Multiarticular chronic tophaceous gout with severe and multiple ulcerations: a case report

<p>Abstract</p> <p>Introduction</p> <p>Gout is a common inflammatory arthritis caused by articular precipitation of monosodium urate crystals. It usually affects the first metatarsophalangeal joint of the foot and less commonly other joints, such as wrists, elbows, knees and ankles.</p> <p>Case presentation</p> <p>We report the case of a 75-year-old Caucasian man with tophaceous multiarticular gout, soft-tissue involvement and ulcerated tophi on the first metatarsophalangeal joint of the left foot, on the first interphalangeal joint of the right foot and on the left thumb.</p> <p>Conclusion</p> <p>Ulcers due to tophaceous gout are currently uncommon considering the positive effect of pharmaceutical treatment in controlling hyperuricemia. Surgical treatment is seldom required for gout and is usually reserved for cases of recurrent attacks with deformities, severe pain, infection and joint destruction.</p

Synthesis and characterization of poly{2-[3-(1H-pyrrol-2-yl)phenyl]-1H-pyrrole} and its copolymer with EDOT

WOS: 000299519300016A pyrrole-functionalized monomer 2-[3-(1H-pyrrol-2-yl)phenyl]-1H-pyrrole (PyPhPy) was synthesized. The structure of monomer was investigated by Nuclear Magnetic Resonance (H-1 NMR) and Fourier Transform Infrared (FTIR) spectroscopy. The chemical polymerization of PyPhPy (CPyPhPy) was realized using FeCl3 as the oxidant. The electrochemical oxidative polymerization of polymer P(PyPhPy) and its copolymer with 3,4-ethylenedioxythiophene poly(2-[3-(1H-pyrrol-2-yl)phenyl]-1H-pyrrole-co-3,4-ethylenedioxythiophene) [P(PyPhPy-co-EDOT)] were achieved via potentiodynamic method by using NaClO4/LiClO4 as the supporting electrolyte in CH3CN. Characterizations of the resulting polymers were performed by cyclic voltammetry (CV), FTIR, scanning electron microscopy (SEM), UV-Visible spectrophotometry (UV-Vis) and thermogravimetry analyses (TGA). Electrical conductivity of CPyPhPy, P(PyPhPy), and P(PyPhPyco-EDOT) were measured by four-probe technique

Synthesis and characterization of poly{2-[3-(1H-pyrrol-2-yl)phenyl]-1H- pyrrole} and its copolymer with EDOT

A pyrrole-functionalized monomer 2-[3-(1H-pyrrol-2-yl)phenyl]-1H-pyrrole (PyPhPy) was synthesized. The structure of monomer was investigated by Nuclear Magnetic Resonance ( 1H NMR) and Fourier Transform Infrared (FTIR) spectroscopy. The chemical polymerization of PyPhPy (CPyPhPy) was realized using FeCl3 as the oxidant. The electrochemical oxidative polymerization of polymer P(PyPhPy) and its copolymer with 3,4-ethylenedioxythiophene poly(2-[3-(1H- pyrrol-2-yl)phenyl]-1H-pyrrole-co-3,4- ethylenedioxythiophene) [P(PyPhPy-co-EDOT)] were achieved via potentiodynamic method by using NaClO 4/ LiClO 4 as the supporting electrolyte in CH 3CN. Characterizations of the resulting polymers were performed by cyclic voltammetry (CV), FTIR, scanning electron microscopy (SEM), UV-Visible spectrophotometry (UV- Vis) and thermogravimetry analyses (TGA). Electrical conductivity of CPyPhPy, P(PyPhPy), and P(PyPhPyco- EDOT) were measured by four-probe technique

Longer tourniquet application time during knee surgery decreases the quadriceps muscle strength: a prospective study on 25 consecutive patients underwent total knee arthroplasty

