Prosthetic rehabilitation with dental implants after treatment of a keratocystic odontogenic tumor: case report

Keratocystic odontogenic tumor (KCOT), formerly known as the odontogenic keratocyst (OKC) is a benign intraosseous lesion, characterized by invasive growth and high rate of recurrences. Although it is not frequently seen, KCOT may be associated with unerupted teeth and without relevant histopathological examinations, might be mistaken with dentigerous cyst. A 26 year-old male patient referred to our department with complaints of two months persisting painless swelling on the left side of mandible. Clinical and radiographic examinations revealed an impaction of the horizontally positioned left lower second premolar surrounded by a well-circumscribed radiolucent mass, located between the left canine and the second molar, suspected to be a cyst. The aim of this report is to present a therapeutical approach to keratocystic odontogenic tumor associated with impacted tooth and prosthetic rehabilitation with dental implants after an initial treatment. The patient is under follow up for 31 months since implant placement was done, without any complaints or complication

SOLID ANEURYSMAL BONE CYST IN THE MANDIBLE: CASE REPORT

The aneurysmal bone cyst is an uncommon, locally destructive osteolytic bone lesion occuring mos commonly in long bones. It is relatively rare in the maxillofacial region. Various treatment options have been proposed as conservative or radical surgery. The importance of the lesion in the maxillofacial surgery pactice is that it may easily confuse with malignancy. It is important the close follow-up of the solid aneurysmal bone cysts due to their aggresive behaviour and the affinity to recurrence. This paper presents a rare case of a solid aneurysmal bone cyst (ABC) involving the left corpus mandible in a 15-year-od-girl, with a 2.5 years of follow-up

Evaluation of the Hemostatic Effects of Ankaferd Blood Stopper During Dental Extractions in Patients on Antithrombotic Therapy

This study evaluated the early hemostatic effects of a novel hemostatic agent (Ankaferd blood stopper [ABS]) during dental extractions in patients on antithrombotic therapy, without interruption or diminution of the medication. In total, 25 patients, who are on antithrombotic therapy and in need of simple dental extractions, were randomized into 2 groups. In group I (control group), which consisted of 10 patients, local hemostasis was achieved with direct packing with gauze. In group II, which consisted of 15 patients, local hemostasis was achieved by the local application of ABS on the extraction sockets. The bleeding time was compared between 2 groups following the tooth extraction. The bleeding time in the dental sockets treated with ABS was statistically lower compared to the sockets of the control group (p = 0.0001). It is concluded that the dental extractions could be performed without interruption of the medication in patients on antithrombotic therapy. The ABS appears to be sufficient as an alternative hemostatic agent

Autonomous Synthesis of Fluorescent Silica Biodots Using Engineered Fusion Proteins

Formation of biological materials is a well-controlled process that is orchestrated by biomolecules such as proteins. Proteins can control the nucleation and mineralization of biomaterials, thereby forming the hard tissues of biological organisms, such as bones, teeth, and shells. In this study, the design and implementation of multifunctional designer proteins are demonstrated for fluorescent silica micro/nanoparticle synthesis. The R5 motif of silaffin polypeptide, which is known for its silicification capability, was fused genetically into three spectrally distinct fluorescent proteins with the intention of forming modified fluorescent proteins. The bifunctional R5 peptide domain served as a tag to provide silica synthesis at ambient conditions. Three functional fusion constructs have been prepared, including GFPmut3-R5, Venus YFP-R5, and mCherry-R5. Recombinant fluorescent proteins were purified using silica-binding peptide tag through silica gel resin. Purified proteins were tested for their binding affinity to silica using quartz crystal microbalance with dissipation monitoring to make sure they can interact strong enough with the silica surfaces. Later, engineered fluorescent proteins were used to synthesize silica nano/microparticles using silica precursor materials. Synthesized silica particles were investigated for their fluorescence properties, including time-resolved fluorescence. Additionally, elemental analysis of the particles was carried out using electron energy loss spectroscopy and energy-filtered transmission electron microscopy. Last, they were tested for their biocompatibility. In this study, we aimed to provide a biomimetic route to synthesize fluorescent silica nanoparticles. Recombinant fluorescent proteins-directed silica nanoparticles synthesis offers a one-step, reliable method to produce fluorescent particles both for biomaterial applications and other nanotechnology applications