The relation between speaking-style categorization and speech recognition in adult cochlear implant users

The current study examined the relation between speaking-style categorization and speech recognition in post-lingually deafened adult cochlear implant users and normal-hearing listeners tested under 4- and 8-channel acoustic noise-vocoder cochlear implant simulations. Across all listeners, better speaking-style categorization of careful read and casual conversation speech was associated with more accurate recognition of speech across those same two speaking styles. Findings suggest that some cochlear implant users and normal-hearing listeners under cochlear implant simulation may benefit from stronger encoding of indexical information in speech, enabling both better categorization and recognition of speech produced in different speaking styles.</p

Acoustic characteristics of depression in older adults’ speech:The role of covariates

Depression in older adults is often associated with various physical conditions and is hence different from depression at a younger age. Ageing may come with cognitive decline, medication use, and frailty, which are known to be predictors of late-life depression. One common symptom of depression is psychomotor retardation, that may also affect speech production. Most speech studies on depression so far have focused on younger or middle-aged adults. In this study, we used speech data from a large longitudinal Dutch study on late-life depression and its comorbid symptoms to compare speech acoustics in persons with depression (PWD) and controls. We investigated whether groups differed by taking several covariates into account (e.g., frailty, slowness, and medication use). Group differences were found in within-vowel F2 range, speech rate and mean pause duration. These data indicate that speech acoustics can be used to differentiate PWDs and controls, even with low-quality speech data

The impact of speaking style on speech recognition in quiet and multi-talker babble in adult cochlear implant users

Contains fulltext : 216114pub.pdf (publisher's version ) (Open Access)8 p

The Holes in the cheese : improving engineering students' generic communicative competencies

Engineers spend considerable time communicating technical details to various audiences. This requires communicative competence which is linked to the underlying knowledge and skills in the engineering disciplines. The metaphor 'holes in the cheese‘ is used to describe a particular group of reading and writing competencies which are not yet adequately developed in students, but which are expected to be in place at their educational level, and which are further characterised as follows: (a) while it is reasonable to include limited revision of prior topics or competencies in a mainstream programme, substantive interventions to address them must be extra-curricular; (b) a significant proportion of students require development in this regard; (c) they are seldom explicitly taught; (d) most engineering academics are not explicitly trained to identify or address them; (e) identifying and addressing them through traditional assessment of written work ('red ink‘) is time-consuming for academics; (f) moreover, addressing them through traditional assessment is seldom successful: while the document may have been corrected, an improvement in competence is seldom established by this method. By way of evidence, this paper attempts to name, explain and illustrate these 'holes in the cheese‘ in terms that are sufficiently explicit and concrete so that fellow engineering academics can readily understand and relate to them. This evidence is illustrative and anecdotal, serving as a point of discussion rather than a conclusion of fact. With regard to reading fluency and comprehension, the reading speeds of students on intake to supplementary interventions, over a three year period, have typically been below the reading speeds regarded as a lower threshold for university students when reading fiction and non-technical materials. With regard to writing, typical challenges include grammatical errors as well as structure, organisation, logic, and integration / synthesis of information from multiple sources

Perceptual learning of time-compressed and natural fast speech

Speakers vary their speech rate considerably during a conversation, and listeners are able to quickly adapt to these variations in speech rate. Adaptation to fast speech rates is usually measured using artificially time-compressed speech. This study examined adaptation to two types of fast speech: artificially time-compressed speech and natural fast speech. Listeners performed a speeded sentence verification task on three series of sentences: normal-speed sentences, time-compressed sentences, and natural fast sentences. Listeners were divided into two groups to evaluate the possibility of transfer of learning between the time-compressed and natural fast conditions. The first group verified the natural fast before the time-compressed sentences, while the second verified the time-compressed before the natural fast sentences. The results showed transfer of learning when the time-compressed sentences preceded the natural fast sentences, but not when natural fast sentences preceded the time-compressed sentences. The results are discussed in the framework of theories on perceptual learning. Second, listeners show adaptation to the natural fast sentences, but performance for this type of fast speech does not improve to the level of time-compressed sentences

