Methyl 3-O-α-d-mannopyranosyl β-d-glucopyran­oside tetra­hydrate

The title compound, C13H24O11·4H2O, forms extended hydrogen-bonded networks. These are present between disaccharides, but not as inter-residue hydrogen bonds, as well as to water mol­ecules that in addition form an inter­molecular chain of hydrogen bonds. The conformation of the disaccharide is described by the glycosidic torsion angles ϕH = −34° and ψH = −5°. Macroscopically, the disaccharide was observed to be hygroscopic

Pupil influence in Swedish compulsory schools, a way of 'learning' and 'living' democracy

Peer reviewedPublisher PD

SPOT: a New Monte Carlo Solver for Fast Alpha Particles

12th International Congress on Plasma Physics, 25-29 October 2004, Nice (France)The predictive transport code CRONOS has been augmented by an orbit following Monte Carlo code, SPOT (Simulation of Particle Orbits in a Tokamak). The SPOT code simulates the dynamics of non-thermal particles, and takes into account effects of finite orbit width and collisional transport of fast ions. Recent developments indicate that it might be difficult to avoid, at least transiently, current holes in a reactor. They occur already on existing tokamaks during advanced tokamak scenarios. For this reason the SPOT code has been used to study the alpha particle behaviour in the presence of current holes for both JET and ITER relevant parameters

The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life

BACKGROUND: Protease inhibitor based antiretroviral therapy (PI-ART) was introduced in 1996 and has greatly reduced the incidence of HIV-related morbidity and mortality in the industrialised world. PI-ART would thus be expected to have a positive effect on health-related quality of life (HRQL). On the other hand, HRQL might be negatively affected by strict adherence requirements as well as by short and long-term adverse effects. The aim of this study was to assess the influence of two years of first generation PI-ART on HRQL in patients with a relatively advanced state of HIV-infection. Furthermore, we wanted to investigate the relation between developments in HRQL and viral response, self-reported adherence and subjective experience of adverse effects in patients with PI-ART. METHODS: HRQL was measured by the Swedish Health-Related Quality of Life Questionnaire (SWED-QUAL). Sixty-three items from the SWED-QUAL forms two single-item and 11 multi-item dimension scales. For this study, two summary SWED-QUAL scores (physical HRQL composite score and emotional HRQL composite score) were created through a data reduction procedure. At the 2-year follow-up measurement (see below), items were added to measure adherence and subjective experience of adverse effects. Demographic and medical data were obtained from specific items in the questionnaires and from the medical files. Seventy-two patients who were among the first to receive PI-ART (indinavir or ritonavir based) responded to the questionnaire before the start of PI-ART. Of these, 54 responded to the same instrument after two years of treatment (13 had died, four had changed clinic and one did not receive the questionnaire). RESULTS: The main findings were that the emotional HRQL deteriorated during two years of PI-ART, while the physical HRQL remained stable. Multiple linear regression analyses showed that experience of adverse effects contributed most to the deterioration of emotional HRQL. CONCLUSION: In this sample of patients with relatively advanced state of HIV-infection, our data suggested that a negative development of physical HRQL had been interrupted by the treatment and that the emotional dimension of HRQL deteriorated during two years after start of PI-ART. Subjective experience of adverse effects made a major contribution to the decrease in emotional HRQL. The results underline the importance of including HRQL measures in the evaluation of new life prolonging therapies

Integrated economic and environmental assessment of waste policy instruments

The need for new policy instruments supporting the on-going transition from end-of-pipe waste treatment to resource management has been recognized in European policy. Instruments need to be carefully assessed before implementation to promote the desired changes and avoid problem shifting. Mathematical models may assist policy makers in such assessments. This paper presents a set of soft-linked models for assessing the economic and environmental impacts of policy instruments for both the prevention and management of waste and discusses its strengths and limitations. Consisting of (1) a macro-economic model, (2) a systems engineering model for waste management and (3) a life cycle assessment model for waste management, the set is primarily suited to assessing market-based instruments and environmental regulations. Considerable resources were needed for developing and using the set, and there are clear limits as to what can be addressed. However, if only one of the models had been used, neither the range of instruments nor the scope of impacts would have been possible to cover. Furthermore, soft-linked models allow many disciplines to contribute within one harmonized framework. Such integrated assessments may become increasingly useful for continuing the implementation of policy for sustainable governance of society’s material resources

Blurring the Boundaries Between Medicine and Food: The Canny Marketing of Läkerol in Early Twentieth-Century Sweden

This paper explores the early marketing practices (1910-1940) of the Swedish cough drop brand Läkerol, demonstrating how it capitalised on the “spaces of confusion” posed by the product’s liminality between food and medicine to create a slick marketing campaign inspired by the tried-and-tested formulas of the food industry. Advertisements used a range of strategies, such as expert and role model testimonials, humorous and serious newsjacking and the introduction of a friend-physician brand mascot to extend Läkerol from a cold remedy to an everyday product necessary for fun and excitement. By telling consumers not just about its benefits, but also connoting that it was part of a contemporary way of living, Läkerol was able to incorporate itself into a daily consumerist lifestyle, growing into a trendy and popular brand consumed daily by Swedes as part of a ritualised practice

Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects

AbstractWe investigated the nuclear localization-like sequence KKRPKP, corresponding to the residues 23–28 in the mouse prion protein (mPrP), for its membrane perturbation activity, by comparing effects of two mPrP-derived peptides, corresponding to residues 1–28 (mPrPp(1–28)) and 23–50 (mPrPp(23–50)), respectively. In erythrocytes, mPrPp(1–28) induced ∼60% haemoglobin leakage after 30 min, whereas mPrPp(23–50) had negligible effects. In calcein-entrapping, large unilamellar vesicles (LUVs), similar results were obtained. Cytotoxicity estimated by lactate dehydrogenase leakage from HeLa cells, was found to be ∼12% for 50 μM mPrPp(1–28), and ∼1% for 50 μM mPrPp(23–50). Circular dichroism spectra showed structure induction of mPrPp(1–28) in the presence of POPC:POPG (4:1) and POPC LUVs, while mPrPp(23–50) remained a random coil. Membrane translocation studies on live HeLa cells showed mPrPp(1–28) co-localizing with dextran, suggesting fluid-phase endocytosis, whereas mPrPp(23–50) hardly translocated at all. We conclude that the KKRPKP-sequence is not sufficient to cause membrane perturbation or translocation but needs a hydrophobic counterpart