117 research outputs found

    Building research capacity in low- and middle-income countries and pandemic preparedness: Lessons learned and future directions

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    Research capacity is a critical component of pandemic preparedness, as highlighted by the challenges faced during the Ebola outbreak in West Africa. Recent global initiatives, such as the Research & Development Task Force of the Global Health Security Agenda and the World Health Assembly\u27s resolution on strengthening clinical trials, emphasize the need for robust research capabilities. This Perspective discusses the experiences of leaders in infectious disease research and capacity building in low- and middle-income countries, focusing on Colombia, Jamaica, and Pakistan. These case studies underscore the importance of collaborative efforts, interdisciplinary training, and global partnerships in pandemic response. The experiences highlight the necessity for rapid pathogen identification, capacity for genomic sequencing, and proactive engagement with policymakers. Challenges faced, including the shortage of trained staff and reliance on imported reagents, emphasize the ongoing need for building research capacity

    Positive College Experiences Moderate the Association Between Resilience and Anxiety Symptoms among Underrepresented College Students

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    Generalized anxiety disorders are among the most prevalent mental health concerns for college students. Resilience, one’s ability to recover from adversity, is a critical component in reducing anxiety. The association between resilience and anxiety may be strengthened by positive college experiences of institutional support and experiential learning, particularly among underrepresented students. This study explored whether positive college experiences (Gallup “Big Six”) moderated the association between resilience (Brief Resilience Scale) and anxiety symptoms (Generalized Anxiety Disorder-7) among underrepresented college students (N = 430; 73.5% first year; 38.1% first generation) at a large public institution. Controlling for demographic variables, greater resilience was associated with lower anxiety (ÎČ = -.42, p \u3c .001). Positive college experiences were not directly associated with anxiety (ÎČ = -.04, p = .45); however, positive college experiences moderated the negative association of resilience and anxiety (ÎČ = -.14, p \u3c .01) such that the association between greater resilience and lower anxiety was stronger for students reporting more positive college experiences. The final model accounted for 21% of the variance in anxiety symptoms (F11,418 = 10.22, p \u3c .001). Findings support a beneficial role of positive college experiences on the association between resilience and anxiety

    Scoping review protocol: Structural racism, housing policy and post-victimization outcomes among female-identifying survivors of intimate partner and sexual violence

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    Objective: The aim of this scoping review is to investigate the role of structural racism in inequitable post-victimization outcomes in female-identifying Black, Indigenous, and People of Color (BIPOC women) survivors of intimate partner and sexual violence (IP/SV) in the context of housing policy. We will examine how structural racism has been defined and conceptualized as well as frameworks and methods used to study inequitable outcomes of housing policy among survivors of IP/SV. Introduction: Women often face housing instability as a result of IP/SV, and BIPOC women are especially vulnerable to discrimination based on gender and racialized group. Policies have been enacted to protect survivors from housing discrimination; however, policy does not equally or equitably serve BIPOC compared to white people. What is not known is the extent to which this injustice has been studied in the context of housing policies that create unjust and avoidable outcomes for female-identifying BIPOC survivors of IP/SV. Inclusion criteria: Studies that include female-identifying adults (ages 18+) who are survivors of IP/SV. Structural racism in the context of housing policies will be the focus; the relationship between housing policies and post-victimization outcomes will be examined. Methods: The search was conducted in March 2023 using CINAHL, Cochrane, Gender Watch, PsycInfo, Scopus, and Social Science Abstracts. Limiters were English language from 2005+. 4,090 de-duplicated articles were identified. Four scholars conducted title and abstract screening using Covidence. Full text and extraction begins in November 2023. An augmented version of the JBI template will be used to extract data. *update 12/7/2023 - author affiliations update

    Evidence-Based Mental Health Programs in Schools: Barriers and Facilitators of Successful Implementation

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    Although schools can improve children’s access to mental health services, not all school-based providers are able to successfully deliver evidence-based practices. Indeed, even when school clinicians are trained in evidence-based practices (EBP), the training does not necessarily result in the implementation of those practices. This study explores factors that influence implementation of a particular EBP, Cognitive Behavioral Intervention for Trauma in Schools (CBITS). Semi-structured telephone interviews with 35 site administrators and clinicians from across the United States were conducted 6–18 months after receiving CBITS training to discuss implementation experiences. The implementation experiences of participants differed, but all reported similar barriers to implementation. Sites that successfully overcame such barriers differed from their unsuccessful counterparts by having greater organizational structure for delivering school services, a social network of other clinicians implementing CBITS, and administrative support for implementation. This study suggests that EBP implementation can be facilitated by having the necessary support from school leadership and peers

