Forced and Aeroelastic Responses of Bird-Damaged Fan Blades: A Comparison and Its Implications

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140641/1/1.C033424.pd

Aeroelastic Response of Bird-Damaged Fan Blades Using a Coupled CFD/CSD Framework

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140712/1/6.2014-0334.pd

Tunneling and Quantum Noise in 1-D Luttinger Liquids

We study non-equilibrium noise in the transmission current through barriers in 1-D Luttinger liquids and in the tunneling current between edges of fractional quantum Hall liquids. The distribution of tunneling events through narrow barriers can be described by a Coulomb gas lying in the time axis along a Keldysh (or non-equilibrium) contour. The charges tend to reorganize as a dipole gas, which we use to describe the tunneling statistics. Intra-dipole correlations contribute to the high-frequency ``Josephson'' noise, which has an algebraic singularity at $\omega=e^*V/\hbar$, whereas inter-dipole correlations are responsible for the low-frequency noise. Inter-dipole interactions give a $1/t^2$ correlation between the tunneling events that results in a $|\omega|$ singularity in the noise spectrum. We present a diagrammatic technique to calculate the correlations in perturbation theory, and show that contributions from terms of order higher than the dipole-dipole interaction should only affect the strength of the $|\omega|$ singularity, but its form should remain $\sim |\omega|$ to all orders in perturbation theory.Comment: RevTex, 9 figures available upon request, cond-mat/yymmnn

High-Resolution 3D MR Microangiography of the Rat Ocular Circulation

To develop high-spatial-resolution magnetic resonance (MR) microangiography techniques to image the rat ocular circulation

Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus

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Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.

Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter

Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine

Background: Methamphetamine (METH), an abused illicit drug, disrupts many cellular processes, including energy metabolism, spermatogenesis, and maintenance of oxidative status. However, many components of the molecular underpinnings of METH toxicity have yet to be established. Network analyses of integrated proteomic, transcriptomic and metabolomic data are particularly well suited for identifying cellular responses to toxins, such as METH, which might otherwise be obscured by the numerous and dynamic changes that are induced. Methodology/Results: We used network analyses of proteomic and transcriptomic data to evaluate pathways in Drosophila melanogaster that are affected by acute METH toxicity. METH exposure caused changes in the expression of genes involved with energy metabolism, suggesting a Warburg-like effect (aerobic glycolysis), which is normally associated with cancerous cells. Therefore, we tested the hypothesis that carbohydrate metabolism plays an important role in METH toxicity. In agreement with our hypothesis, we observed that increased dietary sugars partially alleviated the toxic effects of METH. Our systems analysis also showed that METH impacted genes and proteins known to be associated with muscular homeostasis/ contraction, maintenance of oxidative status, oxidative phosphorylation, spermatogenesis, iron and calcium homeostasis. Our results also provide numerous candidate genes for the METH-induced dysfunction of spermatogenesis, which have not been previously characterized at the molecular level. Conclusion: Our results support our overall hypothesis that METH causes a toxic syndrome that is characterized by the altered carbohydrate metabolism, dysregulation of calcium and iron homeostasis, increased oxidative stress, and disruption of mitochondrial functions

Toward Identifying the Next Generation of Superfund and Hazardous Waste Site Contaminants

Reproduced with permission from Environmental Health Perspectives."This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants." doi:10.1289/ehp.1002497Our aim was to initiate a dynamic, adaptable process for identifying contaminants of emerging concern (CECs) that are likely to be found in future hazardous waste sites, and to identify the gaps in primary research that cause uncertainty in determining future hazardous waste site contaminants. Superfund-relevant CECs can be characterized by specific attributes: they are persistent, bioaccumulative, toxic, occur in large quantities, and have localized accumulation with a likelihood of exposure. Although still under development and incompletely applied, methods to quantify these attributes can assist in winnowing down the list of candidates from the universe of potential CECs. Unfortunately, significant research gaps exist in detection and quantification, environmental fate and transport, health and risk assessment, and site exploration and remediation for CECs. Addressing these gaps is prerequisite to a preventive approach to generating and managing hazardous waste sites.Support for the workshop, from which this article evolved, was provided by the National Institute of Environmental Health Sciences Superfund Research Program (P42-ES04940)

A Reconciled Estimate of Ice-Sheet Mass Balance

We combined an ensemble of satellite altimetry, interferometry, and gravimetry data sets using common geographical regions, time intervals, and models of surface mass balance and glacial isostatic adjustment to estimate the mass balance of Earth's polar ice sheets. We find that there is good agreement between different satellite methods-especially in Greenland and West Antarctica-and that combining satellite data sets leads to greater certainty. Between 1992 and 2011, the ice sheets of Greenland, East Antarctica, West Antarctica, and the Antarctic Peninsula changed in mass by -142 plus or minus 49, +14 plus or minus 43, -65 plus or minus 26, and -20 plus or minus 14 gigatonnes year(sup 1), respectively. Since 1992, the polar ice sheets have contributed, on average, 0.59 plus or minus 0.20 millimeter year(sup 1) to the rate of global sea-level rise