Quiste óseo solitario mandibular. Reporte de un caso y revisión de la literatura

RESUMENEl quiste óseo solitario de la mandíbula es una cavidad intraósea sin recubrimiento epitelial, considerado un pseudoquiste, ha recibido diversas denominaciones debido a su etiología y patogenia inciertas como quiste óseo traumático, quiste óseo solitario y quiste óseo idiopático. Clínicamente suele ser una lesión asintomática, muestra bordes festoneados cuando está localizado entre las raíces dentales, es una cavidad vacía pero puede contener sangre, fluido seroso o serohemático y es descubierta en exámenes radiológicos de rutina. En este artículo se presenta un caso de quiste óseo solitario localizado en el cuerpo mandibular que acomete a un paciente femenino de 17 años de edad con tetralogía de Fallot, revelando aspectos clínicos, diagnósticos e imagenológicos y tratamiento.ABSTRACTSolitary bone cyst of the mandible is an intra-osseous cavity lacking epithelial lining considered a pseudocyst. Due to its uncertain etiology and pathogenesis, it has received several names such as traumatic bone cyst or idiopathic bone cyst. From a clinical perspective, it is oftentimes an asymptomatic lesion, with festooned borders when located between dental roots. It is an empty cavity but might contain blood, serous or serous-hematic fluid and can be perceived in routine X-ray examinations. The present article describes the case of a solitary bone cyst located in the body of the mandible of a 17-year old female patient. Afflicted with Fallot's tetralogy. Clinical, diagnostic and radiologic aspects as well as treatment are described

The Effect of Parental Support on Academic Performance Among Students at Asia-Pacific International University

The purpose of this study was to determine the influence of parental support on college students’ academic performance of Asia-Pacific International University (AIU) in Thailand. The research aimed to investigate the relationship between parental support and academic achievement among Thai and International students at AIU in Thailand.   In addition, the study sought to find out the level of parental support among Thai and International students at AIU, and the differences in parental support. Using stratified sampling, ,60 undergraduate students aged between 17 years to 25 years old from five Asia-Pacific International University (AIU) dormitories were selected to participate in this study. A survey instrument for data collection consisted of a demographic questionnaire and a Likert-scale questionnaire.  The data were analyzed using Statistical Package for Social Sciences (SPSS) for Windows, Version 21.  An independent samples t-test was used to determine the differences between Thai and International students on parental support. Spearman rho correlation coefficients between parental involvement variables and cumulative grade point averages (CGPA) were reported. The findings revealed that academic performance cannot be adequately explained by parental support. Findings of this study also showed that although there is positive influence on the family relationship between the parents and students at the college level, it does not adequately explain academic performance among students. The present study was an attempt to inform college administrators and educators of the importance of parental support at the university level. Therefore, the main recommendation is that,  college administrators should look into how parents support their college students and establish strategies for encouraging emotional and social parental support to children in college...For further research necessary to consider the varying impacts of parental support within the lives of the children, such as investigating the impact of having little or no parental support

Assessing the Health Needs of Chinese Older Adults: Findings from a Community-Based Participatory Research Study in Chicago's Chinatown

The objective of this study is to examine the cultural views of healthy aging, knowledge and barriers to services, and perception of health sciences research among community-dwelling Chinese older adults in Chicago's Chinatown. This qualitative study is guided by the Precede-Proceed conceptual model with community-based participatory research design. Data analysis is based on eight focus group interviews with Chinese older (age 60+) adults (n = 78). We used a grounded theory framework to systematically guide the thematic structure of our data. Findings show participants described cultural conception of health in terms of physical function, psychological well-being, social support, and cognitive function. The availability, affordability, and cultural barriers towards health care services were major negative enabling factors that inhibit participants from fulfilling health needs. Perception and knowledge of health sciences research were also discussed. This study has implications for the delivery of culturally appropriate health care services to the Chinese aging population

A Positive Feedback Loop Between Myc and Aerobic Glycolysis Sustains Tumor Growth in a Drosophila Tumor Model

Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an in vivo tumor model expressing oncogenic Drosophila Homeodomain-interacting protein kinase (Hipk), tumor cells display elevated aerobic glycolysis. Mechanistically, elevated Hipk drives transcriptional upregulation of Drosophila Myc (dMyc; MYC in vertebrates) likely through convergence of multiple perturbed signaling cascades. dMyc induces robust expression of pfk2 (encoding 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase; PFKFB in vertebrates) among other glycolytic genes. Pfk2 catalyzes the synthesis of fructose-2,6-bisphosphate, which acts as a potent allosteric activator of Phosphofructokinase (Pfk) and thus stimulates glycolysis. Pfk2 and Pfk in turn are required to sustain dMyc protein accumulation post-transcriptionally, establishing a positive feedback loop. Disruption of the loop abrogates tumorous growth. Together, our study demonstrates a reciprocal stimulation of Myc and aerobic glycolysis and identifies the Pfk2-Pfk governed committed step of glycolysis as a metabolic vulnerability during tumorigenesis

Evaluation of a peer counselling programme to sustain breastfeeding practice in Hong Kong

<p>Abstract</p> <p>Background</p> <p>Peer counselling is reported to increase breastfeeding rates. We evaluated an intervention consisting of mainly telephone contact peer counselling programme on breastfeeding duration and exclusivity.</p> <p>Methods</p> <p>Peer counsellors (PCs) were mothers who had successfully breastfed and had received formal training. Following a postnatal visit, they provided scheduled telephone consultations (Days 1, 4, 7, Weeks 2, 4, 8, and Month 4) to PC group mothers (n = 100) who continued breastfeeding their infants after discharge. Control group mothers (n = 100) received routine care.</p> <p>Results</p> <p>After adjusting for mothers' previous breastfeeding experiences, mothers' working status and breastfeeding problems, no statistical differences in mothers' feeding methods (exclusive, almost exclusive or predominant breastfeeding) were noted at the three follow-up times for intervention and control mothers respectively (Day 5: 37%/38%, 46%/53%, 57%/63%; Month 3: 10%/9%, 17%/23%, 20%/26%; Month 6: 2%/1%, 18%/18%, 18%/19%). All differences between the groups were not significant. Also, there was no evidence to suggest that PC intervention prolonged breastfeeding duration.</p> <p>Conclusion</p> <p>The lack of effect of our PC intervention may reflect the low baseline breastfeeding rate and low value placed on breastfeeding in our population, the type of PC intervention or group allocation biases.</p> <p>Trial registration</p> <p>ISRCTN93605280.</p

The Compressive Strength Of Concrete With Coconut Ash As Cement Replacement

This study was carried out to produce concrete that is more environmentally friendly by using coconut fiber ash as cement replacement. The reason to use coconut fiber as cement replacement is to reduce the amount of cement usage in concrete mix. It is aimed to achieve the min objectives of this study which are to determine the workability of concrete and to determine the compressive strength of concrete. The ratio of materials used is 1:2:4 to do the concrete mix. Additives which are coconut fiber ash used to replace the cement are 0%, 2% and 4%. The mold used to produce concrete is 100mm length, 100mm width and 100mm height. The concrete will then be let dry and soaked for 1 week before it tested on 7th days, then continued by 14th days and 28th days

康德的道德情感理論及牟宗三先生的批評與闡釋

本論文的題目為「康德的道德情感理論與牟宗三先生的批評與闡釋」。自當代新儒家牟宗三先生援引康德哲學來重新詮釋儒家哲學，中西比較哲學的討論頓時 變得活躍起來，筆者亦因讀到牟先生的著作，而對康德的哲學產生興趣。筆者以“道德情感”為比較康德與牟先生的儒學之開展，是因為注意到道德情感在 兩者哲學中的獨特位置，希望通過探討牟先生對康德的批評與闡釋，能夠指出道德情感所具有的形上意涵。通過比較康德與牟先生的道德哲學，筆者希望能 揭示兩者所採用哲學的方法以至其哲學的系統架構，從而能對兩者作恰如其分的定位

Having a family doctor is associated with some better patient-reported outcomes of primary care consultations

