New methods in provenance studies based on heavy minerals: an example from Miocene sands in Jylland, Denmark

New techniques using Computer Controlled Scanning Electron Microscopy (CCSEM) and Laser Ablation – Inductively Coupled Plasma – Mass Spectroscopy (LA-ICP-MS) have recently been developed at the Geological Survey of Denmark and Greenland (GEUS) to determine source, compositional variation and sedimentary pathways of sandstones. These new time- and cost-efficient methods are highly applicable in petroleum and mineral exploration. This paper illustrates how the provenance and variability of Miocene titanium-rich sands in western and central Jylland have been investigated, but the methods are presently also used offshore the Faroe Islands and in East and West Greenland. CCSEM and LA-ICP-MS utilise simple sample preparation methods, are relatively rapid and less expensive than conventional methods and yield more information

The Billund delta: a possible new giant aquifer in central and western Jutland

The search for new, deep-seated drinking water resources in Denmark has increased significantly during the past five years as a result of the discovery of excessive amounts of nitrate, pesticides and other pollutants in shallow groundwater boreholes (e.g. Nygaard et al. 2004, this volume). To find and map these aquifers, a multidisciplinary sequence stratigraphic approach has successfully been applied to the Miocene deposits of southern Jutland, where especially the Odderup and Ribe Formations are known as a main aquifer for drinking water from several test wells (Rasmussen et al. 2002). Recently, a more systematic study of the Miocene succession in central and western Jutland has been initiated by the Geological Survey of Denmark and Greenland (GEUS) under contract with local authorities. It includes detailed sedimentological descriptions of outcrops, sedimentological and log-interpretations of new stratigraphic boreholes and interpretation of new high-resolution seismic data (Fig. 1). A number of outcrops and wells have been studied palynologically, resulting in a detailed dinoflagellate cyst stratigraphy and in palynofacies interpretations. The results of these studies have been integrated in the regional geological and stratigraphic model (Fig. 2). Two new aquifers have been discovered: the Bastrup sand and the Billund sand. The Bastrup sand has already been exploited as a main aquifer in central and southern Jutland, and has been referred to either the Ribe or Odderup Formations. However, new stratigraphic results reveal that the Bastrup sand is a separate unit in the Miocene succession. The Billund sand is a deep-seated aquifer located more than 100 m and often more than 150 m deep, and is therefore not penetrated by standard water supply wells which rarely reach c. 100 m. The Billund sand was first revealed by multichannel seismic data deriving from former oil-exploration carried out in the Billund area (Fig. 3A). The resolution of these seismic data is very poor, but one interpretation of the dipping reflectors (clinoforms) seen in Fig. 3A was of a delta complex. This agrees with outcrop studies along the fjords of eastern Jutland which suggest that a spit complex was deposited in this area during the Early Miocene. The Billund sand was tested by the Vandel Mark well in 2001, which penetrated c. 40 m of sand at a depth of 200 m. The presence of a regional major sand body was later confirmed by new high-resolution seismic data and by the Billund and Løvlund wells in 2002. The Billund well penetrated 50 m of medium- to coarse-grained sand, and chemical tests of the water quality were good. However, a water supply well at Fjand in western Jutland has had problems with so-called ‘brown water’ – water enriched in organic matter (humus). Saline water may also be expected close to older deep-seated faults. This paper summarises the results of a mapping programme of the Billund sand initiated in the summer of 2003

Long-term enzyme replacement therapy is associated with reduced proteinuria and preserved proximal tubular function in women with Fabry disease

Background Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene. Deficiency of α-galactosidase A (α-Gal A) causes intracellular accumulations of globotriaosylceramide (GL-3) and related glycosphingolipids in all organs, including the kidney, often leading to end-stage renal failure. In women with Fabry disease, accumulation of GL-3 in the glomerular podocytes and other renal cells induces progressive, proteinuric nephropathy, but not as severe as in men. Enzyme replacement therapy (ERT) with recombinant α-Gal A reduces cellular GL-3 deposits in podocytes and tubular epithelial cells. We have previously shown that α-Gal A is delivered to these cells by different pathways involving different receptors. This study investigated the long-term changes in albuminuria, estimated glomerular filtration rate (eGFR) and urinary markers of both glomerular and tubular dysfunction in women with Fabry disease treated with ERT. Methods A retrospective, single centre, cohort study evaluated the long-term association between ERT, albuminuria and eGFR in 13 women with Fabry disease and mild renal involvement. In particular, we analysed the changes in the proteinuric profile, including the glomerular marker IgG, the tubular markers α1-microglobulin and retinol-binding protein (RBP), and the shared tubular and glomerular markers albumin and transferrin. Results ERT was associated with a significant reduction in albuminuria and a relatively stable eGFR. The decrease in albuminuria was paralleled by a decrease in both glomerular and tubular urine protein markers. Conclusions The data indicate that long-term ERT is associated with a reduction in albuminuria and glomerular and tubular urinary protein markers in women with Fabry disease and mild renal manifestation

Pesticide leaching in Danish groundwater: identification of vulnerable areas

In Denmark the supply of drinking water is based almost solely on groundwater. During the past few decades Danish groundwater monitoring has encountered numerous instances of pollution with pesticides and their metabolites (GEUS 2003a). As a result, some hundreds of abstraction wells out of about 8000 in general water supply have been closed. With this background, there is a particular concern for reducing the leaching of pesticides into the groundwater. In the present study an approach for identification of areas potentially prone to pesticide leaching is described. The potential risk of leaching of pesticides from agricultural areas into groundwater is minimised through a procedure of approval; however, some leaching still occurs (GEUS 2003b). The Danish counties are therefore obliged to identify areas where there is a particular risk of pesticide leaching, and where restrictions in use of pesticides may be introduced to reduce the risk (Miljøstyrelsen 2000). The Geological Survey of Denmark and Greenland (GEUS) and the Danish Institute of Agricultural Sciences (DJF) have carried out a project, focusing on sandy agricultural areas, that attempts to establish the necessary background knowledge for identifying areas particularly prone to pesticide leaching. The project aims to distinguish vulnerable and less vulnerable areas, both locally and nationwide, in a cost-effective way

The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study (DOORS)

<p>Abstract</p> <p>Background</p> <p>Coronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be related to the use of cardiopulmonary by-pass (CPB) and aortic cross-clamping. It has been hypothesized that when coronary artery by-pass grafting is performed without the use of CPB, the rate of serious complications is reduced.</p> <p>Methods/Design</p> <p>The trial is designed as an open, randomized, controlled, clinical trial with blinded assessment of end-points. Patients at or above 70 years of age, referred for surgical myocardial revascularisation, are included and randomised to receive coronary artery by-pass grafting either with or without the use of CPB and aortic cross-clamping. Follow-up is performed by clinical, biochemical, electrocardiographic, and angiographic data that are evaluated by independent committees that are blinded with respect to the result of the randomisation. End points include mortality, stroke, myocardial infarction, graft patency, quality of life, and cost-effectiveness. The trial is performed in four different Danish, cardiac surgery centres.</p> <p>Trial registration</p> <p>ClinicalTrials.gov NCT00123981</p