Relationship of glycemic control and diabetes duration with fibromyalgia in patients with type 2 diabetes mellitus

Aim: Fibromyalgia (FM) is a syndrome characterized by chronic widespread musculoskeletal pain, presence of specific tender points and other somatic symptoms. The objective of the present study was to identify the association of glycemic control and diabetes duration with FM based on 2016 American College of Rheumatology (ACR) criteria in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 275 consecutive patients with T2DM admitted to a university hospital setting were included in this cross-sectional study. FM was diagnosed based on ACR 2016 criteria in all patients. Age, gender, diabetes duration, and body mass index (BMI) were recorded and metabolic parameters were determined in all participants. Results: HbA1c and fasting blood glucose were not significantly different between patients with FM and without FM. Diabetes duration was independently associated with FM in patients with T2 DM. Conclusions: Development of FM in patients with T2DM was not associated with glycemic control but associated with diabetes duration. Clinicians should be aware of the possibility of concomitant FM in long term diabetes patients complaining of pain, fatigue and cognitive symptoms because of its devastating effect on quality of life

A study on marital relationship and marital life satisfaction with regard to values of marital couplesEvlilik içi ilişki ile evlilikteki yaşam doyumunun evli çiftlerin değerleri açısından incelenmesi

The aim of this study is to investigate the life satisfaction and marital relationships of married couples with regard to values of them. This study is based on relational scanning model. The scope of this study is composed of married couples living in Konya. The sample of this study consists of voluntarily adults, selected by convenience sampling approach. The sample of this study composed of totally 554 married couples, 377 females (68.1 %) and 177 males (31.9 %). Schwartz Value Survey, Marital Self-efficacy Scale and Marital Life Scale were used in this study. SPSS 16.00 was used to analyze the data.  Pearson product moment correlation coefficient was also used to determine the relationships among marital relationships, marital life satisfaction and values of married couples. A multiple linear regression analysis was used to predict whether the value of married couples explains significantly marital relationships and marital life satisfaction. Results indicated that marital life satisfaction was found to positively and significantly correlate with power, stimulation, benevolence and security sub-dimensions of Schwartz Value Survey. Also, achievement, hedonism, stimulation, universalism, tradition and conformity sub-dimensions of Schwartz Value Survey predicted to marital life satisfaction. ÖzetBu araştırmanın amacı, evlilik içi ilişki ile evlilikte yaşam doyumunun evli çiftlerin değerleri açısından incelenmesidir. Araştırma, ilişkisel tarama modeline uygun olarak yapılmıştır. Araştırmanın evreni Konya da yaşayan evli çiftlerden oluşmaktadır. Örneklem grubu ise araştırmaya gönüllü olarak katılan yetişkinlerden uygun (convenience) örnekleme yöntemi ile seçilmiştir. Örneklem, 377’ si (%68.1) kadın ve 177’ü (%31.9.) erkek olmak üzere 554 evli yetişkinden oluşmaktadır. Araştırmada, Schwartz Değerler Listesi, Evlilikte Öz-yetkinlik Ölçeği ve Evlilik Yaşamı Ölçeği kullanılmıştır. Araştırmada uygulanan ölçeklerden elde edilen verilerin değerlendirilmesi SPSS 16.00 paket programı kullanılarak yapılmıştır. Evli çiftlerin, değerler ile evlilik yaşamı doyumu ve evlilik ilişkisi arasındaki ilişkinin ortaya konulmasında Pearson Momentler Çarpımı Korelasyonu tekniği kullanılmıştır. Evli çiftlerin değerlerinin, evlilik içi ilişki ile evlilikteki yaşam doyumunu anlamlı düzeyde açıklayıp açıklamadığı ise çoklu doğrusal regresyon analizi ile test edilmiştir. Araştırmadan elde edilen bulgulara bakıldığında, evlilik yaşamı doyumunun, değerler ölçeğinin alt boyutlarından güç, uyarılma, yardımseverlik ve güven ile pozitif yönde anlamlı bir ilişki bulunmuştur. Ayrıca değerler ölçeğinin başarı,  hazcılık, uyarılma, evrensellik, geleneksellik ve uyum alt boyutlarının evlilik yaşamı doyumunu yordadığı görülmektedir

