39 research outputs found
Effect of the surfactant benzalkonium chloride in the sorption of paraquat and cadmium on montmorillonite
Pesticides, heavy metals and surfactants can share the same region or site in the environment and thus they may compete for the surface of minerals. A competitive study of the adsorption between the cationic surfactant benzalkonium chloride (BAC) with the heavy metal cadmium (Cd(II)) and the cationic herbicide paraquat (PQ) on montmorillonite is presented. Adsorption isotherms for BAC, PQ and Cd(II) were performed in single solute systems and also in binary solute systems, PQ+BAC and Cd(II)+BAC to evaluate the effects of BAC on the adsorption of the other two substances. The affinities of BAC and PQ were strong and similar, thus BAC affected significantly the adsorption of PQ and vice versa. The affinity of Cd(II) for the montmorillonite surface was low, thus BAC affected appreciably Cd(II) adsorption, but the heavy metal did not modify BAC adsorption. XRD data show that BAC molecules control the magnitude of the basal spacing.Fil: Ilari, Romina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - BahĂa Blanca. Instituto de QuĂmica del Sur. Universidad Nacional del Sur. Departamento de QuĂmica. Instituto de QuĂmica del Sur; ArgentinaFil: Etcheverry, Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - BahĂa Blanca. Instituto de QuĂmica del Sur. Universidad Nacional del Sur. Departamento de QuĂmica. Instituto de QuĂmica del Sur; ArgentinaFil: Zenobi, Maria Cristina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - BahĂa Blanca. Instituto de QuĂmica del Sur. Universidad Nacional del Sur. Departamento de QuĂmica. Instituto de QuĂmica del Sur; ArgentinaFil: Zanini, Graciela Pilar. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - BahĂa Blanca. Instituto de QuĂmica del Sur. Universidad Nacional del Sur. Departamento de QuĂmica. Instituto de QuĂmica del Sur; Argentin
Efficacy of epiphytic bacteria to prevent northern leaf blight caused by Exserohilum turcicum in maize
Eight potential biological control agents (BCAs) were evaluated in planta in order toassess their effectiveness in reducing disease severity of northern leaf blight caused by Exserohilumturcicum. The assay was carried out in greenhouse. Twenty-six-day-old plants, V4 phenologicalstage, were inoculated with antagonists by foliar spray. Only one biocontrol agent wasused per treatment. Ten days after this procedure, all treatments were inoculated with E. turcicumby foliar application. Treatments performed were: C-Et: control of E. turcicum; T1: isolate1 (Enterococcus genus) + E. turcicum; T2: isolate 2 (Corynebacterium genus) + E. turcicum; T3:isolate 3 (Pantoea genus) + E. turcicum; T4: isolate 4 (Corynebacterium genus) + E. turcicum; T5:isolate 5 (Pantoea genus) + E. turcicum; T6: isolate 6 (Bacillus genus) + E. turcicum; T7: isolate 7(Bacillus genus) + E. turcicum; T8: isolate 8 (Bacillus genus) + E. turcicum. Monitoring of antagonistson the phyllosphere was performed at different times. Furthermore, the percentage ofinfected leaves and, plant and leaf incidence were determined. Foliar application of differentbacteria significantly reduced the leaf blight between 30---78% and 39---56% at 20 and 39 daysrespectively. It was observed that in the V10 stage of maize plants, isolate 8 (Bacillus spp.)caused the greatest effect on reducing the severity of northern leaf blight. Moreover, isolate 8was the potential BCA that showed more stability in the phyllosphere. At 39 days, all potentialbiocontrol agents had a significant effect on controlling the disease caused by E. turcicum.Se evaluĂł a 8 potenciales agentes de control biolĂłgico (ACB) en un ensayo in planta, con el objetivo de probar su efectividad en la reducciĂłn del daño provocado por Exserohilum turcicum, agente causal del tizĂłn foliar del maĂz. El ensayo se llevĂł a cabo en invernadero. Plantas de maĂz de 26 dĂas, en estadio fenolĂłgico V4, se inocularon con los potenciales antagonistas por aplicaciĂłn foliar como