A COMPARISON BETWEEN RANDOM AND DETERMINISTIC DYNAMICS OF RIVER DRAINAGE BASINS FORMATION

This work contributes to the discussion on how and why tree networks in drainage basin arises in nature. A fully deterministic erosion model recently developed was used to explain the spontaneous origin of river networks, which until then was assumed to be due to the optimal reduction of the flow resistance in a area to point flow. A random evolution model was devised in order to investigate the contribution of two separate features: the relative area size of the network and the structure (configuration) of the network. Two random models were applied, namely, restricted random choosing selection and fully random. Results showed that indeed the mere presence of low flow resistance portions of the basin does improve global performance and that randomness does not create networks. Further gain in performance is given by the network formation by erosion or by optimization. This suggest that local factors also are important to the explanation of the very existence of natural networks

Design of I-shaped beams and columns with diaphragm bracing

Cold-formed steel panels often are used as wall sheathing, roof decking or floor decking in steel framed buildings or pre-engineered metal buildings. Diaphragms formed by interconnecting these panels have considerable in-plane shear resistance, and can be utilized as bracing against buckling for individual members of a steel frame. For wall columns the diaphragm may be either directly attached or connected to girts which in turn are connected to the columns. A procedure is presented for the design of I-section beams and columns with diaphragm or diaphragm-girt bracing. The procedure is based on the ultimate load capacity of fully braced members, utilizing a conservative estimate of the shear strength and shear rigidity of the diaphragm. Design examples are included. The utilization of existing wall, floor or roof diaphragms as bracing for individual beams and columns can eliminate the need for other types of bracing, and/or reduce required member sizes. Thus it contributes to economical design

The Infra‐Red Absorption Spectrum of Methyl Alcohol

Using a grating spectrometer having a KBr foreprism the spectrum of methyl alcohol vapor was studied in the region from 2.5 to 26μ. This molecule has bands at 3683, 2978, 2845, 2054, 1477, 1455, 1340, 1034.18 cm—1 and a very broad band extending from 860 to beyond 380 cm—1. These bands are typical perpendicular and parallel bands and indicate that the molecule is only slightly asymmetric.From the fine structure of the 1034.18 cm—1 parallel band and from certain assumptions about the structure of the molecule the two largest moments of inertia, A and B, were found to be 35.18 and 33.83×10—40 g cm2, respectively. It was not possible to measure C directly but it was estimated to be approximately 6.8×10—40 g cm2.The low frequency band is probably due to the vibration of the hydroxyl hydrogen atom perpendicular to the O☒H bond and perpendicular to the figure axis of the molecule. The presence of this band indicates that the hydroxyl group is not free to rotate, at least in the ground state. There is evidence of rotation in the structure of the band near the high frequency edge. The spacing increases toward high frequencies and finally there is a group of lines having a spacing of about 40 cm—1 between 600 and 860 cm—1. Since these lines are very weak and occur at such high frequencies it appears that free rotation exists only in states of high excitation. A quantitative study of free rotation in a symmetric molecule has been made. This investigation indicates that in a first approximation free rotation should give rise to groups of lines having a spacing of about 40 cm—1 between each group.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70345/2/JCPSA6-6-9-553-1.pd

Data assimilation of stratospheric constituents: a review

International audienceThe data assimilation of stratospheric constituents is reviewed. The data assimilation method is introduced, with particular consideration to its application to stratospheric constituent measurements. Differences from meteorological data assimilation are outlined. Historically, two approaches have been used to carry out constituent assimilation. One approach has carried constituent assimilation out as part of a numerical weather prediction system; the other has carried it out in a standalone chemical model, often with a more sophisticated representation of chemical processes. Whereas the aim of the numerical weather prediction approach has been to improve weather forecasts, the aims of the chemical model approach have included providing chemical forecasts and analyses of chemical constituents. A range of constituent assimilation systems developed in these two areas is presented and strengths and weaknesses discussed. The use of stratospheric constituent data assimilation to evaluate models, observations and analyses, and to provide analyses of constituents, monitor ozone, and make ozone forecasts is discussed. Finally, the current state of affairs is assessed, future directions are discussed, and potential key drivers identified

