Senior Recital, Colleen Trempe, trombone

The presentation of this senior recital will fulfill in part the requirements for a Bachelor of Music degree in Jazz Studies. Colleen Trempe studies trombone with Antonio J. Garcia

The Gray Needle: Large Grains in the HD 15115 Debris Disk from LBT/PISCES/Ks and LBTI/LMIRcam/L' Adaptive Optics Imaging

We present diffraction-limited \ks band and \lprime adaptive optics images of the edge-on debris disk around the nearby F2 star HD 15115, obtained with a single 8.4 m primary mirror at the Large Binocular Telescope. At \ks band the disk is detected at signal-to-noise per resolution element (SNRE) \about 3-8 from \about 1-2\fasec 5 (45-113 AU) on the western side, and from \about 1.2-2\fasec 1 (63-90 AU) on the east. At \lprime the disk is detected at SNRE \about 2.5 from \about 1-1\fasec 45 (45-90 AU) on both sides, implying more symmetric disk structure at 3.8 \microns . At both wavelengths the disk has a bow-like shape and is offset from the star to the north by a few AU. A surface brightness asymmetry exists between the two sides of the disk at \ks band, but not at \lprime . The surface brightness at \ks band declines inside 1\asec (\about 45 AU), which may be indicative of a gap in the disk near 1\asec. The \ks - \lprime disk color, after removal of the stellar color, is mostly grey for both sides of the disk. This suggests that scattered light is coming from large dust grains, with 3-10 \microns -sized grains on the east side and 1-10 \microns dust grains on the west. This may suggest that the west side is composed of smaller dust grains than the east side, which would support the interpretation that the disk is being dynamically affected by interactions with the local interstellar medium.Comment: Apj-accepted March 27 2012; minor correction

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Age-related neurodegenerative disease has been mechanistically linked with mitochondrial dysfunction via damage from reactive oxygen species produced within the cell. We determined whether increased mitochondrial oxidative stress could modulate or regulate two of the key neurochemical hallmarks of Alzheimer's disease (AD): tau phosphorylation, and ß-amyloid deposition. Mice lacking superoxide dismutase 2 (SOD2) die within the first week of life, and develop a complex heterogeneous phenotype arising from mitochondrial dysfunction and oxidative stress. Treatment of these mice with catalytic antioxidants increases their lifespan and rescues the peripheral phenotypes, while uncovering central nervous system pathology. We examined sod2 null mice differentially treated with high and low doses of a catalytic antioxidant and observed striking elevations in the levels of tau phosphorylation (at Ser-396 and other phospho-epitopes of tau) in the low-dose antioxidant treated mice at AD-associated residues. This hyperphosphorylation of tau was prevented with an increased dose of the antioxidant, previously reported to be sufficient to prevent neuropathology. We then genetically combined a well-characterized mouse model of AD (Tg2576) with heterozygous sod2 knockout mice to study the interactions between mitochondrial oxidative stress and cerebral Aß load. We found that mitochondrial SOD2 deficiency exacerbates amyloid burden and significantly reduces metal levels in the brain, while increasing levels of Ser-396 phosphorylated tau. These findings mechanistically link mitochondrial oxidative stress with the pathological features of AD

ZIKA VIRUS DISEASE AMONG TRAVELERS RETURNING FROM THE AMERICAS BETWEEN JANUARY 2013 AND FEBRUARY 2016: A GEOSENTINEL ANALYSIS

65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta, GA, NOV 13-16, 2016International audienc

ZIKA VIRUS DISEASE AMONG TRAVELERS RETURNING FROM THE AMERICAS BETWEEN JANUARY 2013 AND FEBRUARY 2016: A GEOSENTINEL ANALYSIS

65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta, GA, NOV 13-16, 2016International audienc

SHARK-NIR, first results of the commissioning at LBT

SHARK-NIR is an instrument which provides direct imaging, both coronagraphic and non-coronagraphic and with the possibility to perform dual-band imaging and low-resolution spectroscopy in Y, J and H bands, with the main scientific goal of detecting exoplanets, and characterizing already known planets, young stellar systems, jets and disks. SHARK-NIR takes advantage of the excellent performance of the Large Binocular Telescope AO systems, the wavefront sensors of which have been recently upgraded to SOUL. The latter is delivering a very good performance also at faint magnitude, opening to science otherwise difficult to be achieved, as for example AGN and QSO morphological studies. To fully exploit the just mentioned science cases, binocular observations will be performed using SHARK-NIR in combination with SHARK-VIS (operating in B, V, R and I bands) and LMIRCam of LBTI (operating from K to M bands), in a way to exploit coronagraphic observations in three different wavelengths. The instrument has passed the preliminary acceptance Europe in March 2022, being shipped immediately after at LBT, and re-integrated, installed and characterized daytime in three pre-commissioning run at the telescoped. SHARK-NIR had a very successful first light in January this year, and we will report of the results obtained in the three commissioning runs performed in the first half of 2023

SHARK-NIR, first results of the commissioning at LBT

International audienceSHARK-NIR, first results of the commissioning at LB