Wind powered water pump

Diseñar una pequeña y simple turbina eólica para bombear agua en un país en vías de desarrollo. Tiene que ser transportable y capaz de tomar agua de un pozo de 10 metros de profundidad hasta un tanque de 2 metros de altura (unos 12 metros en total)

An Efficient Platform for the Automatic Extraction of Patterns in Native Code

Different software tools, such as decompilers, code quality analyzers, recognizers of packed executable files, authorship analyzers, and malware detectors, search for patterns in binary code. The use of machine learning algorithms, trained with programs taken from the huge number of applications in the existing open source code repositories, allows finding patterns not detected with the manual approach. To this end, we have created a versatile platform for the automatic extraction of patterns from native code, capable of processing big binary files. Its implementation has been parallelized, providing important runtime performance benefits for multicore architectures. Compared to the single-processor execution, the average performance improvement obtained with the best configuration is 3.5 factors over the maximum theoretical gain of 4 factors

SGLT2 inhibitors and the cardiorenal continuum: a paradigm shift in the treatment of patients with T2D

Type 2 diabetes mellitus (T2D) represents a sig- nificant public health problem, with a dramat- ically increasing prevalence. T2D is considered a progressive disease that develops macro- and microvascular complications such as cardiovas- cular disease (CVD), heart failure (HF), and chronic kidney disease (CKD), which are closely interconnected and constitute the main causes of morbidity and mortality in these patients. Over time, finding new pharmacological approaches to protect against these cardiorenal events (the ‘‘cardiorenal continuum’’) has become the fundamental objective of research aimed at these patients

El protocolo en las Reales Academias. El caso de la Real Academia de Córdoba

Royal Academies are cultural institutions that, in Spain, were born during the eighteenth Century under the protection of the Crown.In the first part of the work a deep bibliographical revision is made on the origin, evolution and meaning of the Royal Academies. Later the concepts of protocol and ceremonial are studied.Although the ceremonial in the Royal Academies is well documented, the study of the protocol in these Corporations is pending task.The second part of the article presents the author's study of the regulations concerning the Royal Academies and the Protocol, at national level and in Andalusia, in a specific way, which has served as a basis for the preparation of the recently approved Regulations of Protocol in the Royal Academy of Cordoba, Sciences, Fine Arts and Noble Arts.Las Reales Academias son instituciones de tipo cultural que, en España, nacen durante el siglo XVIII al amparo de la Ilustración y de la Corona.En la primera parte del trabajo se realiza una profunda revisión bibliográfica sobre el origen, evolución y significado de las Reales Academias, para abordar posteriormente los conceptos de protocolo y ceremonial.Si bien el ceremonial en las Reales Academias está bastante documentado, el estudio del protocolo en estas Corporaciones es tarea pendiente.En la segunda parte del artículo se presenta el estudio realizado por el autor sobre la normativa referente a las Reales Academias y al Protocolo, en el ámbito nacional y en el andaluz, de manera específica, que ha servido de base para la elaboración del recientemente aprobado Reglamento de Protocolo en la Real Academia de Córdoba, de Ciencias, Bellas Letras y Nobles Artes, que se presenta como anexo._______________________Royal Academies are cultural institutions that, in Spain, were born during the eighteenth Century under the protection of the Crown.In the first part of the work a deep bibliographical revision is made on the origin, evolution and meaning of the Royal Academies. Later the concepts of protocol and ceremonial are studied.Although the ceremonial in the Royal Academies is well documented, the study of the protocol in these Corporations is pending task.The second part of the article presents the author's study of the regulations concerning the Royal Academies and the Protocol, at national level and in Andalusia, in a specific way, which has served as a basis for the preparation of the recently approved Regulations of Protocol in the Royal Academy of Cordoba, Sciences, Fine Arts and Noble Arts

Nuevas estrategias terapéuticas en diabetes mellitus tipo 1

El principal determinante del riesgo de complicaciones derivadas de la diabetes mellitus tipo 1 se debe a los altos niveles de glucosa en sangre mantenidos durante largo tiempo. Para conseguir un beneficio terapéutico en pacientes con diabetes mellitus es necesario desarrollar tratamientos que permitan de manera segura, efectiva y estable mantener la normoglucemia. Lamentablemente, el tratamiento de la diabetes mellitus tipo 1 mediante el aporte exógeno de insulina no es capaz de conseguir niveles estables de glucosa en sangre, de manera que con frecuencia se producen casos de severa hipoglucemia o hiperglucemia. Hasta la fecha la única solución para reestablecer de manera permanente la normoglucemia se consigue mediante el trasplante de páncreas o de islotes pancreáticos. Sin embargo, a medida que se incrementa el número de centros especializados en el trasplante de islotes, mayor es la necesidad de islotes para su trasplante. Así pues, el estudio de nuevas fuentes de células productoras de insulina así como de nuevos tratamientos que permitan preservar o incluso aumentar la masa de células beta en los pacientes con diabetes mellitus representa un objetivo de primera necesidad en este campo. En este sentido, en la última década ha habido un avance significativo en el campo de la biología de las células madre. Sin embargo, la identificación de células apropiadas para la generación de nuevas células beta, además del desarrollo de técnicas para la caracterización de estas células, así como de ensayos y modelos animales apropiados para probar su capacidad de diferenciación tanto in vitro como in vivo son de vital importancia para la puesta en marcha de nuevas estrategias terapéuticas basadas en la aplicación de las células madre para el tratamiento de la diabetes mellitus tipo 1

