Rituximab and autologous stem-cell transplantation for high-risk diffuse large B-cell lymphoma - Authors' reply

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Dissecting FLOPs Along Input Dimensions for GreenAI Cost Estimations

The term GreenAI refers to a novel approach to Deep Learning, that is more aware of the ecological impact and the computational efficiency of its methods. The promoters of GreenAI suggested the use of Floating Point Operations (FLOPs) as a measure of the computational cost of Neural Networks; however, that measure does not correlate well with the energy consumption of hardware equipped with massively parallel processing units like GPUs or TPUs. In this article, we propose a simple refinement of the formula used to compute floating point operations for convolutional layers, called alpha-FLOPs, explaining and correcting the traditional discrepancy with respect to different layers, and closer to reality. The notion of alpha-FLOPs relies on the crucial insight that, in case of inputs with multiple dimensions, there is no reason to believe that the speedup offered by parallelism will be uniform along all different axes

Image embedding for denoising generative models

Denoising Diffusion models are gaining increasing popularity in the field of generative modeling for several reasons, including the simple and stable training, the excellent generative quality, and the solid probabilistic foundation. In this article, we address the problem of embedding an image into the latent space of Denoising Diffusion Models, that is finding a suitable “noisy” image whose denoising results in the original image. We particularly focus on Denoising Diffusion Implicit Models due to the deterministic nature of their reverse diffusion process. As a side result of our investigation, we gain a deeper insight into the structure of the latent space of diffusion models, opening interesting perspectives on its exploration, the definition of semantic trajectories, and the manipulation/conditioning of encodings for editing purposes. A particularly interesting property highlighted by our research, which is also characteristic of this class of generative models, is the independence of the latent representation from the networks implementing the reverse diffusion process. In other words, a common seed passed to different networks (each trained on the same dataset), eventually results in identical images

A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid

Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immunofluorescence (linear deposition of IgG at the dermo-epidermal junction). Topical and/or systemic corticosteroids are the first-line treatment. The prognosis is good with a self-limited clinical course. Differential diagnoses include impetigo and other bullous diseases in children, such as dermatitis herpetiformis, linear IgA bullous dermatosis and erythema multiforme. The etiopathogenesis is still unknown, and the role of antigen stimuli such as infections, drugs and vaccination is still debated

Protected designation of origin as driver of change in goat production systems: Beyond added value

