Mires: travail de bachelor : diplôme 2016

Dans le monde de la recherche scientifique et médicale, il est aujourd’hui courant d’utiliser des rats et des souris pour mener diverses expériences. Pour recueillir différentes données sur ces animaux, ceux‐ci sont reliés en permanence à des câbles, ce qui diminue grandement le confort de l’animal, ainsi que celui du personnel lorsqu’ils doivent déplacer les sujets. Ainsi, un premier projet a été réalisé. Celui‐ci se penchait sur la réalisation d’une carte miniature ayant pour but d’être implantée dans les rats. Cette carte devait permettre l’envoi de données par Bluetooth® Low Energy et est alimentée par de petites batteries. Néanmoins, l’utilisation de batteries présente des désavantages majeurs : Le débit est grandement limité et la durée de vie totale du système est réduite. De ce constat est né le projet actuel. Celui‐ci a pour but de supprimer totalement le système d’alimentation par batterie et de le remplacer par une alimentation sans fil

Diversidad cultural y educación : una propuesta de transformación curricular en la institución educativa Marí­a Inmaculada en el Carmen De Bolí­var /

En el presente artí­culo se propone documentar la relación entre escuela y comunidad, en el marco de la diversidad cultural para la construcción de un Proyecto Educativo Institucional (PEI), en consonancia con un currí­culo pertinente para la institución educativa Marí­a Inmaculada del Carmen de Bolí­var. Para ello se plantea como objetivo de investigación la construcción de una propuesta de transformación curricular fundamentada en el concepto de diversidad cultural para la IE, que dé cuenta de las caracterí­sticas culturales manifiestas en el municipio de El Carmen de Bolí­var. En su metodologí­a, el artí­culo se pensó como un estudio cualitativo en el que se recurrió a entrevistas y observación directa para delinear los requerimientos necesarios para la construcción del PEI. De esta manera, se concibe la escuela como la representación del lugar en el cual los maestros con estudiantes, gestores culturales y directivos tienen algo que enseñar, porque aportan saberes cercanos y comunes a la comunidad; no tanto como portadores de conocimiento cientí­fico pues la escuela es un lugar en que se construye conocimiento escolar.Seminario Cultura y Desarrollo Sostenible en el Gran Caribe.Incluye referencias bibliográficas

Imiquimod induces ER stress and Ca2+ influx independently of TLR7 and TLR8

AbstractEndoplasmic reticulum (ER) stress is a physiological response to protein overload or misfolded proteins in the ER. Certain anti-cancer drugs, e.g. bortezomib and nelfinavir, induce ER stress implying that this could be a successful therapeutic strategy against several forms of cancer. To find novel ER-stress inducers we screened a panel of natural and synthetic Toll-like receptor (TLR) agonists against human keratinocytes and identified the anti-cancer drug imiquimod (IMQ) as a potent inducer of ER stress. Other TLR7 and TLR8 agonists, including resiquimod and gardiquimod, did not induce ER stress, demonstrating that IMQ induces ER stress independently of TLR7 and TLR8. We further confirmed this by showing that IMQ could still induce ER stress in mouse Tlr7−/− cells. IMQ also induced a rapid and transient influx of extracellular Ca2+ together with the release of Ca2+ from internal stores. Depletion of Ca2+ from the ER is a known cause of ER stress suggesting that IMQ induces ER stress via depletion of ER Ca2+. The ER-stress inducing property of IMQ is possibly of importance for its efficacy in treating basal cell carcinoma, in situ melanoma, and squamous cell carcinoma. Our data could potentially be harnessed for rational design of even more potent ER-stress inducers and new anti-cancer drugs

Defending Organizational Assets: A Preliminary Framework for Cybersecurity Success and Knowledge Alignment

Cybersecurity governance is a critical issue for organizations engaging in a constant struggle for success in protecting their data, brand, customers, and other assets from malignant actors. The nature of what constitutes successful cybersecurity practices and governance, however, is not yet clear, in part because an appropriate measure for cybersecurity success is not likely to be singular or simple. In this qualitative study, we explore perspectives of cybersecurity success through interviews representing various technical and non-technical roles across a variety of organizations, then provide a preliminary framework for understanding dimensions of cybersecurity success (financial, information integrity, operational, and reputational) as well as their associated knowledge domains and alignments

Ultimate Homophones

Abstract unavailable

The Main and Interaction Effects of Process Rigor, Process Standardization, and Process Agility on System Performance in Distributed IS Development: An Ambidexterity Perspective

Information systems (IS) development is becoming increasingly more geographically dispersed. Although process rigor, process standardization, and process agility are generally believed to have a positive impact on software development, it has not been well understood how these process capabilities affect distributed IS development. More important, no prior research has investigated their interaction effects. Drawing upon prior literature on organizational ambidexterity, we hypothesize: positive main effects of process rigor, process standardization, and process agility; a positive interaction effect of process rigor and process agility; and a positive interaction effect of process standardization and process agility on system performance in distributed development. Our data analysis results support a positive main effect of the three process capabilities. We find a positive interaction effect of process rigor and process agility suggesting positive process ambidexterity of rigor and agility. Surprisingly, we find a negative interaction effect of process agility and process standardization suggesting negative process ambidexterity of agility and standardizatio

Big Data and Analytics: Issues and Challenges for the Past and Next Ten Years

In this paper we continue the minitrack series of papers recognizing issues and challenges identified in the field of Big Data and Analytics, from the past and going forward. As this field has evolved, it has begun to encompass other analytical regimes, notably AI/ML systems. In this paper we focus on two areas: continuing main issues for which some progress has been made and new and emerging issues which we believe form the basis for near-term and future research in Big Data and Analytics. The Bottom Line: Big Data and Analytics is healthy, is growing in scope and evolving in capability, and is finding applicability in more problem domains than ever before

Big Data Redux: New Issues and Challenges Moving Forward

As of the time of this writing, our HICSS-46 proceedings article has enjoyed over 520 Google Scholar citations. We have published several HICSS proceedings, articles and a book on this subject, but none of them have generated this level of interest. In an effort to update our findings six years later, and to understand what is driving this interest, we have downloaded the first 500 citations to our article and the corresponding citing article, when available. We conducted an in-depth literature review of the articles published in top journals and leading conference proceedings, along with articles with a high volume of citations. This paper provides a brief summary of the key concepts in our original paper and reports on the key aspects of interest we found in our review, and also updates our original paper with new directions for future practice and research in big data and analytics

Toxicidad y esterilidad de algunas combinaciones de afolato y tepa sobre Musca doméstica Linneo.

Maestría en CienciasMaestrí