4,813 research outputs found
Predictors of Gains During Inpatient Rehabilitation in Patients with Stroke- A Review.
Stroke remains a major cause of disability. The cost of stroke rehabilitation is substantial. Understanding the factors that predict response to inpatient stroke rehabilitation may be useful, for example, to best individualize the content of therapy, or to maximize the efficiency with which resources are directed. This review reviewed the literature and found that numerous variables were associated with outcome after inpatient stroke rehabilitation. The strongest evidence exists for factors such as age, stroke subtype, nutritional status, psychosocial factors such as living with family prior to stroke or presence of a caregiver. Functional status on admission, urinary incontinence, post-stroke infection, and aphasia each can also impact prognosis. Strengths and weaknesses of cited studies are considered in an attempt to inform design of future studies examining the factors that predict response to inpatient rehabilitation after stroke
Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment
The skeletal system is of paramount importance in advanced stage prostate cancer (PCa) as it is the preferred site of metastasis. Complex mechanisms are employed sequentially by PCa cells to home to and colonize the bone. Bone-resident PCa cells then recruit osteoblasts (OBs), osteoclasts (OCs), and macrophages within the niche into entities that promote cancer cell growth and survival. Since PCa is heavily reliant on androgens for growth and survival, androgen-deprivation therapy (ADT) is the standard of care for advanced disease. Although it significantly improves survival rates, ADT detrimentally affects bone health and significantly increases the risk of fractures. Moreover, whereas the majority patients with advanced PCa respond favorably to androgen deprivation, most experience a relapse of the disease to a hormone-refractory form within 1-2 years of ADT. The tumor adapts to surviving under low testosterone conditions by selecting for mutations in the androgen receptor (AR) that constitutively activate it. Thus, AR signaling remains active in PCa cells and aids in its survival under low levels of circulating androgens and additionally allows the cancer cells to manipulate the bone microenvironment to fuel its growth. Hence, AR and its downstream effectors are attractive targets for therapeutic interventions against PCa. Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2), was recently identified as a key downstream target of AR in coordinating PCa cell growth, survival, and migration. Additionally, this multifunctional serine/threonine protein kinase is a critical mediator of bone remodeling and macrophage function, thus emerging as an attractive therapeutic target downstream of AR in controlling metastatic PCa and preventing ADT-induced bone loss. Here, we discuss the role played by AR-CaMKK2 signaling axis in PCa survival, metabolism, cell growth, and migration as well as the cell-intrinsic roles of CaMKK2 in OBs, OCs, and macrophages within the bone microenvironment
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Evaluating Firm-Level Expected-Return Proxies
We develop and implement a rigorous analytical framework for empirically evaluating the relative performance of firm-level expected-return proxies (ERPs). We show that superior proxies should closely track true expected returns both cross-sectionally and over time (that is, the proxies should exhibit lower measurement-error variances). We then compare five classes of ERPs nominated in recent studies to demonstrate how researchers can easily implement our two-dimensional evaluative framework. Our empirical analyses document a tradeoff between time-series and cross-sectional ERP performance, indicating the optimal choice of proxy may vary across research settings. Our results illustrate how researchers can use our framework to critically evaluate and compare a growing body of ERPs
QCD Radiative Corrections to the Leptonic Decay Rate of the B_c Meson
The QCD radiative corrections to the leptonic decay rate of the meson
are calculated using the formalism of nonrelativistic QCD (NRQCD) to separate
short-distance and long-distance effects. The decay constant is factored
into a sum of NRQCD matrix elements each multiplied by a short-distance
coefficient. The short-distance coefficient for the leading matrix element is
calculated to order by matching a perturbative calculation in full
QCD with the corresponding perturbative calculation in NRQCD. This
short-distance correction decreases the leptonic decay rate by approximately
.Comment: Changed Eq. 2 to read 1/(8 \pi), put in a missing i M_{B_c} in Eq.
