Correlation of [18F]FDG PET activity with expressions of Ki-67 in non-small-cell lung cancer

Background: Lung carcinoma is the most commonly diagnosed cancer throughout the world and is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for up to 80% of newly diagnosed lung cancer cases. This study aimed to investigate the relationship between Ki-67 proliferation index (PI) and the maximum standardized uptake value (SUVmax) obtained from [18F]FDG PET/CT in NSCLCs and whether prognosis was predicted with SUVmax values.Material and methods: This retrospective study included biopsy and resection materials of 41 patients, who were examined in the pathology laboratory of Konya Training and Research Hospital between January 2010 and December 2019, and diagnosed with NSCLC, and whose [18F]FDG PET/CT images were present.Results: There was no significant difference between histopathological subtypes in terms of age (p = 0.077), Ki-67 PI (p = 0.454), and SUVmax (p = 0.143). No correlation was observed between Ki-67 PI and SUVmax values obtained from [18F]FDG PET/CT (p = 0.338, r = 0.153). There was no significant correlation between Ki-67 PI and tumor diameter (p = 0.531). The SUVmax value was found to be lower (12.78 ± 6.14) in tumors measuring ≤ 2.5 in diameter and higher (18.46 ± 7.81) in tumors measuring > 2.5 cm (p = 0.027). Metastases not proven histopathologically but detected in [18F]FDG PET/CT were found to have no significant correlation with Ki-67 and SUVmax values (p = 0.881, p = 0.837).Conclusions: This study showed that there was no significant relationship between Ki-67 PI and SUVmax value obtained from [18F]FDG PET/CT in NSCLC tumors

Case Report Pulmonary Hyalinizing Granuloma Mimicking Metastatic Lung Cancer

Pulmonary hyalinizing granuloma is a very rare benign condition, which usually manifests as solitary and sometimes as multiple pulmonary nodules. Deposition of immune complexes in the lung parenchyma due to hypersensitivity reactions is implicated in the etiology of pulmonary hyalinizing granuloma. A 59-year-old female patient who presented to our clinic with complaints of chest pain and cough had bilateral, multiple, and rounded lesions with regular margins suggesting metastatic lung disease. A transthoracic needle biopsy of the nodule was performed in the left pulmonary anterior segment. Biopsy showed no malignancy. Since no diagnosis was made by the biopsy, the patient underwent a video-assisted thoracic surgery. The wedge biopsy reported pulmonary hyalinizing granuloma. We aimed to present the diagnosis and treatment stages of our patient who was diagnosed with pulmonary hyalinizing granuloma in the light of literature review

Schwannom; 10 yıllık tek merkez deneyimi

Amaç: Schwannomlar, Schwann hücrelerinden köken alan benign periferik sinir kılıfı tümörleridir.Sıklıkla asemptomatik, yavaş büyüyen, gerçek kapsülle çevrili, kesit yüzü pembe, beyaz-sarı renkli, genellikle küçük tümörlerdir. Bu çalışmanın amacı schwannomların görülme yaşı, cinsiyet, boyut, yerleşim yeri gibi özelliklerini ortaya koymak ve bu özellikler arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Konya Eğitim ve Araştırma Hastanesi Patoloji Kliniği’nde 2008-2018 yılları arasında schwannom tanısı alan hastaların verileri retrospektif olarak incelendi. Bulgular: Olguların yaş ortalaması 41.25±18.4’dür. Schwannomlar ortalama 2.96±2.1 cm çapındadır. 101 olgunun 51’i erkek, 50’si kadındır. Olguların 76’sında %75.3 tümör dermal ve subkutan, 11’inde %10.9 mediastinal, 11’inde %10.9 intraabdominal, 3’ünde %2.9 intrakranial ve spinal yerleşimlidir. Dermal ve subkutan schwannomlar DSS ’ın 39’u %51.3 ekstremite, 22’si %29 baş-boyun bölgesi, 15’i %19.7 gövde yerleşimlidir. 97 olguda tümör soliter ve sporadiktir. İntraabdominal schwannomlar İAS ’ın9’u %81.8 kadın, 2’si %18.2 erkektir. Ortalama tümör çapı DSS’da 2.32±1.58 cm, intrakraniyal ve spinal schwannomlar İKSS da 3.40±0.79 cm, mediastinal schwannomlar MS ’da 5.26±2.28 cm, İAS’da 5.00±2.62 cm’dir. MS’lu bir olguda eksizyondan bir yıl sonra tümör nüks etmiştir. Sonuç: Schwannomlar en sık 5.dekatta, genellikle 5 cm’den küçük, sıklıkla dermal ve subkutan yerleşimli olarakekstremite ve baş-boyun bölgesinde, her iki cinsiyette eşit sıklıkta, büyük çoğunluğu soliter ve sporadik olarak izlendi. İAS kadınlarda daha sıktır. DSS,MS ve İAS’lardan daha küçüktür. Nüks nadirdir

