6,498 research outputs found
The Power to Punish Summarily for “Direct” Contempt of Court: An Unnecessary Exception to Due Process
The Power to Punish Summarily for “Direct” Contempt of Court: An Unnecessary Exception to Due Process
How people with dementia collaborate with other people is an area in need of more research and conceptualizations. Collaboration introduces a number of new possibilities and demands concerning cognitive and linguistic abilities and it is suggested that a theoretical framework that emphasize that cognitive resources are not exclusively individual, but are part of cognitive and communicative context. In this article focus is on joint activities and their collaborative organization is analyzed using an example involving persons with dementia working together with staff preparing a meal. The analysis shows that persons with dementia are able to collaborate in fairly advanced activities if they are supported in such a way that they can make use of the cognitive and linguistic resources of others, in particular cognitive functions having to do with planning and execution of actions. The organization of artifacts like kitchen tools can function as an external memory support. The results support a theoretical framework that help to understand what people can do together rather than focus on individual abilities. The results also indicate that is possible to learn how to organize collaboration involving persons with dementia by understanding how other persons abilities as well as artifacts can be used as external resources for support of cognitive and linguistic abilities.
The Signature of Primordial Grain Growth in the Polarized Light of the AU Mic Debris Disk
We have used the Hubble Space Telescope/ACS coronagraph to make polarization
maps of the AU Mic debris disk. The fractional linear polarization rises
monotonically from about 0.05 to 0.4 between 20 and 80 AU. The polarization is
perpendicular to the disk, indicating that the scattered light originates from
micron sized grains in an optically thin disk. Disk models, which
simultaneously fit the surface brightness and polarization, show that the inner
disk (< 40-50 AU) is depleted of micron-sized dust by a factor of more than
300, which means that the disk is collision dominated. The grains have high
maximum linear polarization and strong forward scattering. Spherical grains
composed of conventional materials cannot reproduce these optical properties. A
Mie/Maxwell-Garnett analysis implicates highly porous (91-94%) particles. In
the inner Solar System, porous particles form in cometary dust, where the
sublimation of ices leaves a "bird's nest" of refractory organic and silicate
material. In AU Mic, the grain porosity may be primordial, because the dust
"birth ring" lies beyond the ice sublimation point. The observed porosities
span the range of values implied by laboratory studies of particle coagulation
by ballistic cluster-cluster aggregation. To avoid compactification, the upper
size limit for the parent bodies is in the decimeter range, in agreement with
theoretical predictions based on collisional lifetime arguments. Consequently,
AU Mic may exhibit the signature of the primordial agglomeration process
whereby interstellar grains first assembled to form macroscopic objects.Comment: 12 pages, 8 figures, ApJ, in pres
Sigma models as perturbed conformal field theories
We show that two-dimensional sigma models are equivalent to certain perturbed
conformal field theories. When the fields in the sigma model take values in a
space G/H for a group G and a maximal subgroup H, the corresponding conformal
field theory is the limit of the coset model , and the
perturbation is related to the current of G. This correspondence allows us for
example to find the free energy for the "O(n)" (=O(n)/O(n-1)) sigma model at
non-zero temperature. It also results in a new approach to the CP^{n} model.Comment: 4 pages. v2: corrects typos (including several in the published
version
Temperature-dependent phenology of Plutella xylostella (Lepidoptera: Plutellidae): Simulation and visualization of current and future distributions along the Eastern Afromontane
There is a scarcity of laboratory and field-based results showing the movement of the diamondback moth (DBM) Plutella xylostella (L.) across a spatial scale. We studied the population growth of the diamondback moth (DBM) Plutella xylostella (L.) under six constant temperatures, to understand and predict population changes along altitudinal gradients and under climate change scenarios. Non-linear functions were fitted to continuously model DBM development, mortality, longevity and oviposition. We compiled the best-fitted functions for each life stage to yield a phenology model, which we stochastically simulated to estimate the life table parameters. Three temperature-dependent indices (establishment, generation and activity) were derived from a logistic population growth model and then coupled to collected current (2013) and downscaled temperature data from AFRICLIM (2055) for geospatial mapping. To measure and predict the impacts of temperature change on the pest's biology, we mapped the indices along the altitudinal gradients of Mt. Kilimanjaro (Tanzania) and Taita Hills (Kenya) and assessed the differences between 2013 and 2055 climate scenarios. The optimal temperatures for development of DBM were 32.5, 33.5 and 33ÊC for eggs, larvae and pupae, respectively. Mortality rates increased due to extreme temperatures to 53.3, 70.0 and 52.4% for egg, larvae and pupae, respectively. The net reproduction rate reached a peak of 87.4 female offspring/female/generation at 20ÊC. Spatial simulations indicated that survival and establishment of DBM increased with a decrease in temperature, from low to high altitude. However, we observed a higher number of DBM generations at low altitude. The model predicted DBM population growth reduction in the low and medium altitudes by 2055. At higher altitude, it predicted an increase in the level of suitability for establishment with a decrease in the number of generations per year. If climate change occurs as per the selected scenario, DBM infestation may reduce in the selected region. The study highlights the need to validate these predictions with other interacting factors such as cropping practices, host plants and natural enemies.Peer reviewe
Eculizumab inhibits thrombotic microangiopathy and improves renal function in pediatric patients with atypical hemolytic uremic syndrome
Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome
Atypical hemolytic uremic syndrome (aHUS) is caused by alternative complement pathway dysregulation, leading to systemic thrombotic microangiopathy (TMA) and severe end-organ damage. Based on 2 prospective studies in mostly adults and retrospective data in children, eculizumab, a terminal complement inhibitor, is approved for aHUS treatment. Here we prospectively evaluated efficacy and safety of weight-based dosing of eculizumab in eligible pediatric patients with aHUS in an open-label phase II study. The primary end point was complete TMA response by 26 weeks. Twenty-two patients (aged 5 months-17 years) were treated; 16 were newly diagnosed, 12 had no prior plasma exchange/infusion during current TMA symptomatology, 11 received baseline dialysis, and 2 had prior renal transplants. By week 26, 14 achieved a complete TMA response, 18 achieved hematologic normalization, and 16 had 25% or better improvement in serum creatinine. Plasma exchange/infusion was discontinued in all, and 9 of the 11 patients who required dialysis at baseline discontinued, whereas none initiated new dialysis. Eculizumab was well tolerated; no deaths or meningococcal infections occurred. Bone marrow failure, wrist fracture, and acute respiratory failure were reported as unrelated severe adverse events. Thus, our findings establish the efficacy and safety of eculizumab for pediatric patients with aHUS and are consistent with proposed immediate eculizumab initiation following diagnosis in children
Fragmentation and Evolution of Molecular Clouds. I: Algorithm and First Results
We present a series of simulations of the fragmentation of a molecular cloud,
leading to the formation of a cluster of protostellar cores. The purpose of
these simulations is to address a specific numerical problem called artificial
fragmentation, that plagues SPH simulations of cloud fragmentation. We argue
that this is a serious problem that needs to be addressed, and that the only
reasonable and practical way to address it is to use a relatively new technique
called particle splitting. Our largest simulation has an effective resolution
of 256^3 particles (much higher than most previous SPH simulations of cloud
fragmentation) and results in the formation of a dense cluster containing ~3000
protostellar cores. It is the first simulation of this kind to properly resolve
the Jeans mass throughout the entire system, at all times, thus preventing
artificial fragmentation.Comment: 47 pages, 15 figures (2 grayscale, one color), ApJ Suppl, in pres
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