Porous Membranes on a Basis of Phase-separated Alkali Borosilicate Glasses That Contain PbO and F Additives

The influence of PbO or F presence in the phase-separated alkali borosilicate glasses on a kinetic of their acid leaching as well on a structure of the porous glasses received have been investigated. The structure parameters of the two-phase glasses and of the porous glasses were studied by electron microscopy and by adsorption methods. The electrochemical characteristics of the porous glass membranes have been done

Bilingualism and biculturalism and teaching of modern languages: point of view of a teacher of french from Russia

More than 50% of the world's inhabitants are bilingual, and this percentage is expected to be increasing due to the increasing global mobility. Some people are bilingual because of the characteristics of their families, others because of migration, or because they live in a border area or a country that has several languages. Bilingualism is extremely widespread in Russia and in France. In this article, the actual and complex phenomenon of bilingualism in the contemporary cultural situation, in particular in the teaching of foreign languages, is considere

Online medical discourse during the COVID-19 pandemic: semantic categories and attitude

The paper presents the results of the discourse, semantic and sentiment analysis of the medical professional forum publications. Computer-mediated communication (CMC) within the professional community on the portal MirVracha reveals a diversity of peculiarities of medical professional discourse since the portal includes informal posts and chats alongside official and scientific publication

Ethnical and cultural particularity of gluttonic discourse

The article is devoted to ethnic perculiarity and originality of the Russian and British lingvocultures in line with gustative preference

Functional redundancy between flavodiiron proteins and NDH-1 in Synechocystis sp. PCC 6803

In oxygenic photosynthetic organisms, excluding angiosperms, flavodiiron proteins (FDPs) catalyze light-dependent reduction of O(2)to H2O. This alleviates electron pressure on the photosynthetic apparatus and protects it from photodamage. InSynechocystissp. PCC 6803, four FDP isoforms function as hetero-oligomers of Flv1 and Flv3 and/or Flv2 and Flv4. An alternative electron transport pathway mediated by the NAD(P)H dehydrogenase-like complex (NDH-1) also contributes to redox hemostasis and the photoprotection of photosynthesis. Four NDH-1 types have been characterized in cyanobacteria: NDH-1(1)and NDH-1(2), which function in respiration; and NDH-1(3)and NDH-1(4), which function in CO(2)uptake. All four types are involved in cyclic electron transport. Along with single FDP mutants ( increment flv1and Delta flv3) and the double NDH-1 mutants ( increment d1d2, which is deficient in NDH-1(1,2)and increment d3d4, which is deficient in NDH-1(3,4)), we studied triple mutants lacking one of Flv1 or Flv3, and NDH-1(1,2)or NDH-1(3,4). We show that the presence of either Flv1/3 or NDH-1(1,2), but not NDH-1(3,4), is indispensable for survival during changes in growth conditions from high CO2/moderate light to low CO2/high light. Our results show functional redundancy between FDPs and NDH-1(1,2)under the studied conditions. We suggest that ferredoxin probably functions as a primary electron donor to both Flv1/3 and NDH-1(1,2), allowing their functions to be dynamically coordinated for efficient oxidation of photosystem I and for photoprotection under variable CO(2)and light availability

On the Cauchy Problem for the Korteweg-de Vries Equation with Steplike Finite-Gap Initial Data I. Schwartz-Type Perturbations

We solve the Cauchy problem for the Korteweg-de Vries equation with initial conditions which are steplike Schwartz-type perturbations of finite-gap potentials under the assumption that the respective spectral bands either coincide or are disjoint.Comment: 29 page

Клинико-лабораторные аспекты новой коронавирусной инфекции у новорожденных и детей грудного возраста

Purpose: to identify clinical and laboratory aspects of a new coronavirus infection in newborns and infants. Materials and methods: a retrospective analysis of 131 observations of newborns and infants infected with SARS-CoV-2 treated in children's infectious diseases departments of Izhevsk was carried out. Results. The course of coronavirus infection in newborns and infants who became ill on an outpatient basis and were hospitalized did not have significant specific clinical and laboratory features and was similar to the symptoms of major respiratory infections. Among the hospitalized, 80.9% of children had a mild severity of coronavirus infection, the rest of the children had a moderate course. The clinical picture was dominated by cough (86.3%), nasal congestion (74%) and fever (71.8%). Significant clinical differences were obtained in newborns in the form of predominance of nasal obstruction, and in infants in the predominance of fever and dry cough. Pneumonia was diagnosed in 19.1% in the form of a mild, mainly bilateral lesion.Цель: выявление клинических и лабораторных аспектов новой коронавирусной инфекции у новорожденных и детей грудного возраста. Материалы и методы: проведен ретроспективный анализ 131 наблюдения новорожденных и детей грудного возраста, инфицированных SARS-CoV-2, получавших лечение в детских инфекционных отделениях г. Ижевска. Результаты. Течение коронавирусной инфекции у новорожденных и детей грудного возраста, заболевших в амбулаторных условиях и госпитализированных, не имело значимых специфических клинических и лабораторных особенностей и было схоже с симптомами основных респираторных инфекций. Среди госпитализированных у 80,9% детей преобладала легкая степень тяжести коронавирусной инфекции, у остальных детей отмечалось среднетяжелое течение. В клинической картине преобладал кашель (86,3%), заложенность носа (74%) и лихорадка (71,8%). Получены достоверные клинические различия у новорожденных в виде преобладания обструкции носовых ходов, а у грудных детей в превалировании лихорадки и сухого кашля. Пневмония была диагностирована в 19,1% случаев в виде нетяжелого, преимущественно двустороннего, поражения

