6 research outputs found
Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis
- Author
- A Degterev
- A Müller
- A Müller
- AE Deghmane
- Anke Harsman
- B Shanmugavadivu
- Dirk Günther
- DM Walther
- DR Voelker
- E Gottlieb
- E Gottlieb
- Elke A. Dian-Lothrop
- Eva Hauf
- FJ Bauer
- FJ Castora
- G Kroemer
- G Schatz
- Hank Steven Seifert
- I Guilvout
- IE Gentle
- Ines Herrmann
- J Song
- JE Chipuk
- JF Weel
- Joachim Rassow
- K Hill
- Katharina Ross
- Krishnaraj Rajalingam
- L Scorrano
- LA Pon
- LC Armstrong
- LM Loew
- M Meinecke
- MC Wei
- Michael Meinecke
- MP Bos
- N Bolender
- N Pfanner
- N Wiedemann
- N Wiedemann
- O Kepp
- O Kepp
- Oliver Kepp
- P Massari
- P Massari
- P Mueller
- R Voulhoux
- RD Taylor
- Richard Wagner
- Robert Hurwitz
- RP Zahedi
- S Desagher
- S Kutik
- S Makino
- SA Paschen
- SA Paschen
- T Krimmer
- T Rudel
- Thomas Rudel
- V Kozjak
- V Kozjak-Pavlovic
- V Robert
- Vera Kozjak-Pavlovic
- Volker Brinkmann
- W Neupert
- Publication venue
- Publication date
- 01/01/2009
- Field of study
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial membrane potential (delta psi m). Here, we show that PorB induces the condensation of the mitochondrial matrix and the loss of cristae structures, sensitizing cells to the induction of apoptosis via signaling pathways activated by BH3-only proteins. PorB is imported into mitochondria through the general translocase TOM but, unexpectedly, is not recognized by the SAM sorting machinery, usually required for the assembly of beta-barrel proteins in the mitochondrial outer membrane. PorB integrates into the mitochondrial inner membrane, leading to the breakdown of delta psi m. The PorB channel is regulated by nucleotides and an isogenic PorB mutant defective in ATP-binding failed to induce delta psi m loss and apoptosis, demonstrating that dissipation of delta psi m is a requirement for cell death caused by neisserial infection
MEMO: multi-experiment mixture model analysis of censored data
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis
- Author
- A Degterev
- A Müller
- A Müller
- AE Deghmane
- Anke Harsman
- B Shanmugavadivu
- Dirk Günther
- DM Walther
- DR Voelker
- E Gottlieb
- E Gottlieb
- Elke A. Dian-Lothrop
- Eva Hauf
- FJ Bauer
- FJ Castora
- G Kroemer
- G Schatz
- Hank Steven Seifert
- I Guilvout
- IE Gentle
- Ines Herrmann
- J Song
- JE Chipuk
- JF Weel
- Joachim Rassow
- K Hill
- Katharina Ross
- Krishnaraj Rajalingam
- L Scorrano
- LA Pon
- LC Armstrong
- LM Loew
- M Meinecke
- MC Wei
- Michael Meinecke
- MP Bos
- N Bolender
- N Pfanner
- N Wiedemann
- N Wiedemann
- O Kepp
- O Kepp
- Oliver Kepp
- P Massari
- P Massari
- P Mueller
- R Voulhoux
- RD Taylor
- Richard Wagner
- Robert Hurwitz
- RP Zahedi
- S Desagher
- S Kutik
- S Makino
- SA Paschen
- SA Paschen
- T Krimmer
- T Rudel
- Thomas Rudel
- V Kozjak
- V Kozjak-Pavlovic
- V Robert
- Vera Kozjak-Pavlovic
- Volker Brinkmann
- W Neupert
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
RAD21 Mutations Cause a Human Cohesinopathy
- Author
- Abhinav Rampuria
- Altschul
- Bauerschmidt
- Birkenbihl
- Canudas
- Deardorff
- Deardorff
- Dhawan
- Diana Braunholz
- Dinah Clark
- Dodson
- Dorsett
