N-Benzyl-N-methyl-3-phenyl-3-[4-(tri­fluoro­meth­yl)phen­oxy]propanamine (N-benzylflouoxetine)

In the title compound, C24H24F3NO, the N-benzyl derivative of fluoxetine {N-methyl-3-[4-(trifluoro­meth­yl)phen­oxy]­benzene­propanamine}, the three aromatic rings A, B and C are inclined to one another by 76.77 (12)° for A/B, 17.05 (14)° for A/C and 89.66 (14)° for B/C. In the crystal structure, mol­ecules are linked via C—H⋯π inter­actions to form one-dimensional chains propagating in the [010] direction

2-{1-[(2-Nitro­benzene­sulfonamido)­meth­yl]cyclo­hexyl}acetic acid

In the title compound, C15H20N2O6S, the C—SO2—NH—C torsion angle is 64.54 (14)°. In the mol­ecule, there is a bifurcated N—H⋯(O,O) hydrogen bond, forming S(7) rings. In the crystal, inversion dimers are formed via O—H⋯O hydrogen bonds involving the carboxyl group, so forming R 2 2(8) rings. These dimers are further linked via pairs of C—H⋯O hydrogen bonds, forming a C(6) chain propagating along the c-axis direction

Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System

A new series of tetrahydrocarbazole coupled 1,2-diazoles 4/5/6(a–o) in moderate to excellent yield was synthesized successfully via multicomponent reaction approach by adopting Michael type-addition of hydrazines on in situ generated α,β-unsaturated ketones via aldol type strategy under synthetic microwave radiations and conventional heating. Structural confirmations of all the prepared compounds were achieved by spectroscopic techniques. The best results were achieved when equal amounts of water-acetic acid were used in microwave conditions in 4 minutes

Green Synthesis Characterization and Thermotropic Behaviour of O-Linked Glycopyranosides of Phenolic Esters

Focusing on green chemistry protocols, a series of carbohydrate derivatives (5a–l) have been synthesized by Fischer glycosylation of α-D-glucose, D-xylose, and α-maltose with several nonpolar phenolic ester aglycones (3a–d) derived from menthol by employing solid-supported Si-H+ as the catalyst. In order to study the extent of mesomorphism in target molecules, the thermotropic behaviour has been studied by using the thermoanalytic DSC/TGA technique and polarized optical microscope. Phase transitions in the DSC thermograms of 5a–l with two endothermic melting point peaks and various exothermic crystalline transitions exhibits the existence of mesophases. However, optical photomicrographs revealed that the new glycopyranosides formed smectic A phases. Moreover, all the compounds (3a–d and 5a–l) were confirmed by FTIR and 1H NMR

Green and Facile Reaction of Gabapentin with Sulfonyl Chlorides to Synthesize Lactams and Sulfonamides Derivatives in Aqueous Medium

In the current research, a facile and green one pot synthesis of new gabapentin-lactams (G(2)-G(8)) has been achieved by reacting gabapentin (G(1)) with a variety of sulfonyl chlorides. The new lactamization protocol is furnished under the green solvent i.e., water and reaction was completed in a short period of time by just stirring at room temperature. Whereas in some cases, annulation could not happen and furnished un-cyclized sulfonamide products (G(9)-G(12)). The structures of the targeted compounds were established by elemental analysis, FT-IR, H-1-NMR and mass spectrometry. The crystals of some new lactams (G(2), G(3), G(4), and G(8)) were also evaluated by single crystal X-ray diffraction