Young Widower

John W. Evans was twenty-nine years old and his wife, Katie, was thirty. They had met in the Peace Corps in Bangladesh, taught in Chicago, studied in Miami, and were working for a year in Romania when they set off with friends to hike into the Carpathian Mountains. In an instant their life together was shattered. Katie became separated from the group. When Evans finally found her, he could only watch helplessly as she was mauled to death by a brown bear. In such a love story, such a life story, how could a person ever move forward? That is the question Evans, traumatized and restless, confronts in this book as he learns the language of grief, the rhetoric of survival, and the contrary algorithms of holding fast and letting go. His memories of Katie and their time together, and the strangeness of his life with her family in the year after her death, create an unsentimental but deeply moving picture of loss, the brutality of nature, and the unfairness of needing to narrate a story that nothing can prepare a person to tell. Told with unyielding witness, elegance, and care, Young Widower is a heartbreaking account of a senseless tragedy and the persistence of grief in a young person’s life

Crepuscule

page 1

Young Widower

John W. Evans was twenty-nine years old and his wife, Katie, was thirty. They had met in the Peace Corps in Bangladesh, taught in Chicago, studied in Miami, and were working for a year in Romania when they set off with friends to hike into the Carpathian Mountains. In an instant their life together was shattered. Katie became separated from the group. When Evans finally found her, he could only watch helplessly as she was mauled to death by a brown bear. In such a love story, such a life story, how could a person ever move forward? That is the question Evans, traumatized and restless, confronts in this book as he learns the language of grief, the rhetoric of survival, and the contrary algorithms of holding fast and letting go. His memories of Katie and their time together, and the strangeness of his life with her family in the year after her death, create an unsentimental but deeply moving picture of loss, the brutality of nature, and the unfairness of needing to narrate a story that nothing can prepare a person to tell. Told with unyielding witness, elegance, and care, Young Widower is a heartbreaking account of a senseless tragedy and the persistence of grief in a young person’s life

Board independence, sub-committee independence and firm performance: evidence from Australia

This study investigates whether the monitoring of company management by an independent board of directors serves to enhance firm performance in Australia. The paper explores in detail the impact of the level of independence of the main board and sub-committees including audit, remuneration and nomination on performance in a sample of 250 listed companies. From the perspective of a regulator, the study’s findings have implications and suggest that an independent main board produces superior results. The shareholding of independent directors is also found to negatively impact performance for this data, suggesting that their role as independent arbiter is restricted by shareholding. Interestingly, the returns to firm performance engendered by independence did not extend to the composition of sub-committees, where the presence of outside directors did not significantly influence performance

Coping with Poorly Understood Domains: the Example of Internet Trust

The notion of trust, as required for secure operations over the Internet, is important for ascertaining the source of received messages. How can we measure the degree of trust in authenticating the source? Knowledge in the domain is not established, so knowledge engineering becomes knowledge generation rather than mere acquisition. Special techniques are required, and special features of KBS software become more important than in conventional domains. This paper generalizes from experience with Internet trust to discuss some techniques and software features that are important for poorly understood domains

Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation

The cells and molecules that comprise the immune system are essential for mounting an effective response against microbes. A successful immune response limits pathology within the host while simultaneously eliminating the pathogen. The key to this delicate balance is the correct recognition of the pathogen and the appropriate response of immune cells. Cellular activation originates through receptors that relay information about the state of the microenvironment to different compartments within the cell. The rapid relay of information is called signal transduction and employs a network of signaling mediators such as kinases, phosphatases, adaptor molecules, and transcription factors. IL-2 inducible T cell kinase (Itk) is a non-receptor tyrosine kinase that is an integral component of signal transduction downstream of many immunoreceptors. This dissertation describes two distinct pathways that utilize Itk in both phases of the immune response. T cells use the TCR to sense a multitude of peptide-based ligands and to transmit signals inside the cell to activate cellular function. In this regard, the diversity of ligands the T cells encounter can be portrayed as analog inputs. Once a critical threshold is met, signaling events transpire in close proximity to the plasma membrane to activate major downstream pathways in the cell. The majority of these pathways are digital in nature resulting in the on or off activation of T cells. We find, however, that altering the TCR signal strength that a T cell receives can result in an analog-based response. Here, the graded expression of a transcription factor, IRF4, is modulated through the activity of Itk. We link this graded response to an NFAT-mediated pathway in which the digital vs. analog nature has been previously uncharacterized. Finally, we demonstrate that the repercussions of an analog signaling pathway is the altered expression of a second transcription factor, Eomes, which is important in the differentiation and function of T cells. These results suggest that Itk is crucial in the modulation of TCR signal strength. Mast cells primarily rely on the IgE-bound FcεR1 for pathogen recognition. Crosslinking this receptor activates mast cells and results in degranulation and cytokine production via an expansive signaling cascade. Upon stimulation, Itk is recruited to the plasma membrane and phosphorylated. Little else is known about how Itk operates inside of mast cells. We find that mast cells lacking Itk are hyperresponsive to FcεR1-mediated activation. This is most apparent in the amount of IL-4 and IL-13 produced in comparison to wild-type mast cells. Increased cytokine production was accompanied by elevated and sustained signaling downstream of the FcεR1. Finally, biochemical evidence demonstrates that Itk is part of an inhibitory complex containing the phosphatase SHIP-1. These results indicate a novel function for Itk as a negative regulator in FcεR1- mediated mast cell activation

Adaptive learning, endogenous inattention, and changes in monetary policy

This paper develops an adaptive learning formulation of an extension to the Ball, Mankiw, and Reis (2005) sticky information model that incorporates endogenous inattention. We show that, following an exogenous increase in the policymaker’s preferences for price vs. output stability, the learning process can converge to a new equilibrium in which both output and price volatility are lower.Monetary policy ; Information theory

A Critical Assessment of Theories of Strain Gradient Plasticity

Theories to extend plasticity to the micron scale have been in existence for over a decade, complemented by a growing body of experimental data. Here, materials and mechanics aspects of two prominent strain gradient theories of plasticity, due to Nix and Gao and to Fleck and Hutchinson, are assessed within the context of simple bending. Differences between the theories are highlighted. The theories predict different trends relative to the size dependence of initial yielding and rate of hardening. The dislocation mechanics underpinning the two theories is addressed. Distinctions between lower-order theories and higher-order theories are also drawn, emphasizing the flexibility of higher-order theories to solve problems for a wide range of boundary conditions, especially those where, locally, the dislocations are blocked (pile up) and the plastic strain is zero.Engineering and Applied Science