pH-oscillations in the bromate-sulfite reaction in semibatch and in gel-fed batch reactors

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Effect of genotype and hens' starting body fat content on the changes in the body fat content of the hens and on the weight and composition of the eggs produced in the first egg laying period

The aim of this study was to examine the effect of genotype and hens’ starting body fat content on the changes in the body fat content of the hens and on the weight and composition of the eggs produced in the first egg laying period. The experiment was carried out with altogether 30 hens (15 TETRA SL brown egg layers and 15 TETRA BLANCA white egg layers), which were chosen from altogether 45 TETRA SL and 45 TETRA BLANCA hens based on their CT (computer tomography) predicted body fat content at 20 weeks of age (hens with the highest (n=5), hens with the lowest (n=5) and hens with average (n=5) body fat content in both genotype). For the in vivo determination of changes in the body composition of these hens, computer tomography (CT) measurements were carried out at every fourth week between the 20th and 72nd week of age. During the CT measurements hens were fixed with belts in a special plexiglass container without using any anaesthetics. The measurements covered the whole body of the hens using overlapping 10 mm slice thickness on a Siemens Somatom Emotion 6 multislice CT scanner. After collecting, weighing and breaking the eggs produced by the experimental birds on the days of the CT measurements their yolk ratio was determined. Based on the results, it was established that the body fat content of the hens increased continuously in both of the genotypes in the first phase of the experimental period, while it did not change further in the second phase of the experiment. It was also observed at all examination days, that the body fat content of the white egg layers was higher than that of the brown egg layers. Hens with the highest starting body fat content had the highest body fat content in both genotypes during the whole egg laying period. The egg production of the hens was not influenced by the body fat content of the birds, but it was affected by the genotype. The TETRA SL hens produced significantly more eggs than the TETRA BLANCA hens. The hens with average body fat content produced lighter eggs than the hens with low or high body fat content

TiO2-WO3 kompozit fotokatalizátorok hatékonyságának feltérképezése különböző szerves szennyezők bontása esetén

Among the increasing water pollution, organic dyes have gained growing attention because their environmental persistence and resistance to conventional treatment technologies. The widespread use of organic dyes in textile industry produced a great damage to the ecoenvironment. There are many different organic textile dyes in synthetic-cotton textile industries, for instance, reactive azo dyes or triaryl methane-based dyes, which are known to have carcinogen and mutagenic effects. The aim of our research is to resolve the problems caused by the textile industries using TiO2-WO3 composite photocatalysts. The most efficient composite was characterized by SEM, DRS and XRD and its photocatalytic activity was investigated in-detail. The reusability of the composite was also investigated showing the increased photostability of these materials. The composition of the composite and the most preferable operational pH value was optimized in order to further enhance the efficiency of the composites

Effect of yolk ratio in hen’s eggs on the hatching weight and on the heart and liver ratio in chicks at hatching

The aim of this study was to examine, whether the yolk ratio of hen’s eggs has an effect on the hatching weight and on the heart and liver ratio in chicks at hatching. Altogether 3.500 hen’s eggs – originated from a 24 weeks old TETRA-H parent stock – were involved in the examination. The yolk ratio of these eggs was determined by means of computer tomography in vivo using a SIEMENS Somatom Emotion 6 multislice CT scanner at the Institute of Diagnostic Imaging and Radiation Oncology of the Kaposvár University. Based on the measured values eggs were separated into three groups: eggs with extreme high, eggs with average and eggs with extreme low yolk content (10-10% in each group). All of these eggs (n=350 per group) were incubated thereafter. After hatching 30 chicks per group (15 males and 15 females) were randomly chosen and their liveweight was measured thereafter. After measuring the liveweight chicks were killed and dissected. The weight of the heart and liver was measured and their ratio to the hatching weight was calculated. Based on the results it was established that the hatching weight of the chicks decreased with increasing the yolk ratio in the eggs in both sexes. In spite of the hatching weight the ratio of the heart to the hatching weight was increasing with increasing the yolk ratio in the breeding eggs in the case of the cocks. In the case of the pullets the opposite tendency was observed. The change in the ratio of liver to the hatching weight showed similar tendency in the case of cocks as it was observed in the case of the heart. In the case of the pullets no clear tendency was observed in this trait. Based on the results it was concluded that – according to some former results – the higher albumen content in the eggs results in higher hatching weight and the higher yolk content in the eggs in better body composition in the chicks

Effect of genotype and hens' starting body fat content on the changes in the body fat content of the hens and on the weight and composition of the eggs produced in the first egg laying period