Methodology to Study Demagnetization Risk in Permanent Magnet Machines by Finite Element Method

Nowadays the majority of applications are demanding more and more compact, cost effective and robust solutions for their electric drives. In this context permanent magnet synchronous machines are considered as a good candidate due to their high torque density. This torque density is obtained thanks to high power rare earth magnets with both high remanence and high coercive force. However, the magnets cost has a relevant impact in the final cost of the electrical machine and the uncertainty shown by the rare earth market in the last years has originated high variations in the price of them. Due to that, it is essential to reduce this impact in order to accomplish cost effective drive solutions. Some key points to face this problem are the reduction of the magnets volume or the using of magnets with worse thermal properties (magnets with few dysprosium and with low coercive force). In both cases special attention must be paid on the demagnetization risk of the magnets. To carry out that analysis, in this article a finite element method simulation analysis process for demagnetization of permanent magnets is presented. The developed method has been validated experimentally in a test bench. Good agreement is shown between simulations and experimental results

La utilización de la bandera de España por las fuerzas y cuerpos de seguridad del Estado

The flags are no longer tactical, but as a symbol of the nation, they represent the higher values expressed in the Spanish Constitution of 1978.The Army has kept flags as part of the traditions, and provide great brilliance to the military acts. Instead, in Spanish literature there are few studies about the flag in the State Security Forces.After a brief review of current legislation in Vexillology, this paper deals with the procedure for bestowal of the use the National Flag to different units of the National Security Forces, as well as their modalities, use and placement in official events, honours and protocol.Finally, we analyze the peculiarities of ceremonial in the Act of delivery of the flag, as a distinction that is given in recognition of the work they perform as guarantors of citizen freedoms and public safety, considering the different nature - military and civil- of both security Forces.Las banderas ya no tienen finalidad táctica, pero como símbolo de la nación, representan los valores superiores expresados en la Constitución de 1978.A diferencia de las Fuerzas Armadas, donde las banderas se mantienen como parte de las tradiciones, y aportan gran brillantez a los actos militares, en la literatura española existen pocos estudios relativos a la bandera en el ámbito de las fuerzas y cuerpos de seguridad del Estado.Tras un breve repaso a la normativa vigente en el ámbito de la Vexilología, este trabajo aborda el procedimiento para la concesión del derecho de uso de la enseña Nacional a distintas unidades de las fuerzas y cuerpos de seguridad de ámbito estatal, así como sus modalidades, uso y colocación en actos oficiales, honores y protocolo.Finalmente, se analizan las peculiaridades del ceremonial en el acto de entrega de la bandera, como distinción que se otorga en reconocimiento a la labor que desarrollan como garantes de las libertades públicas y de la seguridad ciudadana, considerando la distinta naturaleza -militar y civil- de ambos cuerpos de seguridad. _________________ The flags are no longer tactical, but as a symbol of the nation, they represent the higher values expressed in the Spanish Constitution of 1978.The Army has kept flags as part of the traditions, and provide great brilliance to the military acts. Instead, in Spanish literature there are few studies about the flag in the State Security Forces.After a brief review of current legislation in Vexillology, this paper deals with the procedure for bestowal of the use the National Flag to different units of the National Security Forces, as well as their modalities, use and placement in official events, honours and protocol.Finally, we analyze the peculiarities of ceremonial in the Act of delivery of the flag, as a distinction that is given in recognition of the work they perform as guarantors of citizen freedoms and public safety, considering the different nature - military and civil- of both security Forces