- Dorsett
- Eddy
- Emma Dickinson
- Eva Rossier
- Fenech
- Frank J. Kaiser
- Gabriele Gillessen-Kaesbach
- Hadjur
- Haering
- Hakon Hakonarson
- Hauf
- Hermann-Josef Lüdecke
- Hooft
- Horsfield
- Hou
- Huiling Xu
- Ian D. Krantz
- Jonathan J. Wilde
- Julia A. Horsfield
- Kagey
- Kalev-Zylinska
- Kawauchi
- Kim
- Krantz
- Krieger
- Krieger
- Krieger
- Laura Daniela Michelis
- Lionel Van Maldergem
- Liu
- Losada
- Lovelock
- Lüdecke
- Mannini
- Maren Mönnich
- MarÃa Concepcion Gil-RodrÃguez
- Matthew A. Deardorff
- McBrien
- McKay
- Melanie Albrecht
- Michael J. McKay
- Misulovin
- Momeni
- Musio
- Musio
- Nasmyth
- Ng
- Peiffer
- Revenkova
- Rhodes
- Robert G. Ramsay
- Rohatgi
- Rupp
- Sally Ann Lynch
- Sara Halbach
- Schüle
- Severin
- Shaikh
- Shintomi
- Sjögren
- Sonoda
- Sprung
- Stephanie Spranger
- Stephanie Tennstedt
- Sunyaev
- Thomas
- Tonkin
- Turner
- Vass
- Vega
- Vrouwe
- Waizenegger
- Wang
- Watrin
- Watrin
- Weizhen Xu
- Wendt
- Westerfield
- Wittwer
- Wojewódzka
- Wuyts
- Xu
- Xu
- Yuqian Yan
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Determinants of robustness in spindle assembly checkpoint signalling
- Author
- A Bar-Even
- A De Antoni
- A Doncic
- A Grallert
- A Matsuyama
- A Oliva
- A Poddar
- A Raj
- A Sigal
- AR Tipton
- B Schwanhausser
- Christian Widmer
- D Emre
- DJ Baker
- DN Millband
- E Chung
- EL Barnhart
- Eva-Maria Geissen
- F Mueller
- FR Neumann
- G Balazsi
- G Rustici
- H Funabiki
- H Windecker
- HY Yamada
- I Hagan
- I Primorac
- J Bahler
- J Capoulade
- J Mansfeld
- J Nilsson
- J Pan
- J Pines
- J Zich
- Jan Hasenauer
- JQ Wu
- JR Newman
- Julia Kamenz
- JV Shah
- K Johnston
- K Uzunova
- KE Gascoigne
- L Jia
- L Sironi
- L Sironi
- LS Michel
- M Castelnuovo
- M Mapelli
- M Sczaniecka
- M Sun
- M Uhlen
- M Vleugel
- M Yang
- MA Rosenow
- MD Ohi
- Michael Knop
- MJ Amorim
- MJ Krien
- N Barkai
- NE Buchler
- Nicole Radde
- P Lara-Gonzalez
- P Russell
- Philipp Drewe
- R Fraschini
- R Heim
- RH Chen
- S Heinrich
- S Marguerat
- S Moreno
- S Yokobayashi
- SC Schuyler
- SD Ryan
- SH Kim
- Silke Hauf
- SK Reddy
- SL Spencer
- Stephanie Heinrich
- Susanne Trautmann
- T Matsumura
- U Schmidt
- V Sudakin
- V Vanoosthuyse
- WC Chao
- X He
- X He
- X Luo
- X Peng
- Y Hiraoka
- Y Iwanaga
- Y Tange
- Y Wu
- YM Yamashita
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Literaturverzeichnis
- Author
- Becker Walter Gustav
- Bennett Jonathan
- Bernsmann Klaus
- Best Dominik
- Beulke Werner
- Biederich
- Bihler Michael
- Bilda Klaus
- Binding Karl
- Binding Karl
- Birnbacher Dieter
- Bittner Wolfgang
- Black Max
- Blei Hermann
- Blei Hermann
- Bockelmann Paul
- Bockelmann Paul
- Bockelmann Paul
- Boecken Winfried
- Boemke
- Bohnert Joachim
- Bork Reinhard
- Brammsen Joerg
- Brandt
- Braun Stefan
- Brehm Wolfgang
- Brekle Herbert E
- Bringewat Peter
- Brocker Lars
- Brodag Wolf-Dietrich
- Brox
- Bruns
- Bubner Rüdiger
- Bulygin Eugenio
- Bung Jochen
- Bung Jochen
- Bung Jochen
- Bung Jochen
- Busse Dietrich
- Böse Martin
- Carnap Rudolf
- Carnap Rudolf
- Carnap Rudolf
- Carnap Rudolf
- Cassani Ursula
- Cattepoel Jan
- Cherkeh Rainer T
- Cherkeh Rainer T
- Chomsky Noam
- Cleric
- Cohen L.