Pulmonary Hyalinizing Granuloma Mimicking Metastatic Lung Cancer

Pulmonary hyalinizing granuloma is a very rare benign condition, which usually manifests as solitary and sometimes as multiple pulmonary nodules. Deposition of immune complexes in the lung parenchyma due to hypersensitivity reactions is implicated in the etiology of pulmonary hyalinizing granuloma. A 59-year-old female patient who presented to our clinic with complaints of chest pain and cough had bilateral, multiple, and rounded lesions with regular margins suggesting metastatic lung disease. A transthoracic needle biopsy of the nodule was performed in the left pulmonary anterior segment. Biopsy showed no malignancy. Since no diagnosis was made by the biopsy, the patient underwent a video-assisted thoracic surgery. The wedge biopsy reported pulmonary hyalinizing granuloma. We aimed to present the diagnosis and treatment stages of our patient who was diagnosed with pulmonary hyalinizing granuloma in the light of literature review

Perianal Median Raphe Cyst: A Rare Lesion with Unusual Histology and Localization

Median raphe cysts present anywhere between the external urethral meatus and the anus. The cysts can occur at parameatus, glans penis, penile shaft, scrotum, or perineum. Perianal region is an extremely rare location for these lesions. Here we present a 50-year-old male patient who presented with a cystic, fluctuant lesion, located at 12 o’clock in perianal region. Microscopic examination revealed a cystic lesion with keratinized and nonkeratinized stratified squamous epithelium, pseudostratified ciliated epithelium, and scattered goblet cells. The final diagnosis of the lesion was median raphe cyst. Ciliated cells and perianal localization in median raphe cysts are extremely rare characteristics

Alt ekstremitenin akut iskemisi ile tetiklenen pyoderma gangrenosum: Olgu sunumu

Uǧur, Oǧuz ( Aksaray, Yazar )Pyoderma gangrenosum is a very rare condition of unclear etiology with an estimated incidence of 3 to 10 cases per million people per year. We report a case of pyoderma gangrenosum triggered by acute ischemia of lower extremity without a prior history. Seventy-seven years old female patient was admitted to the emergency department with necrosis on the anterior side of her left limb. Digital subtraction arteriography revealed total occlusion of the left common femoral artery for which thrombectomy under local anesthesia was performed successfully. The necrotic area was debrided and biopsies were obtained. Pathological examination revealed pyoderma gangrenosum and steroid treatment was began. The patient was discharged on the 10th postoperative day with prednisone 48 mg per day for the following 30 days. During the management of ischemic peripheral artery disease patients with persistent skin findings, pyoderma gangrenosum should be in the list of differential diagnoses

Ectopic Cushing's syndrome due to adrenocorticotropic hormone secreting atypical thymic carcinoid tumor

WOS: 000460612600015PubMed ID: 31180388Cushing's syndromes (CS) due to thymic carcinoids are rarely seen. In this text, a case with CS due to ectopic adrenocorticotropic hormone (ACTH) secreting atypical thymic carcinoid tumor is presented. A 50-year-old Turkish male patient was admitted to our emergency department with typical CS features. Basal hormone profile, low-and high-dose dexamethasone suppression tests, and inferior petrosal sinus sampling results were consistent with ectopic ACTH secretion. Thorax computerized tomography showed an upper mediastinal mass, and trans-thoracic biopsy showed atypical thymic carcinoid with positive ACTH staining. Since the vascular invasion was detected, tumor was accepted inoperable; somatostatine receptor analogs, chemotherapy, and radiotherapy were planned. Ectopic CS can be derived from atypical thymic carcinoid. In this case, ACTH staining was used to confirm ACTH secretion from thymic tissue, and positive staining was detected. ACTH staining routinely was not performed for extra hypophyseal tissue tumors. In suspicious and difficult cases, ACTH staining can be helpful to confirm the presence of ACTH in tumor tissues

Nasopharyngeal carcinoma in a child with Kartagener's syndrome

Background. Kartagener's syndrome, a subgroup of primary ciliary dyskinesia, is characterized by situs inversus totalis, chronic sinusitis and bronchiectasis. To date, the association of malignant diseases and Kartagener's syndrome has been reported and all cases except angioimmunoblastic T cell lymphoma in a child have been seen in adulthood