The use of tourniquets in total knee arthroplasty (TKA) for patients with knee osteoarthritis is controversial. Although surgical techniques are more easily applied in a shorter time; there are some disadvantages associated with tourniquet use in orthopedic surgery. The aim of this study was to evaluate the effect of the tourniquet time on quadriceps strength by isokinetic muscle strength measurements in patients undergoing TKA. Prospective controlled study. Twenty-five knees of 25 patients with primary degenerative joint disease who underwent TKA were evaluated preoperatively and postoperatively at weeks 6 and 12 and month 6 by isokinetic knee extensor muscle strength testing at and American Knee Society Score (AKSS). The tourniquet time of all patients was recorded, and the preoperative results of all patients were compared with those postoperatively. The mean 60º/s angular velocity quadriceps peak torque was significantly lower postoperatively in patients with a longer tourniquet time. Isokinetic tests showed a significant negative correlation between the tourniquet time and mean muscle strength (week 6: r = –0.718, p < 0.01; week 12: r = –0.651, p < 0.01; month 6: r = –0.672, p < 0.01). The highest correlation with tourniquet time was obtained 6 weeks after surgery. Additionally, strong negative correlations were observed between the AKSS and tourniquet times (Knee Score: r = –0.904, p < 0.01; Knee Functional Score: r = –0.878, p < 0.01). Lower postoperative mean quadriceps strength in patients with a longer tourniquet time, suggesting that the tourniquet time affects the quadriceps muscle strength witl longer times resulting lower muscle strengthThe use of tourniquets in total knee arthroplasty (TKA) for patients with knee osteoarthritis is controversial. Although surgical techniques are more easily applied in a shorter time; there are some disadvantages associated with tourniquet use in orthopedic surgery. The aim of this study was to evaluate the effect of the tourniquet time on quadriceps strength by isokinetic muscle strength measurements in patients undergoing TKA. Prospective controlled study. Twenty-five knees of 25 patients with primary degenerative joint disease who underwent TKA were evaluated preoperatively and postoperatively at weeks 6 and 12 and month 6 by isokinetic knee extensor muscle strength testing at and American Knee Society Score (AKSS). The tourniquet time of all patients was recorded, and the preoperative results of all patients were compared with those postoperatively. The mean 60º/s angular velocity quadriceps peak torque was significantly lower postoperatively in patients with a longer tourniquet time. Isokinetic tests showed a significant negative correlation between the tourniquet time and mean muscle strength (week 6: r = –0.718, p < 0.01; week 12: r = –0.651, p < 0.01; month 6: r = –0.672, p < 0.01). The highest correlation with tourniquet time was obtained 6 weeks after surgery. Additionally, strong negative correlations were observed between the AKSS and tourniquet times (Knee Score: r = –0.904, p < 0.01; Knee Functional Score: r = –0.878, p < 0.01). Lower postoperative mean quadriceps strength in patients with a longer tourniquet time, suggesting that the tourniquet time affects the quadriceps muscle strength witl longer times resulting lower muscle strengt

Longer tourniquet application time decreases the quadriceps muscle strength: a prospective study on 25 consecutive patients underwent total knee arthroplasty

The use of tourniquets in total knee arthroplasty (TKA) for patients with knee osteoarthritis is controversial. Although surgical techniques are more easily applied in a shorter time; there are some disadvantages associated with tourniquet use in orthopedic surgery. The aim of this study was to evaluate the effect of the tourniquet time on quadriceps strength by isokinetic muscle strength measurements in patients undergoing TKA. Prospective controlled study. Twenty-five knees of 25 patients with primary degenerative joint disease who underwent TKA were evaluated preoperatively and postoperatively at weeks 6 and 12 and month 6 by isokinetic knee extensor muscle strength testing at and American Knee Society Score (AKSS). The tourniquet time of all patients was recorded, and the preoperative results of all patients were compared with those postoperatively. The mean 60º/s angular velocity quadriceps peak torque was significantly lower postoperatively in patients with a longer tourniquet time. Isokinetic tests showed a significant negative correlation between the tourniquet time and mean muscle strength (week 6: r = 0.718, p &lt; 0.01; week 12: r = 0.651, p &lt; 0.01; month 6: r = 0.672, p &lt; 0.01). The highest correlation with tourniquet time was obtained 6 weeks after surgery. Additionally, strong negative correlations were observed between the AKSS and tourniquet times (Knee Score: r = 0.904, p &lt; 0.01; Knee Functional Score: r = 0.878, p &lt; 0.01). Lower postoperative mean quadriceps strength in patients with a longer tourniquet time, suggesting that the tourniquet time affects the quadriceps muscle strength witl longer times resulting lower muscle strength. [Med-Science 2017; 6(1.000): 86-90

Prognostic and diagnostic importance of the systemic immune-inflammation index in pediatric head trauma

Head trauma is a leading cause of mortality and morbidity in pediatric patients. The trauma itself leads to the activation of a biomolecular cascade of damage. Purinergic receptors and ATP release play an important role in the activation of astroglia, microglia, monocyte-macrophages, neutrophils, and T cells in this process. The systemic immune inflammation index can be easily calculated, cheap, only requires hemogram parameters, and does not include any subjective findings. Therefore, we believe that it could be a prognostic predictor and a diagnostic marker for pediatric head trauma cases. Our study was designed as a retrospective and single-center study. The study was conducted with pediatric patients who presented to the emergency department with isolated head trauma between June 15, 2022, and December 15, 2022. Demographic data, medical history, white blood count, platelet count, neutrophil count, systemic immune inflammation index (SIII), Glasgow Coma Score, and the presence of pathology on brain computed tomography were recorded on the case report form. The study was conducted with 112 cases. In cases with bleeding, the median value of GCS was significantly lower (p [Med-Science 2023; 12(3.000): 656-60