Sicole: diagnóstico y tratamiento computarizado de la dislexia en español

En este articulo realizamos un recorrido sobre las investigaciones más relevantes en el campo de la tecnología aplicada al diseño instruccional, las cuales marcan las pautas de diseño de los programas educativos actuales y presentamos los criterios pedagógicos y tecnológicos que hemos seguido en el diseño e implementación de un ITS para la diagnóstico, evaluación y tratamiento de niños con Dislexia en el lenguaje español. Este trabajo se halla dentro del marco de un proyecto de investigación interdisciplinar titulado SICOLE, formado por psicólogos, pedagogos e informáticos.In this paper we present the most significant researchers in the area of technology applied to instructional design. Also, we describe the pedagogical and technological principles followed in the design and implementation of an Intelligent Tutorial System for assessment and treatment of dyslexic children in Spanish language. This work is result of a multidisciplinary research with engineers, teachers and psychologists and it has been funded by «Fondos Europeos para el Desarrollo Regional» (FEDER), 1FD97-1140, and the «Dirección General de Investigación Científica y Técnica» (DIGICYT). This package has being used in several Spanish schools as part of its validation process

On Soliton-type Solutions of Equations Associated with N-component Systems

The algebraic geometric approach to $N$-component systems of nonlinear integrable PDE's is used to obtain and analyze explicit solutions of the coupled KdV and Dym equations. Detailed analysis of soliton fission, kink to anti-kink transitions and multi-peaked soliton solutions is carried out. Transformations are used to connect these solutions to several other equations that model physical phenomena in fluid dynamics and nonlinear optics.Comment: 43 pages, 16 figure

New variable separation approach: application to nonlinear diffusion equations

The concept of the derivative-dependent functional separable solution, as a generalization to the functional separable solution, is proposed. As an application, it is used to discuss the generalized nonlinear diffusion equations based on the generalized conditional symmetry approach. As a consequence, a complete list of canonical forms for such equations which admit the derivative-dependent functional separable solutions is obtained and some exact solutions to the resulting equations are described.Comment: 19 pages, 2 fig

Rotating 5D-Kaluza-Klein Space-Times from Invariant Transformations

Using invariant transformations of the five-dimensional Kaluza-Klein (KK) field equations, we find a series of formulae to derive axial symmetric stationary exact solutions of the KK theory starting from static ones. The procedure presented in this work allows to derive new exact solutions up to very simple integrations. Among other results, we find exact rotating solutions containing magnetic monopoles, dipoles, quadripoles, etc., coupled to scalar and to gravitational multipole fields.Comment: 24 pages, latex, no figures. To appear in Gen. Rel. Grav., 32, (2000), in pres

Linkage mapping, comparative genome analysis, and QTL detection for growth in a non-model teleost, the meagre Argyrosomus regius, using ddRAD sequencing

Meagre (Argyrosomus regius), is a benthopelagic species rapidly emerging in aquaculture, due to its low food to biomass conversion rate, good fillet yield and ease of production. Tracing a species genomic background along with describing the genetic basis of important traits can greatly influence both conservation strategies and production perspectives. In this study, we employed ddRAD sequencing of 266 fish from six F1 meagre families, to construct a high-density genetic map comprising 4529 polymorphic SNP markers. The QTL mapping analysis provided a genomic appreciation for the weight trait identifying a statistically significant QTL on linkage group 15 (LG15). The comparative genomics analysis with six teleost species revealed an evolutionarily conserved karyotype structure. The synteny observed, verified the already well-known fusion events of the three-spine stickleback genome, reinforced the evidence of reduced evolutionary distance of Sciaenids with the Sparidae family, reflected the evolutionary proximity with Dicentrarchus labrax, traced several putative chromosomal rearrangements and a prominent putative fusion event in meagre’s LG17. This study presents novel elements concerning the genome evolutionary history of a non-model teleost species recently adopted in aquaculture, starts to unravel the genetic basis of the species growth-related traits, and provides a high-density genetic map as a tool that can help to further establish meagre as a valuable resource for research and production.info:eu-repo/semantics/publishedVersio