18, and put in a normalisation factor of 2 M_{B_c} in Eq. 19
Unique molecular identifier-based high-resolution HLA typing and transcript quantitation using long-read sequencing
HLA typing provides essential results for stem cell and solid organ transplants, as well as providing diagnostic benefits for various rheumatology, gastroenterology, neurology, and infectious diseases. It is becoming increasingly clear that understanding the expression of patient HLA transcripts can provide additional benefits for many of these same patient groups. Our study cohort was evaluated using a long-read RNA sequencing methodology to provide rapid HLA genotyping results and normalized HLA transcript expression. Our assay used NGSEngine to determine the HLA genotyping result and normalized mRNA transcript expression using Athlon2. The assay demonstrated an excellent concordance rate of 99.7%. Similar to previous studies, for the class I loci, patients demonstrated significantly lower expression o
Multi-Mission Power Analysis Tool (MMPAT) Version 3
The Multi-Mission Power Analysis Tool (MMPAT) simulates a spacecraft power subsystem including the power source (solar array and/or radioisotope thermoelectric generator), bus-voltage control, secondary battery (lithium-ion or nickel-hydrogen), thermostatic heaters, and power-consuming equipment. It handles multiple mission types including heliocentric orbiters, planetary orbiters, and surface operations. Being parametrically driven along with its user-programmable features can reduce or even eliminate any need for software modifications when configuring it for a particular spacecraft. It provides multiple levels of fidelity, thereby fulfilling the vast majority of a project s power simulation needs throughout the lifecycle. It can operate in a stand-alone mode with a graphical user interface, in batch mode, or as a library linked with other tools. This software can simulate all major aspects of a spacecraft power subsystem. It is parametrically driven to reduce or eliminate the need for a programmer. Added flexibility is provided through user-designed state models and table-driven parameters. MMPAT is designed to be used by a variety of users, such as power subsystem engineers for sizing power subsystem components; mission planners for adjusting mission scenarios using power profiles generated by the model; system engineers for performing system- level trade studies using the results of the model during the early design phases of a spacecraft; and operations personnel for high-fidelity modeling of the essential power aspect of the planning picture
Spin- and charge-density waves in the Hartree-Fock ground state of the two-dimensional Hubbard model
The ground states of the two-dimensional repulsive Hubbard model are studied
within the unrestricted Hartree-Fock (UHF) theory. Magnetic and charge
properties are determined by systematic, large-scale, exact numerical
calculations, and quantified as a function of electron doping . In the
solution of the self-consistent UHF equations, multiple initial configurations
and simulated annealing are used to facilitate convergence to the global
minimum. New approaches are employed to minimize finite-size effects in order
to reach the thermodynamic limit. At low to moderate interacting strengths and
low doping, the UHF ground state is a linear spin-density wave (l-SDW), with
antiferromagnetic order and a modulating wave. The wavelength of the modulating
wave is . Corresponding charge order exists but is substantially weaker
than the spin order, hence holes are mobile. As the interaction is increased,
the l-SDW states evolves into several different phases, with the holes
eventually becoming localized. A simple pairing model is presented with
analytic calculations for low interaction strength and small doping, to help
understand the numerical results and provide a physical picture for the
properties of the SDW ground state. By comparison with recent many-body
calculations, it is shown that, for intermediate interactions, the UHF solution
provides a good description of the magnetic correlations in the true ground
state of the Hubbard model.Comment: 13 pages, 17 figure, 0 table
Perturbative QCD Fragmentation Functions for and Production
The dominant production mechanism for bound states in high
energy processes is the production of a high energy or quark,
followed by its fragmentation into the state. We calculate the
fragmentation functions for the production of the S-wave states and
to leading order in the QCD coupling constant. The fragmentation
probabilities for and
are approximately and , while those
for and are smaller by almost two
orders of magnitude.Comment: Latex, 12 pages, 3 figures available upon request, NUHEP-TH-93-
Anomalous Exponent of the Spin Correlation Function of a Quantum Hall Edge
The charge and spin correlation functions of partially spin-polarized edge
electrons of a quantum Hall bar are studied using effective Hamiltonian and
bosonization techniques. In the presence of the Coulomb interaction between the
edges with opposite chirality we find a different crossover behavior in spin
and charge correlation functions. The crossover of the spin correlation
function in the Coulomb dominated regime is characterized by an anomalous
exponent, which originates from the finite value of the effective interaction
for the spin degree of freedom in the long wavelength limit. The anomalous
exponent may be determined by measuring nuclear spin relaxation rates in a
narrow quantum Hall bar or in a quantum wire in strong magnetic fields.Comment: 4 pages, Revtex file, no figures. To appear in Physical Revews B,
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