The geochemical and geochronological properties of postcollision a-type magmatism (Keban-Elazığ-Turkey)

In this study, the petrographic, geochemical and geochronological characteristics of Late Cretaceous-Middle Eocene Keban igneous rocks were examined in Keban-Elazığ-Turkey. Igneous rocks in the study area are represented by syenite porphyry and quartz monzonites. Petro-graphically, the main mineral paragenesis of rocks showing holocrystalline texture are K-feldspar (Mega-phenocrystalline) + plagioclase ± amphibole ± biotite ± quartz minerals. Secondary mineral phases are represented by calcite, sericite, chlorite and epidote minerals.Accessory mineral phases consist of sphene, apatite, zircon, garnet, pyrite, fluorite and opaque minerals. According to some analysis results, SiO2 (60.09 – 64.37 wt.%), Al2O3 (15.75 – 17.96 wt.%), Fe2O3 (1.18 – 5.30 wt.%), MgO (0.09 – 0.92 wt.%) CaO (2.07 – 4.27 wt.%), Na2O (0.80 – 4.93 wt.%) , K2O (4.69 – 13.42 wt.%), TiO2 (0.22 – 0.37 wt.%), P2O5 (0.05 – 0.26 wt.%), Na2O + K2O (8.22 – 14.22), Zr (200.9 – 665.4 ppm), Hf (4.6 – 18.4 ppm), Ta (1.5 – 2.7 ppm), Nb (24 – 56 ppm) ranges between values. The chondrite normalized rare earth element (REE) patterns display enrichment of light rare earth elements (LREE) compared to the heavy rare earth elements (HREE). The primitive mantle normalized trace element patterns indicate that the large ion lithophile elements (LILE) enriched compared to the high field strength elements (HFSE). According to LA-ICPMS zircon U-Pb crystallization ages ranges between 46.1 ± 0.5, 76.3 ± 0.3, 76.36 ± 0.34 and 77.4 ± 0.3 My. (Late Cretaceous-Middle Eocene). In the tectonic environment diagrams the studied rocks fall into the post-collisional fields (developing after collision). These rocks fall into the A-type granitoid areas and are of shoshonitic character. It falls into the post-collisional region (developed after collision) in the tectonic environment diagrams of the rocks studied. According to the field, petrography, geochemical and geochronological studies are evaluated together, Keban Magmatic rocks are thought to have the characteristics of post-collision developed magmatism

Clopidogrel responsiveness in chronic kidney disease patients with acute coronary syndrome

Objective: Cardiovascular diseases are the leading cause of death in patients with chronic kidney disease (CKD). There is conflicting evidence about effect of CKD on clopidogrel responsiveness. We aimed to evaluate the clopidogrel responsiveness in CKD patients with acute coronary syndrome (ACS). Methods: A total of 101 patients; 55 with moderate to severe CKD and 46 with normal renal function or mild CKD, hospitalized with ACS were included in our study. Multiplate test was used to determine clopidogrel responsiveness. Platelet aggregation results were presented as aggregation unit (AU)*min and values over 470 AU*min were accepted as clopidogrel low responders. Results: The 101 patients (mean age 64.76±8.67 years; 61 [60.4%] male) were grouped into the two study groups as follows: group 1; 55 patients with eGFR<60 ml/min/1.73 m2 and group 2; 46 patients with eGFR>60 ml/min/1.73 m2. 35 patients (34.7%) of the study population were found to have low response to clopidogrel (16 [34.8%] patients in group 1 and 18 [33.3%] patients in group 2, p=0.879) . There was no significant difference between group 1 and 2 for Multiplate test results (414.67±281.21 vs 421.56±316.19 AU*min, p=0.909). Clopidogrel low responsiveness were independently related to Multiplate test results of aspirin responsiveness (OR=1.004, CI 1.002–1.007, p=0.001) and hemoglobin (OR=0.727, CI 0.571–0.925, p=0.010). Multiplate results were also independently related to Multiplate test results of aspirin responsiveness (β=0.402, p<0.0001) and hemoglobin (β=-0.251, p=0.007). Conclusion: Platelet response to clopidogrel does not differ between patients with eGFR < 60 ml/min/1.73 m2 and eGFR>60 ml/min/1.73 m2

