Voyager radio occultation investigations at Saturn

Voyager will use dual-frequency 3.5 and 13 cm wavelength radio occultation techniques to study the atmospheres and ionospheres of Saturn and Titan, and the rings of Saturn. At Titan radio occultation is predicted to probe the atmosphere to the surface. The existence of a surface could be confirmed by detection of an obliquely scattered echo. At Saturn the two Voyager encounters will provide occultation measurements of temperate and equatorial regions of the atmosphere and ionosphere, and of the rings. The atmosphere will also be probed in polar regions during the deepest portions of the occultation. Both frequency and intensity data will be collected and jointly analyzed to study temperature-pressure profiles, and to derive information on atmospheric shape, turbulence, and weather. For the rings, Voyager will provide measurements of the complex (amplitude and phase) radio extinction and angular scattering functions of the ring particles as a function of wavelength, polarization, and radial distance from Saturn

The two-frequency, bistatic radar-occultation method for the study of planetary ionospheres scientific reports no. 1 and no. 7

Method for study of planetary ionospheres based on radio wave propagation between earth and spacecraf

Feasibility model of a high reliability five-year tape transport, volume 2

Analysis of the design features of the modularized tape transport renders a life expectancy in excess of five years. Tests performed on the tape transport were directed toward determining its performance capability. These tests revealed that the tape jitter and skew are in the range achieved by high quality digital tape transports. Guidance of the tape in the lateral sense by the use of the two hybrid crowned rollers proved to be excellent. Tracking was maintained within less than one thousandth inch (approximately 2 micrometers). The guidance capability demonstrated makes possible the achievement of the performance objective of 7.2 x 10 to the 9th power storage capability employing 1500 ft. of one inch wide tape with a packing density of 5,000 bits per inch per track on 80 tracks. Also, the machine showed excellent characteristics operating over a wide range of tape speeds. The basic design concept lends itself to growth and adaptation to a wide range of recorder requirements

Feasibility model of a high reliability five-year tape transport, Volume 1

The development, performance, and test results for the spaceborne magnetic tape transport are discussed. An analytical model of the tape transport was used to optimize its conceptual design. Each of the subsystems was subjected to reliability analyses which included structural integrity, maintenance of system performance within acceptable bounds, and avoidance of fatigue failure. These subsystems were also compared with each other in order to evaluate reliability characteristics. The transport uses no mechanical couplings. Four drive motors, one for each reel and one for each of two capstans, are used in a differential mode. There are two hybrid, spherical, cone tapered-crown rollers for tape guidance. Storage of the magnetic tape is provided by a reel assembly which includes the reel, a reel support structure and bearings, dust seals, and a dc drive motor. A summary of transport test results on tape guidance, flutter, and skew is provided

Preliminary results of the Mariner IV radio occultation measurements of the upper atmosphere of Mars

Mariner IV radio occultation measurements of Mars upper atmospher

Preliminary results of the Mariner IV OCCULATION measurement of the atmosphere of Mars

Mariner IV radio occultation measurement of Mars atmospher

Moral wrongs, disadvantages, and disability: a critique of critical disability studies

Critical disability studies (CDS) has emerged as an approach to the study of disability over the last decade or so and has sought to present a challenge to the predominantly materialist line found in the more conventional disability studies approaches. In much the same way that the original development of the social model resulted in a necessary correction to the overly individualized accounts of disability that prevailed in much of the interpretive accounts which then dominated medical sociology, so too has CDS challenged the materialist line of disability studies. In this paper we review the ideas behind this development and analyse and critique some of its key ideas. The paper starts with a brief overview of the main theorists and approaches contained within CDS and then moves on to normative issues; namely, to the ethical and political applicability of CDS

Computer Simulation of the Effect of Cargo Shifting on Articulated Vehicles Performing Braking and Cornering Maneuvers, Volume 1, Executive Summary

P.0. 6-4-0118The effects of sloshing liquid cargo on the limit performance of articulated trucks have been investigated. The limit performances of four vehicle configurations in cornering and braking maneuvers were simulated using an augmented version of the vehicle simulation program, TDVS (Three Dimensional Vehicle Simulation). The vehicle configurations consisted of tractor with unbaffled, baffled, and compartmentalized tank trailers and a baseline van. Simulated maneuvers were lane change, cornering, straight-line braking, and braking-in-a-turn. Both vehicle configurations and maneuvers were modeled to correspond with the full-scale experiments, "Effect of Cargo Shifting on Vehicle Handling", (DOT-FH-11-9195), conducted by Dynamic Sciences, Inc. This report covers the validation of the augmented TDVS program, and the development and implementation of a methodology for conducting limit of performance simulations. Results are discussed and summarized in the context of the simulation program and in light of experimental data. Finally, recommendations are presented for vehicle dynamics analysis methodology and for future studies

Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer

Objective: PDAC patients who undergo surgical resection and receive effective chemotherapy have the best chance of long-term survival. Unfortunately, we lack predictive biomarkers to guide optimal systemic treatment. Ex-vivo generation of PDO for pharmacotyping may serve as predictive biomarkers in PDAC. The goal of the current study was to demonstrate the clinical feasibility of a PDO-guided precision medicine framework of care. Methods: PDO cultures were established from surgical specimens and endoscopic biopsies, expanded in Matrigel, and used for high-throughput drug testing (pharmacotyping). Efficacy of standard-of-care chemotherapeutics was assessed by measuring cell viability after drug exposure. Results: A framework for rapid pharmacotyping of PDOs was established across a multi-institutional consortium of academic medical centers. Specimens obtained remotely and shipped to a central biorepository maintain viability and allowed generation of PDOs with 77% success. Early cultures maintain the clonal heterogeneity seen in PDAC with similar phenotypes (cystic-solid). Late cultures exhibit a dominant clone with a pharmacotyping profile similar to early passages. The biomass required for accurate pharmacotyping can be minimized by leveraging a high-throughput technology. Twenty-nine cultures were pharmacotyped to derive a population distribution of chemotherapeutic sensitivity at our center. Pharmacotyping rapidly-expanded PDOs was completed in a median of 48 (range 18-102) days. Conclusions: Rapid development of PDOs from patients undergoing surgery for PDAC is eminently feasible within the perioperative recovery period, enabling the potential for pharmacotyping to guide postoperative adjuvant chemotherapeutic selection. Studies validating PDOs as a promising predictive biomarker are ongoing.Peer reviewe

Microsatellite instability in thyroid tumours and tumour-like lesions

Fifty-one thyroid tumours and tumour-like lesions were analysed for instability at ten dinucleotide microsatellite loci and at two coding mononucleotide repeats within the transforming growth factor β (TGF-β) type II receptor (TβRII) and insulin-like growth factor II (IGF-II) receptor (IGFIIR) genes respectively. Microsatellite instability (MI) was detected in 11 out of 51 cases (21.5%), including six (11.7%) with MI at one or two loci and five (9.8%) with Ml at three or more loci (RER+ phenotype). No mutations in the TβRII and IGFIIR repeats were observed. The overall frequency of MI did not significantly vary in relation to age, gender, benign versus malignant status and tumour size. However, widespread MI was significantly more frequent in follicular adenomas and carcinomas than in papillary and Hürthle cell tumours: three out of nine tumours of follicular type (33.3%) resulted in replication error positive (RER+), versus 1 out of 29 papillary carcinomas (3.4%, P = 0.01), and zero out of eight Hürthle cell neoplasms. Regional lymph node metastases were present in five MI-negative primary cancers and resulted in MI-positive in two cases. © 1999 Cancer Research Campaig