espray. Solo un agente de biocontrol fue usado por tratamiento y todos los tratamientos se inocularon con E. turcicum 10 dĂas despuĂ©s, tambiĂ©n por aplicaciĂłn foliar. Los tratamientos desarrollados fueron los siguientes: C-Et: control de E. turcicum; T1: aislamiento 1 (gĂ©nero Enterococcus) + E. turcicum; T2: aislamiento 2 (gĂ©nero Corynebacterium) + E. turcicum; T3: aislamiento 3 (gĂ©nero Pantoea) + E. turcicum; T4: aislamiento 4 (gĂ©nero Corynebacterium) + E. turcicum; T5: aislamiento 5 (gĂ©nero Pantoea) + E. turcicum; T6: aislamiento 6 (gĂ©nero Bacillus) + E. turcicum; T7: aislamiento 7 (gĂ©nero Bacillus) + E. turcicum; T8: aislamiento 8 (gĂ©nero Bacillus) + E. turcicum. La monitorizaciĂłn en la filosfera de los antagonistas se llevĂł a cabo a diferentes tiempos. Además, se determinĂł el porcentaje de hojas infectadas y la incidencia en plantas y hojas. La aplicaciĂłn foliar de diferentes bacterias redujo significativamente la gravedad del tizĂłn del maĂz: entre el 30 y el 78% a los 20 dĂas y entre el 39 y el 56% a los 39 dĂas. En el estadio V10 de las plantas de maĂz se observĂł que el aislamiento 8 (Bacillus spp.) causĂł el mayor efecto de reducciĂłn del tizĂłn foliar. Además, dicho aislamiento fue el potencial agente de biocontrol que mostrĂł mayor estabilidad en la filosfera. A los 39 dĂas, todos los potenciales agentes de biocontrol demostraban un efecto significativo sobre el control de la enfermedad causada por E. turcicum.Fil: Sartori, Melina Victoria. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; ArgentinaFil: Nesci, Andrea VerĂłnica. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; ArgentinaFil: GarcĂa, Julián. Oro Verde, Servicios Fitosanitarios; ArgentinaFil: Passone, Maria Alejandra. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Montemarani, AnalĂa Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Etcheverry, Miriam Graciela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Vanadate-induced nitric oxide production: role in osteoblast growth and differentiation
Nitric oxide NO. has been shown to act as a mediator of cytokines in bone tissue. We have previously demonstrated that vanadium compounds are insulin- and growth factor-mimetic compounds in osteoblasts in culture, although high doses are toxic to these cells. In this study, we measured NO production in two osteoblast-like cells UMR106 and MC3T3E1. incubated with different concentrations 2.5–100 mM. of vanadate. Vanadate induced NO release in a biphasic manner, with levels being significantly increased at concentrations over 50 mM. The NO donor, sodium nitroprusside, mimicked the vanadate effect: it inhibited cell growth and alkaline phosphatase activity in a dose-dependent manner. Vanadate enhanced the NO synthases, the endothelial and inducible eNOS and iNOS. isoforms, in a dose-dependent manner. Experiments performed with the ionophore A23187 and EGTA suggested that vanadate-induced NO production involves Ca2q-dependent and -independent mechanisms. Altogether, our results suggest that NO may play a critical role in the bioactivity of vanadium in osteoblast-like cells. q2000 Elsevier Science B.V. All rights reserved
Vanadate-induced nitric oxide production: role in osteoblast growth and differentiation
Nitric oxide NO. has been shown to act as a mediator of cytokines in bone tissue. We have previously demonstrated that vanadium compounds are insulin- and growth factor-mimetic compounds in osteoblasts in culture, although high doses are toxic to these cells. In this study, we measured NO production in two osteoblast-like cells UMR106 and MC3T3E1. incubated with different concentrations 2.5–100 mM. of vanadate. Vanadate induced NO release in a biphasic manner, with levels being significantly increased at concentrations over 50 mM. The NO donor, sodium nitroprusside, mimicked the vanadate effect: it inhibited cell growth and alkaline phosphatase activity in a dose-dependent manner. Vanadate enhanced the NO synthases, the endothelial and inducible eNOS and iNOS. isoforms, in a dose-dependent manner. Experiments performed with the ionophore A23187 and EGTA suggested that vanadate-induced NO production involves Ca2q-dependent and -independent mechanisms. Altogether, our results suggest that NO may play a critical role in the bioactivity of vanadium in osteoblast-like cells.Facultad de Ciencias Exacta
Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation
Endocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple signal transduction pathways. Together with enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system (ECS), which is involved in different physiological processes in reproduction. The placenta, which is essential for the success of gestation and optimal fetal growth, undergoes constant tissue remodeling. ECS members are expressed in trophoblast cells, and current evidence suggests that this system is involved in placental development, apoptosis, and syncytialization. Impairment of endocannabinoid signaling has been associated with several pathological conditions such as intrauterine growth restriction and preeclampsia. Both clinical entities are characterized by dysregulation on vascular perfusion where nitrergic system performs a pivotal role. Nitric oxide (NO) is a potent local vasodepressor that exerts a critical role in the regulation of hemodynamic flow, contributing to the maintenance of low vascular resistance in the feto-placental circulation. NO production could be affected by different factors and growing evidence suggests that the endocannabinoid mediators may regulate nitrergic signaling. Herein, we review emerging knowledge supporting ECS-mediated regulation of NO production in normal placentation. Finally, we discuss how alterations in these systems could affect homoeostasis and contribute to the occurrence of placental-mediated pregnancy complications. Given the impact on women and perinatal heath, we will focus on current knowledge regarding the effects of ECS on nitrergic system in normal and pathological placentation.Fil: Aban, Cyntia Estefania. FundaciĂłn para la Lucha contra las Enfermedades NeurolĂłgicas de la Infancia; ArgentinaFil: Accialini, Paula Lucia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: Etcheverry, Tomás. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: Leguizamon, Gustavo Federico. Centro de Educaciones MĂ©dicas e InvestigaciĂłn ClĂnica "Norberto Quirno"; ArgentinaFil: Martinez, Nora Alicia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de FisiologĂa y BiofĂsica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de FisiologĂa y BiofĂsica Bernardo Houssay; ArgentinaFil: Farina, Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; Argentina. Red Iberoamericana de Alteraciones Vasculares Asociadas a Trastornos del Embarazo; Argentin
Vanadate-induced nitric oxide production: role in osteoblast growth and differentiation
Nitric oxide NO. has been shown to act as a mediator of cytokines in bone tissue. We have previously demonstrated that vanadium compounds are insulin- and growth factor-mimetic compounds in osteoblasts in culture, although high doses are toxic to these cells. In this study, we measured NO production in two osteoblast-like cells UMR106 and MC3T3E1. incubated with different concentrations 2.5–100 mM. of vanadate. Vanadate induced NO release in a biphasic manner, with levels being significantly increased at concentrations over 50 mM. The NO donor, sodium nitroprusside, mimicked the vanadate effect: it inhibited cell growth and alkaline phosphatase activity in a dose-dependent manner. Vanadate enhanced the NO synthases, the endothelial and inducible eNOS and iNOS. isoforms, in a dose-dependent manner. Experiments performed with the ionophore A23187 and EGTA suggested that vanadate-induced NO production involves Ca2q-dependent and -independent mechanisms. Altogether, our results suggest that NO may play a critical role in the bioactivity of vanadium in osteoblast-like cells.Facultad de Ciencias Exacta
Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
