Geotechnical Observations of the November 3, 2002 M7.9 Denali Fault Earthquake

The M 7.9 earthquake of November 3, 2002 event ruptured more than 340 kilometers on three fault, causing widespread liquefaction in the fluvial deposits of steep alpine valleys of the Alaska Range and eastern lowlands of the Tanana River. The event occurred in a remote and largely undeveloped portion of the rugged Alaskan central range, with few seismometer recordings. The areas affected by liquefaction are largely confined to native Holocene river deposits, areas bounded by stiffer ground moraine, Pleistocene uplands, and bedrock. Liquefaction affected areas of alluvial river valleys draining mountainous and glacier-proximal rivers. The most noteworthy observations are that liquefaction damage was focused towards the eastern end of the rupture area. In the western portion of the rupture zone, localized liquefaction developed in recent deposits of the Susitna and Delta rivers in the immediate vicinity of the surface rupture of the fault. More abundant and severe liquefaction occurred on the eastern Robertson, Slana, Tok, Chisana and, especially, Nabesna Rivers. In the Tanana lowland, liquefaction features were sparse on the western bars of the Tanana River in the vicinity of Fairbanks to west of Delta, but became pervasive throughout the eastern region from Delta to Northway. Though liquefaction observations were abundant, there was a dearth of instrumental recordings useful to relate damage effects to measured intensity. To characterize soil properties and stiffness of liquefaction evaluation sites, we used a portable spectral analysis of surface waves (SASW) apparatus to profile the shear wave velocity of the ground. On the Nabesna and Delta rivers that cross the fault, we only observe liquefaction features in soil deposits where normalized shear wave velocities fall below 230 m/s. Severity of sand boils, fissuring and lateral displacement of liquefied ground dramatically increase in soils of lower shear wave velocity, especially below 170 m/s. Some of the most pronounced ground failures are far from the fault zone (60-100 km) in extremely loose, low velocity (~120 m/s) fine sands of the bars of the Tanana River. Strong motion instrumentation was sparse within 150 kilometers of the fault rupture and the seismometers of Alyeska pump stations PS9 (PGA=0.09), PS10 (PGA=0.36g), and PS11 (PGA=0.09) serve as the principal strong motion recordings. Insufficient strong motion instrumentation is available to identify areas of amplified ground motio

Exponentiation of the Drell-Yan cross section near partonic threshold in the DIS and MSbar schemes

It has been observed that in the DIS scheme the refactorization of the Drell-Yan cross section leading to exponentiation of threshold logarithms can also be used to organize a class of constant terms, most of which arise from the ratio of the timelike Sudakov form factor to its spacelike counterpart. We extend this exponentiation to include all constant terms, and demonstrate how a similar organization may be achieved in the MSbar scheme. We study the relevance of these exponentiations in a two-loop analysis.Comment: 20 pages, JHEP style, no figure

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.

To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae. The MITO-MAP provides a comprehensive view of mitochondrial function including insights into the activity of uncharacterized mitochondrial proteins and the functional connection between mitochondria and the ER. The MITO-MAP also reveals a large inner membrane-associated complex, which we term MitOS for mitochondrial organizing structure, comprised of Fcj1/Mitofilin, a conserved inner membrane protein, and five additional components. MitOS physically and functionally interacts with both outer and inner membrane components and localizes to extended structures that wrap around the inner membrane. We show that MitOS acts in concert with ATP synthase dimers to organize the inner membrane and promote normal mitochondrial morphology. We propose that MitOS acts as a conserved mitochondrial skeletal structure that differentiates regions of the inner membrane to establish the normal internal architecture of mitochondria

Recoil and Threshold Corrections in Short-distance Cross Sections

We identify and resum corrections associated with the kinematic recoil of the hard scattering against soft-gluon emission in single-particle inclusive cross sections. The method avoids double counting and conserves the flow of partonic energy. It reproduces threshold resummation for high-p_T single-particle cross sections, when recoil is neglected, and Q_T-resummation at low Q_T, when higher-order threshold logarithms are suppressed. We exhibit explicit resummed cross sections, accurate to next-to-leading logarithm, for electroweak annihilation and prompt photon inclusive cross sections.Comment: minor modifications of the text, some references added. 51 pages, LaTeX, 6 figures as eps file

