Un panegírico para el sultán Solimán: nueva aproximación al Sulaimānnāma como fuente histórica

En aquest article s’explora el potencial del Sulaimānnāma, una obra el nom de la qual és ben conegut, però que no s’ha estudiat exhaustivament o en profunditat, com a font històrica per a conèixer millor el regnat del sultà otomà Solimà (r. 1520-1566). El meu objectiu és deixar de banda el prejudici causat pel seu llenguatge literari sofisticat i per la designació general de l’obra com un panegíric i mostrar algunes de les formes en què l’obra de l’Arif podria ser d’utilitat per a la investigació de la història cultural i política. El Sulaimānnāma no és ni un simple panegíric ni una senzilla història del regnat del sultà. La presència de versions peculiars d’històries problemàtiques, com la de l’execució del príncep Mustafà, i la quantitat desproporcionada d’informació sobre el funcionament de l’Estat i els cerimonials suggereixen que va ser concebut com un document que el palau volia transmetre a les generacions futures com una memòria, així com un model per a l’emulació. Per aquesta raó, examinar aquesta font multifacètica pot ser particularment útil per a desxifrar els missatges que Solimà i els principals membres de la seva cort volien projectar i per a comprendre millor l’entorn cultural i polític que reflecteixen tant el seu text com les seves imatgesEn este artículo se explora el potencial del Sulaimānnāma —una obra cuyo nombre es bien conocido pero que no se ha estudiado exhaustivamente o enprofundidad— como una fuente histórica para conocer mejor el reinado delsultán otomano Solimán (r. 1520-1566). Mi objetivo es dejar a un lado el prejuiciocausado por su lenguaje literario sofisticado y por la designación general dela obra como un panegírico, y mostrar algunas de las formas en que la obra de‘Arif podría ser de utilidad para la investigación de la historia cultural y política.Sulaimānnāma no es ni un simple panegírico ni una sencilla historia del reinado del sultán. La presencia de versiones peculiares de historias problemáticas, como la de la ejecución del príncipe Mustafá, y la cantidad desproporcionada de información sobre el funcionamiento del Estado y los ceremoniales, sugieren que fue concebido como un documento que el palacio quería transmitir a sus generaciones futuras a modo de memoria, así como un modelo para la emulación. Por consiguiente, examinar esta fuente multifacética puede ser particularmente útil para descifrar los mensajes que Solimán y los principales miembros de su corte querían proyectar y para comprender mejor el entorno cultural y político que reflejan tanto su texto como sus imágenesIn this article I discuss the potential of the Sulaimānnāma, a work well known inname but not studied comprehensively or in depth, as an historical source to understand better the reign of Sultan Süleyman (r. 1520-1566). I aim to castaside the prejudice caused both by its sophisticated literary language and thegeneral designation of the work as a panegyric, and display some of the waysin which shehnām Sulaimānnāma is neither a mere panegyric nor a straight forward history of the sultan’s reign. Both the presence of particular versions of disputed stories, such as that of the execution of Prince Mustafa, and the disproportionate amount of information on the workings of the state and the ceremonial suggest that it was intended as a document that the palace wanted to pass on to future generations as a memorial as well as a model for emulation. Hence, studying this multifaceted source can help us decipher the messages that Sultan Süleyman and the leading members of his court wanted to project, and gain insight into the cultural and political environment that its text and images reflec

Un panegírico para el sultán Solimán: nueva aproximación al Sulaimānnāma como fuente histórica

En aquest article s’explora el potencial del Sulaimānnāma, una obra el nom de la qual és ben conegut, però que no s’ha estudiat exhaustivament o en profunditat, com a font històrica per a conèixer millor el regnat del sultà otomà Solimà (r. 1520-1566). El meu objectiu és deixar de banda el prejudici causat pel seu llenguatge literari sofisticat i per la designació general de l’obra com un panegíric i mostrar algunes de les formes en què l’obra de l’Arif podria ser d’utilitat per a la investigació de la història cultural i política. El Sulaimānnāma no és ni un simple panegíric ni una senzilla història del regnat del sultà. La presència de versions peculiars d’històries problemàtiques, com la de l’execució del príncep Mustafà, i la quantitat desproporcionada d’informació sobre el funcionament de l’Estat i els cerimonials suggereixen que va ser concebut com un document que el palau volia transmetre a les generacions futures com una memòria, així com un model per a l’emulació. Per aquesta raó, examinar aquesta font multifacètica pot ser particularment útil per a desxifrar els missatges que Solimà i els principals membres de la seva cort volien projectar i per a comprendre millor l’entorn cultural i polític que reflecteixen tant el seu text com les seves imatgesIn this article I discuss the potential of the Sulaimānnāma, a work well known inname but not studied comprehensively or in depth, as an historical source to understand better the reign of Sultan Süleyman (r. 1520-1566). I aim to castaside the prejudice caused both by its sophisticated literary language and thegeneral designation of the work as a panegyric, and display some of the waysin which shehnām Sulaimānnāma is neither a mere panegyric nor a straight forward history of the sultan’s reign. Both the presence of particular versions of disputed stories, such as that of the execution of Prince Mustafa, and the disproportionate amount of information on the workings of the state and the ceremonial suggest that it was intended as a document that the palace wanted to pass on to future generations as a memorial as well as a model for emulation. Hence, studying this multifaceted source can help us decipher the messages that Sultan Süleyman and the leading members of his court wanted to project, and gain insight into the cultural and political environment that its text and images reflectEn este artículo se explora el potencial del Sulaimānnāma —una obra cuyo nombre es bien conocido pero que no se ha estudiado exhaustivamente o en profundidad— como una fuente histórica para conocer mejor el reinado del sultán otomano Solimán (r. 1520-1566). Mi objetivo es dejar a un lado el prejuicio causado por su lenguaje literario sofisticado y por la designación general de la obra como un panegírico, y mostrar algunas de las formas en que la obra de ‘Arif podría ser de utilidad para la investigación de la historia cultural y política.Sulaimānnāma no es ni un simple panegírico ni una sencilla historia del reinado del sultán. La presencia de versiones peculiares de historias problemáticas, como la de la ejecución del príncipe Mustafá, y la cantidad desproporcionada de información sobre el funcionamiento del Estado y los ceremoniales, sugieren que fue concebido como un documento que el palacio quería transmitir a sus generaciones futuras a modo de memoria, así como un modelo para la emulación. Por consiguiente, examinar esta fuente multifacética puede ser particularmente útil para descifrar los mensajes que Solimán y los principales miembros de su corte querían proyectar y para comprender mejor el entorno cultural y político que reflejan tanto su texto como sus imágene

Comparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal cancer

Abstract Background The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been the standard of care in this setting as it improved overall survival (OS) compared to placebo. In real-world practice chemotherapy rechallenge is also a preferred option even though supporting evidence is not enough. We aim to compare the efficacy of regorafenib and 5-fluorouracil-based (5-FU) rechallenge treatment in the third line setting of mCRC. Methods In this retrospective multi-institutional trial, mCRC patients from 21 oncology centers who progressed after 2 lines of chemotherapy were analyzed. Patients who were treated with regorafenib or rechallenge therapy in the third-line setting were eligible. Rechallenge chemotherapy was identified as the re-use of the 5-FU based regimen which was administered in one of the previous treatment lines. OS, disease control rate (DCR), progression free survival (PFS) and toxicity were analyzed. Results Three hundred ninety-four mCRC patients were included in the study. 128 (32.5%) were in the rechallenge, and 266 (67.5%) were in the regorafenib group. Median PFS was 5.82 months in rechallenge and 4 months in regorafenib arms (hazard ratio:1.45,95% CI, p = 0.167). DCR was higher in the rechallenge group than regorafenib (77% vs 49.5%, respectively, p =  < 0.001). Median OS after the third-line treatment was 11.99 (95% CI, 9.49–14.49) and 8.08 months (95% CI, 6.88–9.29) for rechallenge and regorafenib groups, respectively (hazard ratio:1.51, 95% CI, p < 0.001). More adverse effects and discontinuation were seen with regorafenib treatment. Conclusion Our study revealed that higher disease control and OS rates were achieved with rechallenge treatment compared to regorafenib, especially in patients who achieved disease control in one of the first two lines of therapy

Childhood interstitial lung disease in Turkey: first data from the national registry

Abstract: The childhood interstitial lung diseases (chILD) Turkey registry (chILD-TR) was established in November 2021 to increase awareness of disease, and in collaboration with the centers to improve the diagnostic and treatment standards. Here, the first results of the chILD registry system were presented. In this prospective cohort study, data were collected using a data‐entry software system. The demographic characteristics, clinical, laboratory, radiologic findings, diagnoses, and treatment characteristics of the patients were evaluated. Clinical characteristics were compared between two main chILD groups ((A) diffuse parenchymal lung diseases (DPLD) disorders manifesting primarily in infancy [group1] and (B) DPLD disorders occurring at all ages [group 2]). There were 416 patients registered from 19 centers. Forty-six patients were excluded due to missing information. The median age of diagnosis of the patients was 6.05 (1.3–11.6) years. Across the study population (n = 370), 81 (21.8%) were in group 1, and 289 (78.1%) were in group 2. The median weight z-score was significantly lower in group 1 (− 2.0 [− 3.36 to − 0.81]) than in group 2 (− 0.80 [− 1.7 to 0.20]) (p < 0.001). When we compared the groups according to chest CT findings, ground-glass opacities were significantly more common in group 1, and nodular opacities, bronchiectasis, mosaic perfusion, and mediastinal lymphadenopathy were significantly more common in group 2. Out of the overall study population, 67.8% were undergoing some form of treatment. The use of oral steroids was significantly higher in group 2 than in group 1 (40.6% vs. 23.3%, respectively; p = 0.040). Conclusion: This study showed that national registry allowed to obtain information about the frequency, types, and treatment methods of chILD in Turkey and helped to see the difficulties in the diagnosis and management of these patients. What is Known: • Childhood interstitial lung diseases comprise many diverse entities which are challenging to diagnose and manage. What is New: • This study showed that national registry allowed to obtain information about the frequency, types and treatment methods of chILD in Turkey and helped to see the difficulties in the diagnosis and management of these patients. Also, our findings reveal that nutrition should be considered in all patients with chILD, especially in A-DPLD disorders manifesting primarily in infancy