Genetic analysis of haematological and plasma biochemical parameters in the Spanish purebred horse exercised on a treadmill

The novel aim of this study was to describe the reference values of different haematological and biochemical parameters in the Spanish purebred horse (Andalusian, SPB) in each of the stages of a programmed exercise on a treadmill system, and to establish heritability and genetic correlations for these haematological and biochemical parameters. For this, 94 young SPB male horses (4.22 6 2.27 years old) were used. An increasing intensity exercise test at 4, 5, 6 and 7 m/s was carried out on a treadmill (6% inclination). Total red blood cells, total white blood cells, neutrophils and lymphocytes counts; haematocrit, haemoglobin, lactate, uric acid, creatinine and total plasma proteins concentrations and aspartate transaminase, lactate dehydrogenase, creatine-quinase activities were determined. To conclude: (i) the reference values for each parameter were determined for each of the exercise test stages (ii) all the parameters analysed manifested a medium-high heritability and a high repeatability. These results will, in the near future, determine the measuring guidelines for improving the SPB horse’s athletic ability on an objective treadmill system and for selecting these animals in response to those parameters.FEDER 1FD97-089

Vocabulario bilingüe de Masonería

Trabajo sistemático de terminología sobre la masonería

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

¿Es la elaboración de un periódico una herramienta válida para trabajar competencias básicas de la profesión elegida?

En el curso 2010-11 se propuso a los alumnos una actividad cuyos resultados fueron publicados bajo el título “Designing an interactive activity to integrate animal physiology in the context of different disciplines” (Escribano et al., 2011). Este curso 16/17 hemos decidido repetirla matizando diversos aspectos. La propuesta consiste en la realización de un periódico con una distribución concreta en secciones y un tema único las “Adaptaciones funcionales al medio”. Dicho título se contextualiza en la asignatura optativa cuatrimestral del mismo nombre que se imparte en 4º de Biología, aunque creemos que el diseño de la actividad pudiera ser extrapolado a otras disciplinas y grados. La pretensión de este trabajo es obligar al alumnado a escribir con terminología técnica, buscar bibliografía concreta en otro idioma, trabajar en equipo organizándose primero en grupos pequeños para integrarse posteriormente en un macrogrupo y por último defender el trabajo realizado ante sus compañero

Equipos docentes y nuevas identidades académicas : en educación superior

Resumen basado en el de la publicaciónLa noción de equipos docentes en Educación Superior define una práctica de coordinación docente, bien para el logro de determinados propósitos transversales, bien en un sentido mucho más estricto, en el despliegue coordinado de una Titulación. Se aborda la pregunta de por qué y sobre qué ha de coordinarse el profesorado universitario, como reto fundamental a la cultura organizativa docente, basada en el ejercicio individual del profesorado y en la fragmentación de tareas, de responsabilidades y del conocimiento. Los cambios apuntados en las diversas contribuciones obedecen a las transformaciones que se están dando en la universidad española como consecuencia de nuevas demandas socio-formativas, las cuales generan nuevas necesidades, funciones y estructuras. Ello da lugar a nuevas identidades académicas. Lo anterior, nos sitúa en un contexto interpretativo de calado más amplio, el de la reconstrucción de las identidades académicas en relación a las funciones ejercidas dentro de ella.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Equipos docentes y nuevas identidades académicas : en educación superior

Resumen basado en el de la publicaciónLa noción de equipos docentes en Educación Superior define una práctica de coordinación docente, bien para el logro de determinados propósitos transversales, bien en un sentido mucho más estricto, en el despliegue coordinado de una Titulación. Se aborda la pregunta de por qué y sobre qué ha de coordinarse el profesorado universitario, como reto fundamental a la cultura organizativa docente, basada en el ejercicio individual del profesorado y en la fragmentación de tareas, de responsabilidades y del conocimiento. Los cambios apuntados en las diversas contribuciones obedecen a las transformaciones que se están dando en la universidad española como consecuencia de nuevas demandas socio-formativas, las cuales generan nuevas necesidades, funciones y estructuras. Ello da lugar a nuevas identidades académicas. Lo anterior, nos sitúa en un contexto interpretativo de calado más amplio, el de la reconstrucción de las identidades académicas en relación a las funciones ejercidas dentro de ella.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study.

Journal Article;BACKGROUND The impact of such recommendations after their implementation of guidelines has not usually been evaluated. Herein, we assessed the impact and compliance with the Spanish Oncology Genitourinary Group (SOGUG) Guidelines for toxicity management of targeted therapies in metastatic renal cell carcinoma (mRCC) in daily clinical practice. METHODS Data on 407 mRCC patients who initiated first-line targeted therapy during the year before and the year after publication and implementation of the SOGUG guideline program were available from 34 Spanish Hospitals. Adherence to SOGUG Guidelines was assessed in every cycle. RESULTS Adverse event (AE) management was consistent with the Guidelines as a whole for 28.7 % out of 966 post-implementation cycles compared with 23.1 % out of 892 pre-implementation cycles (p = 0.006). Analysis of adherence by AE in non-compliant cycles showed significant changes in appropriate management of hypertension (33 % pre-implementation vs. 44.5 % post-implementation cycles; p < 0.0001), diarrhea (74.0 % vs. 80.5 %; p = 0.011) and dyslipemia (25.0 % vs. 44.6 %; p < 0.001). CONCLUSIONS Slight but significant improvements in AE management were detected following the implementation of SOGUG recommendations. However, room for improvement in the management of AEs due to targeted agents still remains and could be the focus for further programs in this direction.This study was funded by Pfizer, S.L.U. Medical writing assistance was provided by Esther Tapia, PhD and was founded by Pfizer.Ye

Role of age and comorbidities in mortality of patients with infective endocarditis.

The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327  There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th