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The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.
AimTo examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.Materials & methodsIn a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined.ResultsFamily income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions.ConclusionFindings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans
Information theory in the study of anisotropic radiation
Information theory is used to perform a thermodynamic study of non
equilibrium anisotropic radiation. We limit our analysis to a second-order
truncation of the moments, obtaining a distribution function which leads to a
natural closure of the hierarchy of radiative transfer equations in the
so-called variable Eddington factor scheme. Some Eddington factors appearing in
the literature can be recovered as particular cases of our two-parameter
Eddington factor. We focus our attention in the study of the thermodynamic
properties of such systems and relate it to recent nonequilibrium thermodynamic
theories. Finally we comment the possibility of introducing a nonequilibrium
chemical potential for photons.Comment: 1 eps figure upon request by e-mail, to appear in Journal of Physics
Nonequilibrium corrections in the pressure tensor due to an energy flux
The physical interpretation of the nonequilibrium corrections in the pressure
tensor for radiation submitted to an energy flux obtained in some previous
works is revisited. Such pressure tensor is shown to describe a moving
equilibrium system but not a real nonequilibrium situation.Comment: 4 pages, REVTeX, Brief Report to appear in PRE Dec 9
Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.
Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV, whereas TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women
The intertwined geopolitics and geoeconomics of hopes/fears:Chinaâs triple economic bubbles and the âOne Belt One Roadâ imaginary
This paper adopts a discursive-cum-material approach to China's new 'One Belt One Road' (OBOR) geostrategic imaginary and its development through the intertwining of geopolitics and geoeconomics of hopes and fears. It first contextualizes this development after the 2008 financial crisis when China promoted a vast stimulus package that inflated existing property and infrastructure bubbles and fuelled another in finance. Resulting debates over crisis management enabled an incoming President Xi to articulate a set of hope-based discourses that came to include 'China Dream', 'New Normal' and the OBOR. Familiar cartographic statecraft techniques and novel spatial metaphors were used to promote the OBOR's allegedly 'win-win' strategy discursively. The OBOR imaginary was translated materially, and importantly, into policies that promoted a grand transregional 'spatial fix' to postpone China's over-accumulation crises. This strategy is consolidating a China-oriented infrastructural mode of growth in production, finance and security. As this absorbs ever more productive and financial capital, we see the emergence of contradictions, antagonisms and conflicts, especially in the use of bilateral loan-debt contractuality to appropriate strategic infrastructure. The paper concludes with a call for an affective turn examining the intertwining of geoeconomics and geopolitics in the analysis of transregional spatial fixes
Conformation and dynamics of human urotensin II and urotensin related peptide in aqueous solution
Conformation
and dynamics of the vasoconstrictive peptides human
urotensin II (UII) and urotensin related peptide (URP) have been investigated
by both unrestrained and enhanced-sampling molecular-dynamics (MD)
simulations and NMR spectroscopy. These peptides are natural ligands
of the G-protein coupled urotensin II receptor (UTR) and have been
linked to mammalian pathophysiology. UII and URP cannot be characterized
by a single structure but exist as an equilibrium of two main classes
of ring conformations, <i>open</i> and <i>folded</i>, with rapidly interchanging subtypes. The <i>open</i> states
are characterized by turns of various types centered at K<sup>8</sup>Y<sup>9</sup> or F<sup>6</sup>W<sup>7</sup> predominantly with no
or only sparsely populated transannular hydrogen bonds. The <i>folded</i> conformations show multiple turns stabilized by highly
populated transannular hydrogen bonds comprising centers F<sup>6</sup>W<sup>7</sup>K<sup>8</sup> or W<sup>7</sup>K<sup>8</sup>Y<sup>9</sup>. Some of these conformations have not been characterized previously.
The equilibrium populations that are experimentally difficult to access
were estimated by replica-exchange MD simulations and validated by
comparison of experimental NMR data with chemical shifts calculated
with density-functional theory. UII exhibits approximately 72% <i>open</i>:28% <i>folded</i> conformations in aqueous
solution. URP shows very similar ring conformations as UII but differs
in an <i>open:folded</i> equilibrium shifted further toward <i>open</i> conformations (86:14) possibly arising from the absence
of folded N-terminal tail-ring interaction. The results suggest that
the different biological effects of UII and URP are not caused by
differences in ring conformations but rather by different interactions
with UTR
Global Warming: Forecasts by Scientists versus Scientific Forecasts
In 2007, the Intergovernmental Panel on Climate Changeâs Working Group One, a panel of experts established by the World Meteorological Organization and the United Nations Environment Programme, issued its Fourth Assessment Report. The Report included predictions of dramatic increases in average world temperatures over the next 92 years and serious harm resulting from the predicted temperature increases. Using forecasting principles as our guide we asked: Are these forecasts a good basis for developing public policy? Our answer is ânoâ. To provide forecasts of climate change that are useful for policy-making, one would need to forecast (1) global temperature, (2) the effects of any temperature changes, and (3) the effects of feasible alternative policies. Proper forecasts of all three are necessary for rational policy making. The IPCC WG1 Report was regarded as providing the most credible long-term forecasts of global average temperatures by 31 of the 51 scientists and others involved in forecasting climate change who responded to our survey. We found no references in the 1056-page Report to the primary sources of information on forecasting methods despite the fact these are conveniently available in books, articles, and websites. We audited the forecasting processes described in Chapter 8 of the IPCCâs WG1 Report to assess the extent to which they complied with forecasting principles. We found enough information to make judgments on 89 out of a total of 140 forecasting principles. The forecasting procedures that were described violated 72 principles. Many of the violations were, by themselves, critical. The forecasts in the Report were not the outcome of scientific procedures. In effect, they were the opinions of scientists transformed by mathematics and obscured by complex writing. Research on forecasting has shown that expertsâ predictions are not useful in situations involving uncertainly and complexity. We have been unable to identify any scientific forecasts of global warming. Claims that the Earth will get warmer have no more credence than saying that it will get colder
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