    Palatal development of preterm and low birthweight infants compared to term infants – What do we know? Part 2: The palate of the preterm/low birthweight infant

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    BACKGROUND: Well-designed clinical studies on the palatal development in preterm and low birthweight infants are desirable because the literature is characterized by contradictory results. It could be shown that knowledge about 'normal' palatal development is still weak as well (Part 1). The objective of this review is therefore to contribute a fundamental analysis of methodologies, confounding factors, and outcomes of studies on palatal development in preterm and low birthweight infants. METHODS: An electronic literature search as well as hand searches were performed based on Cochrane search strategies including sources of more than a century in English, German, and French. Original data were recalculated from studies which primarily dealt with both preterm and term infants. The extracted data, especially those from non-English paper sources, were provided unfiltered for comparison. RESULTS: Seventy-eight out of 155 included articles were analyzed for palatal morphology of preterm infants. Intubation, feeding tubes, feeding mode, tube characteristics, restriction of oral functions, kind of diet, cranial form and birthweight were seen as causes contributing to altered palatal morphology. Changes associated with intubation concern length, depth, width, asymmetry, crossbite, and contour of the palate. The phenomenon 'grooving' has also been described as a complication associated with oral intubation. However, this phenomenon suffers from lack of a clear-cut definition. Head flattening, pressure from the oral tube, pathologic or impaired tongue function, and broadening of the alveolar ridges adjacent to the tube have been raised as causes of 'grooving'. Metrically, the palates of intubated preterm infants remain narrower, which has been examined up to the age of the late mixed dentition. CONCLUSION: There is no evidence that would justify the exclusion of any of the raised causes contributing to palatal alteration. Thus, early orthodontic and logopedic control of formerly orally intubated preterm infants is recommended, as opposed to non-intubated infants. From the orthodontic point of view, nasal intubation should be favored. The role that palatal protection plates and pressure-dispersing pads for the head have in palatal development remains unclear

    Software for the frontiers of quantum chemistry:An overview of developments in the Q-Chem 5 package

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    This article summarizes technical advances contained in the fifth major release of the Q-Chem quantum chemistry program package, covering developments since 2015. A comprehensive library of exchange–correlation functionals, along with a suite of correlated many-body methods, continues to be a hallmark of the Q-Chem software. The many-body methods include novel variants of both coupled-cluster and configuration-interaction approaches along with methods based on the algebraic diagrammatic construction and variational reduced density-matrix methods. Methods highlighted in Q-Chem 5 include a suite of tools for modeling core-level spectroscopy, methods for describing metastable resonances, methods for computing vibronic spectra, the nuclear–electronic orbital method, and several different energy decomposition analysis techniques. High-performance capabilities including multithreaded parallelism and support for calculations on graphics processing units are described. Q-Chem boasts a community of well over 100 active academic developers, and the continuing evolution of the software is supported by an “open teamware” model and an increasingly modular design

    Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

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    Abstract: Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. Methods: This was a national cohort study of patients with early BC undergoing multidisciplinary team (MDT)-guided treatment recommendations during the pandemic, designated ‘standard’ or ‘COVID-altered’, in the preoperative, operative and post-operative setting. Findings: Of 3776 patients (from 64 UK units) in the study, 2246 (59%) had ‘COVID-altered’ management. ‘Bridging’ endocrine therapy was used (n = 951) where theatre capacity was reduced. There was increasing access to COVID-19 low-risk theatres during the study period (59%). In line with national guidance, immediate breast reconstruction was avoided (n = 299). Where adjuvant chemotherapy was omitted (n = 81), the median benefit was only 3% (IQR 2–9%) using ‘NHS Predict’. There was the rapid adoption of new evidence-based hypofractionated radiotherapy (n = 781, from 46 units). Only 14 patients (1%) tested positive for SARS-CoV-2 during their treatment journey. Conclusions: The majority of ‘COVID-altered’ management decisions were largely in line with pre-COVID evidence-based guidelines, implying that breast cancer survival outcomes are unlikely to be negatively impacted by the pandemic. However, in this study, the potential impact of delays to BC presentation or diagnosis remains unknown
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