On the Sensitivity of a Hollow Sphere as a Multi-modal Resonant Gravitational Wave Detector

We present a numerical analysis to simulate the response of a spherical resonant gravitational wave detector and to compute its sensitivity. Under the assump- tion of optimal filtering, we work out the sensitivity curve for a sphere first taking into account only a single transducer, and then using a coherent analysis of the whole set of transducers.Comment: 24 pages, 11 figures, published versio

Visible spectrum extended-focus optical coherence microscopy for label-free sub-cellular tomography

We present a novel extended-focus optical coherence microscope (OCM) attaining 0.7 {\mu}m axial and 0.4 {\mu}m lateral resolution maintained over a depth of 40 {\mu}m, while preserving the advantages of Fourier domain OCM. Our method uses an ultra-broad spectrum from a super- continuum laser source. As the spectrum spans from near-infrared to visible wavelengths (240 nm in bandwidth), we call the method visOCM. The combination of such a broad spectrum with a high-NA objective creates an almost isotropic 3D submicron resolution. We analyze the imaging performance of visOCM on microbead samples and demonstrate its image quality on cell cultures and ex-vivo mouse brain tissue.Comment: 15 pages, 7 figure

Diabetes alone should not be a reason for withholding adjuvant chemotherapy for stage III colon cancer

Background: With increasing prevalence of diabetes mellitus and colon cancer, the number of patients suffering from both diseases is growing, and physicians are being faced with complicated treatment decisions. Objective: To investigate the association between diabetes and treatment/course of stage III colon cancer and the association between colon cancer and course of diabetes. Materials and Methods: Additional information was collected from the medical records of all patients with both stage III colon cancer and diabetes (n=201) and a random sample of stage III colon cancer patients without diabetes (n=206) in the area of the population-based Eindhoven Cancer Registry (1998–2007). Results: Colon cancer patients without diabetes were more likely to receive adjuvant chemotherapy compared with diabetic colon cancer patients (OR 1.8; 95% CI 1.2–2.7). After adjustment for age, this difference was borderline significant (OR 1.6; 95% CI 1.0–2.6). Diabetic patients did not have: significantly more side-effects from surgery or adjuvant chemotherapy; more recurrence from colon cancer; significantly shorter time interval until recurrence; or a poorer disease-free survival or overall survival. Age and withholding of adjuvant chemotherapy were most predictive of all-cause mortality. After colon cancer diagnosis, the dose of antiglycaemic medications was increased in 22% of diabetic patients, resulting in significantly lower glycaemic indexes than before colon cancer diagnosis. Conclusions: Since diabetic patients did not have more side-effects of adjuvant chemotherapy, and adjuvant chemotherapy had a positive effect on survival for both patients with and without diabetes, diabetes alone should not be a reason for withholding adjuvant chemotherapy.Journal of Comorbidity 2011;1(1):19–2

Le débat des langues dans l’enseignement secondaire en Suisse romande au XIXe siècle

L’article traite de trois arguments majeurs ayant traversé les débats relatifs à l’introduction des langues vivantes : le caractère formatif de l’enseignement classique, l’utilité pratique des langues vivantes, leur vocation nationale. En adoptant un point de vue local, centré sur l’enseignement public dans quatre cantons romands (Genève, Vaud, Neuchâtel et Fribourg), en privilégiant les sources produites par les enseignants eux-mêmes, et en analysant l’évolution reliant deux périodes clés de l’histoire de l’institution scolaire, il met en évidence quelques variations que subit cet argumentaire. Il examine du même coup l’évolution des structures scolaires qui accueillent l’enseignement des langues vivantes.This paper deals with three of the main arguments related to the introduction of modern languages in secondary schools: the formative dimension of classical languages, the practical goals of the teaching of modern languages and its meaning for national education. By focussing on the local conditions in the public secondary schools of four French-speaking cantons (Geneva, Vaud, Neuchâtel, Fribourg) in Switzerland, by giving priority to sources produced by teachers themselves, by including two decisive periods of the history of educational institutions, the article points out some variations in these arguments. It thereby examines the evolution of the educational structures concerned with the teaching of modern languages

Le débat des langues dans l’enseignement secondaire en Suisse romande au XIXe siècle