On Propagation of Excitation Waves in Moving Media: The FitzHugh-Nagumo Model

BACKGROUND: Existence of flows and convection is an essential and integral feature of many excitable media with wave propagation modes, such as blood coagulation or bioreactors. METHODS/RESULTS: Here, propagation of two-dimensional waves is studied in parabolic channel flow of excitable medium of the FitzHugh-Nagumo type. Even if the stream velocity is hundreds of times higher that the wave velocity in motionless medium (), steady propagation of an excitation wave is eventually established. At high stream velocities, the wave does not span the channel from wall to wall, forming isolated excited regions, which we called "restrictons". They are especially easy to observe when the model parameters are close to critical ones, at which waves disappear in still medium. In the subcritical region of parameters, a sufficiently fast stream can result in the survival of excitation moving, as a rule, in the form of "restrictons". For downstream excitation waves, the axial portion of the channel is the most important one in determining their behavior. For upstream waves, the most important region of the channel is the near-wall boundary layers. The roles of transversal diffusion, and of approximate similarity with respect to stream velocity are discussed. CONCLUSIONS: These findings clarify mechanisms of wave propagation and survival in flow

In vitro modeling of tumor interclonal interactions using breast cancer cell lines

In the setting of limited resources, natural selection begins to occur between tumor clones. An experimental model of in vitro tumor heterogeneity would allow us to evaluate various types of biological interactions arising from the joint cultivation of phenotypically different tumor clones. Aim: To study the peculiarities of ecological relationships of breast cancer (BC) cell lines MCF-7, BT-474 and MDA-MD-231 under co-culturing conditions. Materials and Methods: Three BC cell lines: luminal A — MCF-7, luminal B — BT-474 and triple-negative — MDA-MD-231 were co-cultured pairwise. Immunocytochemistry was used to differentiate the cell lines in the wells. The effect of the cell-free culture medium on the growth rate of the alternate cell line in the pair was also evaluated. Results: It was shown that when BT-474 cells were co-cultured with MCF-7 and BT-474 cells were co-cultured with MDA-MD-231, two types of ecological interactions could be observed: commensalism and amensalism, respectively. While the cells do not interact with each other in contact, the supernatants of single cultures of MCF-7 and MDAMD-231 exert the same effect on BT-474 as co-cultivation of BT-474 with these cells. Conclusions: The paracrine mechanism of intercellular interaction between different human BC cell lines has been demonstrated. The models used in population ecology can be applicable to identify the types of interaction between cell lines

Gender differences in the pharmacological actions of pegylated glucagon-Like peptide-1 on endothelial progenitor cells and angiogenic precursor cells in a combination of metabolic disorders and lung emphysema

In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD. In the present study, using sodium glutamate, lipopolysaccharide, and cigarette smoke extract, we simulated lipid metabolism disorders, obesity, hyperglycemia, and pulmonary emphysema (comorbidity) in male and female C57BL/6 mice. We assessed the gender-specific impact of lipid metabolism disorders and pulmonary emphysema on angiogenic precursor cells (endothelial progenitor cells (EPC), pericytes, vascular smooth muscle cells, cells of the lumen of the nascent vessel), as well as the biological effects of pegylated glucagon-like peptide 1 (pegGLP-1) in this experimental paradigm. Simulation of MetS/COPD comorbidity caused an accumulation of EPC (CD45−CD31+CD34+), pericytes, and vascular smooth muscle cells in the lungs of female mice. In contrast, the number of cells involved in the angiogenesis decreased in the lungs of male animals. PegGLP-1 had a positive effect on lipids and area under the curve (AUC), obesity, and prevented the development of pulmonary emphysema. The severity of these effects was stronger in males than in females. Furthermore, PegGLP-1 stimulated regeneration of pulmonary endothelium. At the same time, PegGLP-1 administration caused a mobilization of EPC (CD45−CD31+CD34+) into the bloodstream in females and migration of precursors of angiogenesis and vascular smooth muscle cells to the lungs in male animals. Gender differences in stimulatory action of pegGLP-1 on CD31+ endothelial lung cells in vitro were not observed. Based on these findings, we postulated that the cellular mechanism of in vivo regeneration of lung epithelium was at least partly gender-specific. Thus, we concluded that a pegGLP-1-based treatment regime for metabolic disorder and COPD should be further developed primarily for male patients