Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine

The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia- reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ischemia-reperfusion (IR) injury. A total of 30 male Wistar albino rats were equally divided into three groups to be subjected to (i) sham operation (sham), (ii) IR injury via Pringle maneuver (pringle) or (iii) infliximab (IFX) group (IFX was given at a dose 3 mg/kg for 3 days before IR injury). Following reperfusion period of 60 min., intestinal tissue and blood samples were taken and processed by standard histological methods. The Pringle maneuver and following reperfusion caused significant histopathological changes, increased serum transaminases’ activity and the levels of oxidative stress markers and decreased glutathione peroxidase activity. IFX pretreatment partially prevented these changes. Infliximab pretreatment may protect intestinal mucosa against ischemia-reperfusion injury. Further studies are needed to investigate mechanism and evaluate safety and optimal dosing of IFX in humans exposed to the possible tissue damage by ischemia-reperfusion. (Folia Histochemica et Cytobiologica 2014, Vol. 52, No. 1, 36–41

BETTER PATIENT OUTCOMES AND EARLIER DIAGNOSIS OF BRAIN DEATH WITH TRANSCRANIAL AND CAROTID ARTERY DOPPLER ULTRASOUND

WOS: 000411688505179[No abstract available

In vitro evaluation of antimicrobial features of vasopressors

Background: Drugs administered as intravenous infusion may be contaminated during several stages of production or preparation. However studies focusing on antibacterial effects of vasopressor drugs are very rare. This study investigates the in vitro antimicrobial activity of the clinically used forms of vasopressors. Materials and methods: In vitro antimicrobial activities of vasopressor drugs of different concentrations were investigated by using the micro dilution technique. Microorganisms used in the test were Escherichia coli ATCC 25922, Yersinia pseudotuberculosis ATCC 911, Pseudomonas aeruginosa ATCC 10145, Listeria monocytogenes ATCC 43251, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Bacillus cereus 702 Roma, Mycobacterium smegmatis ATCC607, Candida albicans ATCC 60193, and Saccharomyces cerevisiae RSKK 251. Antibacterial assays were performed in Mueller-Hinton broth at pH 7.3 and antifungal assays were performed in buffered Yeast Nitrogen Base at pH 7.0. Results: Two different dopamine preparations showed antimicrobial activity. No other study drug showed any antimicrobial activity. Conclusions: In our opinion, dopamine's antibacterial effects may be advantageous for inhibiting the spread of bacterial contamination during the preparation of the infusion solutions. However, it is important that strict guidelines regarding the need for sterile equipment and deliverables be adhered to during all procedures performed in the intensive care units. Keywords: Antimicrobial activities, Vasopressor drugs, Drug contaminatio

Anti-Nociceptive, Analgesic and Pathohistological Effects of Intrathecal Dexmedetomidine and Bupivacaine in Rats Original Research Article

WOS: 00033012430000

Efficacy of Continuous Epidural Analgesia versus Total Intravenous Analgesia on Postoperative Pain Control in Endovascular Abdominal Aortic Aneurysm Repair: A Retrospective Case-Control Study

Erdivanli, Basar/0000-0002-3955-8242; Ozdemir, Abdullah/0000-0002-4778-9622WOS: 000334764100001PubMed: 24804201We reviewed our experience to compare the effectiveness of epidural analgesia and total intravenous analgesia on postoperative pain control in patients undergoing endovascular abdominal aortic aneurysm repair. Records of 32 patients during a 2- year period were retrospectively investigated. TIVA group (n - 18) received total intravenous anesthesia, and EA group (n - 14) received epidural anesthesia and sedation. Pain assessment was performed on all patients on a daily basis during rest and activity on postoperative days until discharge from ward using the numeric rating scale. Data for demographic variables, required anesthetic level, perioperative hemodynamic variables, postoperative pain, and morbidities were recorded. There were no relevant differences concerning hospital stay (TIVA group: 14.1 +/- 7.0, EA group: 13.5 +/- 7.1), perioperative blood pressure variability (TIVA group: 15.6 +/- 18.1, EA group: 14.8 +/- 11.5), and perioperative hemodynamic complication rate (TIVA group: 17%, EA group: 14%). Postoperative pain scores differed significantly (TIVA group: 5.4 +/- 0.9, EA group: 1.8 +/- 0.8, < 0.001). Epidural anesthesia and postoperative epidural analgesia better reduce postoperative pain better compared with general anesthesia and systemic analgesia, with similar effects on hemodynamic status

Anesthesiologists' Choice of Nutritional Therapy of Intensive Care Patients: A Survey Study

Ozdemir, Abdullah/0000-0002-4778-9622WOS: 000422270200003Objective: Providing adequate nutrition to critical patients as early as possible following internalization is important. Hospitalized patients are among the highest risk groups for malnutrition. Material and Method: A questionnaire including 21 questions about clinician's demographics and nutritional therapies in intensive care units was e-mailed to anesthesiologists only. Partially answered questionnaires were not included in the analysis. Results: A total of 121 questionnaires were analyzed. Every three out of four clinician reported application of nutritional therapy in intensive care unit, and according to the guidelines. While 75% of the clinicians following the guidelines were routinely evaluating nutritional status of their patients, this ratio was only 19% in clinicians not following the guidelines (p=0.0003). Enteral nutrition was the first choice of all clinicians, and majority of the clinicians (90, 74.4%) preferred central venous catheter for parenteral nutrition. the most important criteria for the choice of parenteral nutritional solution were reported as calories per volume and presence of the solution at the hospital by all clinicians. Among the clinicians following the guidelines, 70% were administering fish oil, 95% were administering glutamin to their patients. Among the clinicians not following the guidelines, these ratios were 44% and 80%, respectively (p=0.01 and 0.02). Conclusion: We are in opinion that following the guidelines instead of the clinician's individual forecasts may improve the nutritional therapy