Association Between Bifurcation Angle and Coronary No-reflow Following Primary Percutaneous Coronary Intervention in Patients

Objective:Percutaneous coronary intervention (PCI) has become the treatment method for patients presenting with ST elevation myocardial infarction (STEMI). One of the well-known complications of PCI is no-reflow. Studies demonstrated a relationship between endothelial dysfunction and disturbed vascular flow due to angulation of vascular tree. Although the relationship between hemodynamic alterations and coronary angulation is evident, there is a lack of detailed analysis in terms of hemodynamic changes between vascular geometry and coronary no-reflow. We aimed to elucidate the relationship between vascular geometry and coronary no-reflow.Method:We reviewed PCI database of our hospital and enrolled a total of 120 patients with STEMI, who developed no-reflow following PCI, and sex and age matched 80 patients with normal flow. For each group, demographic and clinical characteristics, laboratory values and two dimensional quantitative coronary angiography measurements were evaluated.Results:Patients with no-reflow had a higher prevalence of hypertension and diabetes mellitus. In addition, serum C-reactive protein levels were higher in patients with no-reflow compared to patients with normal flow (p<0.001). On the other hand, serum hemoglobin levels were significantly lower in patients with no-reflow compared to patients with normal flow (p<0.001). With respect to 3 dimensional coronary measurements, calculated bifurcation angle of left anterior descending artery (LAD) and circumflex artery (CX) was significantly wider in the no-reflow group than in the control group [110.9° (21.8°) vs. 85.9° (15.8°), p<0.001].Conclusion:Our data showed that a strong association existed between bifurcation angle of LAD-CX and no-reflow phenomenon in STEMI patients who underwent PCI

The epidemiology, Clinical Manifestations, radiology, microbiology, treatment, and prognosis of echinococcosis: Results of NENEHATUN study

Aim: Echinococcosis, caused by Echinococcus species, is an important zoonotic disease causing major health problems in humans and animals. Herein, we aimed to evaluate the epidemiology, clinical and laboratory parameters, radiological, serological, pathological, and treatment protocols of followed-up cases of hydatidosis. Methods: A total of 550 patients diagnosed with hydatid cyst disease were included in this study. Patients who were positive for one or more of the enzyme-linked immunosorbent assay or indirect hemagglutination test, pathological results, or radiological findings were examined. The data analyzed were collected from nine centers between 2008 and 2020. Records were examined retrospectively. Results: Among the patients, 292 (53.1%) were women and 258 (46.9%) were men. The patients' mean age was 44.4 +/- 17.4 years. A history of living in rural areas was recorded in 57.4% of the patients. A total of 435 (79.1%) patients were symptomatic. The most common symptoms were abdominal pain in 277 (50.4%), listlessness in 244 (44.4%), and cough in 140 (25.5%) patients. Hepatomegaly was found in 147 (26.7%), and decreased breath sounds were observed in 124 (22.5%) patients. Radiological examination was performed in all cases and serological methods were also applied to 428 (77.8%) patients. The most frequently applied serological test was IHA (37.8%). A single cyst has been found in 66% patients. Hepatic involvement occurred in 327 (59.4%), pulmonary involvement was found in 128 (23.3%), whereas both of them were recorded in 43 (7.8%) patients. Splenic involvement was only detected in nine (1.6%) patients. Echinococcus granulosus (72.5%) was most frequently detected. Cyst diameters of 56.9% of the patients were in the range of 5-10 cm. A total of 414 (75.2%) patients received albendazole as an antiparasitic. Mortality was noted in nine (1.6%) patients. Conclusion: Echinococcosis is an important public health problem in Turkey. It can affect the social, economic, and political structures of the community. Public education and awareness are extremely important

A Survey on LoRaWAN Architecture, Protocol and Technologies

Internet of Things (IoT) expansion led the market to find alternative communication technologies since existing protocols are insufficient in terms of coverage, energy consumption to fit IoT needs. Low Power Wide Area Networks (LPWAN) emerged as an alternative cost-effective communication technology for the IoT market. LoRaWAN is an open LPWAN standard developed by LoRa Alliance and has key features i.e., low energy consumption, long-range communication, builtin security, GPS-free positioning. In this paper, we will introduce LoRaWAN technology, the state of art studies in the literature and provide open opportunities