Protected Designation of Origin (PDO) is one of the EU tools for rural development. Most of the literature on this subject is focused on premium prices and consumers’ willingness to pay for local products, since PDO and other labels aim to provide premium incomes for farmers. Our assumption is that PDO drives unexpected changes of farming styles not only related to processing or market strategies but also related to local resources using and to stablishing of different approach to agriculture and food production. We analyzed the PDO Queso Palmero (La Palma cheese) as a case of a dual label system (brand–certification common label) because it gives us the opportunity to compare farmers involved in a PDO scheme with farmers who works outside such systems. We conclude that private brands are more important than common label certification in price formation, but both are complementary, since PDO reinforces farmers’ efforts to improve quality. Beyond premium price, PDO also drives a radical change in farm structures, since it reconnects products to local resources (grazing vs intensification) and redesigns relationships with markets (shortening and diversifying chains and widening product offer). This change is characterized by implementation of new farming strategies in the context of PDO structure that coexist with classical farming strategies closer to intensification, not only in terms of productivity but also in terms of decoupling from local resources and productive and market specialization. Therefore, PDO is a powerful tool for rural development in a wide sense (resilience, empowerment, local capacity and network formation among others) far beyond its narrow remit of promoting economic growth (local or regional). Therefore, the coupling with local resources and the strength of local network and relationships as source of resilience, knowledge and capabilities improvement, have to be included in performance assessment of GIs in order to broaden the appraisal of role in regional development. Highlights PDO as institution is a powerful tool of farm transformation not only a protection structure of collective heritage or asset. Private brand effect on price is larger than common label effect (PDO label). PDO as institution leads radical changes of goat production systems from more production – oriented toward more market – oriented styles. Market chains and product diversification, focusing on quality, concern about consumers and coupling with local resources are distinctive features of farms involved in PDO.Protected Designation of Origin (PDO) is one of the EU tools for rural development. Most of the literature on this subject is focused on premium prices and consumers’ willingness to pay for local products, since PDO and other labels aim to provide premium incomes for farmers. Our assumption is that PDO drives unexpected changes of farming styles not only related to processing or market strategies but also related to local resources using and to stablishing of different approach to agriculture and food production. We analyzed the PDO Queso Palmero (La Palma cheese) as a case of a dual label system (brand–certification common label) because it gives us the opportunity to compare farmers involved in a PDO scheme with farmers who works outside such systems. We conclude that private brands are more important than common label certification in price formation, but both are complementary, since PDO reinforces farmers’ efforts to improve quality. Beyond premium price, PDO also drives a radical change in farm structures, since it reconnects products to local resources (grazing vs intensification) and redesigns relationships with markets (shortening and diversifying chains and widening product offer). This change is characterized by implementation of new farming strategies in the context of PDO structure that coexist with classical farming strategies closer to intensification, not only in terms of productivity but also in terms of decoupling from local resources and productive and market specialization. Therefore, PDO is a powerful tool for rural development in a wide sense (resilience, empowerment, local capacity and network formation among others) far beyond its narrow remit of promoting economic growth (local or regional). Therefore, the coupling with local resources and the strength of local network and relationships as source of resilience, knowledge and capabilities improvement, have to be included in performance assessment of GIs in order to broaden the appraisal of role in regional development. Highlights PDO as institution is a powerful tool of farm transformation not only a protection structure of collective heritage or asset. Private brand effect on price is larger than common label effect (PDO label). PDO as institution leads radical changes of goat production systems from more production – oriented toward more market – oriented styles. Market chains and product diversification, focusing on quality, concern about consumers and coupling with local resources are distinctive features of farms involved in PDO

Diseño de un objeto virtual de aprendizaje como estrategia para mejorar la presentación de exposiciones escolares de los estudiantes de grado 9º del centro integral José maría córdoba de la jornada mañana

Este proyecto será realizado con el fin de fomentar en los estudiantes el uso de diversos recursos al momento de realizar exposiciones y presentaciones de proyectos, contribuyendo al desarrollo en el uso de las TIC, mediante el diseño e implementación de un Objeto Virtual de Aprendizaje, el cual será aplicado a una muestra de jóvenes de 9° del Centro Integral José María Córdoba en la jornada de la mañana. Con esto se pretende dar cumplimiento a lo planteado por la OEI y el Ministerio de Educación Nacional, en donde se busca fortalecer las competencias comunicativas y tecnológicas de nuestros niños, niñas y jóvenes para la era global

COESÃO E INCLUSÃO SOCIAL COMO POLÍTICA NO/DO CHILE PARA O ENSINO DE CIÊNCIAS NATURAIS

O ensino de ciências no 1º ciclo do ensino fundamental do Chile vem, nas últimas duas décadas, produzindo sentidos em torno de demandas de coesão, equidade e integração social como tentativa de alcançar melhores resultados no desempenho escolar e no alcance da qualidade escolar. Neste artigo, partindo de uma abordagem discursiva apoiadas em pesquisas de Lopes e Macedo para as políticas de currículo, buscamos interpretar os textos produzidos nos documentos curriculares para problematizar a produção de sentidos sobre o ensino de ciências associado à ideia de progresso e adaptabilidade dos sujeitos, eixos centrais nas reformas educativas chilenas. Neles, a ciência é significada como estratégia, não apenas para descobrir e compreender o conhecimento científico, como também para adquirir competências para o desenvolvimento social dos estudantes