Comunicación enriquecida a lo largo de la vida

Speech is a hugely efficient means of communication: a reduced capacity in listening or speaking creates a significant barrier to social inclusion at all points through the lifespan, in education, work and at home. Hearing devices and speech synthesis can help address this reduced capacity but their use imposes greater listener effort. The goal of the EU-funded ENRICH project is to modify or augment speech with additional information to make it easier to process. Enrichment reduces listening burden by minimising cognitive load, while maintaining or improving intelligibility. ENRICH investigates the relationship between cognitive effort and natural and synthetic speech. Non-intrusive metrics for listening effort will be developed and used to design modification techniques which result in low-burden speech. The value of various enrichment approaches will be evaluated with individuals and cohorts with typically sub-optimal communication ability, such as children, hearing-or speech-impaired adults, non-native listeners and individuals engaged in simultaneous tasks.El habla es un medio de comunicación sumamente eficiente: la capacidad reducida para oír o hablar crea barreras importantes para la inclusión social a lo largo de la vida en la educación, en el trabajo o en el hogar. Los audífonos y la síntesis del habla pueden ayudar a abordar esta capacidad reducida, pero su uso impone un mayor esfuerzo por parte del oyente. El objetivo del proyecto europeo ENRICH es modificar o aumentar el habla con información adicional resultando así más fácil de procesar. El enriquecimiento reduce el esfuerzo de escucha minimizando la carga cognitiva, mientras se mantiene o mejora la inteligibilidad. ENRICH investigará la relación entre el esfuerzo cognitivo y las diferentes formas de habla natural y sintética. Se desarrollarán métricas no intrusivas para el esfuerzo de escucha que se utilizarán para diseñar modificaciones que resulten en un habla de baja carga. El valor de los diversos enfoques de enriquecimiento se evaluará con individuos y cohortes con habilidades de comunicación típicamente subóptimas, como niños, adultos con problemas de audición o de habla, oyentes no nativos e individuos que realizan tareas simultáneas.ENRICH has received funding from the EU H2020 research and innovation programme under MSCA GA 675324

Correction: Protocol of the Healthy Brain Study:An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

[This corrects the article DOI: 10.1371/journal.pone.0260952.]

Seeing the talker’s face supports executive processing of speech in steady state noise. Front

Listening to speech in noise depletes cognitive resources, affecting speech processing. The present study investigated how remaining resources or cognitive spare capacity (CSC) can be deployed by young adults with normal hearing. We administered a test of CSC (CSCT

Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

Background: Children with HIV-associated tuberculosis (TB) have few antiretroviral therapy (ART) options. We aimed to evaluate the safety and pharmacokinetics of dolutegravir twice-daily dosing in children receiving rifampicin for HIV-associated TB. Methods: We nested a two-period, fixed-order pharmacokinetic substudy within the open-label, multicentre, randomised, controlled, non-inferiority ODYSSEY trial at research centres in South Africa, Uganda, and Zimbabwe. Children (aged 4 weeks to <18 years) with HIV-associated TB who were receiving rifampicin and twice-daily dolutegravir were eligible for inclusion. We did a 12-h pharmacokinetic profile on rifampicin and twice-daily dolutegravir and a 24-h profile on once-daily dolutegravir. Geometric mean ratios for trough plasma concentration (Ctrough), area under the plasma concentration time curve from 0 h to 24 h after dosing (AUC0–24 h), and maximum plasma concentration (Cmax) were used to compare dolutegravir concentrations between substudy days. We assessed rifampicin Cmax on the first substudy day. All children within ODYSSEY with HIV-associated TB who received rifampicin and twice-daily dolutegravir were included in the safety analysis. We described adverse events reported from starting twice-daily dolutegravir to 30 days after returning to once-daily dolutegravir. This trial is registered with ClinicalTrials.gov (NCT02259127), EudraCT (2014–002632-14), and the ISRCTN registry (ISRCTN91737921). Findings: Between Sept 20, 2016, and June 28, 2021, 37 children with HIV-associated TB (median age 11·9 years [range 0·4–17·6], 19 [51%] were female and 18 [49%] were male, 36 [97%] in Africa and one [3%] in Thailand) received rifampicin with twice-daily dolutegravir and were included in the safety analysis. 20 (54%) of 37 children enrolled in the pharmacokinetic substudy, 14 of whom contributed at least one evaluable pharmacokinetic curve for dolutegravir, including 12 who had within-participant comparisons. Geometric mean ratios for rifampicin and twice-daily dolutegravir versus once-daily dolutegravir were 1·51 (90% CI 1·08–2·11) for Ctrough, 1·23 (0·99–1·53) for AUC0–24 h, and 0·94 (0·76–1·16) for Cmax. Individual dolutegravir Ctrough concentrations were higher than the 90% effective concentration (ie, 0·32 mg/L) in all children receiving rifampicin and twice-daily dolutegravir. Of 18 children with evaluable rifampicin concentrations, 15 (83%) had a Cmax of less than the optimal target concentration of 8 mg/L. Rifampicin geometric mean Cmax was 5·1 mg/L (coefficient of variation 71%). During a median follow-up of 31 weeks (IQR 30–40), 15 grade 3 or higher adverse events occurred among 11 (30%) of 37 children, ten serious adverse events occurred among eight (22%) children, including two deaths (one tuberculosis-related death, one death due to traumatic injury); no adverse events, including deaths, were considered related to dolutegravir. Interpretation: Twice-daily dolutegravir was shown to be safe and sufficient to overcome the rifampicin enzyme-inducing effect in children, and could provide a practical ART option for children with HIV-associated TB