Liderazgo del director y clima escolar en dos instituciones educativas públicas de Huacho - 2014

La presente investigación tiene como problema general determinar la relación entre el liderazgo del director y el y clima escolar en dos instituciones educativas publicas Luis Fabio Xammar Jurado y Félix B. Cárdenas, Huacho - 2014. La investigación realizada en la metodología se aplicó el tipo de estudio descriptivo correlacional y su diseño no experimental y transversal o transeccional, donde se trabajó con una población constituida por 290 docentes de las instituciones educativas públicas Luis Fabio Xammar Jurado y Félix B. Cárdenas de Huacho - 2014. La muestra fue aleatoria simple proporcional. El enfoque de investigación es cuantitativo y se utilizó para la recolección de datos, fichas de observación para cada una de las variables de investigación. Para establecer la confiabilidad del cuestionario, se aplicó una prueba de consistencia interna a una muestra piloto de 20 docentes y se obtuvo el estadístico Alfa de Cronbach para las variables: Potencial Creativo Docente y Motivación Académica. Luego se procesaran los datos, haciendo uso del Programa Estadístico SPSS versión 22.0. Por otro lado de acuerdo a los resultados obtenidos se evidencia que existe relación moderada fuerte positiva entre el liderazgo del director y el y clima escolar en las instituciones educativas publicas Luis Fabio Xammar Jurado y Félix B. Cárdenas, Huacho - 2014. (sig. bilateral = 0.000 < 0.01; Rho = 652)

Control preventivo y gestión financiera en la Empresa de Transportes y Minerales López S.A., Huancayo - 2019

La presente investigación Titulada CONTROL PREVENTIVO Y GESTIÓN FINANCIERA EN LA EMPRESA DE TRANSPORTES Y MINERALES LOPEZ S.A, HUANCAYO- 2019. Se formuló como problema general: ¿Cuál es la relación entre control preventivo y gestión financiera en la empresa de Transportes y Minerales López S.A., Huancayo- 2019? El objetivo de la investigación fue determinar la relación entre control preventivo y gestión financiera en la empresa de Transportes y Minerales López S.A., Huancayo- 2019. La hipótesis de la investigación fue: Existe una relación significativa y directa entre control preventivo y gestión financiera en la empresa de Transportes y Minerales López S.A, Huancayo- 2019. La metodología empleada en este estudio fue la científica de tipo aplicada. El análisis se realizó a 36 trabajadores, para lo cual se utilizó un cuestionario como instrumento para recolectar información. Se determinó que, según la escala de correlación, el Coeficiente de Correlación Rho de Spearman se estimó en 0,582, lo que sugiere una correlación positiva moderada. Con base a este hallazgo, se respaldó la hipótesis general que postula la existencia de una relación significativa y directa entre el control preventivo y la gestión financiera en la empresa de Transportes y Minerales López S.A., Huancayo- 2019. Se recomienda delegar responsabilidades limitadas en función de las capacidades de los colaboradores, con el objetivo de permitirles profundizar sus conocimientos y maximizar su potencial para generar mejoras dentro de la organización

Case Study: Effects of Psychosocial Factors on a Geriatric Patient with Guillain Barré Syndrome

The purpose of this case report is to determine how a change in intrinsic motivation and environmental factors help physical and functional improvements in a 77-year-old male patient with Guillain Barré Syndrome (GBS) in the geriatric population. Interventions to promote this change included patient education about lifestyle choices along with endurance and balance exercises. Patient psychological state, community access, and general education about interventions/dosing had an effect on the patient\u27s participation in his prescribed HEP. His comorbidities hindered his overall progress over the course of his treatment and should be addressed to improve patient outcomes. Activities that were more salient and stimulating to the patient, such as a swimming class or participating in a social event were reported to be more likely to be completed. These types of activities may address the patient’s GBS and associated comorbidities.https://soar.usa.edu/casmsummer2019/1000/thumbnail.jp