L’article traite de trois arguments majeurs ayant traversé les débats relatifs à l’introduction des langues vivantes : le caractère formatif de l’enseignement classique, l’utilité pratique des langues vivantes, leur vocation nationale. En adoptant un point de vue local, centré sur l’enseignement public dans quatre cantons romands (Genève, Vaud, Neuchâtel et Fribourg), en privilégiant les sources produites par les enseignants eux-mêmes, et en analysant l’évolution reliant deux périodes clés de l’histoire de l’institution scolaire, il met en évidence quelques variations que subit cet argumentaire. Il examine du même coup l’évolution des structures scolaires qui accueillent l’enseignement des langues vivantes.This paper deals with three of the main arguments related to the introduction of modern languages in secondary schools: the formative dimension of classical languages, the practical goals of the teaching of modern languages and its meaning for national education. By focussing on the local conditions in the public secondary schools of four French-speaking cantons (Geneva, Vaud, Neuchâtel, Fribourg) in Switzerland, by giving priority to sources produced by teachers themselves, by including two decisive periods of the history of educational institutions, the article points out some variations in these arguments. It thereby examines the evolution of the educational structures concerned with the teaching of modern languages

Characterization of a MEMS-based pulse-shaping device inthedeep ultraviolet

We describe the implementation and characterization of a micro-mirror-array set-up based on Micro-Electro-Mechanical System (MEMS) technology for femtosecond pulse shaping in the deep UV. We demonstrate its capability of re-compressing spectrally broadened UV pulses with a closed-loop approach based on a genetic algorithm. A single-shot synchronization scheme, taking advantage of the limited duty cycle of the device and allowing on-line correction of the signal, is described. The second dimension of the MEMS chip can be used to partially reduce the spatial chirp of the bea

Neutron optical beam splitter from holographically structured nanoparticle-polymer composites

We report a breakthrough in the search for versatile diffractive elements for cold neutrons. Nanoparticles are spatially arranged by holographical means in a photopolymer. These grating structures show remarkably efficient diffraction of cold neutrons up to about 50% for effective thicknesses of only 200 micron. They open up a profound perspective for next generation neutron-optical devices with the capability to tune or modulate the neutron diffraction efficiency.Comment: 4 pages, 2 figure

An electronic application for rapidly calculating Charlson comorbidity score

BACKGROUND: Uncertainty regarding comorbid illness, and ability to tolerate aggressive therapy has led to minimal enrollment of elderly cancer patients into clinical trials and often substandard treatment. Increasingly, comorbid illness scales have proven useful in identifying subgroups of elderly patients who are more likely to tolerate and benefit from aggressive therapy. Unfortunately, the use of such scales has yet to be widely integrated into either clinical practice or clinical trials research. METHODS: This article reviews evidence for the validity of the Charlson Comorbidity Index (CCI) in oncology and provides a Microsoft Excel (MS Excel) Macro for the rapid and accurate calculation of CCI score. The interaction of comorbidity and malignant disease and the validation of the Charlson Index in oncology are discussed. RESULTS: The CCI score is based on one year mortality data from internal medicine patients admitted to an inpatient setting and is the most widely used comorbidity index in oncology. An MS Excel Macro file was constructed for calculating the CCI score using Microsoft Visual Basic. The Macro is provided for download and dissemination. The CCI has been widely used and validated throughout the oncology literature and has demonstrated utility for most major cancers. The MS Excel CCI Macro provides a rapid method for calculating CCI score with or without age adjustments. The calculator removes difficulty in score calculation as a limitation for integration of the CCI into clinical research. The simple nature of the MS Excel CCI Macro and the CCI itself makes it ideal for integration into emerging electronic medical records systems. CONCLUSIONS: The increasing elderly population and concurrent increase in oncologic disease has made understanding the interaction between age and comorbid illness on life expectancy increasingly important. The MS Excel CCI Macro provides a means of increasing the use of the CCI scale in clinical research with the ultimate goal of improving determination of optimal treatments for elderly cancer patients

Individual Differences in Well-Being in Older Breast Cancer Survivors

Older women who survive breast cancer may differ significantly in their long-term well-being. Using a risk and protective factors model, we studied predictors of well-being in 127 women age 70 and above with a history of at least one year\u27s survival of breast cancer. Mean post-cancer survivorship was 5.1 years. Using life satisfaction, depression and general health perceptions as outcome variables, we assessed whether demographic variables, cancer-related variables, health status and psychosocial resources predicted variability in well-being using correlational and hierarchical regression analyses. Higher age predicted increased depression but was not associated with life satisfaction or general health perceptions. Cancer-related variables, including duration of survival, and type of cancer treatment, were not significantly associated with survivors\u27 well-being. Poorer health status was associated with poorer well-being in all three dependent variables. After controlling for demographics, cancer-related variables, and health status, higher levels of psychosocial resources including optimism, mastery, spirituality and social support predicted better outcome in all three dependent variables. While many older women survive breast cancer without severe sequelae, there is considerable variability in their well-being after survivorship. Successful intervention with older breast cancer survivors might include greater attention not only to cancer-specific concerns, but also attention to geriatric syndromes and functional impairment, and enhancement of protective psychosocial resources