&lt;b&gt;Background&lt;/b&gt; Hong Kong (HK) has pluralistic primary care that is provided by a variety of doctors. The aim of our study was to assess patient-reported outcomes of primary care consultations in HK and whether having a family doctor (FD) made any difference.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods&lt;/b&gt; We interviewed by telephone 3148 subjects from 5174 contacted households (response rate 60.8%) randomly selected from the general population of HK about the experience of their last primary care consultations in September 2007 and April 2008. We compared the patient-reported outcomes (PRO) and patient-centered process of care in those with a FD, those with other types of regular primary care doctors (ORD) and those without any regular primary care doctor (NRD). PRO included patient enablement, global improvement in health, overall satisfaction, and likelihood of recommending their doctors to family and friends. Patient-centered process of care indicators was explanations about the illness, and address of patient’s concerns.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt; One thousand one hundred fifty, 746, and 1157 reported to have FD, ORD, and NRD, respectively. Over 80% of those with FD consulted their usual primary care doctors in the last consultation compared with 27% of those with NRD. Compared with subjects having ORD or NRD, subjects with FD reported being more enabled after the consultation and were more likely to recommend their doctors to family and friends. Subjects with FD and ORD were more likely than those having NRD to report a global improvement in health and satisfaction. FD group was more likely than the other two groups to report receiving an explanation on the diagnosis, nature, and expected course of the illness, and having their concerns addressed. Patient enablement was associated with explanation of diagnosis, nature, and expected course of illness, and address of patient’s concerns.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusion&lt;/b&gt; People with a regular FD were more likely to feel being enabled and to experience patient-centered care in consultations

Survival of South African patients on renal replacement therapy

CITATION: Jardine, T. et al. Survival of South African patients on renal replacement therapy. Clinical Kidney Journal, 13(5): 782–790. doi:10.1093/ckj/sfaa012The original publication is available at https://academic.oup.com/ckjBackground The majority of South Africans rely on a resource-constrained public healthcare sector, where access to renal replacement therapy (RRT) is strictly rationed. The incidence of RRT in this sector is only 4.4 per million population (pmp), whereas it is 139 pmp in the private sector, which serves mainly the 16% of South Africans who have medical insurance. Data on the outcomes of RRT may influence policies and resource allocation. This study evaluated, for the first time, the survival of South African patients starting RRT based on data from the South African Renal Registry. Methods The cohort included patients with end-stage kidney disease who initiated RRT between January 2013 and September 2016. Data were collected on potential risk factors for mortality. Failure events included stopping treatment without recovery of renal function and death. Patients were censored at 1 year or upon recovery of renal function or loss to follow-up. The 1-year patient survival was estimated using the Kaplan–Meier method and the association of potential risk factors with survival was assessed using multivariable Cox proportional hazards regression. Results The cohort comprised 6187 patients. The median age was 52.5 years, 47.2% had diabetes, 10.2% were human immunodeficiency virus (HIV) positive and 82.2% had haemodialysis as their first RRT modality. A total of 542 patients died within 1 year of initiating RRT, and overall 1-year survival was 90.4% [95% confidence interval (CI) 89.6–91.2]. Survival was similar in patients treated in the private sector as compared with the public healthcare sector [hazard ratio 0.93 (95% CI 0.72–1.21)]. Higher mortality was associated with older age and a primary renal diagnosis of ‘Other’ or ‘Aetiology unknown’. When compared with those residing in the Western Cape, patients residing in the Northern Cape, Eastern Cape, Mpumalanga and Free State provinces had higher mortality. There was no difference in mortality based on ethnicity, diabetes or treatment modality. The 1-year survival was 95.9 and 94.2% in HIV-positive and -negative patients, respectively. One-fifth of the cohort had no data on HIV status and the survival in this group was considerably lower at 77.1% (P < 0.001). Conclusions The survival rates of South African patients accessing RRT are comparable to those in better-resourced countries. It is still unclear what effect, if any, HIV infection has on survival.https://academic.oup.com/ckj/article/13/5/782/5780430Publishers versio