Motivación y desempeño laboral en los trabajadores de la municipalidad distrital de Malvas, 2021

La presente investigación se desarrolló en la Municipalidad Distrital de Malvas, cuyo objetivo general es determinar la relación que existe entre la motivación y el desempeño laboral en los trabajadores de la municipalidad distrital de Malvas, 2021. El enfoque de la investigación es cuantitativo, diseño no experimental transversal, de nivel correlacional y con variable cualitativa ordinal. Para obtener los resultados de la investigación se elaboró un cuestionario de 20 ítems en la escala Likert teniendo en cuenta las dimensiones e indicadores de Motivación y Desempeño Laboral. Además, el instrumento mencionado se aplicó a 15 trabajadores de la municipalidad. Finalmente se concluye con una significancia asintótica (p-valor = 0.000) menor que el nivel de significancia (p - valor=0.05). Entonces, existe suficiente evidencia estadística para rechazar la hipótesis nula y se aceptar la hipótesis alterna (hipótesis del investigador). Por lo tanto, La motivación tiene relación con el desempeño laboral de los trabajadores en la municipalidad distrital de Malvas, 2021.Además, la correlación de Rho de Spearman es de 0.796, de acuerdo a la escala de Bisquerra dicha correlación es positiva y moderada. Es decir, Es decir, en dicha entidad se aplica la motivación teniendo en cuenta los factores extrínsecos, intrínsecos y trascendentales para estimular al trabajador y obtener mejores resultados basados en eficacia y eficienci

Frecuencia de embarazo en adolescentes de 15 años de edad en el Hospital Materno Infantil de Loma Pytá período enero de 2008 a mayo de 2015

oai:revista.serrana.edu.py:article/2El propósito del trabajo fue determinar la frecuencia de embarazo en adolescentes menores de 15 años, a través de la Historia Clínica de las pacientes atendidas en el Hospital Materno Infantil de Loma Pytá, estudio que se pudo obtener tomando una muestra de 87 embarazadas jóvenes que recibieron atención entre enero de 2008 y mayo de 2015. La metodología de investigación aplicada fue la cuantitativa, por medio de la cual se pudo obtener datos específicos como el rango de edad en que se produce una mayor ocurrencia de embarazos precoces. La investigación fue descriptiva de corte transversal. La población la constituyeron todas las gestantes adolescentes que fueron atendidas en la Unidad de Internado de Gineco–obstetricia de la Institución mencionada. Como resultado de la investigación se pudo constatar que si bien el Estado paraguayo ha asumido el compromiso de invertir en educación sexual, el 24 por ciento de las adolescentes que consultaron en este servicio de salud ya fueron madres antes de los 15 años, un porcentaje que en sí mismo demuestra falencias en la educación en la sexualidad que se provee a las y los niños, niñas y adolescentes del Paraguay. Se detectaron ciertas complicaciones que trae consigo el embarazo precoz, que corren 5 veces mayor riesgo de muerte que una mujer adulta. Entre las complicaciones se mencionan la desproporción céfalo pélvica que es la más severa, seguida de la pre eclampsia. También pueden presentarse complicaciones en el feto como malformaciones, bajo peso y muertes fetales, entre otras

Nanomedicine for the delivery of RNA in cancer

The complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery.This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through project UIDB/50006/2020

The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer

Gastric cancer (GC) is the fifth most frequently diagnosed malignant tumor and the third highest cause of cancer mortality worldwide. For advanced GC, many novel drugs and combinations have been tested, but results are still disappointing, and the disease is incurable in the majority of cases. In this regard, it is critical to investigate the molecular mechanisms underlying GC development. Angiogenesis is one of the hallmarks of cancer with a fundamental role in GC growth and progression. Ramucirumab, a monoclonal antibody that binds to vascular endothelial growth factor-2 (VEGFR-2), is approved in the treatment of advanced and pretreated GC. However, no predictive biomarkers for ramucirumab have been identified so far. Micro RNAs (miRNAs) are a class of evolutionarily-conserved single-stranded non-coding RNAs that play an important role (via post-transcriptional regulation) in essentially all biologic processes, such as cell proliferation, differentiation, apoptosis, survival, invasion, and migration. In our review, we aimed to analyze the available data on the role of angiogenesis-related miRNAs in GC

