47 research outputs found
Personal, Political, Pedagogic: Challenging the binary bind in archaeological teaching, learning and fieldwork
yesIn this paper we consider how we can undercut the various binaries of gender and sexuality in
archaeological practice, and particularly in our teaching. We argue that taking an assemblage theory approach enables us to look at the multiplicity of identities of those practicing archaeology as different and intersecting assemblages that bring one another into being through their connections at different scales. In particular, we examine how this approach can be applied to archaeological pedagogy and how this in turn enables us to move away from modern binary distinctions about sex and gender identities from the "bottom up", fostering an approach in our students that will then go on to be developed in professional practice
Full Spectrum Archaeology
Full Spectrum Archaeology (FSA) is an aspiration stemming from the convergence of archaeology’s fundamental principles with international heritage policies and community preferences. FSA encompasses study and stewardship of the full range of heritage resources in accord with the full range of associated values and through the application of treatments selected from the full range of appropriate options. Late modern states, including British Columbia, Canada, nominally embrace de jure heritage policies consonant with international standards yet also resist de facto heritage management practice grounded in professional ethics and local values and preferences. In response, inheritor communities and their allies in archaeology are demonstrating the benefits of FSA and reclaiming control over cultural heritage. Archaeology and heritage management driven by altruistic articulation of communal, educational, scientific and other values further expose shortcomings and vulnerabilities of late modern states as well as public goods in and from FSA
Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons
Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus and adversely affects the patients’ quality of life. Evidence has accumulated that PDN is associated with hyperexcitability of peripheral nociceptive primary sensory neurons. However, the precise cellular mechanism underlying PDN remains elusive. This may result in the lacking of effective therapies for the treatment of PDN. The phenolic glucoside, gastrodin, which is a main constituent of the Chinese herbal medicine Gastrodia elata Blume, has been widely used as an anticonvulsant, sedative, and analgesic since ancient times. However, the cellular mechanisms underlying its analgesic actions are not well understood. By utilizing a combination of behavioral surveys and electrophysiological recordings, the present study investigated the role of gastrodin in an experimental rat model of STZ-induced PDN and to further explore the underlying cellular mechanisms. Intraperitoneal administration of gastrodin effectively attenuated both the mechanical allodynia and thermal hyperalgesia induced by STZ injection. Whole-cell patch clamp recordings were obtained from nociceptive, capsaicin-sensitive small diameter neurons of the intact dorsal root ganglion (DRG). Recordings from diabetic rats revealed that the abnormal hyperexcitability of neurons was greatly abolished by application of GAS. To determine which currents were involved in the antinociceptive action of gastrodin, we examined the effects of gastrodin on transient sodium currents (INaT) and potassium currents in diabetic small DRG neurons. Diabetes caused a prominent enhancement of INaT and a decrease of potassium currents, especially slowly inactivating potassium currents (IAS); these effects were completely reversed by GAS in a dose-dependent manner. Furthermore, changes in activation and inactivation kinetics of INaT and total potassium current as well as IAS currents induced by STZ were normalized by GAS. This study provides a clear cellular basis for the peripheral analgesic action of gastrodin for the treatment of chronic pain, including PDN
Different expressions of the same mode: a recent dialogue between archaeological and contemporary drawing practices
In this article we explore what we perceive as pertinent features of shared experience at the excavations of an Iron Age Hillfort at Bodfari, North Wales, referencing artist, archaeologist and examples of seminal art works and archaeological records resulting through inter-disciplinary collaboration. We explore ways along which archaeological and artistic practices of improvisation become entangled and productive through their different modes of mark-making. We contend that marks and memories of artist and archaeologist alike emerge interactively, through the mutually constituting effects of the object of study, the tools of exploration, and the practitioners themselves, when they are enmeshed in the cross-modally bound activities. These include, but are not limited to, remote sensing, surveying, mattocking, trowelling, drawing, photographing, videoing and sound recording. These marks represent the co-signatories: the gesture of the often anonymous practitioners, the voice of the deposits, as well as the imprint of the tools, and their interplay creates a multi-threaded narrative documenting their modes of intra-action, in short our practices. They occupy the conceptual space of paradata, and in the process of saturating the interstices of digital cognitive prosthetics they lend probity to their translations in both art form and archive
Emerging New Crop Pests: Ecological Modelling and Analysis of the South American Potato Psyllid Russelliana solanicola (Hemiptera: Psylloidea) and Its Wild Relatives
© 2017 Syfert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The recent contribution of scientific techniques to the study of Nokalakevi in Samegrelo, Georgia
The site of Nokalakevi, in western Georgia, has seen significant excavation since 1973, including, since 2001, a collaborative Anglo-Georgian project. However, the interpretation of the site has largely rested on architectural analysis of standing remains and the relative dating of deposits based on the study of ceramics. Since 2013, the Anglo-Georgian Expedition to Nokalakevi has collected a diverse dataset derived from multiple scientific techniques including optically stimulated luminescence (OSL) dating of ceramics, radiocarbon dating, δ13C and δ15N analysis and 87Sr/86Sr analysis. The full results of these analyses are reported here for the first time along with implications for the interpretation of the archaeology, which include greater detail in the site chronology but also indicators of diet and migration.
Batı Gürcistan’daki Nokalakevi yerleşim yerinde, 2001’de başlamiş olan bir İngiliz-Gürcü ortak projesi de dahil olmak üzere, 1973’ten beri önemli kazılar yapılmıştır. Bununla birlikte, yerleşimin yorumlanması büyük ölçüde ayakta kalmış olan kalıntıların mimari analizine ve seramik çalışmalarına dayanarak yapılmış olan, tabakaların göreceli tarihlendirmesine dayanmaktadir. Nokalakevi’de yapılan İngiliz-Gürcü ortak kazıları 2013’ten bu yana seramikleri, optik uyarmalı lüminesans (OSL) tarihlemesi, radyokarbon tarihlemesi, δ13C ve δ15N analizi ve 87Sr/86Sr analizleri dahil olmak üzere birçok bilimsel teknikten yararlanarak incelemiş ve çeşitli verilere ulaşmıştir. Bu analizlerin tam sonuçları, arkeolojinin yorumlanmasına yönelik çıkarımlarla birlikte ilk kez burada rapor edilmektedir. Bu rapor, yerleşimin kronolojisiyle ilgili daha fazla ayrıntıya ve aynı zamanda beslenme ve göç göstergelerini de içeren bazı çıkarımlara sahiptir
Distinct potassium channels on pain-sensing neurons
Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model of neuropathic pain leads to striking reductions in voltage-gated K(+) (Kv) channel subunit expression in dorsal root ganglia (DRG) neurons, suggesting a potential molecular mechanism for hyperexcitability of injured nerves. Moreover, specific classes of DRG neurons express distinct Kv channel subunit combinations. Importantly, Kv1.4 is the sole Kv1 α subunit expressed in smaller diameter neurons, suggesting that homomeric Kv1.4 channels predominate in Aδ and C fibers arising from these cells. These neurons are presumably nociceptors, because they also express the VR-1 capsaicin receptor, calcitonin gene-related peptide, and/or Na(+) channel SNS/PN3/Nav1.8. In contrast, larger diameter neurons associated with mechanoreception and proprioception express high levels of Kv1.1 and Kv1.2 without Kv1.4 or other Kv1 α subunits, suggesting that heteromers of these subunits predominate on large, myelinated afferent axons that extend from these cells