The onset of labor involves the action of multiple factors and recent reports have postulated the endocannabinoid system as a new regulator of this process. Our objective was to study the role of anandamide, one of the main endocannabinoids, on the regulation of placental molecules that contribute to the onset of labor at term. Placental samples were obtained from patients with laboring vaginal deliveries and from non-laboring elective cesarean sections. Vaginal delivery placentas produced higher prostaglandins levels than cesarean section samples. Besides, no differences were observed in NOS basal activity between groups. Incubation of vaginal delivery placentas with anandamide increased prostaglandins concentration and decreased NOS activity. Antagonism of type-1cannabinoid receptor (CB1) did not alter the effect observed on NOS activity. Conversely, incubation of cesarean section placentas with anandamide reduced prostaglandins levels and enhanced NOS activity, the latter involving the participation of CB1. Furthermore, we observed a differential expression of the main components of the endocannabinoid system between placental samples, being the change in CB1 localization the most relevant finding. Our results suggest that anandamide acts as a modulator of the signals that regulate labor, exerting differential actions depending on CB1 localization in laboring or non-laboring term placentas.Fil: Accialini, Paula Lucia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: Aban, Cyntia Estefania. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: Etcheverry, Tomás. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: Negri Malbrán, Mercedes. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones MĂ©dicas e Investigaciones ClĂnicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: LeguizamĂłn, Gustavo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones MĂ©dicas e Investigaciones ClĂnicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Herlax, Vanesa Silvana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias MĂ©dicas. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: MatĂ©, Sabina MarĂa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias MĂ©dicas. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Farina, Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; Argentin
Anandamide regulates the production of key molecules for labour onset
El inicio del trabajo de parto está controlado por diversas molĂ©culas y estudios recientes han postulado al sistema endocannabinoide como un mediador clave en este proceso. Se observĂł que anandamida (AEA), uno de los principales endocannabinoides, aumenta en el plasma de pacientes con trabajo de parto [1]. Nuestro objetivo fue estudiar la implicancia de AEA sobre la producciĂłn de prostaglandinas (PGs) y Ăłxido nĂtrico (NO) en la placenta humana a tĂ©rmino. Para ello utilizamos explantos de placentas a tĂ©rmino provenientes de partos vaginales (TP, trabajo de parto) o de cesáreas electivas (sin trabajo de parto). Las placentas de TP presentan menor contenido proteico y actividad de FAAH, la enzima que degrada a AEA, que las placentas de cesárea. Esto sugiere un aumento intraplacentario de AEA durante el trabajo de parto. En cultivos de placentas de TP, AEA provocĂł un aumento de la concentraciĂłn de PGs y una disminuciĂłn en los niveles de NO. Contrariamente, en placentas de cesárea AEA provocĂł una disminuciĂłn en la concentraciĂłn de PGs y un incremento en la producciĂłn de NO. Nuestros resultados sugieren que AEA actuarĂa como un modulador en la placenta, regulando la producciĂłn de molĂ©culas claves en el desencadenamiento del parto.Fil: Accialini, Paula Lucia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: Aban, Cyntia Estefania. FundaciĂłn para la Lucha contra las Enfermedades NeurolĂłgicas de la Infancia; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Etcheverry, Tomás. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaFil: LeguizamĂłn, Gustavo. Centro de Educaciones MĂ©dicas e InvestigaciĂłn ClĂnica "Norberto Quirno"; ArgentinaFil: MatĂ©, Sabina MarĂa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias MĂ©dicas. Instituto de Investigaciones BioquĂmicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Farina, Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y Botánicos; ArgentinaIII Simposio Colombiano de Placenta e InteracciĂłn Materno FetalColombiaPontificia Universidad Javerian