The aim of this study was to examine the effect of genotype and hens’ starting body fat content on the changes in the body fat content of the hens and on the weight and composition of the eggs produced in the first egg laying period. The experiment was carried out with altogether 30 hens (15 TETRA SL brown egg layers and 15 TETRA BLANCA white egg layers), which were chosen from altogether 45 TETRA SL and 45 TETRA BLANCA hens based on their CT (computer tomography) predicted body fat content at 20 weeks of age (hens with the highest (n=5), hens with the lowest (n=5) and hens with average (n=5) body fat content in both genotype). For the in vivo determination of changes in the body composition of these hens, computer tomography (CT) measurements were carried out at every fourth week between the 20th and 72nd week of age. During the CT measurements hens were fixed with belts in a special plexiglass container without using any anaesthetics. The measurements covered the whole body of the hens using overlapping 10 mm slice thickness on a Siemens Somatom Emotion 6 multislice CT scanner. After collecting, weighing and breaking the eggs produced by the experimental birds on the days of the CT measurements their yolk ratio was determined. Based on the results, it was established that the body fat content of the hens increased continuously in both of the genotypes in the first phase of the experimental period, while it did not change further in the second phase of the experiment. It was also observed at all examination days, that the body fat content of the white egg layers was higher than that of the brown egg layers. Hens with the highest starting body fat content had the highest body fat content in both genotypes during the whole egg laying period. The egg production of the hens was not influenced by the body fat content of the birds, but it was affected by the genotype. The TETRA SL hens produced significantly more eggs than the TETRA BLANCA hens. The hens with average body fat content produced lighter eggs than the hens with low or high body fat content

A nyugat-nílusi vírus kimutatása humán betegmintákból: nyomon követéses vizsgálatok a 2015. évi szezonális időszakban | Detection of West Nile virus in human samples: follow-up studies during the 2015 seasonal period

Absztrakt: Bevezetés: A nyugat-nílusi vírus Magyarországon is elterjedt, éves rendszerességgel humán megbetegedéseket okozó, szúnyogok által terjesztett virális zoonosis. Az akut infekciók laboratóriumi differenciáldiagnosztikája szerológiai vizsgálatokon alapul, de a molekuláris módszerek alkalmazhatósága is egyre inkább előtérbe kerül. Célkitűzés: Vizsgálatunk célja a 2015. évi akut fertőzöttek vér-, liquor- és vizeletmintáinak molekuláris vizsgálata volt, illetve a pozitív betegek nyomon követése annak megállapítása érdekében, hogy mennyi ideig detektálható a vírus. Módszer: Az akut fertőzött betegek mintáit indirekt immunfluoreszcens, hemagglutináció-gátlási, majd kétféle PCR-módszerrel vizsgáltuk. A pozitív mintákból a vírustörzseket Sanger-szekvenálással azonosítottuk és vírusizolálást végeztünk. Eredmények: Öt páciens esetén nyílt lehetőség a nyomon követést elvégezni, ennek során a betegek vizeletéből hosszú ideig (a tünetek megjelenésétől számítva akár hetekig) és összehasonlítva más mintatípusokkal, magasabb koncentrációban volt kimutatható a vírus. Következtetések: Akut fertőzések fennállásakor a vizeletminták PCR-vizsgálata járványügyi és diagnosztikai szempontból is hasznos információt szolgáltathat, ezért vizeletminták beküldésével javasoljuk kiegészíteni a szerológiai diagnosztikát. Orv Hetil. 2017; 158(20): 791–796. | Abstract: Introduction: West Nile virus, a mosquito-borne viral zoonosis is responsible for human infections in Hungary. Laboratory diagnosis is based on serological tests, however the application of molecular methods has been appreciated. Aim: The aim of the study was to investigate blood, cerebrospinal-fluid and urine samples of acutely ill patients and to follow-up PCR positive cases to ascertain the length of virus excretion. Method: Clinical specimens were examined by indirect-immunofluorescent, haemagglutination-inhibition, two PCR tests and Sanger-sequencing. Virus isolation in case of two patients was successful. Results: A follow-up study could be carried out in case of 5 patients. Viral nucleic acid was detectable in urine even for several weeks after symptom onset and viral RNA was present at higher concentration compared with other samples. Conclusions: PCR analysis of urine could provide useful epidemiological and diagnostic information. Therefore, it is recommended to collect urine samples in order to supplement the serological diagnosis. Orv Hetil. 2017; 158(20): 791–796

Case report: Complex evaluation of coagulation, fibrinolysis and inflammatory cytokines in a SARS-CoV-2 infected pregnant woman with fetal loss