Clinical Course of Hyperprolactinemia in Children and Adolescents: A Review of 21 Cases

Objective: Hyperprolactinemia may be due to various etiological factors and may present with different signs and symptoms. It is relatively less frequent in childhood than in adulthood. The aim of this study was to evaluate retrospectively the clinical course and outcome of hyperprolactinemia in pediatric patients

The impact of low molecular weight heparin on obstetric outcomes among unexplained recurrent miscarriages complicated with methylenetetrahydrofolate reductase gene polymorphism

Objectives: The association between methylenetetrahydrofolate reductase gene polymorphisms and unexplained recurrent miscarriage is elusive. The recommendations for improving pregnancy outcomes in these patients keep changing based on the available evidence. The aim of this study is to analyze the impact of low molecular weight heparin on obstetric outcomes of recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphism. Material and methods: We reviewed medical records of 121 patients with a history of recurrent miscarriage complicated by methylenetetrahydrofolate reductase gene polymorphisms, retrospectively. From among them, 68 patients were treated only with folic acid and iron. The remaining 53 patients were treated with folic acid, iron and prophylactic doses of low molecular weight heparin. The subsequent pregnancy outcomes of these patients were noted. Results: The live birth rate was higher in patients with anticoagulant therapy than in patients without anticoagulant therapy (48.5% vs. 69.8%, respectively, p: 0.015) and the congenital anomaly rate was lower in anticoagulant therapy group (17.6% vs. 3.8%, respectively, p: 0.022). The other obstetric outcomes were found to be similar between the two groups. Conclusions: The current study demonstrated that low molecular weight heparin improved the live birth rates among unex­plained recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphisms. How­ever, the routine use of low molecular weight heparin did not improve the late pregnancy complications in these selected patients in the eastern region of our country. Further studies are needed to discriminate the effect of anticoagulation on the live birth rate of each of methylenetetrahydrofolate reductase gene polymorphism type

Are there fetal stem cells in the maternal brain?

GUZEL, Ali irfan/0000-0002-9720-5920; Tunc, Erdal/0000-0003-4964-1004;WOS: 000317029800002PubMed: 25206703Fetal cells can enter maternal blood during pregnancy but whether they can also cross the blood-brain barrier to enter the maternal brain remains poorly understood. Previous results suggest that fetal cells are summoned to repair damage to the mother's brain. If this is confirmed, it would open up new and safer avenues of treatment for brain damage caused by strokes and neural diseases. in this study, we aimed to investigate whether a baby's stem cells can enter the maternal brain during pregnancy. Deceased patients who had at least one male offspring and no history of abortion and blood transfusion were included in this study. DNA was extracted from brain tissue samples of deceased women using standard phenol-chloroform extraction and ethanol precipitation methods. Genomic DNA was screened by quantitative fluorescent-polymerase chain reaction amplification together with short tandem repeat markers specific to the Y chromosome, and 13, 18, 21 and X. Any foreign DNA residues that could be used to interpret the presence of fetal stem cells in the maternal brain were monitored. Results indicated that fetal stem cells can not cross the blood-brain barrier to enter the maternal brain.Research Funds of University of Cukurova, TurkeyCukurova UniversityThe study was supported by Research Funds of University of Cukurova, Turkey