The effect of lymphatic microsurgical preventive healing approach (LYMPHA) on the development of upper-extremity lymphedema following axillary lymph node dissection in breast cancer patients

Background/Objective: Lymphedema following axillary lymph node dissection (ALND) is a common complication that can negatively impact quality of life as it reduces the functional capacity of the affected arm. It can also predispose patients to serious infectious complications such as limb cellulitis and development of malignancy. The lymphatic microsurgical preventive healing approach (LYMPHA procedure) involves the creation of a lymphatic‐to‐venous bypass at the time of axillary lymph node dissection (ALND) as a means of preventing lymphedema. The goal of our study is to assess the effect of LYMPHA on the development of clinical and subjective post‐operative lymphedema. Methods: This is a prospective longitudinal study in patients with breast cancer who underwent ALND with or without LYMPHA. The incidence of lymphedema was compared between ALND alone and ALND with LYMPHA using descriptive statistics. Limb circumference of both affected and unaffected limbs were measured and used to calculate limb volume by using an equation that converts limb circumference (cm) to volume (cc). Lymphedema was defined as a volume difference of ≥10% between the affected and unaffected limb. Patient symptoms were also assessed and compared between the 2 groups. Patient demographics including age, preoperative body mass index (BMI), smoking history, comorbidities, receipt of neoadjuvant or adjuvant chemotherapy, and receipt of adjuvant radiation were compared between the groups. Results: In our cohort of 139 patients, 104 underwent ALND with LYMPHA, while 35 underwent ALND alone. Of these, 52.5% of patients had documented interlimb circumference measurements. The mean age was 52.6 years old, mean BMI was 30.16 kg/m2, 4 patients (2.9%) had pre‐operative radiation, 102 patients (73.4 %) had post‐operative radiation, 86 patients (61.9 %) had neoadjuvant chemotherapy, 41 and 58 patients (41.7 %) had adjuvant chemotherapy. There were no significant differences between the 2 groups in the above demographics and treatment variables, except those who underwent ALND alone had a significantly higher incidence of diabetes mellitus (25.7% patients with ALND alone vs 11.5% LYMPHA patients (p=0.043)). Based on patient reported symptoms and the need to initiate complete decongestive therapy, 57.1% (n=20) of patients who underwent ALND alone developed lymphedema compared to 26.9% (n=28 patients) of those who had ALND with LYMPHA (p=0.0011). When comparing the relative volume difference, 57.1% (n=8) of ALND alone patients developed lymphedema versus 20.3% (n=12) of LYMPHA patients (p=0.0055). Conclusions: Our data support the universal use of LYMPHA at the time of ALND as a means of preventing upper extremity lymphedema. Further studies are needed to evaluate quality of life and functional differences between those who had LYMPHA and those who did not

