Quantized Maxwell Theory in a Conformally Invariant Gauge

Maxwell theory can be studied in a gauge which is invariant under conformal rescalings of the metric, and first proposed by Eastwood and Singer. This paper studies the corresponding quantization in flat Euclidean 4-space. The resulting ghost operator is a fourth-order elliptic operator, while the operator P on perturbations of the potential is a sixth-order elliptic operator. The operator P may be reduced to a second-order non-minimal operator if a dimensionless gauge parameter tends to infinity. Gauge-invariant boundary conditions are obtained by setting to zero at the boundary the whole set of perturbations of the potential, jointly with ghost perturbations and their normal derivative. This is made possible by the fourth-order nature of the ghost operator. An analytic representation of the ghost basis functions is also obtained.Comment: 8 pages, plain Tex. In this revised version, the calculation of ghost basis functions has been amended, and the presentation has been improve

Euclidean Maxwell Theory in the Presence of Boundaries. II

Zeta-function regularization is applied to complete a recent analysis of the quantized electromagnetic field in the presence of boundaries. The quantum theory is studied by setting to zero on the boundary the magnetic field, the gauge-averaging functional and hence the Faddeev-Popov ghost field. Electric boundary conditions are also studied. On considering two gauge functionals which involve covariant derivatives of the 4-vector potential, a series of detailed calculations shows that, in the case of flat Euclidean 4-space bounded by two concentric 3-spheres, one-loop quantum amplitudes are gauge independent and their mode-by-mode evaluation agrees with the covariant formulae for such amplitudes and coincides for magnetic or electric boundary conditions. By contrast, if a single 3-sphere boundary is studied, one finds some inconsistencies, i.e. gauge dependence of the amplitudes.Comment: 24 pages, plain-tex, recently appearing in Classical and Quantum Gravity, volume 11, pages 2939-2950, December 1994. The authors apologize for the delay in circulating the file, due to technical problems now fixe

Essential self-adjointness in one-loop quantum cosmology

The quantization of closed cosmologies makes it necessary to study squared Dirac operators on closed intervals and the corresponding quantum amplitudes. This paper proves self-adjointness of these second-order elliptic operators.Comment: 14 pages, plain Tex. An Erratum has been added to the end, which corrects section

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages

Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype. Both glioma and infiltrating M/MΦ cells express the Ca(2+)-activated K(+) channel (KCa3.1), and the inhibition of KCa3.1 activity on glioma cells reduces tumor infiltration in the healthy brain parenchyma. We wondered whether KCa3.1 inhibition could prevent the acquisition of a pro-tumor phenotype by M/MΦ cells, thus contributing to reduce glioma development. With this aim, we studied microglia cultured in glioma-conditioned medium or treated with IL-4, as well as M/MΦ cells acutely isolated from glioma-bearing mice and from human glioma biopsies. Under these different conditions, M/MΦ were always polarized toward an anti-inflammatory state, and preventing KCa3.1 activation by 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34), we observed a switch toward a pro-inflammatory, antitumor phenotype. We identified FAK and PI3K/AKT as the molecular mechanisms involved in this phenotype switch, activated in sequence after KCa3.1. Anti-inflammatory M/MΦ have higher expression levels of KCa3.1 mRNA (kcnn4) that are reduced by KCa3.1 inhibition. In line with these findings, TRAM-34 treatment, in vivo, significantly reduced the size of tumors in glioma-bearing mice. Our data indicate that KCa3.1 channels are involved in the inhibitory effects exerted by the glioma microenvironment on infiltrating M/MΦ, suggesting a possible role as therapeutic targets in glioma

Spectral asymptotics of Euclidean quantum gravity with diff-invariant boundary conditions

A general method is known to exist for studying Abelian and non-Abelian gauge theories, as well as Euclidean quantum gravity, at one-loop level on manifolds with boundary. In the latter case, boundary conditions on metric perturbations h can be chosen to be completely invariant under infinitesimal diffeomorphisms, to preserve the invariance group of the theory and BRST symmetry. In the de Donder gauge, however, the resulting boundary-value problem for the Laplace type operator acting on h is known to be self-adjoint but not strongly elliptic. The latter is a technical condition ensuring that a unique smooth solution of the boundary-value problem exists, which implies, in turn, that the global heat-kernel asymptotics yielding one-loop divergences and one-loop effective action actually exists. The present paper shows that, on the Euclidean four-ball, only the scalar part of perturbative modes for quantum gravity are affected by the lack of strong ellipticity. Further evidence for lack of strong ellipticity, from an analytic point of view, is therefore obtained. Interestingly, three sectors of the scalar-perturbation problem remain elliptic, while lack of strong ellipticity is confined to the remaining fourth sector. The integral representation of the resulting zeta-function asymptotics is also obtained; this remains regular at the origin by virtue of a spectral identity here obtained for the first time.Comment: 25 pages, Revtex-4. Misprints in Eqs. (5.11), (5.14), (5.16) have been correcte

