166 research outputs found

    Prions: The New Biology of Proteins

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    Prions and Prion Diseases: Current Perspectives

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    Biogas and bio-fertilizer production potential of abattoir waste as means of sustainable waste management option in Hawassa City, southern Ethiopia

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    The purpose of this study was to assess abattoir waste generation in Hawassa Municipality Abattoir (HMA) andits potential to produce biogas and bio-fertilizer employing a cross-sectional design and mathematical computation based on standard coefficients. The study demonstrated that HMA generates 885,881.6Kg of abattoir waste per year and using anaerobic digestion about 46,951.72m3/year of biogas can be produced. This waste has the potential of generating a total energy of 246,027.01KWh/year. The biogas or energy from the waste can replace the biomass (firewood and charcoal) and the expensive fossil fuels. Using the produced46, 951.72m3/year biogas could reduce the annual CO2 emission of 150,600.10Kg/kWh from kerosene, 150,600.10Kg/kWh from petrol, 132,882.50Kg/kWh from diesel or 132,882.50Kg/kWh from LPG use. The abattoir will be able to produce an estimated 65,112.3 Kg/year dry bio-fertilizer from biogas technology and this bio-fertilizer can be supplied to local farmers for crop production or can be used by city municipality for growing plants used for beautification. This obtainable bio- fertilizer is valued 29,951.66 USDper annum and to a certain extent will contribute to the reduction of domestic demand of chemical fertilizer thus will reduce the annual budget. As a long-term and sustainable waste management solution, installing anaerobic digestion plant is recommended, but using proper disposal method among the existing would serve as a short-term solution.Keywords: - Abattoir, Bio-fertilizer, Biogas, Energy, Hawassa, Wast

    Chronic Wasting Disease and Potential Transmission to Humans

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    Chronic wasting disease (CWD) of deer and elk is endemic in a tri-corner area of Colorado, Wyoming, and Nebraska, and new foci of CWD have been detected in other parts of the United States. Although detection in some areas may be related to increased surveillance, introduction of CWD due to translocation or natural migration of animals may account for some new foci of infection. Increasing spread of CWD has raised concerns about the potential for increasing human exposure to the CWD agent. The foodborne transmission of bovine spongiform encephalopathy to humans indicates that the species barrier may not completely protect humans from animal prion diseases. Conversion of human prion protein by CWD-associated prions has been demonstrated in an in vitro cell-free experiment, but limited investigations have not identified strong evidence for CWD transmission to humans. More epidemiologic and laboratory studies are needed to monitor the possibility of such transmissions

    National Trends in Cessation Counseling, Prescription Medication Use, and Associated Costs Among US Adult Cigarette Smokers