Gender - didactics - interpretation : school Polish philology after performative turn

WOS: 000441502600010PubMed: 30005810Background and objectives: We compared the efficiency of the King Vision video laryngoscope and the Macintosh laryngoscope, when used by experienced anesthesiologists on adult patients with varying intubating conditions, in a prospective randomized controlled clinical trial. Methods: A total of 388 patients with an American Society of Anesthesiologists physical status of I or II, scheduled for general anesthesia with endotracheal intubation. Each patient was intubated with both laryngoscopes successively, in a randomized order. Intubation success rate, time to best glottic view, time to intubation, time to ventilation, Cormack-Lehane laryngoscopy grades, and complications related to the laryngoscopy and intubation were analyzed. Results and conclusions: First pass intubation success rates were similar for the King Vision and the Macintosh (96.6% vs. 94.3%, respectively, p > 0.05). King Vision resulted in a longer average time to glottic view (95% CI 0.5-1.4s, p < 0.001), and time to intubation (95% CI 3-4.6s, p< 0.001). the difference in time to intubation was similar when unsuccessful intubation attempts were excluded (95% CI 2.8-4.4s, p <0.001). Based on the modified Mallampati class at the preoperative visit, the King Vision improved the glottic view in significantly more patients (220 patients, 56.7%) compared with the Macintosh (180 patients, 46.4%) (p< 0.001). None of the patients had peripheral oxygen desaturation below 94%. Experienced anesthesiologists may obtain similar rates of first pass intubation success and airway trauma with both laryngoscopes. King Vision requires longer times to visualize the glottis and to intubate the trachea, but does not cause additional desaturation. (C) 2018 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda

Avaliação in vitro das propriedades antimicrobianas de vasopressores

Justificativa e objetivo: os medicamentos administrados como perfus&#227;o intravenosa podem ser contaminados durante as v&#225;rias etapas de produ&#231;&#227;o ou prepara&#231;&#227;o. No entanto, estudos sobre os efeitos antibacterianos de vasopressores s&#227;o muito raros. Este estudo investiga a atividade antimicrobiana in vitro das formas de vasopressores usados clinicamente. Materiais e m&#233;todos: atividades antimicrobianas in vitro de subst&#226;ncias vasopressoras de diferentes concentra&#231;&#245;es foram investigadas com o uso da t&#233;cnica de microdilui&#231;&#227;o. Os microrganismos empregados no teste foram: Escherichia coli ATCC 25922, Yersinia pseudotuberculosis ATCC 911, Pseudomonas aeruginosa ATCC 10145, Listeria monocytogenes ATCC 43251, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Bacillus cereus 702 Roma, Mycobacterium smegmatis ATCC607, Candida albicans ATCC 60193 e Saccharomyces cerevisiae RSKK 251. Os ensaios antibacterianos foram feitos em caldo de cultura Mueller-Hinton (pH 7,3) e os ensaios antif&#250;ngicos em solu&#231;&#227;o tamp&#227;o de base nitrogenada para levedura (pH 7,0). Resultados: duas prepara&#231;&#245;es diferentes de dopamina mostraram atividade antimicrobiana. Nenhuma outra subst&#226;ncia do estudo mostrou qualquer atividade antimicrobiana. Conclus&#245;es: em nossa opini&#227;o, os efeitos antibacterianos da dopamina podem ser vantajosos para inibir a propaga&#231;&#227;o de contamina&#231;&#227;o bacteriana durante a prepara&#231;&#227;o das solu&#231;&#245;es para perfus&#227;o. Contudo, salientamos a import&#226;ncia do seguimento rigoroso das diretrizes de esteriliza&#231;&#227;o dos equipamentos e de assepsia durante todos os procedimentos feitos em unidades de terapia intensiva

Chronic Abdominal Pain in a Patient with Escobar Syndrome

Erdivanli, Basar/0000-0002-3955-8242WOS: 000348046600011PubMed: 25196531Escobar syndrome is characterized with multiple pterygia or webs of the skin and multiple congenital anomalies. We present a 15-year-old patient with Escobar syndrome who complained of persistent blunt abdominal pain for 1 year. Preoperative evaluation confirmed the diagnosis of imperforate hymen, and the patient underwent hymenectomy under intravenous sedation. the patient's postoperative course was uneventful and her complaints resolved completely. After a 3-month follow-up, she reported having normal menstrual bleeding intervals each month without any complications. Patients with Escobar syndrome may suffer from abdominal pain due to imperforate hymen. Careful evaluation of these patients must include a complete gynaecological assessment and, if indicated, surgical treatment must be performed without delay. (C) 2014 S. Karger AG, Base

Complication of Peribulbar Block: Brainstem Anaesthesia

WOS: 000410003200009PubMed: 28868171Peribulbar block is used to obtain anaesthesia and akinesia of the eye by injecting a local anaesthetic around the musclecone. A patient scheduled for cataract surgery received peribulbar block with 6 mL of 2% lidocaine hydrochloride. Following the injection, confusion, hypotension and dilatation of the contralateral pupil rapidly progressed to loss of consciousness and respiratory arrest. the patient was intubated and mechanically ventilated for 30 min. the patient regained her consciousness, was extubated and transferred to the intensive care unit for further follow-up. Although brainstem anaesthesia because of peribulbar block is very rare, this procedure should be performed with complete monitorisation and resuscitation equipment