BackgroundSARS-CoV-2 infection during pregnancy increases the risk of severe obstetrical complications. Detailed evaluation of COVID-19-associated coagulopathy in a pregnancy with stillbirth hasn’t been described so far. Besides knowledge gaps in the pathomechanism leading to stillbirth in COVID-19 pregnancies, currently, no prognostic biomarker is available to identify pregnant patients who are at imminent risk of COVID-19-associated maternal and fetal complications, requiring immediate medical attention.CaseHere we report the case of a 28-year-old SARS-CoV-2 infected pregnant patient, admitted to our hospital at 28 weeks of gestation with intrauterine fetal loss. The presence of SARS-CoV-2 placentitis was confirmed by immunohistological evaluation of the placenta. She had only mild upper respiratory symptoms and her vital signs were within reference throughout labor and postpartum. The stillborn infant was delivered per vias naturales. Fibrinogen concentrate was administered before and after labor due to markedly decreased fibrinogen levels (1.49 g/l) at admission and excessive bleeding during and after delivery. Although coagulation screening tests were not alarming at admission, the balance of hemostasis was strikingly distorted in the patient. As compared to healthy age- and gestational age-matched pregnant controls, increased D-dimer, low FVIII activity, low FXIII level, marked hypocoagulability as demonstrated by the thrombin generation assay, together with shortened clot lysis and decreased levels of fibrinolytic proteins were observed. These alterations most likely have contributed to the increased bleeding observed during labor and in the early postpartum period. Interestingly, at the same time, only moderately altered inflammatory cytokine levels were found at admission. Serum ACE2 activity did not differ in the patient from that of age- and gestational age-matched healthy controls, suggesting that despite previous speculations in the literature, ACE2 may not be used as a potential biomarker for the prediction of COVID-19 placentitis and threatening fetal loss in SARS-CoV-2-infected pregnancies.ConclusionsAlthough based on this case report no prognostic biomarker could be identified for use in pregnant patients with imminent risk of fetal loss associated with COVID-19 placentitis, the above-described hemostasis alterations warrant awareness of postpartum hemorrhagic complications and could be helpful to identify patients requiring intensified medical attention

Inclusion complexation of the anticancer drug pomalidomide with cyclodextrins: fast dissolution and improved solubility

Pomalidomide (POM), a potent anticancer thalidomide analogue was characterized in terms of cyclodextrin complexation to improve its aqueous solubility and maintain its anti-angiogenic activity. The most promising cyclodextrin derivatives were selected by phase-solubility studies. From the investigated nine cyclodextrins – differing in cavity size, nature of substituents, degree of substitution and charge – the highest solubility increase was observed with sulfobutylether-β-cyclodextrin (SBE-β-CD). The inclusion complexation between POM and SBE-β-CD was further characterized with a wide variety of state-of-the-art analytical techniques, such as nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR), circular dichroism spectroscopy, fluorescence spectroscopy as well as X-ray powder diffraction method (XRD). Job plot titration by NMR and the AL-type phase-solubility diagram indicated 1:1 stoichiometry in a liquid state. Complementary analytical methods were employed for the determination of the stability constant of the complex; the advantages and disadvantages of the different approaches are also discussed. Inclusion complex formation was also assessed by molecular modelling study. Solid state complexation in a 1:1 M ratio was carried out by lyophilization and investigated by IR and XRD. The complex exhibited fast-dissolution with immediate release of POM, when compared to the pure drug at acidic and neutral pH. Kinetic analysis of POM release from lyophilized complex shows that Korsmeyer-Peppas and Weibull model described the best the dissolution kinetics. The cytotoxicity of the complex was tested against the LP-1 human myeloma cell line which revealed that supramolecular interactions did not significantly affect the anti-cancer activity of the drug. Overall, our results suggest that the inclusion complexation of POM with SBE-β-CD could be a promising approach for developing more effective POM formulations with increased solubility