Transect walks : method sensitivity for on-farm welfare evaluation in turkeys

There is increasing consumer demands for livestock and poultry products that meet minimum animal welfare standards during their production cycle. Additionally, a growing number of farmers are aware about full compliance with the animal welfare standards that could play an important economic role in commercial intensive productions. Indeed, animal welfare assessment protocols have meaningful effects to promote and guarantee the on-farm safeguard animal standards. Transect walks method appeared to provide a practical approach to welfare assessment in broilers farms. Because of the similarities of meat poultry production, this method could be considered a reasonable approach for turkey welfare evaluation in terms of time demands, within costs and feasibility. The aim of this study was to determine the sensitivity of this method at 3 commercial turkey farms with similar facilities (Animal Welfare Indicators project, FP7-KBBE-2010-4). In this study, 10 commercial female-turkey flocks (6 houses with identical management), ranging from 3,212 to 6,000 birds and belonging to the same company were evaluated one week before slaughter. On turkey farms, walking through the house is a routine daily procedure to check the health status of the birds. Two previously trained assessors in performing the transect methodology and properly assessing the selected indicators, evaluated each paired house sequentially and independently within the same day by walking through predefined transect bands (1 to 4) in random order. The animal-based indicators considered were: immobility, lameness, wounds and featherless. The statistical model used was GLM in the GENMOD procedure (SAS V9). The results showed that this welfare assessment method highlights even small variation among houses for the considered variables. In fact, there were significant difference across houses (P=0.0021, P=0.0006, P=0.0081 and P=0.0003) for all the evaluated indicators respectively. Differences across observers were detected for wounds and featherless (P<0.0001). These results may be due to the difficulties in assessing equally these parameters while walking. On the contrary, lameness, probably the most important welfare problem in meat poultry, showed a good concordance between observers (P= 0.361). These preliminary findings suggest that this new approach has potential as a tool for on-farm welfare evaluation, which may be worthwhile to be further developed

Real-life management of patients with breakthrough cancer pain caused by bone metastases in Spain

Purpose: We aimed to explore the characteristics, and real-life therapeutic management of patients with breakthrough cancer pain (BTcP) caused by bone metastases in Spain, and to evaluate physicians' opinion of and satisfaction with prescribed BTcP therapy. Participants and methods: For the purposes of this study, an ad-hoc questionnaire was developed consisting of two domains: a) organizational aspects and care standards; b) clinical and treatment variables of bone metastatic BTcP patients. In addition, physicians' satisfaction with their prescribed BTcP therapy was assessed. Specialists collected data from up to five patients receiving treatment for BTcP caused by bone metastasis, all patients gave their consent to participate prior to inclusion. Results: A total of 103 cancer pain specialists (radiation oncologists [38.8%], pain specialists [33.0%], and palliative care (PC) specialists [21.4%]) were polled, and data on 386 BTcP patients with bone metastatic disease were collected. Only 33% of the specialists had implemented specific protocols for BTcP management, and 19.4% had established referral protocols for this group of patients. Half of all participants (50.5%) address quality of life and quality of care in their patients; however, only 27.0% did so from the patient's perspective, as they should do. Most patients had multiple metastases and were prescribed rapid-onset fentanyl preparations (71.2%), followed by immediate-release morphine (9.3%) for the treatment of BTcP. Rapid-onset fentanyl was prescribed more often in PC units (79.0%) than in pain units (75.9%) and radiation oncology units (61.1%) (p<0.01). Furthermore, most physicians (71.8%) were satisfied with the BTcP therapy prescribed. Conclusions: Our results demonstrate the need for routine assessment of quality of life in patients with bone BTcP. These findings also underscore the necessity for a multidisciplinary therapeutic strategy for breakthrough pain in clinical practice in Spain

Substrate choice by turkeys differing in 3-point gait-scoring system in a mobility test

Assessment of pain in poultry flocks\u2019 production is one of the biggest welfare concerns. The aim of this study was to evaluate the walking ability and preferences for three types of substrates by turkeys with different degrees of lameness, in order to verify if birds with higher gait score experience pain and how their choices differ from healthy birds. An experimental test was conducted with 16 male-turkeys 116-day-old (B.U.T.6). Nine birds (56.25%) were considered normal (score 0) whereas 7 (43.75%) were evaluated as having mild to severe lameness (scores 1 or 2) according to 3-point gait-score assessment. A familiar (A: wet litter) and unfamiliar (B: plastic slat) substrate were distributed into three horizontal lines (L1, L2, and L3; each one measuring 150cm length x 60cm width) separated by three concrete empty areas of the same measures. L1 was divided into 75cm of A substrate and the same dimensions of B; L2 had 100cm of A and 50cm of B, while L3 had 50cm of A and 100cm of B. The turkeys\u2019 motivation to pass through the lines was triggered by the presence of conspecifics located at the end of the experimental area. Data were analyzed using ANOVA. There were no significant differences between normal and lame turkeys to the total time spent on three lines (215.00\ub161.59s), (233.57\ub174.81s);the total time spent on the empty area (385.22\ub183.70s), (557.71\ub1124.04s) and the total time to cross the testing areas (581.3\ub191.72s), (791.2\ub1154.44s),respectively. Substrate A was chosen by 71.4% of lame birds even in L1 as L2, while 55.6% of normal turkeys preferred substrate B in L1 and 77.8% chose substrate A in L2. All birds walked on substrate B in L3. According to these preliminary results, it seems that lame birds have no difference in substrate choice, or on the time spent in each part of the experiment