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    Importance: Cigarette smoking is the leading cause of preventable disease and death in the United States. When used separately or in combination, smoking cessation counseling and cessation medications have been associated with increased cessation rates. Objectives: To present trends in self-reported receipt of physician advice to quit smoking and in use of prescription smoking cessation medication along with their associated expenditures among a nationally representative sample of active adult smokers in the United States. Design, Setting, and Participants: This repeated cross-sectional study of US adults aged 18 years or older was conducted from July 5, 2018, through August 15, 2018. Data were collected between January 1, 2006, and December 31, 2015, from the Medical Expenditure Panel Survey, an annual US survey of individuals and families, health care personnel, and employers. Participants (n = 29 106) were noninstitutionalized civilians who were randomly drawn from the respondents of the previous year’s National Health Interview Survey. Multivariable logistic regression models were used to examine the associations between sociodemographic factors and receipt of physician cessation advice and use of cessation prescription medication. A 2-part econometric model was used to assess health care expenditures. Main Outcomes and Measures: Trends in self-reported receipt of physician advice to quit and uptake of prescription smoking cessation medications with associated total and out-of-pocket expenditures. Results: The study sample consisted of 29 106 participants, with a mean (SD) age of 57 (10) years and a composition of 13 670 women (47.0%). The results were weighted to provide estimates for 31.2 million active adult cigarette smokers. The proportion of smokers who reported receiving physician advice to quit increased from 60.2% (95% CI, 58.5%-62.0%) in 2006 to 2007 to 64.9% (95% CI, 62.8%-66.9%) in 2014 to 2015, with a P for trend = .001. The odds of receiving physician cessation advice was statistically significantly higher in women (odds ratio [OR], 1.50; 95% CI, 1.39-1.59) and lower among uninsured participants (OR, 0.58; 95% CI, 0.52-0.65). Overall, prescription smoking cessation medication use decreased with a corresponding reduction in total expenditures from 146million(outofpocketcost,146 million (out-of-pocket cost, 46 million) in 2006 to 2007 to 73million(outofpocketcost,73 million (out-of-pocket cost, 9 million) in 2014 to 2015. Male (odds ratio [OR], 0.78; 95% CI, 0.66-0.91), uninsured (OR, 0.58; 95% CI, 0.41-0.83), and racial/ethnic minority (African American: OR, 0.51 [95% CI, 0.38-0.69]; Asian: OR, 0.31 [95% CI, 0.10-0.93]; Hispanic: OR, 0.53 [95% CI, 0.36-0.78]) participants were less likely to use prescription smoking cessation medications. Conclusions and Relevance: The lower rates of delivery of physician advice to quit smoking and the lower uptake of known prescription smoking cessation medications among men, younger adults, uninsured individuals, racial/ethnic minority groups, and those without smoking-associated comorbidities may be associated with the higher smoking rates among these subgroups despite an all-time low prevalence of smoking in the United States; this finding calls for a more targeted implementation of smoking cessation guidelines

    Barriers to Creutzfeldt-Jakob Disease Autopsies, California

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    Creutzfeldt-Jakob disease (CJD) surveillance relies on autopsy and neuropathologic evaluation. The 1990–2000 CJD autopsy rate in California was 21%. Most neurologists were comfortable diagnosing CJD (83%), but few pathologists felt comfortable diagnosing CJD (35%) or performing autopsy (29%). Addressing obstacles to autopsy is necessary to improve CJD surveillance

    Assessing the application of gender perspectives in land restoration studies in Ethiopia using text mining

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    Restoration of degraded land is key to enhancing land productivity and farmers' wellbeing in sub-Saharan Africa. Evidence shows that the benefits of land restoration are tremendous, ranging from biophysical benefits in soil health, agricultural productivity, ecosystem services, to socio-economic dimensions such as improving farmers’ income and livelihoods. Yet one issue that is rarely considered is how the outcomes of restoration initiatives affect different social groups, specifically women, men, and the marginalized. Our study aims to understand the extent of gender and social inclusion in land restoration studies in Ethiopia. Through analyzing 314 peer-reviewed scientific articles on land restoration initiatives and studies for Ethiopia published between 1985 and 2020, we aimed to: i) develop a novel approach that would allow for the semi-automatization of analyzing gender aspects in a large set of scientific documents using machine learning techniques, ii) assessed the current evidence on gender integration in peer-reviewed studies related to RDL, and iii) identified what gender issues are discussed in RDL literature. We employed text mining techniques to analyze the literature for keywords and to classify articles into three main classes: gender blind, gender sensitive, and gender transformative, based on the extent to which gender and social inclusion keywords appeared in the studies. Our analysis showed that gender and social inclusion are rarely considered in landscape restoration studies in Ethiopia, as most studies and interventions are heavily focused on the biophysical and environmental aspects of restoration. Despite an exponential increase in the use of gender and social inclusion keywords after 2005, most of the research (58 percent of articles) remains gender blind. The most frequently used related terms remained generic, e.g. community, access, participatory, and tenure. Only 38% of the studies could be classified as gender sensitive to a certain degree, and a strikingly low number of articles (4 percent) ― which consider the systematic challenges women face ― could be defined as gender transformative. This implies that scientific evidence about how land restoration has benefited men and women, and to what extent it could transform gender and power dynamics, is lacking. Our findings demonstrate the urgent need to consider gender and social inclusion to ensure associated benefits of land restoration practices
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