity, higher quantum efficiency, and longer excited state lifetime compared to LZO‐based nanophosphors. Moreover, under electronic O2−→Zr4+/Hf4+ transition excitation at 306 nm, undoped LHO nanoparticles (NPs) have only violet blue emission, whereas LZO NPs show violet blue and red emissions. In this study, we have combined experimental and density functional theory (DFT) based theoretical calculation to explain the observed results. First, we calculated the density of state (DOS) based on DFT and studied the energetics of ionized oxygen vacancies in the band gaps of LZO and LHO theoretically, which explain their underlying luminescence difference. For Eu3+‐doped NPs, we performed emission intensity and lifetime calculations and found that the LHOE NPs have higher host to dopant energy transfer efficiency than the LZOE NPs (59.3% vs 24.6%), which accounts for the optical performance superiority of the former over the latter. Moreover, by corroborating our experimental data with the DFT calculations, we suggest that the Eu3+ doping states in LHO present at exact energy position (both in majority and minority spin components) where oxygen defect states are located unlike those in LZO. Lastly, both the NPs show negligible photobleaching highlighting their potential for bioimaging applications. This current report provides a deeper understanding of the advantages of LHO over LZO as an advanced host for phosphors, scintillators, and fluoroimmunoassays