Mycoflora and Ochratoxin A Control in Wheat Grain Using Natural Extracts Obtained from Wine Industry By-Products
The aim of this study was to evaluate the effect of some natural extracts obtained from grape pomace (GPE) and grape seeds (GSE) as compared to a synthetic food, antioxidant-butylated hydroxytoluene (BHT), in order to control fungal population and ochratoxin A (OTA) production in naturally contaminated wheat. The results showed that the addition of these extracts was efficient with OTA content decreasing. On treatment with these extracts the loss of OTA content after 14 days was in the range 7.8–28.3% relative to the control sample, but increased up to 26.48–37% after 28 days. The highest loss in OTA content was recorded for treatment with GPE at the 500 ppm level. Regarding the fungal development, the obtained results show that the total fungal populations were significantly reduced by using natural extracts. The most efficient extract was GPE. Both BHT and GPE inhibit the growth of Penicillium verrrucosum, for all doses, but less with Aspergillus genera. GPE affects the growth of other types of moulds such as Rhizopus microsporus, Fusarium graminearum, Alternaria infectoria and Cladosporium herbarum. Our data suggested that GPE and GSE are able to provide fungicidal and fungistatic protection and to control the OTA accumulation in wheat, at least in a similar manner to BHT
Multicentre observational study on multisystem inflammatory syndrome related to COVID-19 in Argentina
Background: The impact of the pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in low- and middle-income countries remains poorly understood. Our aim was to understand the characteristics and outcomes of PIMS-TS in Argentina. Methods: This observational, prospective, and retrospective multicenter study enrolled patients younger than 18 years-old manifesting PIMS-TS, Kawasaki disease (KD) or Kawasaki shock syndrome (KSS) between March 2020 and May 2021. Patients were followed-up until hospital discharge or death (one case). The primary outcome was pediatric intensive care unit (PICU) admission. Multiple logistic regression was used to identify variables predicting PICU admission. Results: Eighty-one percent, 82%, and 14% of the 176 enrolled patients fulfilled the suspect case criteria for PIMS-TS, KD, and KSS, respectively. Temporal association with SARS-CoV-2 was confirmed in 85% of the patients and 38% were admitted to the PICU. The more common clinical manifestations were fever, abdominal pain, rash, and conjunctival injection. Lymphopenia was more common among PICU-admitted patients (87% vs. 51%, p < 0.0001), who also showed a lower platelet count and higher plasmatic levels of inflammatory and cardiac markers. Mitral valve insufficiency, left ventricular wall motion alterations, pericardial effusion, and coronary artery alterations were observed in 30%, 30%, 19.8%, and 18.6% of the patients, respectively. Days to initiation of treatment, rash, lymphopenia, and low platelet count were significant independent contributions to PICU admission. Conclusion: Rates of severe outcomes of PIMS-TS in the present study agreed with those observed in high-income countries. Together with other published studies, this work helps clinicians to better understand this novel clinical entity.Fil: Vainstein, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez"; ArgentinaFil: Baleani, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez"; ArgentinaFil: Urrutia, Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de PediatrĂa "Juan P. Garrahan"; ArgentinaFil: Affranchino, Nicolás. Gobierno de la Ciudad de Buenos Aires. Hospital de PediatrĂa "Juan P. Garrahan"; ArgentinaFil: Ackerman, Judith. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Cazalas, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez"; ArgentinaFil: Goldsman, Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez"; ArgentinaFil: Sardella, Angela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez"; ArgentinaFil: Tolin, Ana Laura. Gobierno de la Provincia de Mendoza. Hospital Pediátrico Humberto Notti; ArgentinaFil: Goldaracena, Pablo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor MarĂa Ludovica" de La Plata; ArgentinaFil: Fabi, Mariana. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor MarĂa Ludovica" de La Plata; ArgentinaFil: Cosentino, Mariana. Hospital Británico de Buenos Aires; ArgentinaFil: Magliola, Ricardo. Hospital Británico de Buenos Aires; ArgentinaFil: Roggiero, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. NĂ©stor Carlos Kirchner Samic; ArgentinaFil: Manso, Paula. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. NĂ©stor Carlos Kirchner Samic; ArgentinaFil: Triguy, JĂ©sica. Gobierno de la Provincia de Mendoza. Hospital Pediátrico Humberto Notti; ArgentinaFil: Ballester, Celeste. Gobierno de la Provincia de Mendoza. Hospital Pediátrico Humberto Notti; ArgentinaFil: Cervetto, Vanesa. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Vaccarello, MarĂa. Sanatorio de la Trinidad; ArgentinaFil: De Carli, Domingo Norberto. ClĂnica del Niño de Quilmes; ArgentinaFil: De Carli, Maria Estela. ClĂnica del Niño de Quilmes; ArgentinaFil: Ciotti, Ana Laura. Hospital Nacional Profesor Alejandro Posadas; ArgentinaFil: Sicurello, MarĂa Irene. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez"; ArgentinaFil: Rios Leiva, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva PerĂłn"; ArgentinaFil: Villalba, Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de PediatrĂa "Juan P. Garrahan"; ArgentinaFil: Hortas, MarĂa. Sanatorio de la Trinidad; ArgentinaFil: Peña, Sonia. Gobierno de la Provincia de Mendoza. Hospital Pediátrico Humberto Notti; ArgentinaFil: González, Gabriela. Gobierno de la Provincia de Mendoza. Hospital Pediátrico Humberto Notti; ArgentinaFil: Zold, Camila Lidia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de FisiologĂa y BiofĂsica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de FisiologĂa y BiofĂsica Bernardo Houssay; ArgentinaFil: Murer, Mario Gustavo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de FisiologĂa y BiofĂsica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de FisiologĂa y BiofĂsica Bernardo Houssay; ArgentinaFil: Grippo, M.. No especifĂca;Fil: Vázquez, H.. No especifĂca;Fil: MorĂłs, C.. No especifĂca;Fil: Di Santo, M.. No especifĂca;Fil: Villa, A.. No especifĂca;Fil: Lazota, P.. No especifĂca;Fil: Foti, M.. No especifĂca;Fil: Napoli, N.. No especifĂca;Fil: Katsikas, M. M.. No especifĂca;Fil: Tonello, L.. No especifĂca;Fil: Peña, J.. No especifĂca;Fil: Etcheverry, M.. No especifĂca;Fil: Iglesias, D.. No especifĂca;Fil: Alcalde, A. L.. No especifĂca;Fil: Bruera, M.J.. No especifĂca;Fil: Bruzzo, V.. No especifĂca;Fil: Giordano, P.. No especifĂca;Fil: Pena Acero, F.. No especifĂca;Fil: Netri Pelandi, G.. No especifĂca;Fil: Pastaro, D.. No especifĂca;Fil: Bleiz, J.. No especifĂca;Fil: RodrĂguez, M. F.. No especifĂca;Fil: Laghezza, L.. No especifĂca;Fil: Molina, M. B.. No especifĂca;Fil: Patynok, N.. No especifĂca;Fil: Chatelain, M. S.. No especifĂca;Fil: Aguilar, M. J.. No especifĂca;Fil: Gamboa, J.. No especifĂca;Fil: Cervan, M.. No especifĂca;Fil: Ruggeri, A.. No especifĂca;Fil: Marinelli, I.. No especifĂca;Fil: Checcacci, E.. No especifĂca;Fil: Meregalli, C.. No especifĂca;Fil: Damksy Barbosa, J.. No especifĂca;Fil: Fernie, L.. No especifĂca;Fil: Fernández, M. J.. No especifĂca;Fil: Saenz Tejeira, M.M.. No especifĂca;Fil: Cereigido, C.. No especifĂca;Fil: Nunell, A.. No especifĂca;Fil: Villar, D.. No especifĂca;Fil: Mansilla, A. D.. No especifĂca;Fil: Darduin, M. D.. No especifĂca