A Development Environment for Visual Physics Analysis

The Visual Physics Analysis (VISPA) project integrates different aspects of physics analyses into a graphical development environment. It addresses the typical development cycle of (re-)designing, executing and verifying an analysis. The project provides an extendable plug-in mechanism and includes plug-ins for designing the analysis flow, for running the analysis on batch systems, and for browsing the data content. The corresponding plug-ins are based on an object-oriented toolkit for modular data analysis. We introduce the main concepts of the project, describe the technical realization and demonstrate the functionality in example applications

Noise-Induced Transition from Translational to Rotational Motion of Swarms

We consider a model of active Brownian agents interacting via a harmonic attractive potential in a two-dimensional system in the presence of noise. By numerical simulations, we show that this model possesses a noise-induced transition characterized by the breakdown of translational motion and the onset of swarm rotation as the noise intensity is increased. Statistical properties of swarm dynamics in the weak noise limit are further analytically investigated.Comment: 7 pages, 7 figure

Universal deformation rings of modules for algebras of dihedral type of polynomial growth

Let k be an algebraically closed field, and let \Lambda\ be an algebra of dihedral type of polynomial growth as classified by Erdmann and Skowro\'{n}ski. We describe all finitely generated \Lambda-modules V whose stable endomorphism rings are isomorphic to k and determine their universal deformation rings R(\Lambda,V). We prove that only three isomorphism types occur for R(\Lambda,V): k, k[[t]]/(t^2) and k[[t]].Comment: 11 pages, 2 figure

Concepts, Developments and Advanced Applications of the PAX Toolkit

The Physics Analysis eXpert (PAX) is an open source toolkit for high energy physics analysis. The C++ class collection provided by PAX is deployed in a number of analyses with complex event topologies at Tevatron and LHC. In this article, we summarize basic concepts and class structure of the PAX kernel. We report about the most recent developments of the kernel and introduce two new PAX accessories. The PaxFactory, that provides a class collection to facilitate event hypothesis evolution, and VisualPax, a Graphical User Interface for PAX objects

Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness.

Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and the proper engagement of its intracellular signal effector proteins. Src homology (SH) 2 domain-containing leukocyte protein of 65 kDa (SLP65) is the key scaffold protein mediating BCR signaling. In resting B cells, SLP65 colocalizes with Cbl-interacting protein of 85 kDa (CIN85) in cytoplasmic granules whose formation is not fully understood. Here we show that effective B cell activation requires tripartite phase separation of SLP65, CIN85, and lipid vesicles into droplets via vesicle binding of SLP65 and promiscuous interactions between nine SH3 domains of the trimeric CIN85 and the proline-rich motifs (PRMs) of SLP65. Vesicles are clustered and the dynamical structure of SLP65 persists in the droplet phase in vitro. Our results demonstrate that phase separation driven by concerted transient interactions between scaffold proteins and vesicles is a cellular mechanism to concentrate and organize signal transducers

Перспективы развития биотехнологий

В статье затронуты проблемы демографического кризиса. Рассмотрены вопросы развития биотехнологий, а так же существующие виды биотехнологий. Более глубоко рассмотрен такой вид биотехнологии как биомедицина, представлены существующие наработки ученых в этой сфере. При изучении был сделан вывод, что развитие биотехнологии, в честности биомедицины приведет к повышению продолжительности жизни, а вследствие решения демографической проблемы.The article touches upon the problems of the demographic crisis. The questions of development of biotechnologies, as well as existing types of biotechnologies are considered. Deeply considered this kind of biotechnology as biomedicine, presents the existing developments of scientists in this field. The study concluded that the development of biotechnology, in the honesty of biomedicine, will lead to an increase in life expectancy, and as a result of solving the demographic problem

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.

Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences and HLA-II allelic data, we identified 29 HLA-II associated HIV sequence polymorphisms or adaptations (HLA-AP) in an African cohort of chronically HIV-infected individuals. Epitopes encompassing the predicted adaptation (AE) or its non-adapted (NAE) version were evaluated for immunogenicity. Using a CD8-depleted IFN-γ ELISpot assay, we determined that the magnitude of CD4+ T cell responses to the predicted epitopes in controllers was higher compared to non-controllers (p<0.0001). However, regardless of the group, the magnitude of responses to AE was lower as compared to NAE (p<0.0001). CD4+ T cell responses in patients with acute HIV infection (AHI) demonstrated poor immunogenicity towards AE as compared to NAE encoded by their transmitted founder virus. Longitudinal data in AHI off antiretroviral therapy demonstrated sequence changes that were biologically confirmed to represent CD4+ escape mutations. These data demonstrate an innovative application of HLA-associated polymorphisms to identify biologically relevant CD4+ epitopes and suggests CD4+ T cells are active participants in driving HIV evolution