FISIOTERAPIA APLICADA À REABILITAÇÃO DE ARTRITE REUMATÓIDE

Rheumatoid arthritis is a chronic autoimmune disease that affects the body's joints. The exact cause of rheumatoid arthritis is not completely understood, but it is considered an autoimmune disease in which the immune system attacks the body itself. General Objective: to present scientific material that covers a detailed study on the origin, causes and evolution of Rheumatoid Arthritis (RA), as well as to identify the most used approaches in physiotherapeutic treatment. Methodology: This is a bibliographic review. Consultations with research indexers in the databases were: MEDLINE/PubMed, SciELO and LILACS, covering the period from January 2017 to December 2023. Results and Discussion: The initial research resulted in 137 results, of which only 10 met the selection criteria established for the preparation of the bibliographic review. The pathophysiology of rheumatoid arthritis (RA) is complex and involves several immunological and inflammatory processes that lead to chronic joint inflammation and, eventually, the destruction of joint tissue. Final Considerations: Physiotherapy plays a significant role in the rehabilitation of patients with rheumatoid arthritis (RA), providing a series of important benefits to reduce symptoms, especially pain, in addition to improving functionality and quality of life.A artrite reumatoide é uma doença autoimune crônica que afeta as articulações do corpo. A causa exata da artrite reumatoide não é completamente compreendida, mas é considerada uma doença autoimune, na qual o sistema imunológico ataca o próprio corpo. Objetivo Geral:apresentar material científico que abrange estudo detalhado sobre a origem, causas e evolução da Artrite Reumatoide (AR), bem como identificar as abordagens mais utilizadas no tratamento fisioterapêutico. Metodologia: Trata-se de uma revisão bibliográfica.As consultas aos indexadores de pesquisa nas bases de dados foram: MEDLINE/PubMed, SciELO e LILACS, abrangendo o período de janeiro de 2017 a dezembro de 2023.Resultados e Discussão:A pesquisa inicial resultou em 137 resultados, dos quais apenas 10 atenderam aos critérios de seleção estabelecidos para a elaboração da revisão bibliográfica. A fisiopatologia da artrite reumatoide (AR) é complexa e envolve vários processos imunológicos e inflamatórios que levam à inflamação crônica das articulações e, eventualmente, à destruição do tecido articular. Considerações Finais: A fisioterapia desempenha um papel significativo na reabilitação de pacientes com artrite reumatoide (AR), proporcionando uma série de benefícios importantes para reduzir o quadro de sintomas, especialmente a dor, além de melhorar a funcionalidade e a qualidade de vida. &nbsp

The effect of oncoplastic reduction on the incidence of post-operative lymphedema in breast cancer patients undergoing lumpectomy

Purpose: In breast cancer patients with macromastia, breast conservation surgery (BCS) followed by radiation therapy (RT) may be associated with a different complication profile than those without macromastia. Oncoplastic reduction mammoplasty (ORM) aims to reduce breast volume while excising the tumor bed and its margins. Since breast volume was found to be a risk factor for chronic breast lymphedema, this study was performed to determine the impact of ORM on chronic breast lymphedema as well as other complications compared to BCS without ORM. Material & Methods: We performed a retrospective chart review on patients who underwent lumpectomy with RT from 2014 to 2018. Chronic breast lymphedema (CBL) was defined as swelling that persisted \u3e1 year post-RT. Breast volumes (BV) were determined by contoured breast volumes or, if unavailable, estimated by the 95% isodose volumes from the RT treatment planning system. Univariate analysis was used to evaluate patient factors and treatment outcomes in women with BV ≥1300 cc compared to-Evaluate factors associated with ≥1 complication. Identify factors associated with the development of CBL. Results: The total population included 1173 patients: -1122 (95.7%) underwent BCS alone without ORM -51 (4.3%) underwent ORM -733 (62.5%) had a BVcc -440 (37.5%) had BV ≥1300 cc Multivariate regression analysis demonstrated that compared to patients with BV \u3c 1300 cc, patients with BV ≥1300 cc had: -Higher BMI (OR=1.200, P\u3c0.001) -Increased risk of CBL (OR=2.127, P=0.024) -Decreased risk of grade 2 radiation dermatitis (OR=0.457, P=0.002) Conclusion: Our data demonstrates that patients with breast volumes ≥1300 cc were two times more likely to develop CBL. Although patients with ORM had an increased risk for surgical site complications, the ORM procedure may have mitigated their risk for CBL. ORM should be considered at the time of BCS in women with macromastia to reduce their future risk of CBL as there is no cure for this disease.https://scholarlycommons.henryford.com/sarcd2021/1008/thumbnail.jp