On the Zero-Point Energy of a Conducting Spherical Shell

The zero-point energy of a conducting spherical shell is evaluated by imposing boundary conditions on the potential, and on the ghost fields. The scheme requires that temporal and tangential components of perturbations of the potential should vanish at the boundary, jointly with the gauge-averaging functional, first chosen of the Lorenz type. Gauge invariance of such boundary conditions is then obtained provided that the ghost fields vanish at the boundary. Normal and longitudinal modes of the potential obey an entangled system of eigenvalue equations, whose solution is a linear combination of Bessel functions under the above assumptions, and with the help of the Feynman choice for a dimensionless gauge parameter. Interestingly, ghost modes cancel exactly the contribution to the Casimir energy resulting from transverse and temporal modes of the potential, jointly with the decoupled normal mode of the potential. Moreover, normal and longitudinal components of the potential for the interior and the exterior problem give a result in complete agreement with the one first found by Boyer, who studied instead boundary conditions involving TE and TM modes of the electromagnetic field. The coupled eigenvalue equations for perturbative modes of the potential are also analyzed in the axial gauge, and for arbitrary values of the gauge parameter. The set of modes which contribute to the Casimir energy is then drastically changed, and comparison with the case of a flat boundary sheds some light on the key features of the Casimir energy in non-covariant gauges.Comment: 29 pages, Revtex, revised version. In this last version, a new section has been added, devoted to the zero-point energy of a conducting spherical shell in the axial gauge. A second appendix has also been include

Extracting chemical energy by growing disorder: Efficiency at maximum power

We consider the efficiency of chemical energy extraction from the environment by the growth of a copolymer made of two constituent units in the entropy-driven regime. We show that the thermodynamic nonlinearity associated with the information processing aspect is responsible for a branching of the system properties such as power, speed of growth, entropy production, and efficiency, with varying affinity. The standard linear thermodynamics argument which predicts an efficiency of 1/2 at maximum power is inappropriate because the regime of maximum power is located either outside of the linear regime or on a separate bifurcated branch, and because the usual thermodynamic force is not the natural variable for this optimization.Comment: 6 pages, 4 figure

Non-Local Boundary Conditions in Euclidean Quantum Gravity

Non-local boundary conditions for Euclidean quantum gravity are proposed, consisting of an integro-differential boundary operator acting on metric perturbations. In this case, the operator P on metric perturbations is of Laplace type, subject to non-local boundary conditions; by contrast, its adjoint is the sum of a Laplacian and of a singular Green operator, subject to local boundary conditions. Self-adjointness of the boundary-value problem is correctly formulated by looking at Dirichlet-type and Neumann-type realizations of the operator P, following recent results in the literature. The set of non-local boundary conditions for perturbative modes of the gravitational field is written in general form on the Euclidean four-ball. For a particular choice of the non-local boundary operator, explicit formulae for the boundary-value problem are obtained in terms of a finite number of unknown functions, but subject to some consistency conditions. Among the related issues, the problem arises of whether non-local symmetries exist in Euclidean quantum gravity.Comment: 23 pages, plain Tex. The revised version is much longer, and new original calculations are presented in section

Diffeomorphism invariant eigenvalue problem for metric perturbations in a bounded region

We suggest a method of construction of general diffeomorphism invariant boundary conditions for metric fluctuations. The case of $d+1$ dimensional Euclidean disk is studied in detail. The eigenvalue problem for the Laplace operator on metric perturbations is reduced to that on $d$-dimensional vector, tensor and scalar fields. Explicit form of the eigenfunctions of the Laplace operator is derived. We also study restrictions on boundary conditions which are imposed by hermiticity of the Laplace operator.Comment: LATeX file, no figures, no special macro

One-Loop Effective Action for Euclidean Maxwell Theory on Manifolds with Boundary

This paper studies the one-loop effective action for Euclidean Maxwell theory about flat four-space bounded by one three-sphere, or two concentric three-spheres. The analysis relies on Faddeev-Popov formalism and $\zeta$-function regularization, and the Lorentz gauge-averaging term is used with magnetic boundary conditions. The contributions of transverse, longitudinal and normal modes of the electromagnetic potential, jointly with ghost modes, are derived in detail. The most difficult part of the analysis consists in the eigenvalue condition given by the determinant of a $2 \times 2$ or $4 \times 4$ matrix for longitudinal and normal modes. It is shown that the former splits into a sum of Dirichlet and Robin contributions, plus a simpler term. This is the quantum cosmological case. In the latter case, however, when magnetic boundary conditions are imposed on two bounding three-spheres, the determinant is more involved. Nevertheless, it is evaluated explicitly as well. The whole analysis provides the building block for studying the one-loop effective action in covariant gauges, on manifolds with boundary. The final result differs from the value obtained when only transverse modes are quantized, or when noncovariant gauges are used.Comment: 25 pages, Revte