Prognostic limitations of donor t cell chimerism after myeloablative allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndromes

Donor T cell chimerism is associated with relapse outcomes after allogeneic stem cell transplantation (alloSCT) for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). However, measures of statistical association do not adequately assess the performance of a prognostic biomarker, which is best characterized by its sensitivity and specificity for the chosen outcome. We analyzed donor T cell chimerism results at day 100 (D100chim) after myeloablative alloSCT for AML or MDS in 103 patients and determined its sensitivity and specificity for relapse-free survival at 6 months (RFS6) and 12 months (RFS12) post-alloSCT. The area under the receiver operating characteristic curve for RFS6 was .68, demonstrating only modest utility as a predictive biomarker, although this was greater than RFS12 at .62. Using a D100chim threshold of 65%, the specificity for RFS6 was 96.6%; however, sensitivity was poor at 26.7%. This equated to a negative predictive value of 88.5% and positive predictive value of 57.1%. Changing the threshold for D100chim to 75% or 85% modestly improved the sensitivity of D100chim for RFS6; however, this was at the expense of specificity. D100chim is specific but lacks sensitivity as a prognostic biomarker of early RFS after myeloablative alloSCT for AML or MDS. Caution is required when using D100chim to guide treatment decisions including immunologic manipulation, which may expose patients to unwarranted graft-versus-host disease

The Leading Particle Effect from Heavy-Quark Recombination

The leading particle effect in charm hadroproduction is an enhancement of the cross section for a charmed hadron D in the forward direction of the beam when the beam hadron has a valence parton in common with the D. The large D+/D- asymmetry observed by the E791 experiment is an example of this phenomenon. We show that the heavy-quark recombination mechanism provides an economical explanation for this effect. In particular, the D+/D- asymmetry can be fit reasonably well using a single parameter whose value is consistent with a recent determination from charm photoproduction.Comment: Revtex file, 4 pages, 3 figure

Next-to-Leading Order Cross Sections for Tagged Reactions

We extend the phase space slicing method of Giele, Glover and Kosower for performing next-to-leading order jet cross section calculations in two important ways: we show how to include fragmentation functions and how to include massive particles. These extensions allow the application of this method to not just jet cross sections but also to cross sections in which a particular final state particle, including a $D$ or $B$-meson, is tagged.Comment: 36 pages, Latex Small corrections to text. To appear in Phys. Rev.

GJ 1252 b: A 1.2 R\u3csub\u3e⊕\u3c/sub\u3e Planet Transiting An M3 Dwarf At 20.4 pc

We report the discovery of GJ 1252 b, a planet with a radius of 1.193 ± 0.074 R⊕ and an orbital period of 0.52 days around an M3-type star (0.381 ± 0.019 M⊕, 0.391 ± 0.020 R⊕) located 20.385 ± 0.019 pc away. We use Transiting Exoplanet Survey Satellite (TESS) data, ground-based photometry and spectroscopy, Gaia astrometry, and high angular resolution imaging to show that the transit signal seen in the TESS data must originate from a transiting planet. We do so by ruling out all false-positive scenarios that attempt to explain the transit signal as originating from an eclipsing stellar binary. Precise Doppler monitoring also leads to a tentative mass measurement of 2.09 ± 0.56 M⊕. The host star proximity, brightness (V = 12.19 mag, K = 7.92 mag), low stellar activity, and the system\u27s short orbital period make this planet an attractive target for detailed characterization, including precise mass measurement, looking for other objects in the system, and planet atmosphere characterization

Heavy Flavours at Colliders

I review some topics in the production and decays of heavy flavours that are relevant for collider physics. In particular, I discuss the present status and some recent progress related to masses, parton densities and fragmentation functions of heavy quarks, as well as threshold resummation, polarized onium production at high transverse momentum, and a factorization theorem for $B \to\pi\pi$ decays.Comment: 12 pages. Plenary talk given at UK Phenomenology Workshop on Collider Physics, Durham, England, 19-24 Sep 1999 Comments and references adde