Ceremonial y protocolo en las cenas militares de gala en España

Eating and drinking are daily vital needs of all human beings. The solution of the problem has varied depending on time, places and social groups.                The banquet is a social and protocol act that is constituted as a means of communication and an end in itself. For example, from time immemorial we have images of banquets celebrating military victories.                The celebration of acts by military units has always been distinguished by being subject to rules, often unwritten, and to particular rules of the military establishment as a result of the military way of being, constituting a form of external expression of values, traditions, uses and customs.                This work deals with the singularities of the annual military dinners. After analyzing the historical evolution of gala dinners in Spain, the general aspects are collected from the civil point of view and the current regulations applicable in the military field. The work ends detailing and analyzing the organization, the protocol and the concrete ceremony of a military gala dinner today.Comer y beber son necesidades vitales cotidianas de todos los seres humanos. La solución del problema ha variado dependiendo del tiempo, los lugares y los grupos sociales. El banquete es un acto social y protocolario que se constituye como un medio de comunicación y un fin en sí mismo. Por ejemplo, desde tiempos inmemoriales tenemos imágenes de ban­quetes celebrando victorias militares. La celebración de actos por las unidades militares se ha distinguido siempre por estar sujeta a unas normas, muchas veces no escritas, y a reglas particulares del estamento castrense fruto del modo de ser militar, constituyendo una forma de expresión externa de los valores, tradiciones, usos y costumbres.                Este trabajo aborda las singularidades de las cenas anuales militares. Tras analizar la evolución histórica de las cenas de gala en España, se recogen los aspectos generales desde el punto de vista civil y la normativa vigente de aplicación en el ámbito militar. Finaliza el trabajo detallando y analizando la organización, el protocolo y el ceremonial concreto de una cena de gala militar en la actualidad

Association of Patient Profile with Glycemic Control and Hypoglycemia with Insulin Glargine 300 U/mL in Type 2 Diabetes: A Post Hoc Patient-Level Meta-Analysis

ABSTRACT Aims: To examine the association of baseline patient characteristics with study outcomes in people with type 2 diabetes receiving insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100), over a 6-month period. Methods: A post hoc patient-level metaanalysis using data from three multicenter, randomized, open-label, parallel-group, phase 3a studies of similar design, in people previously receiving either basal and prandial insulin, basal insulin ? oral antihyperglycemic drugs, or no prior insulin (EDITION 1, 2 and 3, respectively). The endpoints, glycated hemoglobin (HbA1c), hypoglycemia, body weight change, and insulin dose were investigated by subgroups: age (\65 and C 65 years), body mass index (BMI; \ 30 and C 30 kg/m2), age at onset (\40, 40–50, and [ 50 years), and diabetes duration (\ 10 and C 10 years). Results: Reduction in HbA1c was comparable between insulins, regardless of subgroup. The lower risk of C 1 nocturnal (00:00–05:59 h) confirmed (B 3.9 mmol/L [B 70 mg/dL]) or severe hypoglycemic event with Gla-300 versus Gla-100 was also unaffected by participant characteristics. While heterogeneity of treatment effect between diabetes duration subgroups was seen for the risk of C 1 confirmed (B 3.9 mmol/L [B 70 mg/dL]) or severe hypoglycemic event at any time (24 h), treatment effect consistently favored Gla-300; no evidence of heterogeneity was observed for the other subgroups. Annualized rates of confirmed (B 3.9 mmol/L [B 70 mg/dL]) or severe hypoglycemia and body weight change were not influenced by participant characteristics; a similar pattern was observed with insulin dose. Conclusions: Comparable glycemic control was observed with Gla-300 versus Gla-100, with less hypoglycemia, regardless of age, BMI, age at onset or diabetes duration. Funding: Sanofi. Plain Language Summary: Plain language summary available for this article. Keywords: Glycated Hemoglobin A; Hypoglycemia; Insulin Glargine; Type 2 Diabetes PLAIN LANGUAGE SUMMARY Treatments for patients with type 2 diabetes aim to reduce the levels of blood glucose and can include injections with insulin. However, care must be taken to prevent blood glucose levels falling too low (a state called hypoglycemia). Previous studies have shown that insulin glargine 300 units/mL (Gla-300) provides similar reductions in blood glucose levels as insulin glargine 100 units/mL (Gla-100) but is less likely to cause hypoglycemia. However, different patients may respond differently to treatments depending on their individual clinical and biological characteristics. The aim of this study was to evaluate how different profiles of patients with type 2 diabetes responded to Gla-300 and Gla-100 injections. Patients were grouped by different ages, weights, age at diabetes diagnosis, and number of years since diagnosis of diabetes. We found that Gla-300 and Gla-100 reduced glycated hemoglobin (HbA1c; a marker of blood glucose control over the previous 2–3 months) similarly, regardless of how patients were grouped. However, patients treated with Gla-300 were less likely to experience hypoglycemia than those treated with Gla-100, and this association was also true regardless of different patient characteristics. We therefore concluded that Gla-300 is an effective and safe treatment in patients with type 2 diabetes, regardless of their age, weight, age at diabetes diagnosis, and years since diagnosis