Tick bite cases among hazelnut farm workers in Giresun

Ticks are arthropod vectors of many diseases. The prevalence of Lyme disease transmitted by Ixodes is not known in Turkey. The disease is caused by Borrelia species and can also be seen in domestic animals. The aim of this study is to identify the ticks, which are collected from the agricultural workers who admitted to hospitals during the hazelnut harvest season between August and September 2015, at species and genus level and investigate whether these ticks vector of Borrelia spp. Method: In this study, 152 ticks collected from 134 patients were investigated. Of all samples including larvae and nymphs, 95.24% were collected in September. All patients who admitted with complaints of tick bites were agricultural workers collecting nuts in the gardens at sea level. The ticks were identified at species and genus level with stereomicroskop, hemolymph fluid examined directly by dark-field microscope and cultured in the Borellia BarbourStoenner-Kelly (BSK-H) medium. Results: Of all the ticks, 126 (82.9%) were adults, 13 (8.55%) were nymphs and 13 (8.55%) were larvae. Stereoscopic examination of the ticks revealed that 125 (82.2%) of the adults were Ixodes ricinus and 1 (0.65%) was Rhipicephalus sanguineus. All of the 13 nymphs (8.55%) and 13 larvae (8.55%) were identified as Ixodes spp.. All forms of development cycle were detected in the samples and the forms were inconsistent with the expected development cycle. Borrelia spp., the agent of Lyme disease, was investigated in the 146 ticks defined as I. ricinus and Ixodes spp. Borrelia spp were detected by dark field microscope in 3 (2.05%) of the 146 Ixodes and Borrelia spp. were identified in 5 (3.4%) of the cultures. Conclusions: These results demonstrate that Lyme disease can be seen in our region and the most probable vector is Ixodes ricinus

Resolution of Autoimmune Oophoritis after Thymectomy in a Myasthenia Gravis Patient

Myasthenia gravis (MG) is an autoimmune disorder characterized by autoantibodies against acetylcholine receptors. MG is generally an isolated disorder but may occur concomitantly with other autoimmune diseases. We describe an eighteen-year-old girl with MG who was admitted to our clinic with secondary amenorrhea and diagnosed as autoimmune oophoritis. Since her myasthenic symptoms did not resolve with anticholinesterase therapy, thymectomy was performed. After thymectomy, her menses have been regular without any hormonal replacement therapy. To our knowledge, this is the first report on a patient with autoimmune ovarian insufficiency and MG in whom premature ovarian insufficiency resolved after thymectomy, without hormonal therapy

Orthopedic Treatment of Skeletal Class III Malocclusions With Maxillary Deficiency

Objective:The purpose of this study was to compare the treatment effects of a double-plate appliance (DPA) and a double-plate appliance and facemask combination (DPA-FM) in correcting Class III malocclusions.Materials and Methods:The material consisted of lateral cephalometric radiographs of 40 children with skeletal and dental Class III malocclusion. In the first treatment group, 13 patients (mean age: 10 years 3 months) were treated with DPA. In the second treatment group, 15 patients (mean age: 10 years 9 months) were treated with DPA-FM. In the third group, 12 patients (mean age: 10 years 6 months) were observed without treatment for 9 months. Statistical evaluation was made by ANOVA, Duncan, and paired t tests.Results:The increases in SNA and ANB angles were significantly greater in the DPA-FM group than in the DPA group. The proclination of upper incisors (U1/NA) and retroclination of lower incisors (L1/NB) were significantly greater in the DPA group than in the DPA-FM group. The retroclination of lower incisors (L1/NB) in the DPA group showed a significant difference compared with the control group. The increase in ANS-Me length was significantly greater in the DPA-FM group than in the control group.Conclusion:The DPA-FM treatment was more effective in sagittal correction of the maxilla than the DPA treatment. The dental contribution to Class III treatment seemed to be greater in the DPA group, but in this group vertical skeletal changes were more satisfying

A genomic snapshot of demographic and cultural dynamism in Upper Mesopotamia during the Neolithic Transition

Upper Mesopotamia played a key role in the Neolithic Transition in Southwest Asia through marked innovations in symbolism, technology, and foodways. We present thirteen ancient genomes (c.8500-7500 calBCE) from Pre-Pottery Neolithic Çayönü in the Tigris basin together with bioarchaeological and material culture data. Our findings reveal that Çayönü was a genetically diverse population, carrying a mixed ancestry from western and eastern Fertile Crescent, and that the community received immigrants. Our results further suggest that the community was organised along biological family lines. We document bodily interventions such as head-shaping and cauterization among the individuals examined, reflecting Çayönü's cultural ingenuity. Finally, we identify Upper Mesopotamia as the likely source of eastern gene flow into Neolithic Anatolia, in line with material culture evidence. We hypothesise that Upper Mesopotamia's cultural dynamism during the Neolithic Transition was the product not only of its fertile lands but also of its interregional demographic connections