- Cordier Franz
- Cramer
- Cramer Peter
- Cramer Peter
- Dannecker Gerhard
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- Dannecker Gerhard
- Dannecker Gerhard
- Davidson Donald
- Davidson Donald
- Davidson Donald
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- Davidson Donald
- Davidson Donald
- Davidson Donald
- Davidson Donald
- Dencker Friedrich
- Deubner Karl G
- Deutscher Axel
- Deutscher Jörg
- Dewey John
- Dopslaff Ulrich
- Dray William
- Duttge Gunnar
- Duttge Gunnar
- Dörner Heinrich
- Eberle Lutz
- Ehrlich Eugen
- Eidam Lutz
- Eiden Joachim
- Eiden Joachim
- Eisele Jörg
- Eisenhardt Ulrich
- Ellenberger Jürgen
- Engisch Karl
- Engisch Karl
- Engisch Karl
- Erb Volker
- Eser
- Eser Albin
- Eser Albin
- Fabricius Fritz
- Fahl Christian
- Faust Florian
- Feinendegen Markus
- Feuerborn Andreas
- Fiedler Herbert
- Fikentscher
- Fikentscher Wolfgang
- Fischer Thomas
- Frank Ulrich
- Frankfurt Harry G
- Frege Gottlob
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- Freund Georg
- Frisch Wolfgang
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- Gallandi Volker
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- Garbe Thorsten
- Gast Wolfgang
- Gauf Heinrich
- Gauger Michael
- Gehring Klaus
- Geisler Claudius
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- Gernhuber Joachim
- Goeckenjan Ingke
- Grau Kevin
- Graul Eva
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- Grewendorf Günther
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- Grotz Stefan
- Grotz Stefan
- Grunst Bettina
- Gröschler Peter
- Gröseling Nadine
- Grüneberg
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- Grünwald Gerald
- Grützner Thomas
- Gössel
- Gössel
- Haarmann Wilhelm
- Habermas
- Habermas Jürgen
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- Haft Fritjof
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- Hansen Uwe
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- Hassemer Raimund
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- Hauf
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- Hecker Bernd
- Hecker Bernd
- Hedemann
- Hefendehl Roland
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- Hefendehl Roland
- Hefermehl Wolfgang
- Heger Martin
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- Heghmanns Michael
- Heine Günter
- Hellmann
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- Hellmann Uwe
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- Hempel Carl G
- Hennings Frank
- Henssler Martin
- Herberger
- Hernµndez Basualto HØctor
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- Hillenkamp Thomas
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- Hoffmann Klaus
- Hohloch Gerhard
- Hohmann
- Hohmann Olaf
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- Hoyer Andreas
- Hruschka Joachim
- Hruschka Joachim
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- Hubmann Heinrich
- Hume David
- Hungerland Isabel C
- Huschka Hubert
- Hälschner Hugo
- Höpfner Clemens
- Hübner Heinz
- Idler Martin
- Illmer Martin
- Jacoby
- Jaguttis
- Jahn Matthias
- Jahn Matthias
- Jakobs Günther
- Jauernig Othmar
- Jecht Hans
- Jerouschek Günter
- Jescheck
- Joecks Wolfgang
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- Jørgensen Stig
- Kaiser Eberhard
- Kalinowski Georges
- Kindhäuser Urs
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- Klawitter Tim
- Klein Kerstin
- Knauth Alfons
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- Koch Christian Alexander
- Krack Ralf
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- Kramer Ernst A
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- Krebs Peter
- Krehl Christoph
- Krey
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- Krämer Sybille
- Kubiciel Michael
- Kugelmann
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- Kurth
- Köbler Gerhard
- Köhler Helmut
- Köhler Helmut
- Köhler Helmut
- Köhler Michael
- Kölbel Ralf
- Kühl Kristian
- Kühne Hans Heiner
- Küper Wilfried
- Lackner
- Lackner Karl
- Lampe
- Lampe Ernst-Joachim
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- Larenz
- Larenz Karl
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- Leipold Dieter
- Lenk Hans
- Lesch Heiko
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- Loos Fritz
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- Maaß Wolfgang
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- Maiwald Manfred
- Mansel Heinz-Peter
- Marberth-Kubicki Anette
- Martin Sigmund
- Maurach
- Maurach Reinhart
- Mayer
- Mayer Hellmuth
- Medicus Dieter
- Meggle Georg
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- Meggle Georg
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- Müller
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- Müller Bernd
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- Naucke Wolfgang
- Neumann Ulfrid
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- Noak Torsten
- Noll
- Nowell-Smith
- O'Hair S. G.