Design recommendations for diaphragm-braced beams, columns and wall-studs

INTRODUCTION Light gage steel panels are often used as wall sheathing, roof decking or floor covering in steel framed buildings. These panels carry loads normal to their plane by virtue of their bending strength. Also, diaphragms formed by interconnecting such panels can resist shear deformation in their plane. Because of this shear resisting capacity, diaphragms can be very effective in bracing columns and beams of a steel frame against lateral buckling and, thus, increase the load carrying capacity of these members. For wall columns, such diaphragm bracing may be either directly attached or connected to girts which in turn are connected to the columns. The ribs of the panels must be perpendicular to the members to which they are attached. These diaphragms as wall, roof or floor, must be present in any event, and therefore, are available at no extra cost. If properly utilized for bracing, they can lead to economical design of beams and columns. Research has been conducted at Cornell University since 1961* (1),(2),(3) to determine the increased load carrying capacities of beams and columns due to diaphragm or diaphragmgirt bracing. Based on the results of the investigation to date, recommendations are made in this report for the design of beams and columns considering the effect of diaphragm braci~g. * Superscripts in parentheses refer to the numbers in the References. Design criteria are given in Part 2; the general design procedure in Part 3, and the specific design formulae in Part 4 are illustrated by some practical examples in Part 5. The design procedure suggested herein is based on the ultimate load capacity of the beams or columns, utilizing a conservative estimate of the strength and rigidity of the diaphragm bracing. Effectiveness of diaphragm bracing or diaphragm-girt bracing in preventing lateral buckling of beams and columns depends on its two fundamental characteristics: (1) rigidity, and (2) strength. In general, it is not economical to provide anything less than fUll bracing, where full bracing is defined as bracing such that any increase in rigidity or strength of diaphragm will not cause any substantial increase in the load carrying capacity of the braced members. Therefore, the design procedure in this report is limited to only fullyli braced beams and columns. The procedure is based on analyses of I-section beams under uniform moment, and I-section columns under axial load. These analyses have been substantiated by tests of thirtyfive diaphragm-braced assemblies as reported in the references. Information regarding the load carrying capacities of beams and columns with less than full bracing can be obtained from Reference 3. The capacity of channel and Z-section beams SUbjected to uniform moment also is discussed in Reference 3. Cantilever beams and channel and Z-section beams subjected to loads in the plane of the web are currently under investigation. Light wall studs braced by wallboard on one or both faces are no different basically from columns braced by light steel diaphragms. In order to make the methods developed here applicable to such wall studs, the Appendix gives a few typical test values for diaphragm rigidity and strength of customary types of wallboard

Harmonisation and diagnostics of MIPAS ESA CH4 and N2O profiles using data assimilation

This paper discusses assimilation experiments of methane (CH4) and nitrous oxide (N2O) profiles retrieved from the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS). Here we focus on data versions 6 and 7 provided by the ESA processor. These data sets have been assimilated by the Belgian Assimilation System for Chemical ObsErvations (BASCOE). The CH4 and N2O retrieved profiles can oscillate, especially in the tropical lower stratosphere. Using the averaging kernels of the observations and a background error covariance matrix, which has previously been calibrated, allows the system to partly remedy this issue and provide assimilated fields that are more regular vertically. In general, there is a good agreement between the BASCOE analyses and independent observations from ACE–FTS (CH4 and N2O) and MLS (N2O), demonstrating the general good quality of CH4 and N2O retrievals provided by MIPAS ESA. Nevertheless, this study also identifies two issues in these data sets. First, time series of the observations show unexpected discontinuities due to an abrupt change in the gain of MIPAS band B, generally occurring after the instrument decontamination. Since the calibration is performed weekly, the abrupt change in the gain affects the measurements until the subsequent calibration is performed. Second, the correlations between BASCOE analyses and independent observations are poor in the lower stratosphere, especially in the tropics, probably due to the presence of outliers in the assimilated data. In this region, we recommend using MIPAS CH4 and N2O retrievals with caution

Evaluation of the N2_2O Rate of Change to Understand the Stratospheric Brewer‐Dobson Circulation in a Chemistry‐Climate Model