Loci Memoriae Hungaricae

Előszó (S. Varga Pál) - 9 ; 1. A magyar emlékezethelyek kutatásának elméleti alapjai - 23 ; 1.1. Vita - 25 ; Gyáni Gábor: A magyar „emlékezet helyei” és a traumatikus múlt - 27 ; Fata Márta: A magyar emlékezethelyek specifikumai (Hozzászólás Gyáni Gábor vitaindítójához) - 36 ; Takáts József: A klasszikus és az új nacionalizmus (Hozzászólás Gyáni Gábor vitaindítójához) - 39 ; 1.2. Történelem és emlékezet - 43 ; Balogh László Levente: A Trianon-emlékművek és az áldozatdiskurzus - 45 ; Erős Vilmos: A történetírás-történet mint emlékezethely - 58 ; Gerő András: A nemzeti emlékezethelytől a nemzeti emlékhelyig - 69 ; 1.3. Emlékezethely és medialitás - 79 ; Kerékgyártó Béla: Építészet, identitás és emlékezet (Aldo Rossi elmélete ; és a lakótelepek példája) - 81 ; Bujdosó Ágnes: A televízió mint az emlékezés médiuma (Medialitás és emlékezés sajátos összefüggései a Delta magazin főcímének kapcsán) - 96 ; Dunai Tamás: A Kádár-kori képregény mint emlékezethely - 106 ; Puskás István: „A Maradandóság Városában maradékomból élek.” (A nyolcvanas évek debreceni underground kultúrájának emlékezete) - 114 ; 1.4. Szociokulturális megközelítések - 125 ; Biczó Gábor: A kulturális emlékezet a szociokulturális konszenzusgyakorlatban: magyar–román együttélési közösségek példája - 127 ; Pék Győző–Almássy Zsuzsa–Szabó Gergely–Máth János–Kőszeghy Attila: Kollektív traumatikus eseményt követő kommunikáció vizsgálata (A magyarországi „vörösiszap-katasztrófá”-val kapcsolatos információfeldolgozás és érzelmi reakciók) - 140 ; 1.5. Az emlékezethely-kutatás nemzetközi eredményei - 151 ; Pabis Eszter: Az emlékezethelyek kutatásának eredményeiről Németországban és Svájcban - 153 ; Kovács Szilvia: Az emlékezet helyei a kultúratudományok térbeli fordulatának aspektusából (Moritz Csáky, Peter Stachel: Die Verortung von Gedächtnis) - 164 ; Pusztai Gábor: Németalföld emlékezete: holland és flamand nemzeti emlékezethelyek (Jo Tollebeek [red.]: Het geheugen van de Lage Landen) - 171 ; Réti Zsófia: Emlékezethelyek Hollandiában – A Lieux de mémoire et identités nationales című kötetről - 176 ; Száraz Orsolya: Olasz emlékezethelyek – három kötetben (I luoghi della memoria, a cura di Mario Isnenghi) - 183 ; Friedrich Judit: A kulturális emlékezet kutatása az ELTE Anglisztika Tanszékén (Egy OTKA-projektről és a Confrontations and Interactions című, angol nyelvű konferenciakötetről) - 191 ; 2. Mohács mint reprezentatív emlékezethely - 199 ; 2.1. Mohács a modern emlékezetkultúra küszöbén - 201 ; 2.1.1. A verbális közeg tanúsága - 201 ; Bitskey István: Mohács emlékezete egy kora újkori hitvitában - 203 ; Debreczeni Attila: Nemzeti nagylét, nagy temető és – Batsányi (Egy nemzeti narratíva formálódása) - 208 ; Orbán László: Az útbaigazított emlékezet Kazinczynál (Identitásminták Kazinczy önéletrajzi szöveghálózatában – a kulturális emlékezethely gondolatának megjelenése) - 227 ; S. Varga Pál: „…keressetek alkalmat a hajdanra visszanézhetni…” (Mohács emlékezethellyé válása a 19. század elejének magyar irodalmában) - 240 ; Brigovácz László: Intések az utókornak – Mohács hagyatéka reformkori szentbeszédekben - 250 ; 2.1.2. A festészet tanúsága - 259 ; Veszprémi Nóra: A magyar történeti festészet kezdetei? (A mohácsi csata képi ábrázolásai a 18. század végén és a 19. század elején) - 261 ; Keserü Katalin: Mohácsról szól-e a Mohács-kép 1848/49 után? - 274 ; 2.2. Mohács emlékezete a modern korban – a történetírás, a politika és az irodalom tanúsága - 285 ; Szendrei Ákos: „Mohács-kép” a Szilágyi Sándor szerkesztette millenniumi A magyar nemzet történetében - 287 ; Erős Vilmos: Magyar Historikerstreit? (A Mohács-vita az 1960-as és 70-es években) - 301 ; Kerepeszki Róbert: Horthy Miklós mohácsi beszéde, 1926 (Emlékezethely a politikai gondolkodásban és a nemzetközi kapcsolatok történetében) - 313 ; Kovács Szilvia: Mohács – a történettudomány és a kulturális emlékezet narratívái (Krúdy Gyula: Mohács) - 325 ; 2.3. Idegenek szemében - 337 ; Györkös Attila: Mohács és a török–francia szövetség, avagy a „Nyugat árulásá”-nak mítosza - 339 ; Jakó Klára: Foglalkozik-e Moháccsal és a magyarsággal a 16. század vége és a 18. század eleje között a moldvai és havasalföldi krónikairodalom? - 352 ; Dobrovits Mihály: Nekik Mohács kell (A török Mohács-percepció kérdőjelei) - 362 ; Bárány Attila: Adalékok Mohács emlékezetéhez a Habsburgok államaiban: II. Lajos ábrázolásai a brüsszeli katedrálisban - 367 ; 2.4. Alternatív Mohács-képek - 385 ; Csorba Dávid: Az Angyalok kápolnája mint emlékezeti hely - 387 ; Baltavári Tamás: A mohácsi csata számítógépes rekonstrukciója és animációs megjelenítése - 397; A kötet szerzői - 403 ; Névmutató - 41