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- Oertmann Paul
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- Oldigs Dirk
- Ordemann W.
- Ottemann Heike
- Otto Harro
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- Otto Harro
- Otto Harro
- Otto Harro
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- Pfeiffer Thomas
- Philipps Lothar
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- Popp Andreas
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- Puppe Ingeborg
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- Quine W. V. O.
- Radtke Henning
- Ranft Otfried
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- Ranft Otfried
- Rath Gesinnungsstrafrecht
- Reese Jürgen
- Reinhart Michael
- Reitemeier Wiebke
- Rengier Rudolf
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- Rescher Nicholas
- Richter Alarich
- Riemann Thomas
- Riggert Rainer
- Rorty Richard
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- Roth Günter H
- Rothenfußer Christoph
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- Roxin Claus
- Roxin Claus
- Rudolphi
- Rudolphi Hans-Joachim
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- Rönnau Thomas
- Rüthers
- Rüthers
- Samson Erich
- Satzger Helmut
- Satzger Helmut
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- Schack Haimo
- Schauer Renate
- Schellhammer Kurt
- Schild Wolfgang
- Schlösser Jan
- Schlösser Jan
- Schmidhäuser Eberhard
- Schmidhäuser Eberhard
- Schmidhäuser Eberhard
- Schmidt
- Schmidt Jürgen
- Schmidt Rolf
- Schmidt-Kessel Martin
- Schmitz Roland
- Schmitz Roland
- Schmoller Kurt
- Schmoller Kurt
- Schmoller Kurt
- Schnapp Friedrich E
- Schneider Hendrik
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- Schroeder
- Schroeder Friedrich Christian
- Schroth Ulrich
- Schröder Horst
- Schröder Horst
- Schröder Horst
- Schuhr Jan C
- Schulz Joachim
- Schulze Frank-Thomas
- Schulze Reiner
- Schumann Heribert
- Schwarz
- Schweichel Heinrich
- Schöne Wolfgang
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- Schünemann Bernd
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- Searle John
- Seebode M.
- Seelmann Kurt
- Seelmann Kurt
- Sehon Scott R
- Seibert Thomas
- Seier Jürgen
- Sieber Ulrich
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- Sonnenberger
- Soyka Martin
- Soyka Martin
- Stadler Astrid
- Stegemann-Boehl Stefanie
- Stegmüller Wolfgang
- Stegmüller Wolfgang
- Stoffers Kristian F
- Strawson P. F.
- Stree
- Stree Walter
- Streng Franz
- Strätz
- Stuckenberg
- Tarski Alfred
- Teichmann Arndt
- Thomma Susanne
- Thommen Marc
- Tiedemann Klaus
- Tiedemann Klaus
- Tiedemann Klaus
- Tiedemann Klaus
- Timpe Gerhard
- Timpe Gerhard
- Toulmin Stephen
- Traeger Ludwig
- Triffterer Otto
- Triffterer Otto
- Tugendhat Ernst
- Tuhr
- Tönnies Sibylle
- Ullmann Stephen
- Valerius Brian
- Valerius Brian
- Verwendung der Modalverben
- Vitt Elmar
- Vogel Joachim
- Volk Klaus
- Volk Klaus
- Völger Marion
- Waismann Friedrich
- Walder Hans
- Walker
- Walter Tonio
- Walter Tonio
- Walter Tonio
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- Weber Ralph
- Weber Ulrich
- Weigend Thomas
- Weinberger Ota
- Weinberger Ota
- Weinberger Ota
- Weinrich Harald
- Weißer Bettina
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- Wellmer Albrecht
- Wellmer Sprachphilosophie
- Welzel Hans
- Wendtland Holger
- Wersdörfer Rudolf
- Wessels
- Wessels
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- Wittgenstein Ludwig
- Wittgenstein Ludwig
- Wittgenstein Ludwig
- Wittgenstein Ludwig
- Wittgenstein Ludwig
- Wittig Petra
- Wittig Petra
- Wittig Petra
- Wohlers Wolfgang
- Wohlers Wolfgang
- Wolf Manfred
- Wolff
- Wrage Nikolaus
- Wright
- Wright
- Wright
- Wright Richard A
- Wunderlich Dieter
- Wunderlich Dieter
- Yi Sang-Don
- Zaefferer Dietmar
- Zahn Gesche
- Zerres Thomas
- Zieschang Frank
- Zieschang Frank
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- Zoglauer Thomas
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study