The Brewer-Dobson Circulation (BDC) determines the distribution of long-lived tracers in the stratosphere; therefore, their changes can be used to diagnose changes in the BDC. We evaluate decadal (2005–2018) trends of nitrous oxide (N$_2$O) in two versions of the Whole Atmosphere Chemistry-Climate Model (WACCM) by comparing them with measurements from four Fourier transform infrared (FTIR) ground-based instruments, the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS), and with a chemistry-transport model (CTM) driven by four different reanalyses. The limited sensitivity of the FTIR instruments can hide negative N$_2$O trends in the mid-stratosphere because of the large increase in the lowermost stratosphere. When applying ACE-FTS measurement sampling on model datasets, the reanalyses from the European Center for Medium Range Weather Forecast (ECMWF) compare best with ACE-FTS, but the N$_2$O trends are consistently exaggerated. The N$_2$O trends obtained with WACCM disagree with those obtained from ACE-FTS, but the new WACCM version performs better than the previous above the Southern Hemisphere in the stratosphere. Model sensitivity tests show that the decadal N$_2$O trends reflect changes in the stratospheric transport. We further investigate the N$_2$O Transformed Eulerian Mean (TEM) budget in WACCM and in the CTM simulation driven by the latest ECMWF reanalysis. The TEM analysis shows that enhanced advection affects the stratospheric N$_2$O trends in the Tropics. While no ideal observational dataset currently exists, this model study of N$_2$O trends still provides new insights about the BDC and its changes because of the contribution from relevant sensitivity tests and the TEM analysis

A Study of the Natural History of Vitreomacular Traction Syndrome by OCT

PURPOSE: To examine the natural history of vitreomacular traction syndrome (VMTS) in the absence of other ocular comorbidities. DESIGN: Retrospective clinical case series. PARTICIPANTS: A total of 183 eyes of 159 patients diagnosed with VMTS with no other ocular comorbidity. METHODS: Patients with VMTS were identified from an OCT database at Moorfields Eye Hospital, London. Sequential OCT scans and patient notes were reviewed over a minimum period of 6 months. Data collected included patient demographics, best-corrected visual acuity, and OCT features of vitreomacular adhesion. Contingency tests and binary logistic modeling were used to identify baseline predictors of stability and progression. MAIN OUTCOME MEASURES: The rates of spontaneous resolution (defined by release of traction), progression to full-thickness macular hole, and surgical intervention were analyzed. RESULTS: Presenting visual acuity was 0.3±0.3 logMAR units. The mean length of follow-up was 17.4±12.1 months. During this period, VMTS persisted in 60% and resolved in 20% (occurring on average at 15 months). Of the remainder, 12% developed a macular hole and 8% elected to proceed with surgery for symptoms. Focal adhesion <1500 μm was present in 87%. A premacular membrane with macular pucker (PMM) was present in 20%. With persistent VMTS, vision and central foveal thickness remained unchanged. The relative risk of resolution increased in those cases with better presenting visual acuities, lesser foveal thicknesses, and no associated PMMs; vision significantly improved in those cases with resolution. CONCLUSIONS: VMTS persists in the majority of patients but despite this, visual acuities did not deteriorate significantly over the study period unless patients developed a full-thickness macular hole or required surgical intervention for symptoms. Resolution spontaneously occurred in 20%, with an improvement in vision

Hypothesis: primary antiangiogenic method proposed to treat early stage breast cancer

<p>Abstract</p> <p>Background</p> <p>Women with Down syndrome very rarely develop breast cancer even though they now live to an age when it normally occurs. This may be related to the fact that Down syndrome persons have an additional copy of chromosome 21 where the gene that codes for the antiangiogenic protein Endostatin is located. Can this information lead to a primary antiangiogenic therapy for early stage breast cancer that indefinitely prolongs remission? A key question that arises is when is the initial angiogenic switch thrown in micrometastases? We have conjectured that avascular micrometastases are dormant and relatively stable if undisturbed but that for some patients angiogenesis is precipitated by surgery. We also proposed that angiogenesis of micrometastases very rarely occurs before surgical removal of the primary tumor. If that is so, it seems possible that we could suggest a primary antiangiogenic therapy but the problem then arises that starting a therapy before surgery would interfere with wound healing.</p> <p>Results</p> <p>The therapy must be initiated at least one day prior to surgical removal of the primary tumor and kept at a Down syndrome level perhaps indefinitely. That means the drug must have virtually no toxicity and not interfere meaningfully with wound healing. This specifically excludes drugs that significantly inhibit the VEGF pathway since that is important for wound healing and because these agents have some toxicity. Endostatin is apparently non-toxic and does not significantly interfere with wound healing since Down syndrome patients have no abnormal wound healing problems.</p> <p>Conclusion</p> <p>We propose a therapy for early stage breast cancer consisting of Endostatin at or above Down syndrome levels starting at least one day before surgery and continuing at that level. This should prevent micrometastatic angiogenesis resulting from surgery or at any time later. Adjuvant chemotherapy or hormone therapy should not be necessary. This can be continued indefinitely since there is no acquired resistance that develops, as happens in most cancer therapies.</p